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Gene: CDC45 (cell division cycle 45) Homo sapiens
Symbol: CDC45
Name: cell division cycle 45
Description: Predicted to have DNA replication origin binding activity; chromatin binding activity; and single-stranded DNA binding activity. Predicted to be involved in several processes, including DNA-dependent DNA replication; double-strand break repair via break-induced replication; and positive regulation of G1/S transition of mitotic cell cycle. Localizes to centrosome and nucleoplasm. Implicated in Meier-Gorlin syndrome 7.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CDC45 (cell division cycle 45, S.cerevisiae, homolog)-like; CDC45 cell division cycle 45 homolog; CDC45 cell division cycle 45-like; CDC45-related protein; CDC45L; CDC45L2; cell division control protein 45 homolog; cell division cycle 45 homolog; cell division cycle 45-like 2; human CDC45; MGORS7; PORC-PI-1
Mus musculus (house mouse) : Cdc45 (cell division cycle 45)  MGI  Alliance
Rattus norvegicus (Norway rat) : Cdc45 (cell division cycle 45)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cdc45 (cell division cycle 45)
Pan paniscus (bonobo/pygmy chimpanzee) : CDC45 (cell division cycle 45)
Canis lupus familiaris (dog) : CDC45 (cell division cycle 45)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cdc45 (cell division cycle 45)
Sus scrofa (pig) : CDC45 (cell division cycle 45)
Chlorocebus sabaeus (African green monkey) : CDC45 (cell division cycle 45)
Heterocephalus glaber (naked mole-rat) : Cdc45 (cell division cycle 45)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl2219,479,457 - 19,520,612 (+)EnsemblGRCh38hg38GRCh38
GRCh382219,479,294 - 19,520,612 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372219,466,984 - 19,508,135 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362217,847,416 - 17,888,135 (+)NCBINCBI36hg18NCBI36
Build 342217,841,969 - 17,882,688NCBI
Celera223,319,674 - 3,360,395 (+)NCBI
Cytogenetic Map22q11.21NCBI
HuRef223,088,162 - 3,128,966 (+)NCBIHuRef
CHM1_12219,466,920 - 19,507,702 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on CDC45
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1352573
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-06-23
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.