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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:1,3-thiazolemonocarboxylic acid
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Accession:CHEBI:48652 term browser browse the term
Synonyms:related_synonym: 1,3-thiazolemonocarboxylic acids


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febuxostat term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP Febuxostat inhibits the reaction [Doxorubicin results in increased expression of BAX protein] CTD PMID:26036690 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP Febuxostat inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein] CTD PMID:26036690 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Casp3 caspase 3 multiple interactions EXP Febuxostat inhibits the reaction [Doxorubicin results in increased expression of CASP3 protein] CTD PMID:26036690 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression ISO Febuxostat results in increased expression of CCL2 mRNA CTD PMID:26641773 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Got2 glutamic-oxaloacetic transaminase 2 multiple interactions ISO Febuxostat inhibits the reaction [[myelin oligodendrocyte glycoprotein (35-55) co-treated with Freund's Adjuvant] results in decreased expression of GOT2 mRNA]; Febuxostat inhibits the reaction [[myelin oligodendrocyte glycoprotein (35-55) co-treated with Freund's Adjuvant] results in decreased expression of GOT2 protein] CTD PMID:29107957 NCBI chr19:9,587,637...9,613,323
Ensembl chr19:9,587,653...9,613,340
JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions EXP Febuxostat inhibits the reaction [Doxorubicin results in increased expression of IKBKB protein] CTD PMID:26036690 NCBI chr16:74,177,233...74,230,809
Ensembl chr16:74,177,215...74,230,815
JBrowse link
G Nppb natriuretic peptide B multiple interactions EXP Febuxostat inhibits the reaction [Doxorubicin results in increased expression of NPPB protein] CTD PMID:26036690 NCBI chr 5:164,796,176...164,797,538
Ensembl chr 5:164,796,185...164,797,531
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP Febuxostat inhibits the reaction [Doxorubicin results in increased expression of RELA protein] CTD PMID:26036690 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions EXP Febuxostat inhibits the reaction [Doxorubicin results in decreased expression of SOD2 protein] CTD PMID:26036690 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
EXP
ISO
Febuxostat inhibits the reaction [Doxorubicin results in increased expression of TNF protein]
Febuxostat results in increased expression of TNF mRNA
CTD PMID:26036690, PMID:26641773 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      chemical role 19248
        donor 18377
          Bronsted acid 18240
            oxoacid 18192
              carbon oxoacid 18071
                carboxylic acid 18060
                  monocarboxylic acid 17406
                    1,3-thiazolemonocarboxylic acid 10
                      (4S)-2-[(1Z)-1-aminoprop-1-en-1-yl]-4,5-dihydro-1,3-thiazole-4-carboxylic acid 0
                      (S)-4,5-dihydro-2-(6-hydroxy-1,3-benzothiazol-2-yl)-1,3-thiazole-4-carboxylic acid 0
                      1,3-thiazole-4-carboxylic acid 0
                      5-(1-methylethyl)-2-[(3S)-1,2,3,4-tetrahydroisoquinolin-3-yl]-1,3-thiazole-4-carboxylic acid 0
                      ADP-5-ethyl-4-methylthiazole-2-carboxylic acid 0
                      L-cysteine thiazolecarboxylic acid 0
                      L-lysine thiazolecarboxylic acid 0
                      L-phenylalanine thiazolecarboxylic acid 0
                      L-serine thiazolecarboxylic acid 0
                      Photinus luciferin + 0
                      dehydroluciferin 0
                      ent-Photinus luciferin + 0
                      febuxostat 10
                      firefly sulfoluciferin 0
                      glycine thiazolecarboxylic acid 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic molecule 19486
                              organic cyclic compound 19282
                                organic heterocyclic compound 18407
                                  heteroarene 16445
                                    monocyclic heteroarene 13300
                                      azole 12468
                                        thiazoles 1241
                                          1,3-thiazoles 634
                                            1,3-thiazolemonocarboxylic acid 10
                                              (4S)-2-[(1Z)-1-aminoprop-1-en-1-yl]-4,5-dihydro-1,3-thiazole-4-carboxylic acid 0
                                              (S)-4,5-dihydro-2-(6-hydroxy-1,3-benzothiazol-2-yl)-1,3-thiazole-4-carboxylic acid 0
                                              1,3-thiazole-4-carboxylic acid 0
                                              5-(1-methylethyl)-2-[(3S)-1,2,3,4-tetrahydroisoquinolin-3-yl]-1,3-thiazole-4-carboxylic acid 0
                                              ADP-5-ethyl-4-methylthiazole-2-carboxylic acid 0
                                              L-cysteine thiazolecarboxylic acid 0
                                              L-lysine thiazolecarboxylic acid 0
                                              L-phenylalanine thiazolecarboxylic acid 0
                                              L-serine thiazolecarboxylic acid 0
                                              Photinus luciferin + 0
                                              dehydroluciferin 0
                                              ent-Photinus luciferin + 0
                                              febuxostat 10
                                              firefly sulfoluciferin 0
                                              glycine thiazolecarboxylic acid 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.