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ONTOLOGY REPORT - ANNOTATIONS


Term:levamisole
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Accession:CHEBI:6432 term browser browse the term
Definition:A 6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazole that has S configuration. It is used (generally as the monohydrochloride salt) to treat parasitic worm infections in pigs, sheep and cattle and was formerly used in humans as an adjuvant to chemotherapy for the treatment of various cancers. It is also widely used as an adulterant to coccaine.
Synonyms:exact_synonym: (6S)-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazole
 related_synonym: (-)-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazole;   (-)-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole;   (-)-tetramisole;   (S)-(-)-levamisole;   (S)-(-)-tetramisole;   (S)-2,3,5,6-tetrahydro-6-phenylimidazo[2,1-b]thiazole;   Formula=C11H12N2S;   InChI=1S/C11H12N2S/c1-2-4-9(5-3-1)10-8-13-6-7-14-11(13)12-10/h1-5,10H,6-8H2/t10-/m1/s1;   InChIKey=HLFSDGLLUJUHTE-SNVBAGLBSA-N;   Ketrax;   Lepuron;   Levomysol;   Levovermax;   SMILES=C1CN2C[C@@H](N=C2S1)c1ccccc1;   Totalon;   Wormicid;   levamisol;   levamisolum
 xref: CAS:14769-73-4;   DrugBank:DB00848;   Drug_Central:1561;   HMDB:HMDB0014986;   KEGG:C07070;   KEGG:D08114;   LINCS:LSM-6655
 xref_mesh: MESH:D007978
 xref: PMID:10701095;   PMID:12232676;   PMID:12749943;   PMID:15109274;   PMID:1618599;   PMID:17608969;   PMID:189006;   PMID:2050823;   PMID:22337783;   PMID:22607692;   PMID:23041983;   PMID:23152411;   PMID:23543977;   PMID:23577329;   PMID:23649929;   PMID:23921349;   PMID:24365689;   PMID:24440755;   PMID:365327;   PMID:366135;   PMID:366137;   PMID:669135;   PMID:6995092;   PMID:6995094;   PMID:7051554;   PMID:827785;   Patent:US3274209;   Patent:US3565907;   Patent:US3579530;   Reaxys:4233256;   VSDB:1798;   Wikipedia:Levamisole
 cyclic_relationship: is_enantiomer_of CHEBI:77282


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levamisole term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Alpl alkaline phosphatase, biomineralization associated JBrowse link 5 156,086,496 156,141,513 RGD:6480464
G Atg5 autophagy related 5 JBrowse link 20 49,301,783 49,393,147 RGD:6480464
G Atg7 autophagy related 7 JBrowse link 4 146,570,113 146,777,093 RGD:6480464
G Bak1 BCL2-antagonist/killer 1 JBrowse link 20 5,609,620 5,618,899 RGD:6480464
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:6480464
G Becn1 beclin 1 JBrowse link 10 89,209,944 89,225,297 RGD:6480464
G Cldn1 claudin 1 JBrowse link 11 77,815,216 77,830,373 RGD:6480464
G Clu clusterin JBrowse link 15 42,626,612 42,665,858 RGD:6480464
G Dcc DCC netrin 1 receptor JBrowse link 18 66,518,213 67,629,801 RGD:6480464
G Edn1 endothelin 1 JBrowse link 17 22,136,814 22,143,745 RGD:6480464
G Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 JBrowse link 1 21,748,201 21,813,205 RGD:6480464
G Fos Fos proto-oncogene, AP-1 transcription factor subunit JBrowse link 6 109,300,433 109,303,299 RGD:6480464
G Foxp3 forkhead box P3 JBrowse link X 15,753,175 15,768,648 RGD:6480464
G Gata3 GATA binding protein 3 JBrowse link 17 72,419,752 72,452,043 RGD:6480464
G Ifng interferon gamma JBrowse link 7 61,337,383 61,341,419 RGD:6480464
G Il15 interleukin 15 JBrowse link 19 23,542,606 23,624,366 RGD:6480464
G Il17a interleukin 17A JBrowse link 9 26,841,299 26,844,786 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:6480464
G Il2 interleukin 2 JBrowse link 2 123,847,150 123,851,854 RGD:6480464
G Il21 interleukin 21 JBrowse link 2 123,965,021 123,972,356 RGD:6480464
G Il23a interleukin 23 subunit alpha JBrowse link 7 2,710,609 2,712,723 RGD:6480464
G Il4 interleukin 4 JBrowse link 10 38,963,979 38,969,531 RGD:6480464
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:6480464
G Nos3 nitric oxide synthase 3 JBrowse link 4 7,321,908 7,342,404 RGD:6480464
G Phex phosphate regulating endopeptidase homolog, X-linked JBrowse link X 40,460,047 40,717,982 RGD:6480464
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 13 67,351,230 67,356,920 RGD:6480464
G Rb1 RB transcriptional corepressor 1 JBrowse link 15 55,081,582 55,209,060 RGD:6480464
G Rela RELA proto-oncogene, NF-kB subunit JBrowse link 1 220,992,770 221,003,249 RGD:6480464
G Rorc RAR-related orphan receptor C JBrowse link 2 195,612,471 195,636,797 RGD:6480464
G Tbx21 T-box transcription factor 21 JBrowse link 10 85,032,799 85,049,331 RGD:6480464
G Tgfb3 transforming growth factor, beta 3 JBrowse link 6 109,913,757 109,936,217 RGD:6480464
G Tjp1 tight junction protein 1 JBrowse link 1 126,146,489 126,515,359 RGD:6480464
G Tlr2 toll-like receptor 2 JBrowse link 2 182,840,171 182,846,061 RGD:6480464
G Tlr6 toll-like receptor 6 JBrowse link 14 45,024,351 45,041,188 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19790
    role 19738
      biological role 19737
        immunomodulator 13696
          levamisole 36
            tetramisole 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19790
    subatomic particle 19788
      composite particle 19788
        hadron 19788
          baryon 19788
            nucleon 19788
              atomic nucleus 19788
                atom 19788
                  main group element atom 19674
                    p-block element atom 19674
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic molecule 19483
                              organic cyclic compound 19246
                                organic heterocyclic compound 18366
                                  organic heteropolycyclic compound 17709
                                    organic heterobicyclic compound 16486
                                      imidazothiazole 107
                                        6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazole 36
                                          levamisole 36
                                            tetramisole 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.