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1-ribosylbenzimidazole - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:1-ribosylbenzimidazole
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Accession:CHEBI:47917 term browser browse the term
Synonyms:related_synonym: 1-ribosylbenzimidazoles

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5,6-dichloro-1-beta-D-ribofuranosyl-1H-benzimidazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO Dichlororibofuranosylbenzimidazole inhibits the reaction [mangiferin results in increased expression of ABCB1 protein]; Dichlororibofuranosylbenzimidazole inhibits the reaction [sodium arsenite results in increased expression of ABCB1 protein] CTD PMID:16121039 PMID:20513373 NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase decreases expression
multiple interactions 		ISO Dichlororibofuranosylbenzimidazole results in decreased expression of ABL1 protein
Bortezomib promotes the reaction [Dichlororibofuranosylbenzimidazole results in decreased expression of ABL1 protein] 		CTD PMID:15039284 NCBI chr 3:35,377,587...35,480,843
Ensembl chr 3:14,979,853...15,083,065 		JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO Dichlororibofuranosylbenzimidazole inhibits the reaction [[Tetrachlorodibenzodioxin binds to and results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA] CTD PMID:12917420 NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions
increases expression 		ISO Dexamethasone inhibits the reaction [Dichlororibofuranosylbenzimidazole results in increased expression of BCL2L1 protein] CTD PMID:9326359 NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO Dichlororibofuranosylbenzimidazole inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein co-treated with Cryptoxanthins] promotes the reaction [Zinc Sulfate results in increased expression of CASP3 mRNA]]; Dichlororibofuranosylbenzimidazole inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein co-treated with Zinc Sulfate] promotes the reaction [Cryptoxanthins results in increased expression of CASP3 mRNA]]; Dichlororibofuranosylbenzimidazole inhibits the reaction [Cryptoxanthins promotes the reaction [Zinc Sulfate results in increased expression of CASP3 mRNA]]; Dichlororibofuranosylbenzimidazole inhibits the reaction [Genistein promotes the reaction [[Zinc Sulfate co-treated with CSF1 protein co-treated with TNFSF11 protein] results in increased expression of CASP3 mRNA]]; Dichlororibofuranosylbenzimidazole inhibits the reaction [Genistein promotes the reaction [Zinc Sulfate results in increased expression of CASP3 mRNA]]; Dichlororibofuranosylbenzimidazole inhibits the reaction [Zinc Sulfate promotes the reaction [Cryptoxanthins results in increased expression of CASP3 mRNA]] CTD PMID:17295206 PMID:18636177 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO Dichlororibofuranosylbenzimidazole inhibits the reaction [romidepsin results in increased expression of CDKN1A protein] CTD PMID:15014036 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Ces2h carboxylesterase 2H multiple interactions ISO Dichlororibofuranosylbenzimidazole inhibits the reaction [Methoxsalen results in increased expression of CES2 mRNA]; Dichlororibofuranosylbenzimidazole inhibits the reaction [Rifampin results in increased expression of CES2 mRNA] CTD PMID:17003103 NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830 		JBrowse link
G Cftr CF transmembrane conductance regulator multiple interactions ISO Dichlororibofuranosylbenzimidazole inhibits the reaction [sodium arsenite results in decreased expression of CFTR protein] CTD PMID:16121039 NCBI chr 4:47,422,084...47,694,646
Ensembl chr 4:46,560,885...46,728,756 		JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions ISO Dichlororibofuranosylbenzimidazole inhibits the reaction [Cryptoxanthins results in increased expression of COL1A1 mRNA] CTD PMID:15962303 NCBI chr10:80,380,458...80,397,461
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Csf1 colony stimulating factor 1 multiple interactions ISO Dichlororibofuranosylbenzimidazole inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein co-treated with Cryptoxanthins] promotes the reaction [Zinc Sulfate results in increased expression of CASP3 mRNA]]; Dichlororibofuranosylbenzimidazole inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein co-treated with Zinc Sulfate] promotes the reaction [Cryptoxanthins results in increased expression of CASP3 mRNA]]; Dichlororibofuranosylbenzimidazole inhibits the reaction [Genistein promotes the reaction [[Zinc Sulfate co-treated with CSF1 protein co-treated with TNFSF11 protein] results in increased expression of CASP3 mRNA]] CTD PMID:17295206 PMID:18636177 NCBI chr 2:198,065,400...198,084,774
Ensembl chr 2:195,377,215...195,411,704 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO Dichlororibofuranosylbenzimidazole inhibits the reaction [[Tetrachlorodibenzodioxin binds to and results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA] CTD PMID:12917420 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions EXP Dichlororibofuranosylbenzimidazole inhibits the reaction [Benzo(a)pyrene promotes the reaction [TNF protein results in increased expression of CYP1B1 mRNA]]; Dichlororibofuranosylbenzimidazole inhibits the reaction [Benzo(a)pyrene promotes the reaction [TNF protein results in increased expression of CYP1B1 protein]] CTD PMID:25233930 NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO Dichlororibofuranosylbenzimidazole inhibits the reaction [Methoxsalen results in increased expression of CYP3A4 mRNA]; Dichlororibofuranosylbenzimidazole inhibits the reaction [Rifampin results in increased expression of CYP3A4 mRNA] CTD PMID:17003103 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Fbl fibrillarin affects localization ISO Dichlororibofuranosylbenzimidazole analog affects the localization of FBL protein CTD PMID:10942594 NCBI chr 1:83,469,832...83,478,932
Ensembl chr 1:83,469,832...83,478,932 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO Dichlororibofuranosylbenzimidazole inhibits the reaction [TNF protein results in increased expression of HIF1A protein] CTD PMID:12479793 NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO Dichlororibofuranosylbenzimidazole inhibits the reaction [Hemin results in increased activity of HMOX1 protein]; Dichlororibofuranosylbenzimidazole inhibits the reaction [Hemin results in increased expression of HMOX1 mRNA]; Dichlororibofuranosylbenzimidazole inhibits the reaction [Hemin results in increased expression of HMOX1 protein] CTD PMID:16109301 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hnrnpa1 heterogeneous nuclear ribonucleoprotein A1 multiple interactions
affects localization 		ISO Dichlororibofuranosylbenzimidazole affects the reaction [HNRNPA1 protein binds to CYP2A5 mRNA]
Dichlororibofuranosylbenzimidazole affects the localization of HNRNPA1 protein 		CTD PMID:12754101 NCBI chr 7:136,253,633...136,260,085
Ensembl chr 7:134,375,150...134,381,609 		JBrowse link
G Hnrnpk heterogeneous nuclear ribonucleoprotein K multiple interactions EXP Dichlororibofuranosylbenzimidazole inhibits the reaction [Glycine results in increased expression of HNRNPK mRNA] CTD PMID:24990929 NCBI chr17:6,269,302...6,280,429
Ensembl chr17:6,262,998...6,274,997 		JBrowse link
G Ifnb1 interferon beta 1 multiple interactions ISO Dichlororibofuranosylbenzimidazole inhibits the reaction [IFNB1 protein promotes the reaction [NELFA protein binds to IFIT1 promoter]]; Dichlororibofuranosylbenzimidazole inhibits the reaction [IFNB1 protein promotes the reaction [NELFA protein binds to ISG15 promoter]]; Dichlororibofuranosylbenzimidazole inhibits the reaction [IFNB1 protein promotes the reaction [NELFA protein binds to MX1 promoter]] CTD PMID:23589332 NCBI chr 5:108,066,650...108,067,487
Ensembl chr 5:103,020,969...103,021,523 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO Dichlororibofuranosylbenzimidazole inhibits the reaction [deoxynivalenol promotes the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]]; Dichlororibofuranosylbenzimidazole inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA] CTD PMID:11295263 PMID:12185005 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Isg15 ISG15 ubiquitin-like modifier multiple interactions ISO Dichlororibofuranosylbenzimidazole inhibits the reaction [IFNB1 protein promotes the reaction [NELFA protein binds to ISG15 promoter]] CTD PMID:23589332 NCBI chr 5:166,784,148...166,785,435
Ensembl chr 5:166,784,148...166,785,435 		JBrowse link
G Mt1 metallothionein 1 multiple interactions ISO Dichlororibofuranosylbenzimidazole inhibits the reaction [Cadmium Chloride results in increased expression of MT1 mRNA]; Dichlororibofuranosylbenzimidazole inhibits the reaction [Zinc Sulfate results in increased expression of MT1 mRNA] CTD PMID:15142038 NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049
Ensembl chr17:10,826,032...10,827,049
Ensembl chr  X:10,826,032...10,827,049 		JBrowse link
G Mx1 MX dynamin like GTPase 1 multiple interactions ISO Dichlororibofuranosylbenzimidazole inhibits the reaction [IFNB1 protein promotes the reaction [NELFA protein binds to MX1 promoter]] CTD PMID:23589332 NCBI chr11:36,799,659...36,825,209
Ensembl chr11:36,799,660...36,823,507 		JBrowse link
G Nelfa negative elongation factor complex member A multiple interactions ISO Dichlororibofuranosylbenzimidazole inhibits the reaction [IFNB1 protein promotes the reaction [NELFA protein binds to IFIT1 promoter]]; Dichlororibofuranosylbenzimidazole inhibits the reaction [IFNB1 protein promotes the reaction [NELFA protein binds to ISG15 promoter]]; Dichlororibofuranosylbenzimidazole inhibits the reaction [IFNB1 protein promotes the reaction [NELFA protein binds to MX1 promoter]] CTD PMID:23589332 NCBI chr14:76,808,920...76,832,998
Ensembl chr14:76,808,870...76,832,994 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions ISO Dichlororibofuranosylbenzimidazole inhibits the reaction [Dexamethasone affects the localization of NR3C1 protein] CTD PMID:21569845 NCBI chr18:31,522,783...31,644,508
Ensembl chr18:31,271,681...31,393,375 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO [Dichlororibofuranosylbenzimidazole co-treated with Bortezomib] results in increased cleavage of PARP1 protein CTD PMID:15039284 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Polr2a RNA polymerase II subunit A decreases phosphorylation
multiple interactions 		ISO Dichlororibofuranosylbenzimidazole results in decreased phosphorylation of POLR2A protein
Bortezomib promotes the reaction [Dichlororibofuranosylbenzimidazole results in decreased phosphorylation of POLR2A protein]; sodium arsenite inhibits the reaction [Dichlororibofuranosylbenzimidazole results in decreased phosphorylation of POLR2A protein] 		CTD PMID:8126066 PMID:15039284 PMID:24102143 NCBI chr10:54,452,438...54,478,486
Ensembl chr10:54,452,441...54,478,455 		JBrowse link
G Rgn regucalcin multiple interactions ISO Dichlororibofuranosylbenzimidazole inhibits the reaction [Zinc Sulfate results in increased expression of RGN mRNA] CTD PMID:18327666 NCBI chr  X:1,619,030...1,634,456
Ensembl chr  X:1,619,032...1,634,450 		JBrowse link
G Runx2 RUNX family transcription factor 2 multiple interactions ISO Dichlororibofuranosylbenzimidazole inhibits the reaction [Cryptoxanthins results in increased expression of RUNX2 mRNA]; Dichlororibofuranosylbenzimidazole inhibits the reaction [Zinc Sulfate results in increased expression of RUNX2 mRNA] CTD PMID:15962303 PMID:18327666 NCBI chr 9:23,661,278...23,990,248
Ensembl chr 9:16,167,482...16,492,167 		JBrowse link
G Slc30a1 solute carrier family 30 member 1 multiple interactions ISO Dichlororibofuranosylbenzimidazole inhibits the reaction [Cadmium Chloride results in increased expression of SLC30A1 mRNA]; Dichlororibofuranosylbenzimidazole inhibits the reaction [Zinc Sulfate results in increased expression of SLC30A1 mRNA] CTD PMID:15142038 NCBI chr13:106,022,019...106,025,892
Ensembl chr13:103,491,037...103,494,910 		JBrowse link
G Slc38a2 solute carrier family 38, member 2 affects expression ISO Dichlororibofuranosylbenzimidazole affects the expression of SLC38A2 protein CTD PMID:15581851 NCBI chr 7:129,730,450...129,742,619
Ensembl chr 7:127,851,267...127,863,436 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP 		Dichlororibofuranosylbenzimidazole affects the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Dichlororibofuranosylbenzimidazole inhibits the reaction [deoxynivalenol promotes the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]
Dichlororibofuranosylbenzimidazole inhibits the reaction [Benzo(a)pyrene promotes the reaction [TNF protein results in increased expression of CYP1B1 mRNA]]; Dichlororibofuranosylbenzimidazole inhibits the reaction [Benzo(a)pyrene promotes the reaction [TNF protein results in increased expression of CYP1B1 protein]]
Dichlororibofuranosylbenzimidazole inhibits the reaction [TNF protein results in increased expression of HIF1A protein] 		CTD PMID:11295263 PMID:12185005 PMID:12479793 PMID:25233930 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions ISO Dichlororibofuranosylbenzimidazole inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein co-treated with Cryptoxanthins] promotes the reaction [Zinc Sulfate results in increased expression of CASP3 mRNA]]; Dichlororibofuranosylbenzimidazole inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein co-treated with Zinc Sulfate] promotes the reaction [Cryptoxanthins results in increased expression of CASP3 mRNA]]; Dichlororibofuranosylbenzimidazole inhibits the reaction [Genistein promotes the reaction [[Zinc Sulfate co-treated with CSF1 protein co-treated with TNFSF11 protein] results in increased expression of CASP3 mRNA]]; Dichlororibofuranosylbenzimidazole inhibits the reaction [Zinc Sulfate results in increased expression of TNFSF11 mRNA] CTD PMID:17295206 PMID:18327666 PMID:18636177 NCBI chr15:60,083,008...60,114,479
Ensembl chr15:53,673,877...53,705,445 		JBrowse link
G Tp53 tumor protein p53 increases phosphorylation ISO Dichlororibofuranosylbenzimidazole results in increased phosphorylation of TP53 protein CTD PMID:24102143 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Tyms thymidylate synthetase multiple interactions ISO Dichlororibofuranosylbenzimidazole inhibits the reaction [Fluorouracil results in increased expression of TYMS protein] CTD PMID:23056627 NCBI chr 9:120,760,057...120,776,149
Ensembl chr 9:113,313,452...113,329,536 		JBrowse link
G Xdh xanthine dehydrogenase multiple interactions EXP Dichlororibofuranosylbenzimidazole inhibits the reaction [Oxygen deficiency results in increased phosphorylation of and results in increased activity of XDH protein] CTD PMID:11278616 NCBI chr 6:27,282,319...27,344,022
Ensembl chr 6:21,530,113...21,592,268 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20856
    chemical entity 20854
      atom 20854
        nonmetal atom 20762
          nitrogen atom 19594
            nitrogen molecular entity 19594
              organonitrogen compound 19401
                N-glycosyl compound 5900
                  1-ribosylbenzimidazole 36
                    (2R,4R,5R)-2-(5,6-dichloro-1-benzimidazolyl)-5-(hydroxymethyl)oxolane-3,4-diol 0
                    (3S,4R)-2-(5,6-dichloro-1-benzimidazolyl)-5-(hydroxymethyl)oxolane-3,4-diol 0
                    1-(5-O-phosphono-alpha-D-ribofuranosyl)-1H-benzimidazole 0
                    5,6-dichloro-1-beta-D-ribofuranosyl-1H-benzimidazole 36
                    5,6-dimethyl-1-(3-O-phosphono-alpha-D-ribofuranosyl)-1H-benzimidazole 0
                    5-methoxy-1-(5-O-phosphono-alpha-D-ribofuranosyl)-1H-benzimidazole 0
                    5-methyl-1-(5-O-phosphono-alpha-D-ribofuranosyl)-1H-benzimidazole 0
                    N1-(alpha-D-ribosyl)-5,6-dimethyl-benzimidazole 0
                    alpha-ribazole + 0
                    alpha-ribazole 5'-phosphate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20856
    subatomic particle 20854
      composite particle 20854
        hadron 20854
          baryon 20854
            nucleon 20854
              atomic nucleus 20854
                atom 20854
                  main group element atom 20777
                    p-block element atom 20777
                      carbon group element atom 20710
                        carbon atom 20704
                          organic molecular entity 20704
                            heteroorganic entity 20215
                              organochalcogen compound 19902
                                organooxygen compound 19804
                                  carbohydrates and carbohydrate derivatives 15436
                                    carbohydrate 15436
                                      carbohydrate derivative 14453
                                        glycosyl compound 13161
                                          N-glycosyl compound 5900
                                            1-ribosylbenzimidazole 36
                                              (2R,4R,5R)-2-(5,6-dichloro-1-benzimidazolyl)-5-(hydroxymethyl)oxolane-3,4-diol 0
                                              (3S,4R)-2-(5,6-dichloro-1-benzimidazolyl)-5-(hydroxymethyl)oxolane-3,4-diol 0
                                              1-(5-O-phosphono-alpha-D-ribofuranosyl)-1H-benzimidazole 0
                                              5,6-dichloro-1-beta-D-ribofuranosyl-1H-benzimidazole 36
                                              5,6-dimethyl-1-(3-O-phosphono-alpha-D-ribofuranosyl)-1H-benzimidazole 0
                                              5-methoxy-1-(5-O-phosphono-alpha-D-ribofuranosyl)-1H-benzimidazole 0
                                              5-methyl-1-(5-O-phosphono-alpha-D-ribofuranosyl)-1H-benzimidazole 0
                                              N1-(alpha-D-ribosyl)-5,6-dimethyl-benzimidazole 0
                                              alpha-ribazole + 0
                                              alpha-ribazole 5'-phosphate 0
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