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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:tetrahydrofolic acid
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Accession:CHEBI:26907 term browser browse the term
Definition:A group of heterocyclic compounds based on the 5,6,7,8-tetrahydropteroic acid skeleton conjugated with one or more L-glutamic acid units.
Synonyms:related_synonym: tetrahydrofolate;   tetrahydrofolates;   tetrahydrofolic acids
 cyclic_relationship: is_conjugate_acid_of CHEBI:67016


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10-formyltetrahydrofolic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALDH1L2 aldehyde dehydrogenase 1 family member L2 increases metabolic processing EXP ALDH1L2 protein results in increased metabolism of 10-formyltetrahydropteroylglutamic acid CTD PMID:21238436 NCBI chr12:105,019,790...105,084,458
Ensembl chr12:105,019,784...105,107,643 		JBrowse link
5,10-methylenetetrahydrofolic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MTHFR methylenetetrahydrofolate reductase increases metabolic processing
increases reduction		 EXP MTHFR protein results in increased metabolism of 5,10-methylenetetrahydrofolic acid
MTHFR protein results in increased reduction of 5,10-methylenetetrahydrofolic acid		 CTD PMID:7647779 PMID:16187112 NCBI chr 1:11,785,723...11,805,964
Ensembl chr 1:11,785,723...11,806,455 		JBrowse link
5,6,7,8-tetrahydrofolic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALDH1L2 aldehyde dehydrogenase 1 family member L2 increases chemical synthesis EXP ALDH1L2 protein results in increased chemical synthesis of 5,6,7,8-tetrahydrofolic acid CTD PMID:21238436 NCBI chr12:105,019,790...105,084,458
Ensembl chr12:105,019,784...105,107,643 		JBrowse link
G ALPI alkaline phosphatase, intestinal multiple interactions EXP 5,6,7,8-tetrahydrofolic acid inhibits the reaction [Methotrexate results in increased activity of ALPI protein] CTD PMID:16598758 NCBI chr 2:232,456,153...232,460,753
Ensembl chr 2:232,456,125...232,460,753 		JBrowse link
G IGF1R insulin like growth factor 1 receptor decreases expression EXP 5,6,7,8-tetrahydrofolic acid results in decreased expression of IGF1R mRNA CTD PMID:16728583 NCBI chr15:98,648,539...98,964,530
Ensembl chr15:98,648,539...98,964,530 		JBrowse link
G MTR 5-methyltetrahydrofolate-homocysteine methyltransferase multiple interactions EXP 5,6,7,8-tetrahydrofolic acid inhibits the reaction [Methotrexate results in decreased expression of MTR protein]; [Thymidine co-treated with Hypoxanthine co-treated with 5,6,7,8-tetrahydrofolic acid] inhibits the reaction [Methotrexate results in decreased expression of MTR protein] CTD PMID:16598758 NCBI chr 1:236,795,281...236,903,981
Ensembl chr 1:236,795,260...236,921,278 		JBrowse link
G SLC19A1 solute carrier family 19 member 1 multiple interactions
decreases activity		 ISO 5,6,7,8-tetrahydrofolic acid inhibits the reaction [SLC19A1 protein affects the transport of Methotrexate]
5,6,7,8-tetrahydrofolic acid results in decreased activity of SLC19A1 protein		 CTD PMID:14612385 NCBI chr21:45,502,517...45,563,025
Ensembl chr21:45,493,572...45,573,365 		JBrowse link
G TYMS thymidylate synthetase increases activity ISO 5,6,7,8-tetrahydrofolic acid results in increased activity of TYMS protein CTD PMID:187325 NCBI chr18:657,653...673,578
Ensembl chr18:657,653...673,578 		JBrowse link
5-formyltetrahydrofolic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC2 ATP binding cassette subfamily C member 2 multiple interactions ISO Leucovorin inhibits the reaction [Methotrexate results in decreased expression of ABCC2 protein] CTD PMID:16925582 NCBI chr10:99,782,640...99,852,594
Ensembl chr10:99,782,640...99,852,594 		JBrowse link
G ALB albumin multiple interactions EXP [Leucovorin co-treated with Cisplatin co-treated with Fluorouracil] results in decreased expression of ALB protein CTD PMID:20180123 NCBI chr 4:73,404,287...73,421,482
Ensembl chr 4:73,397,114...73,421,482 		JBrowse link
G ANGPTL2 angiopoietin like 2 multiple interactions EXP ANGPTL2 mRNA results in increased susceptibility to [Leucovorin co-treated with Fluorouracil co-treated with irinotecan] CTD PMID:17327601 NCBI chr 9:127,087,348...127,122,635
Ensembl chr 9:127,087,348...127,122,635 		JBrowse link
G ARL6IP5 ARF like GTPase 6 interacting protein 5 multiple interactions EXP ARL6IP5 protein affects the susceptibility to [Fluorouracil co-treated with Leucovorin co-treated with Cisplatin]; ARL6IP5 protein affects the susceptibility to [Fluorouracil co-treated with Leucovorin co-treated with oxaliplatin] CTD PMID:22452940 NCBI chr 3:69,084,937...69,106,092
Ensembl chr 3:69,084,937...69,106,092 		JBrowse link
G ATP5PO ATP synthase peripheral stalk subunit OSCP multiple interactions EXP ATP5PO mRNA results in increased susceptibility to [Leucovorin co-treated with Fluorouracil co-treated with irinotecan] CTD PMID:17327601 NCBI chr21:33,903,453...33,915,804
Ensembl chr21:33,903,453...33,915,814 		JBrowse link
G AXIN2 axin 2 multiple interactions ISO [Methotrexate co-treated with Leucovorin] results in increased expression of AXIN2 mRNA CTD PMID:25187349 NCBI chr17:65,528,563...65,561,648
Ensembl chr17:65,528,563...65,561,648 		JBrowse link
G BCL6 BCL6 transcription repressor multiple interactions EXP Leucovorin inhibits the reaction [Pyrimethamine inhibits the reaction [Oncostatin M results in increased expression of BCL6 mRNA]] CTD PMID:34953855 NCBI chr 3:187,721,377...187,745,468
Ensembl chr 3:187,721,377...187,745,725 		JBrowse link
G BGLAP bone gamma-carboxyglutamate protein multiple interactions ISO [Methotrexate co-treated with Leucovorin] results in increased expression of BGLAP mRNA CTD PMID:25187349 NCBI chr 1:156,242,184...156,243,317
Ensembl chr 1:156,242,184...156,243,317 		JBrowse link
G BOLL boule homolog, RNA binding protein multiple interactions EXP BOLL mRNA results in increased susceptibility to [Leucovorin co-treated with Fluorouracil co-treated with irinotecan] CTD PMID:17327601 NCBI chr 2:197,726,890...197,786,206
Ensembl chr 2:197,726,879...197,786,762 		JBrowse link
G CASP3 caspase 3 multiple interactions EXP [10-hydroxycamptothecin co-treated with Fluorouracil co-treated with Leucovorin] results in increased activity of CASP3 protein CTD PMID:12934351 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062 		JBrowse link
G CAT catalase multiple interactions ISO [Fluorouracil co-treated with Leucovorin co-treated with 1,2-Dimethylhydrazine] results in increased expression of CAT protein CTD PMID:32524861 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060 		JBrowse link
G CCND1 cyclin D1 multiple interactions ISO [Methotrexate co-treated with Leucovorin] results in increased expression of CCND1 mRNA CTD PMID:25187349 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474 		JBrowse link
G CCNE1 cyclin E1 multiple interactions EXP [Leucovorin co-treated with Fluorouracil] results in increased expression of CCNE1 mRNA CTD PMID:15342418 NCBI chr19:29,811,991...29,824,312
Ensembl chr19:29,811,991...29,824,312 		JBrowse link
G CDC45 cell division cycle 45 multiple interactions EXP [Leucovorin co-treated with Fluorouracil] results in increased expression of CDC45 mRNA CTD PMID:15342418 NCBI chr22:19,479,466...19,520,612
Ensembl chr22:19,479,457...19,520,612 		JBrowse link
G CDC6 cell division cycle 6 multiple interactions EXP [Leucovorin co-treated with Fluorouracil] results in increased expression of CDC6 mRNA CTD PMID:15342418 NCBI chr17:40,287,879...40,304,657
Ensembl chr17:40,287,879...40,304,657 		JBrowse link
G CDK1 cyclin dependent kinase 1 multiple interactions EXP [Leucovorin co-treated with Fluorouracil] results in increased expression of CDK1 mRNA CTD PMID:15342418 NCBI chr10:60,778,331...60,794,852
Ensembl chr10:60,778,331...60,794,852 		JBrowse link
G CDK2 cyclin dependent kinase 2 multiple interactions EXP [Leucovorin co-treated with Fluorouracil] results in increased expression of CDK2 mRNA CTD PMID:15342418 NCBI chr12:55,966,830...55,972,789
Ensembl chr12:55,966,781...55,972,789 		JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A multiple interactions EXP [Leucovorin co-treated with Fluorouracil] results in increased expression of CDKN1A mRNA CTD PMID:15342418 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,397 		JBrowse link
G CTNNB1 catenin beta 1 multiple interactions ISO [Methotrexate co-treated with Leucovorin] results in increased expression of CTNNB1 protein CTD PMID:25187349 NCBI chr 3:41,199,505...41,240,443
Ensembl chr 3:41,194,741...41,260,096 		JBrowse link
G CYP11A1 cytochrome P450 family 11 subfamily A member 1 multiple interactions ISO Leucovorin affects the reaction [Methotrexate results in decreased expression of CYP11A1 mRNA]; Leucovorin affects the reaction [Methotrexate results in decreased expression of CYP11A1 protein] CTD PMID:21213337 NCBI chr15:74,337,762...74,367,646
Ensembl chr15:74,337,759...74,367,646 		JBrowse link
G DHFR dihydrofolate reductase multiple interactions
increases expression		 EXP Leucovorin inhibits the reaction [DHFR gene mutant form results in decreased abundance of Folic Acid]
Leucovorin results in increased expression of DHFR protein		 CTD PMID:16712799 PMID:21310277 NCBI chr 5:80,626,226...80,654,983
Ensembl chr 5:80,626,226...80,654,983 		JBrowse link
G DPYD dihydropyrimidine dehydrogenase multiple interactions EXP [Leucovorin co-treated with Fluorouracil] results in decreased activity of DPYD protein CTD PMID:7503095 NCBI chr 1:97,077,743...97,921,059
Ensembl chr 1:97,077,743...97,995,000 		JBrowse link
G DRD5 dopamine receptor D5 multiple interactions EXP DRD5 mRNA results in increased susceptibility to [Leucovorin co-treated with Fluorouracil co-treated with irinotecan] CTD PMID:17327601 NCBI chr 4:9,781,634...9,784,009
Ensembl chr 4:9,781,634...9,784,009 		JBrowse link
G EDN1 endothelin 1 increases expression ISO Leucovorin results in increased expression of EDN1 mRNA; Leucovorin results in increased expression of EDN1 protein CTD PMID:16925845 NCBI chr 6:12,230,516...12,297,194
Ensembl chr 6:12,290,361...12,297,194 		JBrowse link
G EML2 EMAP like 2 multiple interactions EXP EML2 mRNA results in increased susceptibility to [Leucovorin co-treated with Fluorouracil co-treated with irinotecan] CTD PMID:17327601 NCBI chr19:45,609,400...45,645,629
Ensembl chr19:45,606,994...45,645,602 		JBrowse link
G ERCC1 ERCC excision repair 1, endonuclease non-catalytic subunit multiple interactions EXP ERCC1 gene SNP affects the susceptibility to [Fluorouracil co-treated with Leucovorin co-treated with oxaliplatin] CTD PMID:17401013 NCBI chr19:45,407,334...45,451,547
Ensembl chr19:45,407,334...45,478,828 		JBrowse link
G ERCC2 ERCC excision repair 2, TFIIH core complex helicase subunit multiple interactions EXP ERCC2 gene SNP affects the susceptibility to [Fluorouracil co-treated with Leucovorin co-treated with oxaliplatin] CTD PMID:17401013 NCBI chr19:45,349,837...45,370,573
Ensembl chr19:45,349,837...45,370,918 		JBrowse link
G F8 coagulation factor VIII multiple interactions EXP F8 mRNA results in increased susceptibility to [Leucovorin co-treated with Fluorouracil co-treated with irinotecan] CTD PMID:17327601 NCBI chr  X:154,835,792...155,022,723
Ensembl chr  X:154,835,788...155,026,940 		JBrowse link
G FABP4 fatty acid binding protein 4 multiple interactions ISO Leucovorin inhibits the reaction [Methotrexate results in increased expression of FABP4 protein] CTD PMID:25187349 NCBI chr 8:81,478,419...81,483,233
Ensembl chr 8:81,478,419...81,483,236 		JBrowse link
G FOLR1 folate receptor alpha multiple interactions EXP FOLR1 protein affects the reaction [Leucovorin results in increased phosphorylation of STAT3 protein] CTD PMID:25841994 NCBI chr11:72,189,709...72,196,323
Ensembl chr11:72,189,558...72,196,323 		JBrowse link
G FSHB follicle stimulating hormone subunit beta multiple interactions ISO Leucovorin affects the reaction [Methotrexate results in increased expression of FSHB protein] CTD PMID:21213337 NCBI chr11:30,231,014...30,235,194
Ensembl chr11:30,231,014...30,235,261 		JBrowse link
G G6PD glucose-6-phosphate dehydrogenase multiple interactions ISO Leucovorin inhibits the reaction [Methotrexate results in decreased activity of G6PD protein] CTD PMID:21213337 NCBI chr  X:154,531,390...154,547,569
Ensembl chr  X:154,517,825...154,547,572 		JBrowse link
G GOLGA8A golgin A8 family member A multiple interactions EXP GOLGA8A mRNA results in increased susceptibility to [Leucovorin co-treated with Fluorouracil co-treated with irinotecan] CTD PMID:17327601 NCBI chr15:34,379,068...34,437,808
Ensembl chr15:34,378,935...34,437,808 		JBrowse link
G HAND2 heart and neural crest derivatives expressed 2 increases expression ISO Leucovorin results in increased expression of HAND2 mRNA; Leucovorin results in increased expression of HAND2 protein CTD PMID:16925845 NCBI chr 4:173,526,091...173,530,229
Ensembl chr 4:173,524,969...173,530,229 		JBrowse link
G HSPB1 heat shock protein family B (small) member 1 multiple interactions EXP HSPB1 protein affects the susceptibility to [Cisplatin co-treated with Fluorouracil co-treated with Leucovorin] CTD PMID:19088045 NCBI chr 7:76,302,673...76,304,292
Ensembl chr 7:76,302,673...76,305,813 		JBrowse link
G IL1B interleukin 1 beta multiple interactions EXP Leucovorin inhibits the reaction [Methotrexate results in increased expression of IL1B mRNA] CTD PMID:24444433 NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816 		JBrowse link
G IL6 interleukin 6 multiple interactions EXP Leucovorin inhibits the reaction [Methotrexate results in increased expression of IL6 mRNA] CTD PMID:24444433 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G IL6ST interleukin 6 cytokine family signal transducer multiple interactions EXP IL6ST protein affects the reaction [Leucovorin results in increased phosphorylation of STAT3 protein] CTD PMID:25841994 NCBI chr 5:55,935,095...55,994,963
Ensembl chr 5:55,935,095...55,995,022 		JBrowse link
G LEF1 lymphoid enhancer binding factor 1 multiple interactions ISO [Methotrexate co-treated with Leucovorin] results in increased expression of LEF1 mRNA CTD PMID:25187349 NCBI chr 4:108,047,548...108,168,932
Ensembl chr 4:108,047,545...108,168,956 		JBrowse link
G LGALS8 galectin 8 multiple interactions EXP LGALS8 mRNA results in increased susceptibility to [Leucovorin co-treated with Fluorouracil co-treated with irinotecan] CTD PMID:17327601 NCBI chr 1:236,518,214...236,552,981
Ensembl chr 1:236,518,000...236,552,981 		JBrowse link
G LHB luteinizing hormone subunit beta multiple interactions ISO Leucovorin affects the reaction [Methotrexate results in increased expression of LHB protein] CTD PMID:21213337 NCBI chr19:49,015,980...49,019,498
Ensembl chr19:49,015,980...49,017,091 		JBrowse link
G MAT2A methionine adenosyltransferase 2A multiple interactions EXP Leucovorin inhibits the reaction [Methotrexate results in decreased expression of MAT2A mRNA] CTD PMID:22193356 NCBI chr 2:85,539,168...85,545,281
Ensembl chr 2:85,539,168...85,545,281 		JBrowse link
G MTHFR methylenetetrahydrofolate reductase multiple interactions EXP MTHFR gene polymorphism results in increased susceptibility to [Fluorouracil co-treated with Leucovorin] CTD PMID:18633250 NCBI chr 1:11,785,723...11,805,964
Ensembl chr 1:11,785,723...11,806,455 		JBrowse link
G PPARG peroxisome proliferator activated receptor gamma multiple interactions ISO [Methotrexate co-treated with Leucovorin] results in increased expression of PPARG mRNA; [Methotrexate co-treated with Leucovorin] results in increased expression of PPARG protein CTD PMID:25187349 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356 		JBrowse link
G PSG9 pregnancy specific beta-1-glycoprotein 9 multiple interactions EXP PSG9 mRNA results in increased susceptibility to [Leucovorin co-treated with Fluorouracil co-treated with irinotecan] CTD PMID:17327601 NCBI chr19:43,253,282...43,269,530
Ensembl chr19:43,211,791...43,269,530 		JBrowse link
G SERPINE2 serpin family E member 2 multiple interactions EXP SERPINE2 mRNA results in increased susceptibility to [Leucovorin co-treated with Fluorouracil co-treated with irinotecan] CTD PMID:17327601 NCBI chr 2:223,975,045...224,039,286
Ensembl chr 2:223,975,045...224,039,318 		JBrowse link
G SFRP1 secreted frizzled related protein 1 multiple interactions ISO Leucovorin inhibits the reaction [Methotrexate results in increased expression of SFRP1 mRNA]; Leucovorin inhibits the reaction [Methotrexate results in increased expression of SFRP1 protein] CTD PMID:25187349 NCBI chr 8:41,261,962...41,309,473
Ensembl chr 8:41,261,962...41,309,473 		JBrowse link
G SLC19A1 solute carrier family 19 member 1 multiple interactions EXP Leucovorin inhibits the reaction [SLC19A1 protein results in increased transport of Methotrexate] CTD PMID:21879757 NCBI chr21:45,502,517...45,563,025
Ensembl chr21:45,493,572...45,573,365 		JBrowse link
G SLC22A6 solute carrier family 22 member 6 multiple interactions
increases uptake		 ISO
EXP		 Leucovorin inhibits the reaction [Methotrexate results in decreased expression of SLC22A6 protein]
SLC22A6 protein results in increased uptake of Leucovorin		 CTD PMID:16098483 PMID:16925582 NCBI chr11:62,976,597...62,984,967
Ensembl chr11:62,936,385...62,984,967 		JBrowse link
G SLC22A8 solute carrier family 22 member 8 multiple interactions
increases uptake		 ISO
EXP		 Leucovorin inhibits the reaction [Methotrexate results in decreased expression of SLC22A8 protein]
SLC22A8 protein results in increased uptake of Leucovorin		 CTD PMID:16098483 PMID:16925582 NCBI chr11:62,992,824...63,015,841
Ensembl chr11:62,989,154...63,015,841 		JBrowse link
G SLC46A1 solute carrier family 46 member 1 decreases activity
multiple interactions		 EXP Leucovorin results in decreased activity of SLC46A1 protein
Leucovorin inhibits the reaction [SLC46A1 protein results in increased transport of Folic Acid]		 CTD PMID:17475902 NCBI chr17:28,394,642...28,406,592
Ensembl chr17:28,394,642...28,407,197 		JBrowse link
G SOCS3 suppressor of cytokine signaling 3 multiple interactions EXP Leucovorin inhibits the reaction [Pyrimethamine results in decreased expression of SOCS3 mRNA] CTD PMID:34953855 NCBI chr17:78,356,778...78,360,925
Ensembl chr17:78,356,778...78,360,077 		JBrowse link
G SP7 Sp7 transcription factor multiple interactions ISO [Methotrexate co-treated with Leucovorin] results in increased expression of SP7 mRNA CTD PMID:25187349 NCBI chr12:53,326,575...53,344,793
Ensembl chr12:53,326,575...53,345,315 		JBrowse link
G STAR steroidogenic acute regulatory protein multiple interactions ISO Leucovorin affects the reaction [Methotrexate results in decreased expression of STAR mRNA]; Leucovorin affects the reaction [Methotrexate results in decreased expression of STAR protein] CTD PMID:21213337 NCBI chr 8:38,142,700...38,150,952
Ensembl chr 8:38,142,700...38,150,992 		JBrowse link
G STAT3 signal transducer and activator of transcription 3 multiple interactions EXP FOLR1 protein affects the reaction [Leucovorin results in increased phosphorylation of STAT3 protein]; IL6ST protein affects the reaction [Leucovorin results in increased phosphorylation of STAT3 protein]; Leucovorin results in increased activity of and results in increased phosphorylation of STAT3 protein CTD PMID:25841994 NCBI chr17:42,313,324...42,388,442
Ensembl chr17:42,313,324...42,388,568 		JBrowse link
G TYMP thymidine phosphorylase multiple interactions EXP TYMP mRNA affects the susceptibility to [irinotecan co-treated with Fluorouracil co-treated with Leucovorin] CTD PMID:17454858 NCBI chr22:50,525,752...50,530,085
Ensembl chr22:50,525,752...50,530,032 		JBrowse link
G TYMS thymidylate synthetase multiple interactions EXP
ISO		 [Arsenic Trioxide co-treated with Fluorouracil co-treated with Leucovorin] results in decreased expression of TYMS mRNA; TYMS gene polymorphism results in increased susceptibility to [Leucovorin co-treated with Fluorouracil co-treated with Cisplatin co-treated with Paclitaxel]; TYMS mRNA affects the susceptibility to [Irinotecan co-treated with Fluorouracil co-treated with Leucovorin]; TYMS promoter polymorphism results in increased susceptibility to [Fluorouracil co-treated with Leucovorin co-treated with Oxaliplatin co-treated with Docetaxel]; TYMS protein affects the susceptibility to [Fluorouracil co-treated with Leucovorin]
Leucovorin promotes the reaction [Fluorouracil results in decreased expression of TYMS]		 CTD PMID:9050858 PMID:16424979 PMID:17454858 PMID:18676755 PMID:19074750 More... NCBI chr18:657,653...673,578
Ensembl chr18:657,653...673,578 		JBrowse link
G WNT10B Wnt family member 10B multiple interactions ISO [Methotrexate co-treated with Leucovorin] results in increased expression of WNT10B mRNA CTD PMID:25187349 NCBI chr12:48,965,340...48,971,735
Ensembl chr12:48,965,340...48,971,735 		JBrowse link
G XRCC1 X-ray repair cross complementing 1 multiple interactions EXP XRCC1 protein affects the susceptibility to [Fluorouracil co-treated with Leucovorin co-treated with Cisplatin]; XRCC1 protein affects the susceptibility to [Fluorouracil co-treated with Leucovorin co-treated with oxaliplatin] CTD PMID:22452940 NCBI chr19:43,543,311...43,575,527
Ensembl chr19:43,543,311...43,580,473 		JBrowse link
G ZNF32 zinc finger protein 32 multiple interactions EXP ZNF32 mRNA results in increased susceptibility to [Leucovorin co-treated with Fluorouracil co-treated with irinotecan] CTD PMID:17327601 NCBI chr10:43,643,862...43,648,881
Ensembl chr10:43,643,860...43,648,881 		JBrowse link
G ZNF582 zinc finger protein 582 multiple interactions EXP ZNF582 mRNA results in increased susceptibility to [Leucovorin co-treated with Fluorouracil co-treated with irinotecan] CTD PMID:17327601 NCBI chr19:56,382,751...56,393,534
Ensembl chr19:56,375,846...56,393,538 		JBrowse link
G ZRSR2 zinc finger CCCH-type, RNA binding motif and serine/arginine rich 2 multiple interactions EXP ZRSR2 mRNA results in increased susceptibility to [Leucovorin co-treated with Fluorouracil co-treated with irinotecan] CTD PMID:17327601 NCBI chr  X:15,790,484...15,823,260
Ensembl chr  X:15,790,156...15,830,694 		JBrowse link
5-methyltetrahydrofolic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALDH1L1 aldehyde dehydrogenase 1 family member L1 decreases abundance EXP ALDH1L1 protein results in decreased abundance of 5-methyltetrahydrofolate CTD PMID:16627483 NCBI chr 3:126,103,570...126,197,945
Ensembl chr 3:126,103,562...126,197,994 		JBrowse link
G FOLR1 folate receptor alpha increases uptake EXP FOLR1 protein results in increased uptake of 5-methyltetrahydrofolate CTD PMID:17473184 NCBI chr11:72,189,709...72,196,323
Ensembl chr11:72,189,558...72,196,323 		JBrowse link
G GNMT glycine N-methyltransferase affects binding ISO GNMT protein binds to 5-methyltetrahydrofolate CTD PMID:17158459 NCBI chr 6:42,960,754...42,963,880
Ensembl chr 6:42,960,754...42,963,880 		JBrowse link
G MTHFR methylenetetrahydrofolate reductase increases chemical synthesis EXP MTHFR protein results in increased chemical synthesis of 5-methyltetrahydrofolate CTD PMID:7647779 PMID:9719624 NCBI chr 1:11,785,723...11,805,964
Ensembl chr 1:11,785,723...11,806,455 		JBrowse link
G MTR 5-methyltetrahydrofolate-homocysteine methyltransferase affects binding EXP 5-methyltetrahydrofolate binds to MTR protein CTD PMID:17477549 NCBI chr 1:236,795,281...236,903,981
Ensembl chr 1:236,795,260...236,921,278 		JBrowse link
G MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase affects abundance ISO MTRR protein affects the abundance of 5-methyltetrahydrofolate CTD PMID:17369066 NCBI chr 5:7,850,859...7,901,113
Ensembl chr 5:7,851,186...7,906,025 		JBrowse link
G PCNA proliferating cell nuclear antigen multiple interactions EXP [Docosahexaenoic Acids co-treated with 5-methyltetrahydrofolate] results in increased expression of PCNA protein CTD PMID:16870008 NCBI chr20:5,114,953...5,126,622
Ensembl chr20:5,114,953...5,126,626 		JBrowse link
G SLC19A1 solute carrier family 19 member 1 multiple interactions
decreases activity		 EXP
ISO		 [5-methyltetrahydrofolate results in decreased activity of SLC19A1 protein] which results in decreased uptake of Folic Acid
5-methyltetrahydrofolate inhibits the reaction [SLC19A1 protein affects the transport of Methotrexate]		 CTD PMID:14612385 PMID:17034785 NCBI chr21:45,502,517...45,563,025
Ensembl chr21:45,493,572...45,573,365 		JBrowse link
G SLC46A1 solute carrier family 46 member 1 multiple interactions
decreases activity		 EXP 5-methyltetrahydrofolate inhibits the reaction [SLC46A1 protein results in increased transport of Folic Acid]
5-methyltetrahydrofolate results in decreased activity of SLC46A1 protein		 CTD PMID:17475902 NCBI chr17:28,394,642...28,406,592
Ensembl chr17:28,394,642...28,407,197 		JBrowse link
G STK11 serine/threonine kinase 11 multiple interactions EXP 5-methyltetrahydrofolate inhibits the reaction [Palmitic Acid results in decreased phosphorylation of STK11 protein]; dorsomorphin inhibits the reaction [5-methyltetrahydrofolate inhibits the reaction [Palmitic Acid results in decreased phosphorylation of STK11 protein]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [5-methyltetrahydrofolate inhibits the reaction [Palmitic Acid results in decreased phosphorylation of STK11 protein]] CTD PMID:26400185 NCBI chr19:1,205,778...1,228,431
Ensembl chr19:1,177,558...1,228,431 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26504
    role 26326
      biological role 26305
        biochemical role 25518
          ferroptosis inducer 16895
            L-glutamic acid 10551
              L-glutamic acid derivative 9589
                folic acids 9588
                  tetrahydrofolic acid 71
                    5,6,7,8-tetrahydrofolic acid + 14
                    5-Formiminotetrahydrofolic acid 0
                    5-methyltetrahydrofolic acid + 10
                    6R-Tetrahydrofolic acid 0
                    Calcium folinate 0
                    formimidoyltetrahydrofolic acid + 0
                    formyltetrahydrofolic acid + 63
                    methylenetetrahydrofolic acid + 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 26504
    subatomic particle 26480
      composite particle 26480
        hadron 26480
          baryon 26480
            nucleon 26480
              atomic nucleus 26480
                atom 26480
                  main group element atom 26217
                    main group molecular entity 26217
                      s-block molecular entity 25454
                        hydrogen molecular entity 24861
                          hydrides 23080
                            inorganic hydride 20556
                              pnictogen hydride 20498
                                nitrogen hydride 20283
                                  azane 20008
                                    ammonia 20007
                                      organic amino compound 20007
                                        amino acid 17304
                                          alpha-amino acid 14772
                                            L-alpha-amino acid 13150
                                              glutamine family amino acid 10616
                                                L-glutamic acid 10551
                                                  L-glutamic acid derivative 9589
                                                    folic acids 9588
                                                      tetrahydrofolic acid 71
                                                        5,6,7,8-tetrahydrofolic acid + 14
                                                        5-Formiminotetrahydrofolic acid 0
                                                        5-methyltetrahydrofolic acid + 10
                                                        6R-Tetrahydrofolic acid 0
                                                        Calcium folinate 0
                                                        formimidoyltetrahydrofolic acid + 0
                                                        formyltetrahydrofolic acid + 63
                                                        methylenetetrahydrofolic acid + 1
paths to the root