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Accession:CHEBI:31596 term browser browse the term
Definition:A 1,3-thiazolemonocarboxylic acid that is 4-methyl-1,3-thiazole-5-carboxylic acid which is substituted by a 3-cyano-4-(2-methylpropoxy)phenyl group at position 2. It is an orally-active, potent, and selective xanthine oxidase inhibitor used for the treatment of chronic hyperuricaemia in patients with gout.
Synonyms:related_synonym: 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-1,3-thiazole-5-carboxylic acid;   2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methyl-1,3-thiazole-5-carboxylic acid;   Donifoxate;   Febuday;   Formula=C16H16N2O3S;   Goturic;   Goutex;   InChI=1S/C16H16N2O3S/c1-9(2)8-21-13-5-4-11(6-12(13)7-17)15-18-10(3)14(22-15)16(19)20/h4-6,9H,8H2,1-3H3,(H,19,20);   InChIKey=BQSJTQLCZDPROO-UHFFFAOYSA-N;   SMILES=C1(=CC(=C(C=C1)OCC(C)C)C#N)C2=NC(=C(S2)C(=O)O)C;   TEI 6720;   TMX-67;   Zurig;   adenuric;   feburic;   febuxostatum;   uloric
 alt_id: CHEBI:45943
 xref: CAS:144060-53-7 "ChemIDplus";   CAS:144060-53-7 "KEGG COMPOUND";   DrugBank:DB04854;   Drug_Central:1137 "DrugCentral";   KEGG:D01206;   LINCS:LSM-3064
 xref_mesh: MESH:D000069465
 xref: PDBeChem:TEI;   PMID:25724536 "Europe PMC";   PMID:30844048 "Europe PMC";   PMID:30919894 "Europe PMC";   PMID:31267805 "Europe PMC";   PMID:31332638 "Europe PMC";   PMID:31335677 "Europe PMC";   PMID:31378626 "Europe PMC";   PMID:31447893 "Europe PMC";   PMID:31449565 "Europe PMC";   PMID:31499267 "Europe PMC";   PMID:31531831 "Europe PMC";   PMID:31560952 "Europe PMC";   Wikipedia:Febuxostat

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febuxostat term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:6480464
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Ccl2 C-C motif chemokine ligand 2 JBrowse link 10 69,412,065 69,413,863 RGD:6480464
G Got2 glutamic-oxaloacetic transaminase 2 JBrowse link 19 9,587,637 9,613,323 RGD:6480464
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta JBrowse link 16 74,177,233 74,230,809 RGD:6480464
G Nppb natriuretic peptide B JBrowse link 5 164,796,176 164,797,538 RGD:6480464
G Rela RELA proto-oncogene, NF-kB subunit JBrowse link 1 220,992,770 221,003,249 RGD:6480464
G Sod2 superoxide dismutase 2 JBrowse link 1 47,914,757 47,921,587 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19716
    chemical entity 19714
      group 19628
        pseudohalo group 2772
          cyano group 2772
            nitrile 2772
              febuxostat 10
Path 2
Term Annotations click to browse term
  CHEBI ontology 19716
    subatomic particle 19712
      composite particle 19712
        hadron 19712
          baryon 19712
            nucleon 19712
              atomic nucleus 19712
                atom 19712
                  main group element atom 19598
                    p-block element atom 19598
                      carbon group element atom 19486
                        carbon atom 19480
                          organic molecular entity 19480
                            organic molecule 19402
                              organic cyclic compound 19158
                                organic heterocyclic compound 18245
                                  heteroarene 15295
                                    monocyclic heteroarene 11645
                                      azole 10501
                                        thiazoles 397
                                          1,3-thiazoles 340
                                            1,3-thiazolemonocarboxylic acid 10
                                              febuxostat 10
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.