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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:TRPA1 channel agonist
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Accession:CHEBI:137514 term browser browse the term
Definition:An agonist at the transient receptor potential cation channel A1 (TRPA1).
Synonyms:related_synonym: TRPA1 channel agonists;   transient receptor potential ankyrin 1 agonist;   transient receptor potential ankyrin 1 agonists;   transient receptor potential cation channel A1 agonist;   transient receptor potential cation channel A1 agonists
 xref: Wikipedia:TRPA1



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carvacrol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions
decreases activity
EXP [propiconazole co-treated with carvacrol] results in decreased activity of ACHE protein
carvacrol results in decreased activity of ACHE protein
CTD PMID:29852196 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions EXP carvacrol inhibits the reaction [Poloxamer results in decreased secretion of ADIPOQ protein]; carvacrol promotes the reaction [Simvastatin inhibits the reaction [Poloxamer results in decreased secretion of ADIPOQ protein]] CTD PMID:29071762 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions
increases activity
ISO [4-cymene co-treated with gamma-terpinene co-treated with Thymol co-treated with carvacrol] inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]; [4-cymene co-treated with gamma-terpinene co-treated with Thymol co-treated with carvacrol] results in increased activity of AHR protein; carvacrol inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]
carvacrol results in increased activity of AHR protein
CTD PMID:29191726 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP carvacrol inhibits the reaction [Ethanol results in increased expression of BAX protein] CTD PMID:37499997 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP carvacrol inhibits the reaction [Ethanol results in decreased expression of BCL2 protein] CTD PMID:37499997 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
ISO
EXP
carvacrol results in increased activity of CASP3 protein
carvacrol inhibits the reaction [Poloxamer results in increased expression of CASP3 protein]; carvacrol inhibits the reaction [propiconazole results in increased expression of CASP3 protein]; carvacrol inhibits the reaction [Simvastatin promotes the reaction [Poloxamer results in increased expression of CASP3 protein]]
CTD PMID:23146755 PMID:29071762 PMID:29852196 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cat catalase multiple interactions EXP
ISO
carvacrol inhibits the reaction [Ethanol results in decreased expression of CAT protein]; carvacrol inhibits the reaction [Poloxamer results in decreased activity of CAT protein]; carvacrol inhibits the reaction [propiconazole results in decreased activity of CAT protein]; carvacrol promotes the reaction [Simvastatin inhibits the reaction [Poloxamer results in decreased activity of CAT protein]]
carvacrol inhibits the reaction [Benzo(a)pyrene results in decreased activity of CAT protein]
carvacrol inhibits the reaction [Diethylhexyl Phthalate results in increased activity of CAT protein]
CTD PMID:29019276 PMID:29071762 PMID:29852196 PMID:35521929 PMID:37499997 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ckm creatine kinase, M-type multiple interactions EXP carvacrol inhibits the reaction [Poloxamer results in increased secretion of CKM protein]; carvacrol inhibits the reaction [Simvastatin results in increased secretion of CKM protein] CTD PMID:29071762 NCBI chr 1:79,061,390...79,071,721
Ensembl chr 1:79,061,456...79,071,720
JBrowse link
G Cryz crystallin zeta multiple interactions ISO carvacrol inhibits the reaction [Benzo(a)pyrene results in decreased activity of CRYZ protein] CTD PMID:29019276 NCBI chr 2:243,552,037...243,580,369
Ensembl chr 2:243,552,119...243,579,758
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions ISO 2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [carvacrol inhibits the reaction [irinotecan results in increased expression of CXCL1 protein]]; carvacrol inhibits the reaction [irinotecan results in increased expression of CXCL1 protein] CTD PMID:27838229 NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
multiple interactions
ISO carvacrol results in increased expression of CYP1A1 mRNA
carvacrol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
CTD PMID:29191726 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Egfr epidermal growth factor receptor increases phosphorylation
multiple interactions
ISO carvacrol results in increased phosphorylation of EGFR protein
KN 93 inhibits the reaction [carvacrol results in increased phosphorylation of EGFR protein]; TRPV3 protein affects the reaction [carvacrol results in increased phosphorylation of EGFR protein]
CTD PMID:32535744 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions EXP carvacrol inhibits the reaction [propiconazole results in increased expression of GFAP protein] CTD PMID:29852196 NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions EXP carvacrol inhibits the reaction [Ethanol results in decreased expression of GPX1 protein] CTD PMID:37499997 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
JBrowse link
G Gpx4 glutathione peroxidase 4 affects binding ISO carvacrol binds to GPX4 protein CTD PMID:37499997 NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982
JBrowse link
G Htr3a 5-hydroxytryptamine receptor 3A increases activity ISO carvacrol results in increased activity of HTR3A protein CTD PMID:26456648 NCBI chr 8:49,242,018...49,254,475
Ensembl chr 8:49,242,020...49,254,389
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO 2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [carvacrol inhibits the reaction [irinotecan results in increased expression of IL1B protein]]; carvacrol inhibits the reaction [irinotecan results in increased expression of IL1B protein]
carvacrol inhibits the reaction [Acetaminophen results in increased expression of IL1B mRNA]
CTD PMID:26801986 PMID:27838229 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Lep leptin multiple interactions EXP carvacrol inhibits the reaction [Poloxamer results in increased secretion of LEP protein] CTD PMID:29071762 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
JBrowse link
G Mb myoglobin multiple interactions EXP carvacrol inhibits the reaction [Poloxamer results in increased secretion of MB protein] CTD PMID:29071762 NCBI chr 7:108,759,903...108,767,134
Ensembl chr 7:108,759,904...108,767,383
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO 2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [carvacrol inhibits the reaction [irinotecan results in increased activity of MPO protein]]; carvacrol inhibits the reaction [irinotecan results in increased activity of MPO protein] CTD PMID:27838229 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO
EXP
carvacrol inhibits the reaction [irinotecan results in increased expression of NFKB1 protein]
carvacrol inhibits the reaction [Ethanol results in increased expression of NFKB1 protein]
CTD PMID:27838229 PMID:37499997 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO carvacrol inhibits the reaction [Benzo(a)pyrene results in increased expression of NOS2 protein] CTD PMID:29019276 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nox1 NADPH oxidase 1 multiple interactions
affects binding
EXP
ISO
carvacrol inhibits the reaction [Ethanol results in increased expression of NOX1 protein]
carvacrol binds to NOX1 protein
CTD PMID:37499997 NCBI chr  X:97,279,058...97,332,291
Ensembl chr  X:97,279,056...97,302,236
JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions EXP carvacrol inhibits the reaction [Ethanol results in increased expression of NOX4 protein] CTD PMID:37499997 NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406
JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha multiple interactions
increases phosphorylation
ISO Erlotinib Hydrochloride inhibits the reaction [carvacrol results in increased phosphorylation of PIK3CA protein]; TRPV3 protein affects the reaction [carvacrol results in increased phosphorylation of PIK3CA protein] CTD PMID:32535744 NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO
EXP
carvacrol inhibits the reaction [Benzo(a)pyrene results in increased expression of PTGS2 protein]; carvacrol inhibits the reaction [Irinotecan results in increased expression of PTGS2 protein]
carvacrol inhibits the reaction [propiconazole results in increased expression of PTGS2 protein]
CTD PMID:27838229 PMID:29019276 PMID:29852196 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases phosphorylation
ISO Erlotinib Hydrochloride inhibits the reaction [carvacrol results in increased phosphorylation of RELA protein]; TRPV3 protein affects the reaction [carvacrol results in increased phosphorylation of RELA protein] CTD PMID:32535744 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Tgfa transforming growth factor alpha increases secretion
multiple interactions
ISO carvacrol results in increased secretion of TGFA protein
KN 93 inhibits the reaction [carvacrol results in increased secretion of TGFA protein]
CTD PMID:32535744 NCBI chr 4:118,618,043...118,700,897
Ensembl chr 4:118,618,269...118,700,894
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [carvacrol inhibits the reaction [irinotecan results in increased expression of TNF protein]]; carvacrol inhibits the reaction [irinotecan results in increased expression of TNF protein]
carvacrol inhibits the reaction [Ethanol results in increased expression of TNF protein]
carvacrol inhibits the reaction [Acetaminophen results in increased expression of TNF mRNA]
CTD PMID:26801986 PMID:27838229 PMID:37499997 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 increases activity EXP
ISO
carvacrol results in increased activity of TRPA1 protein CTD PMID:16617338 PMID:22935519 NCBI chr 5:4,379,862...4,434,133
Ensembl chr 5:4,379,999...4,433,570
JBrowse link
G Trpv3 transient receptor potential cation channel, subfamily V, member 3 increases activity
multiple interactions
increases response to substance
affects response to substance
ISO
EXP
carvacrol results in increased activity of TRPV3 protein
[carvacrol results in increased activity of TRPV3 protein] which results in increased transport of Calcium
[carvacrol binds to and results in increased activity of TRPV3 protein] which results in increased transport of Calcium; [carvacrol results in increased activity of TRPV3 protein] which results in increased transport of Calcium; carvacrol binds to and results in increased activity of TRPV3 protein; Ruthenium Red inhibits the reaction [[carvacrol binds to and results in increased activity of TRPV3 protein] which results in increased transport of Calcium]
TRPV3 protein results in increased susceptibility to carvacrol
TRPV3 protein affects the reaction [carvacrol results in increased phosphorylation of EGFR protein]; TRPV3 protein affects the reaction [carvacrol results in increased phosphorylation of PIK3CA protein]; TRPV3 protein affects the reaction [carvacrol results in increased phosphorylation of RELA protein]
TRPV3 protein affects the susceptibility to carvacrol
CTD PMID:16617338 PMID:20086034 PMID:29658714 PMID:32535744 NCBI chr10:57,883,546...57,915,865
Ensembl chr10:57,883,546...57,913,296
JBrowse link
G Xdh xanthine dehydrogenase multiple interactions ISO carvacrol inhibits the reaction [Benzo(a)pyrene results in increased activity of XDH protein] CTD PMID:29019276 NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268
JBrowse link

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  CHEBI ontology 19808
    role 19784
      biological role 19782
        pharmacological role 19026
          agonist 18570
            TRPA1 channel agonist 32
              carvacrol 32
              oleuropein aglycone 0
              optovin 0
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