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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:levamisole
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Accession:CHEBI:6432 term browser browse the term
Definition:A 6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazole that has S configuration. It is used (generally as the monohydrochloride salt) to treat parasitic worm infections in pigs, sheep and cattle and was formerly used in humans as an adjuvant to chemotherapy for the treatment of various cancers. It is also widely used as an adulterant to coccaine.
Synonyms:exact_synonym: (6S)-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazole
 related_synonym: (-)-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazole;   (-)-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole;   (-)-tetramisole;   (S)-(-)-levamisole;   (S)-(-)-tetramisole;   (S)-2,3,5,6-tetrahydro-6-phenylimidazo[2,1-b]thiazole;   Formula=C11H12N2S;   InChI=1S/C11H12N2S/c1-2-4-9(5-3-1)10-8-13-6-7-14-11(13)12-10/h1-5,10H,6-8H2/t10-/m1/s1;   InChIKey=HLFSDGLLUJUHTE-SNVBAGLBSA-N;   Ketrax;   Lepuron;   Levomysol;   Levovermax;   SMILES=C1CN2C[C@@H](N=C2S1)c1ccccc1;   Totalon;   Wormicid;   levamisol;   levamisolum
 xref: CAS:14769-73-4;   DrugBank:DB00848;   Drug_Central:1561;   HMDB:HMDB0014986;   KEGG:C07070;   KEGG:D08114;   LINCS:LSM-6655
 xref_mesh: MESH:D007978
 xref: PMID:10701095;   PMID:12232676;   PMID:12749943;   PMID:15109274;   PMID:1618599;   PMID:17608969;   PMID:189006;   PMID:2050823;   PMID:22337783;   PMID:22607692;   PMID:23041983;   PMID:23152411;   PMID:23543977;   PMID:23577329;   PMID:23649929;   PMID:23921349;   PMID:24365689;   PMID:24440755;   PMID:365327;   PMID:366135;   PMID:366137;   PMID:669135;   PMID:6995092;   PMID:6995094;   PMID:7051554;   PMID:827785;   Patent:US3274209;   Patent:US3565907;   Patent:US3579530;   Reaxys:4233256;   VSDB:1798;   Wikipedia:Levamisole
 cyclic_relationship: is_enantiomer_of CHEBI:77282


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levamisole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alpl alkaline phosphatase, biomineralization associated multiple interactions
decreases activity
increases response to substance
ISO Levamisole inhibits the reaction [beta-glycerophosphoric acid results in increased activity of ALPL protein]; Levamisole inhibits the reaction [beta-glycerophosphoric acid results in increased expression of ALPL mRNA]
Levamisole results in decreased activity of ALPL protein
ALPL gene mutant form results in increased susceptibility to Levamisole
[ALPL gene mutant form results in increased susceptibility to Levamisole] which results in increased expression of FOS mRNA
CTD PMID:18500657 PMID:27466191 NCBI chr 5:156,086,496...156,141,513
Ensembl chr 5:156,086,497...156,141,537
JBrowse link
G Atg5 autophagy related 5 multiple interactions ISO Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of ATG5 protein] CTD PMID:32151603 NCBI chr20:49,301,783...49,393,147
Ensembl chr20:49,318,308...49,393,140
JBrowse link
G Atg7 autophagy related 7 multiple interactions ISO Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of ATG7 protein] CTD PMID:32151603 NCBI chr 4:146,570,113...146,777,093
Ensembl chr 4:146,598,413...146,777,124
JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases expression ISO Levamisole results in increased expression of BAK1 protein CTD PMID:11139434 NCBI chr20:5,609,620...5,618,899
Ensembl chr20:5,609,625...5,618,260
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Levamisole results in decreased expression of BCL2 protein CTD PMID:11139434 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Becn1 beclin 1 multiple interactions ISO Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of BECN1 protein] CTD PMID:32151603 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297
JBrowse link
G Cldn1 claudin 1 multiple interactions ISO Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of CLDN1 protein] CTD PMID:32151603 NCBI chr11:77,815,216...77,830,373
Ensembl chr11:77,815,181...77,830,416
JBrowse link
G Clu clusterin decreases expression ISO Levamisole results in decreased expression of CLU mRNA CTD PMID:11139434 NCBI chr15:42,626,612...42,665,858
Ensembl chr15:42,640,146...42,665,857
JBrowse link
G Dcc DCC netrin 1 receptor multiple interactions ISO DCC protein results in increased susceptibility to [Fluorouracil co-treated with Levamisole] CTD PMID:15148649 NCBI chr18:66,518,213...67,629,801
Ensembl chr18:66,523,120...67,224,566
JBrowse link
G Edn1 endothelin 1 decreases expression ISO Levamisole results in decreased expression of EDN1 mRNA CTD PMID:11139434 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 multiple interactions ISO Levamisole inhibits the reaction [beta-glycerophosphoric acid results in increased activity of ENPP1 protein]; Levamisole inhibits the reaction [beta-glycerophosphoric acid results in increased expression of ENPP1 mRNA] CTD PMID:18500657 NCBI chr 1:21,748,201...21,813,205
Ensembl chr 1:21,748,261...21,813,371
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO [ALPL gene mutant form results in increased susceptibility to Levamisole] which results in increased expression of FOS mRNA CTD PMID:27466191 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Foxp3 forkhead box P3 multiple interactions ISO Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of FOXP3 protein] CTD PMID:32151603 NCBI chr  X:15,753,175...15,768,648
Ensembl chr  X:15,753,175...15,768,522
JBrowse link
G Gata3 GATA binding protein 3 multiple interactions ISO Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of GATA3 protein] CTD PMID:32151603 NCBI chr17:72,419,752...72,452,043
Ensembl chr17:72,429,618...72,450,681
JBrowse link
G Ifng interferon gamma multiple interactions
increases expression
ISO
EXP
Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of IFNG mRNA]; Levamisole inhibits the reaction [Cyclophosphamide results in decreased secretion of IFNG protein]
Levamisole results in increased expression of IFNG mRNA; Levamisole results in increased expression of IFNG protein
CTD PMID:10886398 PMID:23395935 PMID:32151603 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il15 interleukin 15 multiple interactions ISO Levamisole inhibits the reaction [Cyclophosphamide results in decreased secretion of IL15 protein] CTD PMID:23395935 NCBI chr19:23,542,606...23,624,366
Ensembl chr19:23,542,889...23,554,594
JBrowse link
G Il17a interleukin 17A multiple interactions ISO Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of IL17A protein] CTD PMID:32151603 NCBI chr 9:26,841,299...26,844,786
Ensembl chr 9:26,841,299...26,844,786
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of IL1B protein] CTD PMID:32151603 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il2 interleukin 2 multiple interactions ISO Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of IL2 mRNA]; Levamisole inhibits the reaction [Cyclophosphamide results in decreased secretion of IL2 protein] CTD PMID:23395935 PMID:32151603 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Il21 interleukin 21 multiple interactions ISO Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of IL21 protein] CTD PMID:32151603 NCBI chr 2:123,965,021...123,972,356
Ensembl chr 2:123,965,021...123,972,356
JBrowse link
G Il23a interleukin 23 subunit alpha multiple interactions ISO Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of IL23A protein]; Levamisole inhibits the reaction [Cyclophosphamide results in decreased secretion of IL23A protein] CTD PMID:23395935 PMID:32151603 NCBI chr 7:2,710,609...2,712,723
Ensembl chr 7:2,710,609...2,712,723
JBrowse link
G Il4 interleukin 4 multiple interactions
decreases expression
EXP
ISO
Levamisole inhibits the reaction [Mercuric Chloride results in increased expression of IL4 mRNA]
Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of IL4 protein]
Levamisole results in decreased expression of IL4 mRNA
CTD PMID:10886398 PMID:32151603 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Levamisole inhibits the reaction [Cyclophosphamide results in decreased secretion of IL6 protein] CTD PMID:23395935 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Nos3 nitric oxide synthase 3 decreases expression ISO Levamisole results in decreased expression of NOS3 protein CTD PMID:11139434 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Phex phosphate regulating endopeptidase homolog, X-linked multiple interactions ISO Levamisole inhibits the reaction [beta-glycerophosphoric acid results in increased expression of PHEX mRNA] CTD PMID:18500657 NCBI chr  X:40,460,047...40,717,982
Ensembl chr  X:40,460,047...40,717,982
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO Levamisole inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; Levamisole inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:15047127 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions
decreases expression
ISO Acetylcysteine inhibits the reaction [Levamisole results in decreased expression of RB1 protein]; Glutathione inhibits the reaction [Levamisole results in decreased expression of RB1 protein] CTD PMID:11139434 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Levamisole inhibits the reaction [Lipopolysaccharides affects the localization of and results in increased activity of RELA protein] CTD PMID:15047127 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rorc RAR-related orphan receptor C multiple interactions ISO Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of RORC protein] CTD PMID:32151603 NCBI chr 2:195,612,471...195,636,797
Ensembl chr 2:195,617,021...195,637,630
JBrowse link
G Tbx21 T-box transcription factor 21 multiple interactions ISO Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of TBX21 protein] CTD PMID:32151603 NCBI chr10:85,032,799...85,049,331
Ensembl chr10:85,032,799...85,049,331
JBrowse link
G Tgfb3 transforming growth factor, beta 3 multiple interactions ISO Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of TGFB3 protein] CTD PMID:32151603 NCBI chr 6:109,913,757...109,936,217
Ensembl chr 6:109,913,757...109,935,533
JBrowse link
G Tjp1 tight junction protein 1 multiple interactions ISO Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of TJP1 protein] CTD PMID:32151603 NCBI chr 1:126,146,489...126,515,359
Ensembl chr 1:126,146,489...126,227,469
JBrowse link
G Tlr2 toll-like receptor 2 multiple interactions ISO Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of TLR2 mRNA] CTD PMID:32151603 NCBI chr 2:182,840,171...182,846,061
Ensembl chr 2:182,840,727...182,846,061
JBrowse link
G Tlr6 toll-like receptor 6 multiple interactions ISO Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of TLR6 mRNA] CTD PMID:32151603 NCBI chr14:45,024,351...45,041,188
Ensembl chr14:45,024,351...45,046,446
JBrowse link
G Tnf tumor necrosis factor decreases expression ISO Levamisole results in decreased expression of TNF protein CTD PMID:17397355 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 decreases expression ISO Levamisole results in decreased expression of TP53 mRNA; Levamisole results in decreased expression of TP53 protein CTD PMID:11139434 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19786
    role 19732
      biological role 19732
        immunomodulator 14901
          levamisole 36
            tetramisole 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19786
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19675
                    p-block element atom 19675
                      carbon group element atom 19596
                        carbon atom 19586
                          organic molecular entity 19586
                            organic molecule 19519
                              organic cyclic compound 19349
                                organic heterocyclic compound 18574
                                  organic heteropolycyclic compound 18065
                                    organic heterobicyclic compound 16858
                                      imidazothiazole 107
                                        6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazole 36
                                          levamisole 36
                                            tetramisole 0
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