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Gene: XRCC1 (X-ray repair cross complementing 1) Homo sapiens
Symbol: XRCC1
Name: X-ray repair cross complementing 1
RGD ID: 732968
Description: Exhibits enzyme binding activity and oxidized DNA binding activity. Predicted to contribute to 3' overhang single-stranded DNA endodeoxyribonuclease activity. Involved in several processes, including negative regulation of protein ADP-ribosylation; positive regulation of DNA metabolic process; and replication-born double-strand break repair via sister chromatid exchange. Localizes to nuclear chromatin; nucleolus; and nucleoplasm. Implicated in several diseases, including autosomal recessive spinocerebellar ataxia 26; hematologic cancer (multiple); hepatobiliary system cancer (multiple); reproductive organ cancer (multiple); and urinary system cancer (multiple). Biomarker of liver cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DNA repair protein XRCC1; RCC; SCAR26; X-ray repair complementing defective repair in Chinese hamster cells 1; x-ray repair cross-complementing group 1 protein; X-ray repair cross-complementing protein 1; X-ray-repair, complementing defective, repair in Chinese hamster
Mus musculus (house mouse) : Xrcc1 (X-ray repair complementing defective repair in Chinese hamster cells 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Xrcc1 (X-ray repair cross complementing 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Xrcc1 (X-ray repair cross complementing 1)
Pan paniscus (bonobo/pygmy chimpanzee) : XRCC1 (X-ray repair cross complementing 1)
Canis lupus familiaris (dog) : XRCC1 (X-ray repair cross complementing 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Xrcc1 (X-ray repair cross complementing 1)
Sus scrofa (pig) : XRCC1 (X-ray repair cross complementing 1)
Chlorocebus sabaeus (African green monkey) : XRCC1 (X-ray repair cross complementing 1)
Heterocephalus glaber (naked mole-rat) : Xrcc1 (X-ray repair cross complementing 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl1943,543,040 - 43,580,473 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl1943,543,311 - 43,580,473 (-)EnsemblGRCh38hg38GRCh38
GRCh381943,543,311 - 43,575,527 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371944,047,464 - 44,079,730 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361948,739,304 - 48,771,555 (-)NCBINCBI36hg18NCBI36
Build 341948,739,303 - 48,771,555NCBI
Celera1940,850,091 - 40,882,209 (-)NCBI
Cytogenetic Map19q13.31NCBI
HuRef1940,478,136 - 40,510,489 (-)NCBIHuRef
CHM1_11944,049,115 - 44,081,452 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on XRCC1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 732968
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-09-08
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.