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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:febuxostat
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Accession:CHEBI:31596 term browser browse the term
Definition:A 1,3-thiazolemonocarboxylic acid that is 4-methyl-1,3-thiazole-5-carboxylic acid which is substituted by a 3-cyano-4-(2-methylpropoxy)phenyl group at position 2. It is an orally-active, potent, and selective xanthine oxidase inhibitor used for the treatment of chronic hyperuricaemia in patients with gout.
Synonyms:exact_synonym: 2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methyl-1,3-thiazole-5-carboxylic acid
 related_synonym: 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-1,3-thiazole-5-carboxylic acid;   Adenuric;   Donifoxate;   Febuday;   Feburic;   Formula=C16H16N2O3S;   Goturic;   Goutex;   InChI=1S/C16H16N2O3S/c1-9(2)8-21-13-5-4-11(6-12(13)7-17)15-18-10(3)14(22-15)16(19)20/h4-6,9H,8H2,1-3H3,(H,19,20);   InChIKey=BQSJTQLCZDPROO-UHFFFAOYSA-N;   SMILES=C1(=CC(=C(C=C1)OCC(C)C)C#N)C2=NC(=C(S2)C(=O)O)C;   TEI 6720;   TMX-67;   Uloric;   Zurig;   febuxostatum
 alt_id: CHEBI:45943
 xref: CAS:144060-53-7;   DrugBank:DB04854;   Drug_Central:1137;   KEGG:D01206;   LINCS:LSM-3064
 xref_mesh: MESH:D000069465
 xref: PDBeChem:TEI;   PMID:25724536;   PMID:30844048;   PMID:30919894;   PMID:31267805;   PMID:31332638;   PMID:31335677;   PMID:31378626;   PMID:31447893;   PMID:31449565;   PMID:31499267;   PMID:31531831;   PMID:31560952;   Wikipedia:Febuxostat


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febuxostat term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ager advanced glycosylation end product-specific receptor multiple interactions EXP Febuxostat inhibits the reaction [Paraquat results in decreased secretion of AGER protein modified form]; Febuxostat inhibits the reaction [Paraquat results in increased expression of AGER mRNA] CTD PMID:30726711 NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP Febuxostat inhibits the reaction [Doxorubicin results in increased expression of BAX protein] CTD PMID:26036690 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP Febuxostat inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein] CTD PMID:26036690 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 multiple interactions EXP Febuxostat inhibits the reaction [Doxorubicin results in increased expression of CASP3 protein] CTD PMID:26036690 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression ISO Febuxostat results in increased expression of CCL2 mRNA CTD PMID:26641773 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions EXP Febuxostat inhibits the reaction [Paraquat results in increased expression of CTNNB1 protein] CTD PMID:30726711 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Dusp10 dual specificity phosphatase 10 increases expression ISO Febuxostat results in increased expression of DUSP10 mRNA CTD PMID:35866629 NCBI chr13:95,613,716...95,651,716
Ensembl chr13:95,614,292...95,651,716 		JBrowse link
G Dusp4 dual specificity phosphatase 4 increases expression ISO Febuxostat results in increased expression of DUSP4 mRNA CTD PMID:35866629 NCBI chr16:57,376,659...57,398,161
Ensembl chr16:57,377,229...57,398,138 		JBrowse link
G Dusp5 dual specificity phosphatase 5 increases expression ISO Febuxostat results in increased expression of DUSP5 mRNA CTD PMID:35866629 NCBI chr 1:252,538,408...252,555,320
Ensembl chr 1:252,538,449...252,551,818 		JBrowse link
G Dusp8 dual specificity phosphatase 8 increases expression ISO Febuxostat results in increased expression of DUSP8 mRNA CTD PMID:35866629 NCBI chr 1:197,167,392...197,184,285
Ensembl chr 1:197,169,422...197,182,921 		JBrowse link
G Gadd45g growth arrest and DNA-damage-inducible, gamma increases expression ISO Febuxostat results in increased expression of GADD45G mRNA CTD PMID:35866629 NCBI chr17:13,376,842...13,378,587
Ensembl chr17:13,376,839...13,378,610 		JBrowse link
G Got2 glutamic-oxaloacetic transaminase 2 multiple interactions ISO Febuxostat inhibits the reaction [[myelin oligodendrocyte glycoprotein (35-55) co-treated with Freund's Adjuvant] results in decreased expression of GOT2 mRNA]; Febuxostat inhibits the reaction [[myelin oligodendrocyte glycoprotein (35-55) co-treated with Freund's Adjuvant] results in decreased expression of GOT2 protein] CTD PMID:29107957 NCBI chr19:9,174,304...9,199,995
Ensembl chr19:9,174,311...9,199,994 		JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions EXP Febuxostat inhibits the reaction [Paraquat results in increased expression of HMGB1 mRNA] CTD PMID:30726711 NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions EXP Febuxostat inhibits the reaction [Doxorubicin results in increased expression of IKBKB protein] CTD PMID:26036690 NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250 		JBrowse link
G Il1rap interleukin 1 receptor accessory protein increases expression ISO Febuxostat results in increased expression of IL1RAP mRNA CTD PMID:35866629 NCBI chr11:74,062,999...74,199,530
Ensembl chr11:74,070,304...74,199,530 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation ISO Febuxostat results in increased phosphorylation of MAPK8 protein CTD PMID:35866629 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions EXP Febuxostat inhibits the reaction [Paraquat results in increased expression of MMP9 protein] CTD PMID:30726711 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mras muscle RAS oncogene homolog increases expression ISO Febuxostat results in increased expression of MRAS mRNA CTD PMID:35866629 NCBI chr 8:99,944,036...100,006,771
Ensembl chr 8:99,944,036...99,996,408 		JBrowse link
G Nppb natriuretic peptide B multiple interactions EXP Febuxostat inhibits the reaction [Doxorubicin results in increased expression of NPPB protein] CTD PMID:26036690 NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168 		JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 increases expression ISO Febuxostat results in increased expression of NR4A1 mRNA CTD PMID:35866629 NCBI chr 7:132,368,399...132,389,300
Ensembl chr 7:132,374,840...132,389,297 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP Febuxostat inhibits the reaction [Paraquat results in increased expression of PTGS2 mRNA] CTD PMID:30726711 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP Febuxostat inhibits the reaction [Doxorubicin results in increased expression of RELA protein] CTD PMID:26036690 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions EXP Febuxostat inhibits the reaction [Doxorubicin results in decreased expression of SOD2 protein] CTD PMID:26036690 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression		 EXP
ISO		 Febuxostat inhibits the reaction [Doxorubicin results in increased expression of TNF protein]
Febuxostat results in increased expression of TNF mRNA		 CTD PMID:26036690 PMID:26641773 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions EXP Febuxostat inhibits the reaction [Paraquat results in increased expression of VEGFA protein] CTD PMID:30726711 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
G Xdh xanthine dehydrogenase decreases activity ISO Febuxostat results in decreased activity of XDH protein CTD PMID:35866629 NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19834
    chemical entity 19832
      group 19791
        pseudohalo group 4573
          cyano group 4573
            nitrile 4573
              febuxostat 26
Path 2
Term Annotations click to browse term
  CHEBI ontology 19834
    subatomic particle 19832
      composite particle 19832
        hadron 19832
          baryon 19832
            nucleon 19832
              atomic nucleus 19832
                atom 19832
                  main group element atom 19782
                    p-block element atom 19782
                      carbon group element atom 19731
                        carbon atom 19727
                          organic molecular entity 19727
                            organic molecule 19680
                              organic cyclic compound 19493
                                organic heterocyclic compound 18871
                                  heteroarene 17142
                                    monocyclic heteroarene 14874
                                      azole 14379
                                        thiazoles 1789
                                          1,3-thiazoles 1218
                                            1,3-thiazolemonocarboxylic acid 26
                                              febuxostat 26
paths to the root