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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:1,3-thiazolemonocarboxylic acid
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Accession:CHEBI:48652 term browser browse the term
Synonyms:related_synonym: 1,3-thiazolemonocarboxylic acids


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febuxostat term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ager advanced glycosylation end product-specific receptor multiple interactions EXP Febuxostat inhibits the reaction [Paraquat results in decreased secretion of AGER protein modified form]; Febuxostat inhibits the reaction [Paraquat results in increased expression of AGER mRNA] CTD PMID:30726711 NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP Febuxostat inhibits the reaction [Doxorubicin results in increased expression of BAX protein] CTD PMID:26036690 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP Febuxostat inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein] CTD PMID:26036690 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Casp3 caspase 3 multiple interactions EXP Febuxostat inhibits the reaction [Doxorubicin results in increased expression of CASP3 protein] CTD PMID:26036690 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression ISO Febuxostat results in increased expression of CCL2 mRNA CTD PMID:26641773 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions EXP Febuxostat inhibits the reaction [Paraquat results in increased expression of CTNNB1 protein] CTD PMID:30726711 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Got2 glutamic-oxaloacetic transaminase 2 multiple interactions ISO Febuxostat inhibits the reaction [[myelin oligodendrocyte glycoprotein (35-55) co-treated with Freund's Adjuvant] results in decreased expression of GOT2 mRNA]; Febuxostat inhibits the reaction [[myelin oligodendrocyte glycoprotein (35-55) co-treated with Freund's Adjuvant] results in decreased expression of GOT2 protein] CTD PMID:29107957 NCBI chr19:9,174,304...9,199,995
Ensembl chr19:9,174,311...9,199,994
JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions EXP Febuxostat inhibits the reaction [Paraquat results in increased expression of HMGB1 mRNA] CTD PMID:30726711 NCBI chr12:5,973,062...5,978,565 JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions EXP Febuxostat inhibits the reaction [Doxorubicin results in increased expression of IKBKB protein] CTD PMID:26036690 NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions EXP Febuxostat inhibits the reaction [Paraquat results in increased expression of MMP9 protein] CTD PMID:30726711 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Nppb natriuretic peptide B multiple interactions EXP Febuxostat inhibits the reaction [Doxorubicin results in increased expression of NPPB protein] CTD PMID:26036690 NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP Febuxostat inhibits the reaction [Paraquat results in increased expression of PTGS2 mRNA] CTD PMID:30726711 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP Febuxostat inhibits the reaction [Doxorubicin results in increased expression of RELA protein] CTD PMID:26036690 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions EXP Febuxostat inhibits the reaction [Doxorubicin results in decreased expression of SOD2 protein] CTD PMID:26036690 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
EXP
ISO
Febuxostat inhibits the reaction [Doxorubicin results in increased expression of TNF protein]
Febuxostat results in increased expression of TNF mRNA
CTD PMID:26036690 PMID:26641773 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions EXP Febuxostat inhibits the reaction [Paraquat results in increased expression of VEGFA protein] CTD PMID:30726711 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    role 19769
      chemical role 19345
        donor 18654
          Bronsted acid 18537
            oxoacid 18498
              carbon oxoacid 18378
                carboxylic acid 18373
                  monocarboxylic acid 17636
                    1,3-thiazolemonocarboxylic acid 16
                      (4S)-2-[(1Z)-1-aminoprop-1-en-1-yl]-4,5-dihydro-1,3-thiazole-4-carboxylic acid 0
                      (S)-4,5-dihydro-2-(6-hydroxy-1,3-benzothiazol-2-yl)-1,3-thiazole-4-carboxylic acid 0
                      1,3-thiazole-4-carboxylic acid 0
                      5-(1-methylethyl)-2-[(3S)-1,2,3,4-tetrahydroisoquinolin-3-yl]-1,3-thiazole-4-carboxylic acid 0
                      ADP-5-ethyl-4-methylthiazole-2-carboxylic acid 0
                      L-cysteine thiazolecarboxylic acid 0
                      L-lysine thiazolecarboxylic acid 0
                      L-phenylalanine thiazolecarboxylic acid 0
                      L-serine thiazolecarboxylic acid 0
                      Photinus luciferin + 0
                      dehydroluciferin 0
                      ent-Photinus luciferin + 0
                      febuxostat 16
                      firefly sulfoluciferin 0
                      glycine thiazolecarboxylic acid 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      carbon group element atom 19640
                        carbon atom 19630
                          organic molecular entity 19630
                            organic molecule 19569
                              organic cyclic compound 19360
                                organic heterocyclic compound 18591
                                  heteroarene 16530
                                    monocyclic heteroarene 13437
                                      azole 12628
                                        thiazoles 1712
                                          1,3-thiazoles 1157
                                            1,3-thiazolemonocarboxylic acid 16
                                              (4S)-2-[(1Z)-1-aminoprop-1-en-1-yl]-4,5-dihydro-1,3-thiazole-4-carboxylic acid 0
                                              (S)-4,5-dihydro-2-(6-hydroxy-1,3-benzothiazol-2-yl)-1,3-thiazole-4-carboxylic acid 0
                                              1,3-thiazole-4-carboxylic acid 0
                                              5-(1-methylethyl)-2-[(3S)-1,2,3,4-tetrahydroisoquinolin-3-yl]-1,3-thiazole-4-carboxylic acid 0
                                              ADP-5-ethyl-4-methylthiazole-2-carboxylic acid 0
                                              L-cysteine thiazolecarboxylic acid 0
                                              L-lysine thiazolecarboxylic acid 0
                                              L-phenylalanine thiazolecarboxylic acid 0
                                              L-serine thiazolecarboxylic acid 0
                                              Photinus luciferin + 0
                                              dehydroluciferin 0
                                              ent-Photinus luciferin + 0
                                              febuxostat 16
                                              firefly sulfoluciferin 0
                                              glycine thiazolecarboxylic acid 0
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