The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
A C-glycosyl compound that is 3,4,5-trihydroxycyclohexa-2,5-dien-1-one which is substituted by beta-D-glucosyl groups at positions 2 and 4, and by a p-hydroxycinnamoyl group at position 6. It is the main bioactive compound of a traditional Chinese medicine obtained from safflower (Carthamus tinctorius).
Synonyms:
related_synonym:
2,4-di-beta-D-glucopyranosyl-3,4,5-trihydroxy-6-[(2E)-3-(4-hydroxyphenyl-1-oxo-2-propen-1-yl)]-2,5-cyclohexadien-1-one; 2,4-di-beta-D-glucopyranosyl-3,4,5-trihydroxy-6-[(2E)-3-(4-hydroxyphenyl-1-oxo-prop-2-en-1-yl)]cyclohexa-2,5-dien-1-one; Formula=C27H32O16; HSYA; InChI=1S/C27H32O16/c28-7-12-16(32)19(35)21(37)23(42-12)15-18(34)14(11(31)6-3-9-1-4-10(30)5-2-9)24(39)27(41,25(15)40)26-22(38)20(36)17(33)13(8-29)43-26/h1-6,12-13,16-17,19-23,26,28-30,32-33,35-41H,7-8H2/b6-3+/t12-,13-,16-,17-,19+,20+,21-,22-,23+,26-,27?/m1/s1; InChIKey=LIPJRCGLQNIXGO-ONZBGLOFSA-N; SMILES=O1[C@H]([C@H](O)[C@@H](O)[C@H](O)[C@H]1CO)C2=C(O)C(C(O)=C(C2=O)C(=O)/C=C/C3=CC=C(O)C=C3)(O)[C@@H]4O[C@@H]([C@@H](O)[C@H](O)[C@H]4O)CO; safflomin A
HK1 protein affects the reaction [hydroxysafflor yellow A inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased activity of CASP1 protein]]; hydroxysafflor yellow A inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased activity of and results in increased cleavage of CASP1 protein] hydroxysafflor yellow A inhibits the reaction [Dextran Sulfate results in increased activity of and results in increased cleavage of CASP1 protein]
hydroxysafflor yellow A inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [Particulate Matter results in increased expression of CD40 protein]]; hydroxysafflor yellow A inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [Vehicle Emissions results in increased expression of CD40 protein]]; hydroxysafflor yellow A inhibits the reaction [Vehicle Emissions results in increased expression of CD40 protein]
hydroxysafflor yellow A inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [Particulate Matter results in increased expression of CD40LG protein]]; hydroxysafflor yellow A inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [Vehicle Emissions results in increased expression of CD40LG protein]]; hydroxysafflor yellow A inhibits the reaction [Particulate Matter results in increased expression of CD40LG protein]; hydroxysafflor yellow A inhibits the reaction [Vehicle Emissions results in increased expression of CD40LG protein]
HK1 protein affects the reaction [hydroxysafflor yellow A inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased cleavage of GSDMD protein]]; hydroxysafflor yellow A inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased cleavage of GSDMD protein] hydroxysafflor yellow A inhibits the reaction [Dextran Sulfate results in increased cleavage of GSDMD protein]
hydroxysafflor yellow A inhibits the reaction [Dextran Sulfate results in increased expression of HK1 protein] HK1 protein affects the reaction [hydroxysafflor yellow A inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased activity of CASP1 protein]]; HK1 protein affects the reaction [hydroxysafflor yellow A inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased cleavage of GSDMD protein]]; HK1 protein affects the reaction [hydroxysafflor yellow A inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased secretion of IL1B protein]]; hydroxysafflor yellow A inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of HK1 protein]
hydroxysafflor yellow A inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [Particulate Matter results in increased expression of ICAM1 protein]]; hydroxysafflor yellow A inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [Vehicle Emissions results in increased expression of ICAM1 protein]]; hydroxysafflor yellow A inhibits the reaction [Particulate Matter results in increased expression of ICAM1 protein]; hydroxysafflor yellow A inhibits the reaction [Vehicle Emissions results in increased expression of ICAM1 protein] hydroxysafflor yellow A inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 mRNA] hydroxysafflor yellow A results in decreased expression of ICAM1 protein
HK1 protein affects the reaction [hydroxysafflor yellow A inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased secretion of IL1B protein]]; hydroxysafflor yellow A inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased cleavage of IL1B protein]; hydroxysafflor yellow A inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased secretion of IL1B protein] hydroxysafflor yellow A inhibits the reaction [Dextran Sulfate results in increased cleavage of IL1B protein]; hydroxysafflor yellow A inhibits the reaction [Dextran Sulfate results in increased secretion of IL1B protein]; hydroxysafflor yellow A inhibits the reaction [Ovalbumin results in increased expression of IL1B protein]
hydroxysafflor yellow A inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [Particulate Matter results in increased expression of IL6 protein]]; hydroxysafflor yellow A inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [Vehicle Emissions results in increased expression of IL6 protein]]; hydroxysafflor yellow A inhibits the reaction [Particulate Matter results in increased expression of IL6 protein]; hydroxysafflor yellow A inhibits the reaction [Vehicle Emissions results in increased expression of IL6 protein] hydroxysafflor yellow A inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased secretion of IL6 protein]; hydroxysafflor yellow A inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA] hydroxysafflor yellow A inhibits the reaction [Dextran Sulfate results in increased secretion of IL6 protein]; hydroxysafflor yellow A inhibits the reaction [Ovalbumin results in increased expression of IL6 protein]
hydroxysafflor yellow A inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [Particulate Matter results in increased expression of ITGB3 protein]]; hydroxysafflor yellow A inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [Vehicle Emissions results in increased expression of ITGB3 protein]]; hydroxysafflor yellow A inhibits the reaction [Particulate Matter results in increased expression of ITGB3 protein]; hydroxysafflor yellow A inhibits the reaction [Vehicle Emissions results in increased expression of ITGB3 protein]
hydroxysafflor yellow A inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [Particulate Matter results in increased expression of MMP9 protein]]; hydroxysafflor yellow A inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [Vehicle Emissions results in increased expression of MMP9 protein]]; hydroxysafflor yellow A inhibits the reaction [Particulate Matter results in increased expression of MMP9 protein]; hydroxysafflor yellow A inhibits the reaction [Vehicle Emissions results in increased expression of MMP9 protein] hydroxysafflor yellow A results in decreased expression of MMP9 protein
hydroxysafflor yellow A inhibits the reaction [Dextran Sulfate results in increased activity of MPO protein]; hydroxysafflor yellow A inhibits the reaction [Ovalbumin results in increased expression of MPO protein]
hydroxysafflor yellow A inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [Particulate Matter results in decreased expression of PPARG protein]]; hydroxysafflor yellow A inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [Vehicle Emissions results in decreased expression of PPARG protein]]; hydroxysafflor yellow A inhibits the reaction [Particulate Matter results in decreased expression of PPARG protein]; hydroxysafflor yellow A inhibits the reaction [Vehicle Emissions results in decreased expression of PPARG protein]
hydroxysafflor yellow A inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [Particulate Matter results in decreased activity of PRKACA protein]]; hydroxysafflor yellow A inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [Vehicle Emissions results in decreased activity of PRKACA protein]]; hydroxysafflor yellow A inhibits the reaction [Particulate Matter results in decreased activity of PRKACA protein]; hydroxysafflor yellow A inhibits the reaction [Vehicle Emissions results in decreased activity of PRKACA protein]
hydroxysafflor yellow A inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased secretion of TNF protein]; hydroxysafflor yellow A inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA] hydroxysafflor yellow A inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [Particulate Matter results in increased expression of TNF protein]]; hydroxysafflor yellow A inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [Vehicle Emissions results in increased expression of TNF protein]]; hydroxysafflor yellow A inhibits the reaction [Particulate Matter results in increased expression of TNF protein]; hydroxysafflor yellow A inhibits the reaction [Vehicle Emissions results in increased expression of TNF protein] hydroxysafflor yellow A results in decreased expression of TNF protein hydroxysafflor yellow A inhibits the reaction [Dextran Sulfate results in increased secretion of TNF protein]; hydroxysafflor yellow A inhibits the reaction [Ovalbumin results in increased expression of TNF protein]
hydroxysafflor yellow A inhibits the reaction [Lipopolysaccharides results in increased expression of VCAM1 mRNA] hydroxysafflor yellow A inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [Particulate Matter results in increased expression of VCAM1 protein]]; hydroxysafflor yellow A inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [Vehicle Emissions results in increased expression of VCAM1 protein]]; hydroxysafflor yellow A inhibits the reaction [Particulate Matter results in increased expression of VCAM1 protein]; hydroxysafflor yellow A inhibits the reaction [Vehicle Emissions results in increased expression of VCAM1 protein] hydroxysafflor yellow A results in decreased expression of VCAM1 protein
browse the term
