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G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
decreases activity |
EXP |
1,9-dideoxyforskolin results in decreased activity of ABCB1A protein |
CTD |
PMID:12202523 |
|
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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G |
Abcb1b |
ATP-binding cassette, sub-family B member 1B |
decreases activity |
EXP |
1,9-dideoxyforskolin results in decreased activity of ABCB1B protein |
CTD |
PMID:12202523 |
|
NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199
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G |
Abcb4 |
ATP binding cassette subfamily B member 4 |
decreases activity |
EXP |
1,9-dideoxyforskolin results in decreased activity of ABCB4 protein |
CTD |
PMID:12202523 |
|
NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
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G |
Abcc4 |
ATP binding cassette subfamily C member 4 |
multiple interactions |
ISO |
[andrographolide co-treated with beta-Naphthoflavone] results in increased expression of ABCC4 mRNA |
CTD |
PMID:19737545 |
|
NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283
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G |
Acta2 |
actin alpha 2, smooth muscle |
decreases expression multiple interactions |
EXP ISO |
andrographolide results in decreased expression of ACTA2 mRNA; andrographolide results in decreased expression of ACTA2 protein andrographolide inhibits the reaction [Bleomycin results in increased expression of ACTA2 protein] andrographolide inhibits the reaction [N-acetyl-4-benzoquinoneimine results in increased expression of ACTA2 mRNA]; andrographolide inhibits the reaction [N-acetyl-4-benzoquinoneimine results in increased expression of ACTA2 protein]; andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of ACTA2 protein]; IL6 protein promotes the reaction [andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of ACTA2 protein]] andrographolide inhibits the reaction [Acetaminophen results in increased expression of ACTA2 mRNA]; andrographolide inhibits the reaction [Acetaminophen results in increased expression of ACTA2 protein]; andrographolide inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]; andrographolide inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of ACTA2 protein]; NFE2L2 gene mutant form inhibits the reaction [andrographolide inhibits the reaction [Acetaminophen results in increased expression of ACTA2 protein]] |
CTD |
PMID:29355602 PMID:31128153 PMID:31706003 |
|
NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
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G |
Adh7 |
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide |
multiple interactions |
ISO |
[andrographolide co-treated with beta-Naphthoflavone] results in increased expression of ADH7 mRNA |
CTD |
PMID:19737545 |
|
NCBI chr 2:226,748,724...226,763,183
Ensembl chr 2:226,741,788...226,763,182
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G |
Ankrd1 |
ankyrin repeat domain 1 |
multiple interactions |
ISO |
[andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of ANKRD1 mRNA |
CTD |
PMID:19737545 |
|
NCBI chr 1:233,815,851...233,834,891
Ensembl chr 1:233,815,851...233,834,919
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G |
Atf2 |
activating transcription factor 2 |
multiple interactions |
ISO |
andrographolide inhibits the reaction [cobaltous chloride results in increased expression of ATF2 protein modified form]; DUSP10 protein promotes the reaction [andrographolide inhibits the reaction [cobaltous chloride results in increased expression of ATF2 protein modified form]] |
CTD |
PMID:29165873 |
|
NCBI chr 3:58,718,323...58,795,280
Ensembl chr 3:58,718,332...58,795,236
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G |
B4galt1 |
beta-1,4-galactosyltransferase 1 |
increases expression |
ISO |
andrographolide results in increased expression of B4GALT1 mRNA |
CTD |
PMID:35724838 |
|
NCBI chr 5:55,935,614...55,982,461
Ensembl chr 5:55,935,615...55,982,461
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G |
Bad |
BCL2-associated agonist of cell death |
increases expression |
ISO |
andrographolide results in increased expression of BAD protein |
CTD |
PMID:35917943 |
|
NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
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G |
Bax |
BCL2 associated X, apoptosis regulator |
affects folding increases expression multiple interactions |
ISO |
andrographolide affects the folding of BAX protein andrographolide results in increased expression of BAX mRNA; andrographolide results in increased expression of BAX protein [andrographolide co-treated with Cisplatin] results in increased expression of BAX mRNA; andrographolide promotes the reaction [Cisplatin results in increased expression of BAX protein]; Fluorouracil promotes the reaction [andrographolide affects the folding of BAX protein] |
CTD |
PMID:19097688 PMID:23845849 PMID:24563380 PMID:35917943 |
|
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bbc3 |
Bcl-2 binding component 3 |
increases expression |
ISO |
andrographolide results in increased expression of BBC3 mRNA |
CTD |
PMID:35724838 |
|
NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509
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G |
Bcl2 |
BCL2, apoptosis regulator |
decreases expression multiple interactions |
ISO |
andrographolide results in decreased expression of BCL2 protein [andrographolide co-treated with Cisplatin] results in decreased expression of BCL2 mRNA |
CTD |
PMID:23845849 PMID:24563380 PMID:35917943 |
|
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Bhmt |
betaine-homocysteine S-methyltransferase |
multiple interactions |
ISO |
[andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of BHMT mRNA |
CTD |
PMID:19737545 |
|
NCBI chr 2:24,859,871...24,879,449
Ensembl chr 2:24,859,873...24,879,742
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G |
Bid |
BH3 interacting domain death agonist |
multiple interactions increases expression |
EXP ISO |
andrographolide inhibits the reaction [Copper Sulfate results in decreased expression of and results in increased cleavage of BID protein]; andrographolide promotes the reaction [Penicillamine inhibits the reaction [Copper Sulfate results in decreased expression of and results in increased cleavage of BID protein]]; Penicillamine promotes the reaction [andrographolide inhibits the reaction [Copper Sulfate results in decreased expression of and results in increased cleavage of BID protein]] [andrographolide co-treated with Cisplatin] results in increased expression of BID mRNA andrographolide results in increased expression of BID mRNA; andrographolide results in increased expression of BID protein |
CTD |
PMID:20946909 PMID:24563380 |
|
NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
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G |
Birc3 |
baculoviral IAP repeat-containing 3 |
increases expression multiple interactions |
ISO |
andrographolide results in increased expression of BIRC3 mRNA [andrographolide co-treated with TNF protein] results in decreased expression of BIRC3 mRNA |
CTD |
PMID:35724838 |
|
NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802
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G |
Birc5 |
baculoviral IAP repeat-containing 5 |
decreases expression |
ISO |
andrographolide results in decreased expression of BIRC5 protein |
CTD |
PMID:23845849 |
|
NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
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G |
Blvrb |
biliverdin reductase B |
multiple interactions |
ISO |
[andrographolide co-treated with beta-Naphthoflavone] results in increased expression of BLVRB mRNA |
CTD |
PMID:19737545 |
|
NCBI chr 1:82,738,646...82,756,312
Ensembl chr 1:82,738,695...82,770,375
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G |
Casp3 |
caspase 3 |
increases activity increases cleavage multiple interactions increases expression |
ISO EXP |
andrographolide results in increased activity of CASP3 protein andrographolide results in increased cleavage of CASP3 protein andrographolide inhibits the reaction [TGFB1 protein results in decreased cleavage of CASP3 protein] andrographolide results in increased expression of CASP3 mRNA [andrographolide co-treated with Cisplatin] results in increased expression of CASP3 mRNA; CASP8 affects the reaction [Fluorouracil promotes the reaction [andrographolide results in increased activity of CASP3 protein]]; Fluorouracil promotes the reaction [andrographolide results in increased activity of CASP3 protein] andrographolide inhibits the reaction [Copper Sulfate results in increased cleavage of CASP3 protein]; andrographolide promotes the reaction [Penicillamine inhibits the reaction [Copper Sulfate results in increased cleavage of CASP3 protein]]; Penicillamine promotes the reaction [andrographolide inhibits the reaction [Copper Sulfate results in increased cleavage of CASP3 protein]] |
CTD |
PMID:19097688 PMID:20946909 PMID:24563380 PMID:31706003 PMID:35917943 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp8 |
caspase 8 |
increases activity increases expression multiple interactions |
ISO EXP |
andrographolide results in increased activity of CASP8 protein andrographolide results in increased expression of CASP8 mRNA [andrographolide co-treated with Cisplatin] results in increased expression of CASP8 mRNA; CASP8 affects the reaction [Fluorouracil promotes the reaction [andrographolide results in increased activity of CASP3 protein]]; CASP8 affects the reaction [Fluorouracil promotes the reaction [andrographolide results in increased activity of CASP9 protein]]; CASP8 results in increased susceptibility to [andrographolide co-treated with Fluorouracil]; Fluorouracil promotes the reaction [andrographolide results in increased activity of CASP8 protein] andrographolide inhibits the reaction [Copper Sulfate results in increased activity of CASP8 protein] |
CTD |
PMID:19097688 PMID:20946909 PMID:24563380 |
|
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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G |
Casp9 |
caspase 9 |
increases activity increases expression multiple interactions |
ISO EXP |
andrographolide results in increased activity of CASP9 protein andrographolide results in increased expression of CASP9 mRNA andrographolide inhibits the reaction [Copper Sulfate results in increased activity of CASP9 protein]; andrographolide promotes the reaction [Penicillamine inhibits the reaction [Copper Sulfate results in increased activity of CASP9 protein]]; Penicillamine promotes the reaction [andrographolide inhibits the reaction [Copper Sulfate results in increased activity of CASP9 protein]] [andrographolide co-treated with Cisplatin] results in increased expression of CASP9 mRNA; CASP8 affects the reaction [Fluorouracil promotes the reaction [andrographolide results in increased activity of CASP9 protein]]; Fluorouracil promotes the reaction [andrographolide results in increased activity of CASP9 protein] |
CTD |
PMID:19097688 PMID:20946909 PMID:24563380 |
|
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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G |
Cat |
catalase |
multiple interactions |
ISO EXP |
[andrographolide co-treated with Polylactic Acid-Polyglycolic Acid Copolymer] inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]; andrographolide inhibits the reaction [sodium arsenite results in decreased activity of CAT protein] andrographolide inhibits the reaction [Freund's Adjuvant results in decreased activity of CAT protein] |
CTD |
PMID:26485141 PMID:32061742 |
|
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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G |
Cbr1 |
carbonyl reductase 1 |
multiple interactions |
ISO |
[andrographolide co-treated with beta-Naphthoflavone] results in increased expression of CBR1 mRNA |
CTD |
PMID:19737545 |
|
NCBI chr11:32,860,571...32,862,981
Ensembl chr11:32,908,950...32,911,393 Ensembl chr11:32,908,950...32,911,393
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G |
Cbr3 |
carbonyl reductase 3 |
multiple interactions increases expression |
ISO |
[andrographolide co-treated with beta-Naphthoflavone] results in increased expression of CBR3 mRNA andrographolide results in increased expression of CBR3 mRNA |
CTD |
PMID:19737545 |
|
NCBI chr11:33,008,615...33,016,877
Ensembl chr11:33,008,615...33,016,875
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G |
Ccl2 |
C-C motif chemokine ligand 2 |
multiple interactions increases expression |
ISO |
[andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of CCL2 mRNA andrographolide results in increased expression of CCL2 mRNA |
CTD |
PMID:19737545 PMID:35724838 |
|
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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G |
Ccl20 |
C-C motif chemokine ligand 20 |
increases expression |
ISO |
andrographolide results in increased expression of CCL20 mRNA |
CTD |
PMID:35724838 |
|
NCBI chr 9:84,389,031...84,391,629
Ensembl chr 9:84,388,904...84,391,629
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G |
Ccn2 |
cellular communication network factor 2 |
multiple interactions |
ISO |
[andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of CCN2 mRNA |
CTD |
PMID:19737545 |
|
NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734
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G |
Ccna2 |
cyclin A2 |
multiple interactions decreases expression |
ISO |
andrographolide inhibits the reaction [CCNA2 protein binds to CDK2 protein] andrographolide results in decreased expression of CCNA2 protein |
CTD |
PMID:18619950 |
|
NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
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G |
Ccnd1 |
cyclin D1 |
multiple interactions decreases expression |
ISO |
andrographolide inhibits the reaction [CCND1 protein binds to CDK4 protein] andrographolide results in decreased expression of CCND1 protein |
CTD |
PMID:18619950 PMID:23845849 PMID:35917943 |
|
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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G |
Ccne1 |
cyclin E1 |
decreases expression multiple interactions |
ISO |
andrographolide results in decreased expression of CCNE1 protein andrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CCNE1 protein] |
CTD |
PMID:23845849 PMID:27475717 |
|
NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
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G |
Cdh1 |
cadherin 1 |
multiple interactions increases expression |
ISO |
andrographolide inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of CDH1 protein] andrographolide results in increased expression of CDH1 protein andrographolide inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of CDH1 protein]; IL6 protein promotes the reaction [andrographolide inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of CDH1 protein]] |
CTD |
PMID:31128153 PMID:35917943 |
|
NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
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G |
Cdh17 |
cadherin 17 |
decreases expression multiple interactions |
ISO |
andrographolide results in decreased expression of CDH17 mRNA [andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of CDH17 mRNA |
CTD |
PMID:19737545 |
|
NCBI chr 5:25,262,820...25,314,884
Ensembl chr 5:25,262,758...25,314,884
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G |
Cdh2 |
cadherin 2 |
multiple interactions decreases expression |
ISO |
andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CDH2 protein] andrographolide results in decreased expression of CDH2 protein andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CDH2 protein]; IL6 protein promotes the reaction [andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CDH2 protein]] |
CTD |
PMID:31128153 PMID:35917943 |
|
NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167
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G |
Cdk2 |
cyclin dependent kinase 2 |
decreases expression multiple interactions |
ISO |
andrographolide results in decreased expression of CDK2 protein andrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CDK2 protein] andrographolide inhibits the reaction [CCNA2 protein binds to CDK2 protein] |
CTD |
PMID:18619950 PMID:27475717 |
|
NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
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G |
Cdk4 |
cyclin-dependent kinase 4 |
multiple interactions decreases expression |
ISO |
andrographolide inhibits the reaction [CCND1 protein binds to CDK4 protein] andrographolide results in decreased expression of CDK4 protein |
CTD |
PMID:18619950 |
|
NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403
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G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
increases expression |
ISO |
andrographolide results in increased expression of CDKN1A protein |
CTD |
PMID:18619950 PMID:23845849 |
|
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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G |
Cebpa |
CCAAT/enhancer binding protein alpha |
multiple interactions |
ISO |
andrographolide affects the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] affects the expression of CEBPA mRNA]; andrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CEBPA protein] |
CTD |
PMID:27475717 |
|
NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412
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G |
Cebpb |
CCAAT/enhancer binding protein beta |
multiple interactions |
ISO |
andrographolide affects the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] affects the expression of CEBPB mRNA]; andrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of and results in increased phosphorylation of CEBPB protein] |
CTD |
PMID:27475717 |
|
NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473
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G |
Ces3a |
carboxylesterase 3a |
multiple interactions increases expression |
ISO |
[andrographolide co-treated with beta-Naphthoflavone] results in increased expression of CES3 mRNA andrographolide results in increased expression of CES3 mRNA |
CTD |
PMID:19737545 |
|
NCBI chr19:32,992,386...33,000,562
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G |
Cish |
cytokine inducible SH2-containing protein |
multiple interactions |
ISO |
[andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of CISH mRNA |
CTD |
PMID:19737545 |
|
NCBI chr 8:107,972,306...107,977,254
Ensembl chr 8:107,972,306...107,977,250
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G |
Cnn2 |
calponin 2 |
multiple interactions |
ISO |
[andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of CNN2 mRNA |
CTD |
PMID:19737545 |
|
NCBI chr 7:9,712,505...9,719,678
Ensembl chr 7:9,712,516...9,719,656
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G |
Col1a1 |
collagen type I alpha 1 chain |
multiple interactions decreases expression |
ISO EXP |
andrographolide inhibits the reaction [N-acetyl-4-benzoquinoneimine results in increased expression of COL1A1 mRNA] andrographolide inhibits the reaction [Acetaminophen results in increased expression of COL1A1 mRNA]; andrographolide inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA] andrographolide results in decreased expression of COL1A1 mRNA |
CTD |
PMID:29355602 PMID:31706003 |
|
NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
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G |
Col1a2 |
collagen type I alpha 2 chain |
decreases expression multiple interactions |
ISO EXP |
andrographolide results in decreased expression of COL1A2 mRNA andrographolide inhibits the reaction [Acetaminophen results in increased expression of COL1A2 mRNA] |
CTD |
PMID:29355602 |
|
NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867
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G |
Col3a1 |
collagen type III alpha 1 chain |
decreases expression multiple interactions |
EXP ISO |
andrographolide results in decreased expression of COL3A1 mRNA andrographolide inhibits the reaction [N-acetyl-4-benzoquinoneimine results in increased expression of COL3A1 mRNA] andrographolide inhibits the reaction [Acetaminophen results in increased expression of COL3A1 mRNA]; andrographolide inhibits the reaction [TGFB1 protein results in increased expression of COL3A1 mRNA]; andrographolide inhibits the reaction [TGFB1 protein results in increased expression of COL3A1 protein] |
CTD |
PMID:29355602 PMID:31706003 |
|
NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547
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G |
Crct1 |
cysteine-rich C-terminal 1 |
multiple interactions |
ISO |
[andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of CRCT1 mRNA |
CTD |
PMID:19737545 |
|
NCBI chr 2:178,633,789...178,635,274
Ensembl chr 2:178,634,092...178,634,394
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G |
Ctnnb1 |
catenin beta 1 |
multiple interactions decreases expression |
ISO |
KYA1797K promotes the reaction [andrographolide results in decreased expression of CTNNB1 protein] |
CTD |
PMID:35917943 |
|
NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
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G |
Cxcl1 |
C-X-C motif chemokine ligand 1 |
multiple interactions increases expression |
ISO |
[andrographolide co-treated with TNF protein] results in decreased expression of CXCL1 mRNA andrographolide results in increased expression of CXCL1 mRNA |
CTD |
PMID:35724838 |
|
NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
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G |
Cxcl13 |
C-X-C motif chemokine ligand 13 |
multiple interactions |
ISO |
[andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of CXCL13 mRNA |
CTD |
PMID:19737545 |
|
NCBI chr14:13,608,894...13,613,965
Ensembl chr14:13,608,902...13,613,933
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G |
Cxcl2 |
C-X-C motif chemokine ligand 2 |
multiple interactions increases expression |
EXP ISO |
andrographolide inhibits the reaction [Freund's Adjuvant results in increased expression of CXCL2 protein] andrographolide results in increased expression of CXCL2 mRNA |
CTD |
PMID:32061742 PMID:35724838 |
|
NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
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G |
Cxcl3 |
C-X-C motif chemokine ligand 3 |
multiple interactions increases expression |
ISO |
[andrographolide co-treated with TNF protein] results in decreased expression of CXCL1 mRNA andrographolide results in increased expression of CXCL1 mRNA |
CTD |
PMID:35724838 |
|
NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511
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G |
Cyp17a1 |
cytochrome P450, family 17, subfamily a, polypeptide 1 |
multiple interactions |
ISO |
[andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of CYP17A1 mRNA |
CTD |
PMID:19737545 |
|
NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
multiple interactions increases expression increases activity |
ISO |
[andrographolide co-treated with benz(a)anthracene] results in increased expression of CYP1A1 mRNA; [andrographolide co-treated with beta-Naphthoflavone] results in increased expression of CYP1A1 mRNA; [andrographolide co-treated with Tetrachlorodibenzodioxin] results in increased expression of CYP1A1 mRNA; Acetylcysteine affects the reaction [andrographolide affects the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]]; andrographolide affects the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]; andrographolide promotes the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]; Ascorbic Acid affects the reaction [andrographolide affects the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]]; beta-Naphthoflavone promotes the reaction [andrographolide results in increased expression of CYP1A1 mRNA]; Buthionine Sulfoximine promotes the reaction [andrographolide affects the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]]; Glutathione affects the reaction [andrographolide affects the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]]; Hydrogen Peroxide promotes the reaction [andrographolide affects the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]]; resveratrol inhibits the reaction [[andrographolide co-treated with benz(a)anthracene] results in increased expression of CYP1A1 mRNA] andrographolide results in increased activity of CYP1A1 protein |
CTD |
PMID:17825862 PMID:19737545 PMID:21094198 PMID:21963808 |
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NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
decreases expression multiple interactions increases expression |
ISO EXP |
andrographolide results in decreased expression of CYP1A2 mRNA andrographolide affects the reaction [CYP1A2 protein results in increased metabolism of Theophylline] andrographolide results in increased expression of CYP1A2 mRNA [andrographolide co-treated with benz(a)anthracene] results in increased expression of CYP1A2 mRNA; [andrographolide co-treated with beta-Naphthoflavone] results in increased expression of CYP1A2 mRNA |
CTD |
PMID:17825862 PMID:19041297 PMID:19737545 PMID:20096675 |
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NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
multiple interactions |
ISO |
[andrographolide co-treated with benz(a)anthracene] results in increased expression of CYP1B1 mRNA; andrographolide promotes the reaction [beta-Naphthoflavone results in increased expression of CYP1B1 mRNA] |
CTD |
PMID:17825862 PMID:19737545 |
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NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
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G |
Cyp2a3 |
cytochrome P450, family 2, subfamily a, polypeptide 3 |
increases expression multiple interactions |
ISO |
andrographolide results in increased expression of CYP2A4 mRNA beta-Naphthoflavone promotes the reaction [andrographolide results in increased expression of CYP2A4 mRNA] |
CTD |
PMID:19737545 |
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NCBI chr 1:82,171,914...82,179,980
Ensembl chr 1:82,169,949...82,179,979
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G |
Cyp2b3 |
cytochrome P450, family 2, subfamily b, polypeptide 3 |
increases activity increases expression multiple interactions |
ISO |
andrographolide results in increased activity of CYP2B10 protein andrographolide results in increased expression of CYP2B10 mRNA [andrographolide co-treated with beta-Naphthoflavone] results in increased expression of CYP2B10 mRNA |
CTD |
PMID:19737545 PMID:21094198 |
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NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
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G |
Cyp2c11 |
cytochrome P450, subfamily 2, polypeptide 11 |
decreases expression |
EXP |
andrographolide results in decreased expression of CYP2C11 mRNA; andrographolide results in decreased expression of CYP2C11 protein |
CTD |
PMID:19041297 |
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NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
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G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
decreases expression |
ISO |
andrographolide results in decreased expression of CYP3A4 mRNA |
CTD |
PMID:19041297 |
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NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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G |
Cyp3a23-3a1 |
cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 |
decreases expression |
EXP |
andrographolide results in decreased expression of CYP3A23-3A1 mRNA |
CTD |
PMID:19041297 |
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NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030 Ensembl chr12:9,254,475...9,285,030
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G |
Cyp8b1 |
cytochrome P450 family 8 subfamily B member 1 |
increases expression |
ISO |
andrographolide results in increased expression of CYP8B1 mRNA |
CTD |
PMID:19737545 |
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NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166
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G |
Ddc |
dopa decarboxylase |
multiple interactions increases expression |
ISO |
[andrographolide co-treated with beta-Naphthoflavone] results in increased expression of DDC mRNA andrographolide results in increased expression of DDC mRNA |
CTD |
PMID:19737545 |
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NCBI chr14:86,378,685...86,469,189
Ensembl chr14:86,378,685...86,469,208
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G |
Ddit3 |
DNA-damage inducible transcript 3 |
increases expression |
ISO |
andrographolide results in increased expression of DDIT3 protein |
CTD |
PMID:35724838 |
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NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
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G |
Dusp10 |
dual specificity phosphatase 10 |
increases expression multiple interactions |
ISO |
andrographolide results in increased expression of DUSP10 mRNA; andrographolide results in increased expression of DUSP10 protein 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [andrographolide results in increased expression of DUSP10 mRNA]; 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [andrographolide results in increased expression of DUSP10 protein]; DUSP10 protein promotes the reaction [andrographolide inhibits the reaction [cobaltous chloride results in increased expression of ATF2 protein modified form]]; DUSP10 protein promotes the reaction [andrographolide inhibits the reaction [cobaltous chloride results in increased expression of HIF1A mRNA]]; HMOX1 protein promotes the reaction [andrographolide results in increased expression of DUSP10 protein]; zinc protoporphyrin inhibits the reaction [andrographolide results in increased expression of DUSP10 mRNA]; zinc protoporphyrin inhibits the reaction [andrographolide results in increased expression of DUSP10 protein] |
CTD |
PMID:29165873 |
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NCBI chr13:95,613,716...95,651,716
Ensembl chr13:95,614,292...95,651,716
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G |
Edn1 |
endothelin 1 |
multiple interactions increases expression |
ISO |
andrographolide inhibits the reaction [cobaltous chloride results in increased expression of EDN1 mRNA]; andrographolide inhibits the reaction [cobaltous chloride results in increased expression of EDN1 protein]; Vanadates inhibits the reaction [andrographolide inhibits the reaction [cobaltous chloride results in increased expression of EDN1 mRNA]]; Vanadates inhibits the reaction [andrographolide inhibits the reaction [cobaltous chloride results in increased expression of EDN1 protein]] andrographolide results in increased expression of EDN1 mRNA |
CTD |
PMID:27297870 PMID:29165873 PMID:35724838 |
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NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
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G |
Egln1 |
egl-9 family hypoxia-inducible factor 1 |
multiple interactions increases expression |
ISO |
EGLN1 mutant form inhibits the reaction [andrographolide results in decreased expression of HIF1A protein]; EGLN1 mutant form inhibits the reaction [andrographolide results in decreased expression of VEGFA protein]; TGFB1 protein inhibits the reaction [andrographolide results in increased expression of EGLN1 mRNA]; TGFB1 protein inhibits the reaction [andrographolide results in increased expression of EGLN1 protein] andrographolide results in increased expression of EGLN1 mRNA; andrographolide results in increased expression of EGLN1 protein |
CTD |
PMID:21134392 PMID:27297870 |
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NCBI chr19:52,867,900...52,907,308
Ensembl chr19:52,869,486...52,907,777
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G |
Egln3 |
egl-9 family hypoxia-inducible factor 3 |
increases expression |
ISO |
andrographolide results in increased expression of EGLN3 protein |
CTD |
PMID:27297870 |
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NCBI chr 6:71,650,297...71,675,766
Ensembl chr 6:71,650,297...71,675,766
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G |
Eid3 |
EP300 interacting inhibitor of differentiation 3 |
multiple interactions |
ISO |
[andrographolide co-treated with beta-Naphthoflavone] results in increased expression of EID3 mRNA |
CTD |
PMID:19737545 |
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NCBI chr 7:20,860,073...20,861,395
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G |
Elane |
elastase, neutrophil expressed |
multiple interactions |
EXP |
andrographolide inhibits the reaction [Freund's Adjuvant results in increased expression of ELANE protein] |
CTD |
PMID:32061742 |
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NCBI chr 7:9,817,251...9,819,174
Ensembl chr 7:9,817,252...9,819,100
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G |
Ezh2 |
enhancer of zeste 2 polycomb repressive complex 2 subunit |
multiple interactions |
ISO |
andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of EZH2 protein]; IL6 protein promotes the reaction [andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of EZH2 protein]] |
CTD |
PMID:31128153 |
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NCBI chr 4:76,624,399...76,687,362
Ensembl chr 4:76,624,399...76,687,362
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G |
Fas |
Fas cell surface death receptor |
multiple interactions increases expression |
ISO |
[andrographolide co-treated with Cisplatin] promotes the reaction [FAS protein binds to FASLG protein]; [andrographolide co-treated with Cisplatin] results in increased expression of FAS mRNA; [andrographolide co-treated with Cisplatin] results in increased expression of FAS protein; andrographolide promotes the reaction [FAS protein binds to FASLG protein] andrographolide results in increased expression of FAS mRNA; andrographolide results in increased expression of FAS protein |
CTD |
PMID:24563380 |
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NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
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G |
Faslg |
Fas ligand |
multiple interactions increases expression |
ISO |
[andrographolide co-treated with Cisplatin] promotes the reaction [FAS protein binds to FASLG protein]; [andrographolide co-treated with Cisplatin] results in increased expression of FASLG mRNA; [andrographolide co-treated with Cisplatin] results in increased expression of FASLG protein; andrographolide promotes the reaction [FAS protein binds to FASLG protein] andrographolide results in increased expression of FASLG mRNA; andrographolide results in increased expression of FASLG protein |
CTD |
PMID:24563380 |
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NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
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G |
Fasn |
fatty acid synthase |
multiple interactions |
ISO |
andrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of FASN mRNA]; andrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of FASN protein] |
CTD |
PMID:27475717 |
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NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
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G |
Flt1 |
Fms related receptor tyrosine kinase 1 |
decreases expression |
ISO |
andrographolide results in decreased expression of FLT1 mRNA |
CTD |
PMID:28651835 |
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NCBI chr12:7,296,899...7,468,626
Ensembl chr12:7,297,292...7,468,626
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G |
Fn1 |
fibronectin 1 |
multiple interactions |
ISO |
andrographolide inhibits the reaction [TGFB1 protein results in increased expression of FN1 protein] |
CTD |
PMID:31706003 |
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NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
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G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
ISO |
andrographolide results in decreased localization of and results in decreased activity of FOS protein |
CTD |
PMID:19426720 |
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NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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G |
Gclc |
glutamate-cysteine ligase, catalytic subunit |
increases expression multiple interactions decreases expression |
EXP ISO |
andrographolide results in increased expression of GCLC mRNA; andrographolide results in increased expression of GCLC protein [andrographolide co-treated with TNF protein] results in increased expression of GCLC mRNA andrographolide results in decreased expression of GCLC mRNA andrographolide inhibits the reaction [Acetaminophen results in decreased expression of GCLC mRNA] |
CTD |
PMID:25110055 PMID:29355602 PMID:35724838 |
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NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
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G |
Gclm |
glutamate cysteine ligase, modifier subunit |
multiple interactions decreases expression increases expression |
ISO EXP |
[andrographolide co-treated with beta-Naphthoflavone] results in increased expression of GCLM mRNA; andrographolide inhibits the reaction [Acetaminophen results in decreased expression of GCLM mRNA] [andrographolide co-treated with TNF protein] results in increased expression of GCLM mRNA andrographolide results in decreased expression of GCLM mRNA andrographolide results in increased expression of GCLM protein andrographolide results in increased expression of GCLM mRNA; andrographolide results in increased expression of GCLM protein |
CTD |
PMID:19737545 PMID:25110055 PMID:29355602 PMID:35724838 |
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NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
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G |
Gpt |
glutamic--pyruvic transaminase |
multiple interactions |
ISO |
[polylactic acid-polyglycolic acid copolymer co-treated with andrographolide] inhibits the reaction [sodium arsenite results in increased activity of GPT protein] |
CTD |
PMID:26485141 |
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NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
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G |
Gsk3b |
glycogen synthase kinase 3 beta |
multiple interactions decreases phosphorylation |
ISO |
andrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased phosphorylation of GSK3B protein] andrographolide results in decreased phosphorylation of GSK3B protein |
CTD |
PMID:27475717 PMID:35917943 |
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NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
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G |
Gsr |
glutathione-disulfide reductase |
increases activity |
EXP |
andrographolide results in increased activity of GSR protein |
CTD |
PMID:25110055 |
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NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
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G |
Gstm2 |
glutathione S-transferase mu 2 |
multiple interactions |
ISO |
[andrographolide co-treated with beta-Naphthoflavone] results in increased expression of GSTM2 mRNA |
CTD |
PMID:19737545 |
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NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961
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G |
Gstm4 |
glutathione S-transferase mu 4 |
increases expression multiple interactions |
ISO |
andrographolide results in increased expression of GSTM4 mRNA [andrographolide co-treated with beta-Naphthoflavone] results in increased expression of GSTM4 mRNA |
CTD |
PMID:19737545 |
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NCBI chr 2:195,667,940...195,685,315
Ensembl chr 2:195,680,004...195,685,323
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G |
Gstm5 |
glutathione S-transferase, mu 5 |
increases expression multiple interactions |
ISO |
andrographolide results in increased expression of GSTM3 mRNA [andrographolide co-treated with beta-Naphthoflavone] results in increased expression of GSTM3 mRNA |
CTD |
PMID:19737545 |
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NCBI chr 2:195,531,599...195,534,562
Ensembl chr 2:195,531,495...195,534,553
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G |
Hdac1 |
histone deacetylase 1 |
decreases expression |
ISO |
andrographolide results in decreased expression of HDAC1 protein |
CTD |
PMID:28651835 |
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NCBI chr 5:141,853,992...141,881,057
Ensembl chr 5:141,853,989...141,881,111
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G |
Hif1a |
hypoxia inducible factor 1 subunit alpha |
multiple interactions decreases expression increases expression |
ISO |
[andrographolide co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] results in increased ubiquitination of HIF1A protein; [andrographolide co-treated with cobaltous chloride] results in increased hydroxylation of HIF1A protein; andrographolide inhibits the reaction [cobaltous chloride results in increased expression of HIF1A mRNA]; andrographolide inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein]; andrographolide inhibits the reaction [HIF1A protein binds to VEGFA promoter]; andrographolide results in decreased expression of and affects the localization of HIF1A protein; andrographolide results in decreased expression of and results in increased degradation of HIF1A protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [andrographolide results in decreased expression of HIF1A protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [andrographolide results in increased degradation of HIF1A protein]; DUSP10 protein promotes the reaction [andrographolide inhibits the reaction [cobaltous chloride results in increased expression of HIF1A mRNA]]; EGLN1 mutant form inhibits the reaction [andrographolide results in decreased expression of HIF1A protein]; HMOX1 protein affects the reaction [andrographolide inhibits the reaction [cobaltous chloride results in increased expression of HIF1A mRNA]]; NFE2L2 protein affects the reaction [andrographolide inhibits the reaction [cobaltous chloride results in increased expression of HIF1A mRNA]]; pyrazolanthrone inhibits the reaction [andrographolide results in decreased expression of HIF1A protein]; Vanadates inhibits the reaction [andrographolide inhibits the reaction [cobaltous chloride results in increased expression of HIF1A mRNA]]; Vanadates inhibits the reaction [andrographolide inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein]] andrographolide results in increased expression of HIF1A protein modified form |
CTD |
PMID:21134392 PMID:27297870 PMID:28651835 PMID:29165873 |
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NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
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G |
Hmox1 |
heme oxygenase 1 |
increases expression decreases expression multiple interactions |
EXP ISO |
andrographolide results in increased expression of HMOX1 mRNA; andrographolide results in increased expression of HMOX1 protein andrographolide results in decreased expression of HMOX1 mRNA andrographolide inhibits the reaction [Acetaminophen results in decreased expression of HMOX1 mRNA] [andrographolide co-treated with TNF protein] results in increased expression of HMOX1 mRNA; HMOX1 protein affects the reaction [andrographolide inhibits the reaction [cobaltous chloride results in increased expression of HIF1A mRNA]]; HMOX1 protein promotes the reaction [andrographolide results in increased expression of DUSP10 protein] |
CTD |
PMID:25110055 PMID:27297870 PMID:29165873 PMID:29355602 PMID:35724838 |
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NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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G |
Hp |
haptoglobin |
multiple interactions |
ISO |
[andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of HP mRNA |
CTD |
PMID:19737545 |
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NCBI chr19:37,539,626...37,544,178
Ensembl chr19:37,539,627...37,544,523
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G |
Hpgd |
15-hydroxyprostaglandin dehydrogenase |
multiple interactions |
ISO |
[andrographolide co-treated with beta-Naphthoflavone] results in increased expression of HPGD mRNA |
CTD |
PMID:19737545 |
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NCBI chr16:33,986,265...34,024,228
Ensembl chr16:33,986,266...34,024,228
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G |
Icam1 |
intercellular adhesion molecule 1 |
multiple interactions |
ISO |
[andrographolide co-treated with TNF protein] results in decreased expression of ICAM1 mRNA; andrographolide inhibits the reaction [IL1B protein results in increased expression of ICAM1 protein]; andrographolide inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] |
CTD |
PMID:35724838 |
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NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
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G |
Ikbke |
inhibitor of nuclear factor kappa B kinase subunit epsilon |
multiple interactions |
ISO |
[andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of IKBKE mRNA |
CTD |
PMID:19737545 |
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NCBI chr13:42,712,154...42,738,470
Ensembl chr13:42,712,159...42,737,143
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G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO |
andrographolide inhibits the reaction [IL1B protein affects the localization of NFKBIA protein]; andrographolide inhibits the reaction [IL1B protein affects the localization of RELA protein]; andrographolide inhibits the reaction [IL1B protein results in increased expression of ICAM1 protein]; andrographolide inhibits the reaction [IL1B protein results in increased expression of TNFAIP3 protein] |
CTD |
PMID:35724838 |
|
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il6 |
interleukin 6 |
multiple interactions |
ISO EXP |
andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased secretion of IL6 protein]; IL6 protein promotes the reaction [andrographolide inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of CDH1 protein]]; IL6 protein promotes the reaction [andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of ACTA2 protein]]; IL6 protein promotes the reaction [andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CDH2 protein]]; IL6 protein promotes the reaction [andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of EZH2 protein]]; IL6 protein promotes the reaction [andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of HOTAIR mRNA]]; IL6 protein promotes the reaction [andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of VIM protein]]; IL6 protein promotes the reaction [andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased phosphorylation of STAT3 protein]]; IL6 protein promotes the reaction [andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased secretion of IL6 protein]] andrographolide inhibits the reaction [Freund's Adjuvant results in increased expression of IL6 protein] andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of IL6 mRNA]; andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased secretion of IL6 protein] |
CTD |
PMID:31128153 PMID:32061742 |
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NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Ins1 |
insulin 1 |
multiple interactions |
ISO |
andrographolide affects the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] affects the expression of CEBPA mRNA]; andrographolide affects the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] affects the expression of CEBPB mRNA]; andrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of and results in increased phosphorylation of CEBPB protein]; andrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CCNE1 protein]; andrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CDK2 protein]; andrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CEBPA protein]; andrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of FASN mRNA]; andrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of FASN protein]; andrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of PPARG protein]; andrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of SCD1 mRNA]; andrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of SCD1 protein]; andrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased phosphorylation of GSK3B protein]; andrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased phosphorylation of MAPK1 protein]; andrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:27475717 |
|
NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536
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G |
Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
ISO |
andrographolide results in decreased localization of and results in decreased activity of JUN protein |
CTD |
PMID:19426720 |
|
NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
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G |
Kdr |
kinase insert domain receptor |
multiple interactions decreases expression |
ISO |
[andrographolide co-treated with KDR protein] inhibits the reaction [VEGFA protein binds to KDR protein]; andrographolide inhibits the reaction [VEGFA protein results in increased phosphorylation of KDR protein] andrographolide results in decreased expression of KDR mRNA |
CTD |
PMID:24814888 PMID:28651835 |
|
NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018
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G |
Keap1 |
Kelch-like ECH-associated protein 1 |
decreases expression |
ISO |
andrographolide results in decreased expression of KEAP1 mRNA; andrographolide results in decreased expression of KEAP1 protein |
CTD |
PMID:29355602 PMID:35724838 |
|
NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862
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G |
Krt5 |
keratin 5 |
multiple interactions |
ISO |
[andrographolide co-treated with beta-Naphthoflavone] results in increased expression of KRT5 mRNA |
CTD |
PMID:19737545 |
|
NCBI chr 7:132,846,132...132,851,861
Ensembl chr 7:132,846,136...132,851,850
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G |
Mafg |
MAF bZIP transcription factor G |
decreases expression |
ISO |
andrographolide results in decreased expression of MAFG mRNA |
CTD |
PMID:35724838 |
|
NCBI chr10:105,903,307...105,911,808
Ensembl chr10:105,903,237...105,912,026
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G |
Map2k4 |
mitogen activated protein kinase kinase 4 |
multiple interactions |
ISO |
andrographolide inhibits the reaction [VEGFA protein results in increased phosphorylation of MAP2K4 protein] |
CTD |
PMID:24814888 |
|
NCBI chr10:50,343,227...50,447,956
Ensembl chr10:50,344,915...50,447,993
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G |
Map2k6 |
mitogen-activated protein kinase kinase 6 |
multiple interactions |
ISO |
andrographolide inhibits the reaction [VEGFA protein results in increased phosphorylation of MAP2K6 protein] |
CTD |
PMID:24814888 |
|
NCBI chr10:95,373,304...95,490,406
Ensembl chr10:95,373,204...95,488,293
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G |
Map2k7 |
mitogen activated protein kinase kinase 7 |
multiple interactions |
ISO |
andrographolide inhibits the reaction [VEGFA protein results in increased phosphorylation of MAP2K7 protein] |
CTD |
PMID:24814888 |
|
NCBI chr12:2,591,312...2,600,534
Ensembl chr12:2,591,219...2,604,222
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G |
Map3k5 |
mitogen-activated protein kinase kinase kinase 5 |
multiple interactions |
ISO |
andrographolide inhibits the reaction [VEGFA protein results in increased phosphorylation of MAP3K5 protein] |
CTD |
PMID:24814888 |
|
NCBI chr 1:14,685,776...14,904,935
Ensembl chr 1:14,685,492...14,904,800
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions |
ISO |
andrographolide inhibits the reaction [VEGFA protein results in increased phosphorylation of MAPK1 protein] andrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased phosphorylation of MAPK1 protein]; andrographolide inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:24814888 PMID:27475717 PMID:31706003 |
|
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions |
ISO |
andrographolide inhibits the reaction [VEGFA protein results in increased phosphorylation of MAPK3 protein] andrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased phosphorylation of MAPK3 protein]; andrographolide inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:24814888 PMID:27475717 PMID:31706003 |
|
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Mmp2 |
matrix metallopeptidase 2 |
multiple interactions decreases expression |
ISO |
andrographolide inhibits the reaction [TGFB1 protein results in increased expression of MMP2 mRNA] andrographolide results in decreased expression of MMP2 protein |
CTD |
PMID:31706003 PMID:35917943 |
|
NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
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G |
Mmp7 |
matrix metallopeptidase 7 |
decreases expression multiple interactions |
ISO |
andrographolide results in decreased expression of MMP7 mRNA; andrographolide results in decreased expression of MMP7 protein andrographolide results in decreased expression of and results in decreased activity of MMP7 protein |
CTD |
PMID:19426720 PMID:35917943 |
|
NCBI chr 8:4,848,186...4,855,908
Ensembl chr 8:4,848,186...4,855,902
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G |
Mmp9 |
matrix metallopeptidase 9 |
multiple interactions decreases expression |
ISO |
andrographolide inhibits the reaction [TGFB1 protein results in increased expression of MMP9 mRNA] andrographolide results in decreased expression of MMP9 protein |
CTD |
PMID:31706003 PMID:35917943 |
|
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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G |
Mpo |
myeloperoxidase |
multiple interactions |
EXP |
andrographolide inhibits the reaction [Freund's Adjuvant results in increased expression of MPO protein] |
CTD |
PMID:32061742 |
|
NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
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G |
Mta1 |
metastasis associated 1 |
decreases expression |
ISO |
andrographolide results in decreased expression of MTA1 mRNA; andrographolide results in decreased expression of MTA1 protein |
CTD |
PMID:28651835 |
|
NCBI chr 6:132,178,608...132,217,641
Ensembl chr 6:132,178,853...132,217,641
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G |
Myc |
MYC proto-oncogene, bHLH transcription factor |
decreases expression |
ISO |
andrographolide results in decreased expression of MYC protein |
CTD |
PMID:35917943 |
|
NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
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G |
Myo18b |
myosin XVIIIb |
decreases expression |
ISO |
andrographolide results in decreased expression of MYO18B mRNA |
CTD |
PMID:19737545 |
|
NCBI chr12:43,747,003...43,953,694
Ensembl chr12:43,747,010...43,953,695
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G |
Necab1 |
N-terminal EF-hand calcium binding protein 1 |
multiple interactions |
ISO |
[andrographolide co-treated with beta-Naphthoflavone] results in increased expression of NECAB1 mRNA |
CTD |
PMID:19737545 |
|
NCBI chr 5:28,357,859...28,578,642
Ensembl chr 5:28,357,859...28,578,642 Ensembl chr 5:28,357,859...28,578,642
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G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
increases activity decreases response to substance multiple interactions |
EXP ISO |
andrographolide results in increased activity of NFE2L2 protein NFE2L2 gene mutant form results in decreased susceptibility to andrographolide NFE2L2 gene mutant form inhibits the reaction [andrographolide inhibits the reaction [Acetaminophen results in increased expression of ACTA2 protein]] andrographolide results in increased expression of and affects the localization of NFE2L2 protein; NFE2L2 protein affects the reaction [andrographolide inhibits the reaction [cobaltous chloride results in increased expression of HIF1A mRNA]] |
CTD |
PMID:25110055 PMID:27297870 PMID:29355602 PMID:35724838 |
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NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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G |
Nfkbia |
NFKB inhibitor alpha |
multiple interactions |
ISO |
andrographolide inhibits the reaction [IL1B protein affects the localization of NFKBIA protein]; andrographolide inhibits the reaction [TNF protein affects the localization of NFKBIA protein] |
CTD |
PMID:35724838 |
|
NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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G |
Nfkbie |
NFKB inhibitor epsilon |
increases expression |
ISO |
andrographolide results in increased expression of NFKBIE mRNA |
CTD |
PMID:35724838 |
|
NCBI chr 9:15,443,600...15,450,437
Ensembl chr 9:15,436,941...15,450,437
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G |
Ngb |
neuroglobin |
multiple interactions |
ISO |
[andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of NGB mRNA |
CTD |
PMID:19737545 |
|
NCBI chr 6:106,744,378...106,749,830
Ensembl chr 6:106,744,378...106,749,830
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G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
increases expression decreases expression multiple interactions |
ISO EXP |
andrographolide results in increased expression of NQO1 mRNA andrographolide results in decreased expression of NQO1 mRNA andrographolide results in increased expression of NQO1 protein [andrographolide co-treated with beta-Naphthoflavone] results in increased expression of NQO1 mRNA; andrographolide promotes the reaction [Acetaminophen results in increased expression of NQO1 mRNA] |
CTD |
PMID:19737545 PMID:29355602 PMID:35724838 |
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NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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G |
Olr1 |
oxidized low density lipoprotein receptor 1 |
increases expression |
ISO |
andrographolide results in increased expression of OLR1 mRNA |
CTD |
PMID:35724838 |
|
NCBI chr 4:162,926,436...162,949,057
Ensembl chr 4:162,926,439...162,948,523
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G |
OR6c8 |
olfactory receptor family 6 subfamily C member 8 |
decreases expression |
ISO |
andrographolide results in decreased expression of OR6C8 mRNA |
CTD |
PMID:19737545 |
|
NCBI chr 7:1,502,160...1,503,089
Ensembl chr 7:1,501,940...1,507,336
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
increases cleavage |
ISO |
andrographolide results in increased cleavage of PARP1 protein |
CTD |
PMID:35917943 |
|
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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G |
Pcna |
proliferating cell nuclear antigen |
multiple interactions decreases expression |
ISO |
andrographolide inhibits the reaction [TGFB1 protein results in increased expression of PCNA protein] andrographolide results in decreased expression of PCNA protein |
CTD |
PMID:31706003 PMID:35917943 |
|
NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
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G |
Pdgfb |
platelet derived growth factor subunit B |
increases expression |
ISO |
andrographolide results in increased expression of PDGFB mRNA |
CTD |
PMID:35724838 |
|
NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984
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G |
Pdzrn3 |
PDZ domain containing RING finger 3 |
multiple interactions |
ISO |
[andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of PDZRN3 mRNA |
CTD |
PMID:19737545 |
|
NCBI chr 4:133,770,736...133,996,959
Ensembl chr 4:133,770,736...133,996,959
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G |
Pecam1 |
platelet and endothelial cell adhesion molecule 1 |
decreases expression |
ISO |
andrographolide results in decreased expression of PECAM1 protein |
CTD |
PMID:28651835 |
|
NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116
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G |
Phospho1 |
phosphoethanolamine/phosphocholine phosphatase 1 |
multiple interactions |
ISO |
[andrographolide co-treated with beta-Naphthoflavone] results in increased expression of PHOSPHO1 mRNA |
CTD |
PMID:19737545 |
|
NCBI chr10:80,762,062...80,769,596
Ensembl chr10:80,760,792...80,770,342
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G |
Plau |
plasminogen activator, urokinase |
increases expression |
ISO |
andrographolide results in increased expression of PLAU mRNA |
CTD |
PMID:35724838 |
|
NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775
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G |
Plscr1 |
phospholipid scramblase 1 |
multiple interactions |
ISO |
[andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of PLSCR1 mRNA |
CTD |
PMID:19737545 |
|
NCBI chr 8:92,784,279...92,804,698
Ensembl chr 8:92,784,356...92,804,692
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G |
Por |
cytochrome p450 oxidoreductase |
multiple interactions |
ISO |
[andrographolide co-treated with beta-Naphthoflavone] results in increased expression of POR mRNA |
CTD |
PMID:19737545 |
|
NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
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G |
Pparg |
peroxisome proliferator-activated receptor gamma |
multiple interactions |
ISO |
andrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of PPARG protein] |
CTD |
PMID:27475717 |
|
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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G |
Prkag2 |
protein kinase AMP-activated non-catalytic subunit gamma 2 |
increases expression |
ISO |
andrographolide results in increased expression of PRKAG2 mRNA |
CTD |
PMID:35724838 |
|
NCBI chr 4:10,010,890...10,252,155
Ensembl chr 4:10,010,890...10,252,142
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G |
Ptgr1 |
prostaglandin reductase 1 |
multiple interactions |
ISO |
[andrographolide co-treated with beta-Naphthoflavone] results in increased expression of PTGR1 mRNA |
CTD |
PMID:19737545 |
|
NCBI chr 5:73,784,000...73,802,624
Ensembl chr 5:73,784,009...73,802,666
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G |
Raf1 |
Raf-1 proto-oncogene, serine/threonine kinase |
multiple interactions |
ISO |
andrographolide inhibits the reaction [VEGFA protein results in increased phosphorylation of RAF1 protein] |
CTD |
PMID:24814888 |
|
NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317
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G |
Rb1 |
RB transcriptional corepressor 1 |
decreases phosphorylation |
ISO |
andrographolide results in decreased phosphorylation of RB1 protein |
CTD |
PMID:18619950 |
|
NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
andrographolide inhibits the reaction [IL1B protein affects the localization of RELA protein]; andrographolide inhibits the reaction [TNF protein affects the localization of RELA protein]; andrographolide results in decreased expression of and results in decreased localization of RELA protein; pyrrolidine dithiocarbamic acid promotes the reaction [andrographolide results in decreased expression of and results in decreased localization of RELA protein] |
CTD |
PMID:35724838 PMID:35917943 |
|
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
S100a4 |
S100 calcium-binding protein A4 |
multiple interactions |
EXP |
andrographolide inhibits the reaction [Bleomycin results in increased expression of S100A4 protein] |
CTD |
PMID:31706003 |
|
NCBI chr 2:176,090,951...176,093,258
Ensembl chr 2:176,091,804...176,093,254
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G |
Scd |
stearoyl-CoA desaturase |
multiple interactions |
ISO |
andrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of SCD1 mRNA]; andrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of SCD1 protein] |
CTD |
PMID:27475717 |
|
NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562
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G |
Serpina7 |
serpin family A member 7 |
multiple interactions |
ISO |
[andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of SERPINA7 mRNA |
CTD |
PMID:19737545 |
|
NCBI chr X:102,663,242...102,722,319
Ensembl chr X:102,663,405...102,669,040
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G |
Slc1a4 |
solute carrier family 1 member 4 |
multiple interactions increases expression |
ISO |
[andrographolide co-treated with beta-Naphthoflavone] results in increased expression of SLC1A4 mRNA andrographolide results in increased expression of SLC1A4 mRNA |
CTD |
PMID:19737545 |
|
NCBI chr14:94,530,801...94,560,190
Ensembl chr14:94,529,084...94,560,418
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G |
Slc3a2 |
solute carrier family 3 member 2 |
decreases expression |
ISO |
andrographolide results in decreased expression of SLC3A2 mRNA |
CTD |
PMID:35724838 |
|
NCBI chr 1:205,604,468...205,618,931
Ensembl chr 1:205,604,468...205,618,931
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G |
Slc7a11 |
solute carrier family 7 member 11 |
increases expression |
ISO |
andrographolide results in increased expression of SLC7A11 mRNA |
CTD |
PMID:19737545 |
|
NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536
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G |
Smad2 |
SMAD family member 2 |
multiple interactions |
ISO |
andrographolide inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein] |
CTD |
PMID:31706003 |
|
NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323
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G |
Smad3 |
SMAD family member 3 |
multiple interactions |
ISO |
andrographolide inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] |
CTD |
PMID:31706003 |
|
NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960
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G |
Snai1 |
snail family transcriptional repressor 1 |
decreases expression |
ISO |
andrographolide results in decreased expression of SNAI1 protein |
CTD |
PMID:35917943 |
|
NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969
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G |
Sod1 |
superoxide dismutase 1 |
increases expression |
EXP |
andrographolide results in increased expression of SOD1 mRNA; andrographolide results in increased expression of SOD1 protein |
CTD |
PMID:25110055 |
|
NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
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G |
Spp1 |
secreted phosphoprotein 1 |
multiple interactions |
ISO |
[andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of SPP1 mRNA |
CTD |
PMID:19737545 |
|
NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
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G |
Sqstm1 |
sequestosome 1 |
increases expression decreases expression |
ISO |
andrographolide results in increased expression of SQSTM1 protein andrographolide results in decreased expression of SQSTM1 mRNA |
CTD |
PMID:29355602 PMID:35724838 |
|
NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673
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G |
Srxn1 |
sulfiredoxin 1 |
multiple interactions decreases expression increases expression |
ISO |
[andrographolide co-treated with beta-Naphthoflavone] results in increased expression of SRXN1 mRNA andrographolide results in decreased expression of SRXN1 mRNA [andrographolide co-treated with TNF protein] results in increased expression of SRXN1 mRNA andrographolide results in increased expression of SRXN1 protein andrographolide results in increased expression of SRXN1 mRNA |
CTD |
PMID:19737545 PMID:35724838 |
|
NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448
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G |
Stat3 |
signal transducer and activator of transcription 3 |
decreases activity multiple interactions |
ISO |
andrographolide results in decreased activity of STAT3 protein andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased phosphorylation of STAT3 protein] andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased phosphorylation of STAT3 protein]; IL6 protein promotes the reaction [andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased phosphorylation of STAT3 protein]] |
CTD |
PMID:23845849 PMID:31128153 |
|
NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
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G |
Steap4 |
STEAP4 metalloreductase |
multiple interactions |
ISO |
[andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of STEAP4 mRNA |
CTD |
PMID:19737545 |
|
NCBI chr 4:26,077,182...26,099,859
Ensembl chr 4:26,054,671...26,099,859
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|
G |
Tap1 |
transporter 1, ATP binding cassette subfamily B member |
increases expression |
ISO |
andrographolide results in increased expression of TAP1 mRNA |
CTD |
PMID:35724838 |
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NCBI chr20:4,656,262...4,666,634
Ensembl chr20:4,656,263...4,666,901
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G |
Tdo2 |
tryptophan 2,3-dioxygenase |
multiple interactions increases expression |
ISO |
[andrographolide co-treated with beta-Naphthoflavone] results in increased expression of TDO2 mRNA andrographolide results in increased expression of TDO2 mRNA |
CTD |
PMID:19737545 |
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NCBI chr 2:167,269,581...167,287,511
Ensembl chr 2:167,269,579...167,287,511
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G |
Tgfb1 |
transforming growth factor, beta 1 |
decreases expression multiple interactions |
ISO EXP |
andrographolide results in decreased expression of TGFB1 protein andrographolide inhibits the reaction [TGFB1 protein results in decreased cleavage of CASP3 protein]; andrographolide inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]; andrographolide inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; andrographolide inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]; andrographolide inhibits the reaction [TGFB1 protein results in increased expression of COL3A1 mRNA]; andrographolide inhibits the reaction [TGFB1 protein results in increased expression of COL3A1 protein]; andrographolide inhibits the reaction [TGFB1 protein results in increased expression of FN1 protein]; andrographolide inhibits the reaction [TGFB1 protein results in increased expression of MMP2 mRNA]; andrographolide inhibits the reaction [TGFB1 protein results in increased expression of MMP9 mRNA]; andrographolide inhibits the reaction [TGFB1 protein results in increased expression of PCNA protein]; andrographolide inhibits the reaction [TGFB1 protein results in increased expression of TIMP1 mRNA]; andrographolide inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK1 protein]; andrographolide inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK3 protein]; andrographolide inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein]; andrographolide inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] andrographolide inhibits the reaction [Bleomycin results in increased expression of TGFB1 protein] TGFB1 protein inhibits the reaction [andrographolide results in increased expression of EGLN1 mRNA]; TGFB1 protein inhibits the reaction [andrographolide results in increased expression of EGLN1 protein] |
CTD |
PMID:21134392 PMID:31706003 |
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NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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G |
Thbs1 |
thrombospondin 1 |
multiple interactions decreases expression |
ISO |
[andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of THBS1 mRNA andrographolide results in decreased expression of THBS1 mRNA |
CTD |
PMID:19737545 |
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NCBI chr 3:105,056,293...105,071,445
Ensembl chr 3:105,056,292...105,071,440
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G |
Timp1 |
TIMP metallopeptidase inhibitor 1 |
multiple interactions |
ISO |
andrographolide inhibits the reaction [TGFB1 protein results in increased expression of TIMP1 mRNA] |
CTD |
PMID:31706003 |
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NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664
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G |
Tmprss11f |
transmembrane serine protease 11F |
multiple interactions |
ISO |
[andrographolide co-treated with beta-Naphthoflavone] results in increased expression of TMPRSS11F mRNA |
CTD |
PMID:19737545 |
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NCBI chr14:21,492,896...21,534,792
Ensembl chr14:21,429,418...21,534,809
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
EXP ISO |
andrographolide inhibits the reaction [Copper Sulfate results in increased expression of TNF protein]; andrographolide inhibits the reaction [Freund's Adjuvant results in increased expression of TNF protein] [andrographolide co-treated with TNF protein] results in decreased expression of BIRC3 mRNA; [andrographolide co-treated with TNF protein] results in decreased expression of CXCL1 mRNA; [andrographolide co-treated with TNF protein] results in decreased expression of ICAM1 mRNA; [andrographolide co-treated with TNF protein] results in decreased expression of TNFAIP3 mRNA; [andrographolide co-treated with TNF protein] results in increased expression of GCLC mRNA; [andrographolide co-treated with TNF protein] results in increased expression of GCLM mRNA; [andrographolide co-treated with TNF protein] results in increased expression of HMOX1 mRNA; [andrographolide co-treated with TNF protein] results in increased expression of SRXN1 mRNA; andrographolide inhibits the reaction [TNF protein affects the localization of NFKBIA protein]; andrographolide inhibits the reaction [TNF protein affects the localization of RELA protein]; andrographolide inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; andrographolide inhibits the reaction [TNF protein results in increased expression of TNFAIP3 protein] |
CTD |
PMID:20946909 PMID:32061742 PMID:35724838 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Tnfaip3 |
TNF alpha induced protein 3 |
increases expression multiple interactions |
ISO |
andrographolide results in increased expression of TNFAIP3 mRNA; andrographolide results in increased expression of TNFAIP3 protein [andrographolide co-treated with TNF protein] results in decreased expression of TNFAIP3 mRNA; andrographolide inhibits the reaction [IL1B protein results in increased expression of TNFAIP3 protein]; andrographolide inhibits the reaction [TNF protein results in increased expression of TNFAIP3 protein] |
CTD |
PMID:35724838 |
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NCBI chr 1:13,709,211...13,724,291
Ensembl chr 1:13,709,206...13,725,282
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G |
Tnfrsf9 |
TNF receptor superfamily member 9 |
increases expression |
ISO |
andrographolide results in increased expression of TNFRSF9 mRNA |
CTD |
PMID:35724838 |
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NCBI chr 5:161,381,662...161,408,003
Ensembl chr 5:161,381,662...161,408,000
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G |
Tp53 |
tumor protein p53 |
multiple interactions increases expression |
ISO |
andrographolide results in increased expression of and results in increased phosphorylation of TP53 protein; Fluorouracil promotes the reaction [andrographolide results in increased expression of TP53] |
CTD |
PMID:18619950 PMID:19097688 |
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NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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G |
Trib3 |
tribbles pseudokinase 3 |
decreases expression |
ISO |
andrographolide results in decreased expression of TRIB3 mRNA |
CTD |
PMID:35724838 |
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NCBI chr 3:140,809,634...140,815,230
Ensembl chr 3:140,809,043...140,814,497
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G |
Txnrd1 |
thioredoxin reductase 1 |
decreases expression |
ISO |
andrographolide results in decreased expression of TXNRD1 mRNA |
CTD |
PMID:35724838 |
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NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
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G |
Ugt1a6 |
UDP glucuronosyltransferase family 1 member A6 |
multiple interactions increases expression |
ISO |
[andrographolide co-treated with beta-Naphthoflavone] results in increased expression of UGT1A6 mRNA andrographolide results in increased expression of UGT1A6 mRNA |
CTD |
PMID:19737545 |
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NCBI chr 9:88,747,213...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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G |
Vcam1 |
vascular cell adhesion molecule 1 |
multiple interactions increases expression |
ISO |
[andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of VCAM1 mRNA andrographolide results in increased expression of VCAM1 mRNA |
CTD |
PMID:19737545 PMID:35724838 |
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NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
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G |
Vegfa |
vascular endothelial growth factor A |
multiple interactions decreases expression |
ISO |
[andrographolide co-treated with KDR protein] inhibits the reaction [VEGFA protein binds to KDR protein]; andrographolide inhibits the reaction [HIF1A protein binds to VEGFA promoter]; andrographolide inhibits the reaction [VEGFA protein results in increased phosphorylation of KDR protein]; andrographolide inhibits the reaction [VEGFA protein results in increased phosphorylation of MAP2K4 protein]; andrographolide inhibits the reaction [VEGFA protein results in increased phosphorylation of MAP2K6 protein]; andrographolide inhibits the reaction [VEGFA protein results in increased phosphorylation of MAP2K7 protein]; andrographolide inhibits the reaction [VEGFA protein results in increased phosphorylation of MAP3K5 protein]; andrographolide inhibits the reaction [VEGFA protein results in increased phosphorylation of MAPK1 protein]; andrographolide inhibits the reaction [VEGFA protein results in increased phosphorylation of MAPK3 protein]; andrographolide inhibits the reaction [VEGFA protein results in increased phosphorylation of RAF1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [andrographolide results in decreased expression of VEGFA mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [andrographolide results in decreased expression of VEGFA protein]; EGLN1 mutant form inhibits the reaction [andrographolide results in decreased expression of VEGFA protein]; pyrazolanthrone inhibits the reaction [andrographolide results in decreased expression of VEGFA mRNA]; pyrazolanthrone inhibits the reaction [andrographolide results in decreased expression of VEGFA protein] andrographolide results in decreased expression of VEGFA mRNA; andrographolide results in decreased expression of VEGFA protein |
CTD |
PMID:21134392 PMID:24814888 PMID:28651835 PMID:35724838 |
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NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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G |
Vil1 |
villin 1 |
multiple interactions |
ISO |
[andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of VIL1 mRNA |
CTD |
PMID:19737545 |
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NCBI chr 9:75,991,141...76,018,860
Ensembl chr 9:75,991,141...76,018,858
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G |
Vim |
vimentin |
multiple interactions decreases expression |
ISO |
[andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of VIM mRNA; andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of VIM protein] andrographolide results in decreased expression of VIM protein andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of VIM protein]; IL6 protein promotes the reaction [andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of VIM protein]] |
CTD |
PMID:19737545 PMID:31128153 PMID:35917943 |
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NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
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G |
Xiap |
X-linked inhibitor of apoptosis |
decreases expression |
ISO |
andrographolide results in decreased expression of XIAP protein |
CTD |
PMID:23845849 |
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NCBI chr X:120,890,537...120,938,413
Ensembl chr X:120,897,907...120,934,700
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G |
Zfand2a |
zinc finger AN1-type containing 2A |
decreases expression |
ISO |
andrographolide results in decreased expression of ZFAND2A mRNA |
CTD |
PMID:35724838 |
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NCBI chr12:15,161,601...15,172,679
Ensembl chr12:15,161,639...15,172,677
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G |
Zg16b |
zymogen granule protein 16B |
multiple interactions decreases expression |
ISO |
[andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of SBPL mRNA andrographolide results in decreased expression of SBPL mRNA |
CTD |
PMID:19737545 |
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NCBI chr10:12,970,888...12,984,170
Ensembl chr10:12,979,020...12,983,572
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G |
Slc6a4 |
solute carrier family 6 member 4 |
increases activity |
ISO |
forskolin increases activity of SLC6A4 protein in placental choriocarcinoma cells |
RGD |
PMID:8408014 |
RGD:36947876 |
NCBI chr10:61,824,208...61,858,924
Ensembl chr10:61,826,123...61,858,384
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G |
Acp5 |
acid phosphatase 5, tartrate resistant |
multiple interactions decreases expression |
ISO |
sclareol inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 mRNA]; sclareol inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 protein] sclareol results in decreased expression of ACP5 mRNA; sclareol results in decreased expression of ACP5 protein |
CTD |
PMID:33423118 |
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NCBI chr 8:20,663,984...20,670,604
Ensembl chr 8:20,663,985...20,667,929
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G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions decreases phosphorylation |
ISO |
sclareol results in decreased expression of and results in decreased phosphorylation of AKT1 protein sclareol results in decreased phosphorylation of AKT1 protein |
CTD |
PMID:33164868 PMID:33423118 |
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NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
Atp6v0d2 |
ATPase H+ transporting V0 subunit D2 |
decreases expression multiple interactions |
ISO |
sclareol results in decreased expression of ATP6V0D2 mRNA sclareol inhibits the reaction [TNFSF11 protein results in increased expression of ATP6V0D2 mRNA] |
CTD |
PMID:33423118 |
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NCBI chr 5:33,336,257...33,385,354
Ensembl chr 5:33,336,264...33,385,354
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G |
Bcl2 |
BCL2, apoptosis regulator |
decreases expression |
ISO |
sclareol results in decreased expression of BCL2 protein |
CTD |
PMID:37850667 |
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NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Bcl2l1 |
Bcl2-like 1 |
decreases expression |
ISO |
sclareol results in decreased expression of BCL2L1 protein |
CTD |
PMID:37850667 |
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NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
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G |
Bglap |
bone gamma-carboxyglutamate protein |
increases expression |
ISO |
sclareol results in increased expression of BGLAP mRNA |
CTD |
PMID:33423118 |
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NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495
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G |
Birc5 |
baculoviral IAP repeat-containing 5 |
decreases expression |
ISO |
sclareol results in decreased expression of BIRC5 protein |
CTD |
PMID:37850667 |
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NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
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G |
Casp3 |
caspase 3 |
increases cleavage multiple interactions |
ISO |
sclareol results in increased cleavage of CASP3 protein [ferrostatin-1 co-treated with sclareol] results in increased cleavage of CASP3 protein |
CTD |
PMID:37850667 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp9 |
caspase 9 |
increases cleavage |
ISO |
sclareol results in increased cleavage of CASP9 protein |
CTD |
PMID:37850667 |
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NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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G |
Ccn1 |
cellular communication network factor 1 |
increases expression multiple interactions |
ISO |
sclareol results in increased expression of CCN1 mRNA; sclareol results in increased expression of CCN1 protein [sclareol co-treated with SB 203580] results in increased expression of CCN1 protein; sclareol inhibits the reaction [TNFSF11 protein results in decreased expression of CCN1 protein] |
CTD |
PMID:33423118 |
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NCBI chr 2:234,562,410...234,565,370
Ensembl chr 2:234,562,408...234,565,484
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G |
Ccnd1 |
cyclin D1 |
decreases expression |
ISO |
sclareol results in decreased expression of CCND1 protein |
CTD |
PMID:37850667 |
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NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
increases expression |
ISO |
sclareol results in increased expression of CDKN1A protein |
CTD |
PMID:37850667 |
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NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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G |
Cdkn2a |
cyclin-dependent kinase inhibitor 2A |
increases expression |
ISO |
sclareol results in increased expression of CDKN2A protein |
CTD |
PMID:37850667 |
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NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149
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G |
Ctsk |
cathepsin K |
decreases expression multiple interactions |
ISO |
sclareol results in decreased expression of CTSK mRNA; sclareol results in decreased expression of CTSK protein sclareol inhibits the reaction [TNFSF11 protein results in increased expression of CTSK mRNA]; sclareol inhibits the reaction [TNFSF11 protein results in increased expression of CTSK protein] |
CTD |
PMID:33423118 |
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NCBI chr 2:183,058,586...183,069,551
Ensembl chr 2:183,058,569...183,069,550
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G |
Dcstamp |
dendrocyte expressed seven transmembrane protein |
decreases expression multiple interactions |
ISO |
sclareol results in decreased expression of DCSTAMP mRNA sclareol inhibits the reaction [TNFSF11 protein results in increased expression of DCSTAMP mRNA] |
CTD |
PMID:33423118 |
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NCBI chr 7:70,807,455...70,822,067
Ensembl chr 7:70,807,581...70,822,078
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G |
Ercc1 |
ERCC excision repair 1, endonuclease non-catalytic subunit |
multiple interactions decreases expression |
ISO |
[sclareol co-treated with Cisplatin] results in decreased expression of ERCC1 protein sclareol results in decreased expression of ERCC1 protein |
CTD |
PMID:33164868 |
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NCBI chr 1:78,971,310...79,007,963
Ensembl chr 1:78,996,390...79,007,963
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G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
decreases expression multiple interactions |
ISO |
sclareol results in decreased expression of FOS protein sclareol results in decreased expression of FOS mRNA; sclareol results in decreased expression of FOS protein sclareol inhibits the reaction [TNFSF11 protein results in increased expression of FOS mRNA]; sclareol inhibits the reaction [TNFSF11 protein results in increased expression of FOS protein] |
CTD |
PMID:33164868 PMID:33423118 |
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NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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G |
Fth1 |
ferritin heavy chain 1 |
decreases expression |
ISO |
sclareol results in decreased expression of FTH1 protein |
CTD |
PMID:37850667 |
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NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424
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G |
Gpx4 |
glutathione peroxidase 4 |
multiple interactions decreases expression |
ISO |
[ferrostatin-1 co-treated with sclareol] results in decreased expression of GPX4 protein sclareol results in decreased expression of GPX4 protein |
CTD |
PMID:37850667 |
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NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982
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G |
Gsk3b |
glycogen synthase kinase 3 beta |
decreases phosphorylation |
ISO |
sclareol results in decreased phosphorylation of GSK3B protein |
CTD |
PMID:33164868 |
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NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
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G |
Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
decreases expression |
ISO |
sclareol results in decreased expression of JUN protein |
CTD |
PMID:33164868 |
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NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions decreases phosphorylation |
ISO |
[sclareol co-treated with TNFSF11 protein] results in decreased phosphorylation of MAPK1 protein sclareol results in decreased phosphorylation of MAPK1 protein |
CTD |
PMID:33423118 |
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NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
decreases phosphorylation multiple interactions |
ISO |
sclareol results in decreased phosphorylation of MAPK3 protein [sclareol co-treated with TNFSF11 protein] results in decreased phosphorylation of MAPK3 protein |
CTD |
PMID:33423118 |
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NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Nfatc1 |
nuclear factor of activated T-cells 1 |
decreases expression multiple interactions |
ISO |
sclareol results in decreased expression of NFATC1 mRNA; sclareol results in decreased expression of NFATC1 protein sclareol inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA]; sclareol inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein] |
CTD |
PMID:33423118 |
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NCBI chr18:74,046,422...74,156,041
Ensembl chr18:74,046,904...74,156,028
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
increases cleavage |
ISO |
sclareol results in increased cleavage of PARP1 protein |
CTD |
PMID:37850667 |
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NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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G |
Runx2 |
RUNX family transcription factor 2 |
increases expression |
ISO |
sclareol results in increased expression of RUNX2 mRNA; sclareol results in increased expression of RUNX2 protein |
CTD |
PMID:33423118 |
|
NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167
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G |
Slc40a1 |
solute carrier family 40 member 1 |
decreases expression |
ISO |
sclareol results in decreased expression of SLC40A1 protein |
CTD |
PMID:37850667 |
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NCBI chr 9:48,033,526...48,053,876
Ensembl chr 9:48,033,526...48,051,481
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G |
Snai1 |
snail family transcriptional repressor 1 |
decreases expression |
ISO |
sclareol results in decreased expression of SNAI1 protein |
CTD |
PMID:33164868 |
|
NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969
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G |
Spp1 |
secreted phosphoprotein 1 |
increases expression |
ISO |
sclareol results in increased expression of SPP1 mRNA; sclareol results in increased expression of SPP1 protein |
CTD |
PMID:33423118 |
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NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
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G |
Tfrc |
transferrin receptor |
decreases expression |
ISO |
sclareol results in decreased expression of TFRC protein |
CTD |
PMID:37850667 |
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NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257
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G |
Tnfsf11 |
TNF superfamily member 11 |
multiple interactions |
ISO |
[sclareol co-treated with TNFSF11 protein] results in decreased phosphorylation of MAPK1 protein; [sclareol co-treated with TNFSF11 protein] results in decreased phosphorylation of MAPK3 protein; sclareol inhibits the reaction [TNFSF11 protein results in decreased expression of CCN1 protein]; sclareol inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 mRNA]; sclareol inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 protein]; sclareol inhibits the reaction [TNFSF11 protein results in increased expression of ATP6V0D2 mRNA]; sclareol inhibits the reaction [TNFSF11 protein results in increased expression of CTSK mRNA]; sclareol inhibits the reaction [TNFSF11 protein results in increased expression of CTSK protein]; sclareol inhibits the reaction [TNFSF11 protein results in increased expression of DCSTAMP mRNA]; sclareol inhibits the reaction [TNFSF11 protein results in increased expression of FOS mRNA]; sclareol inhibits the reaction [TNFSF11 protein results in increased expression of FOS protein]; sclareol inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA]; sclareol inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein] |
CTD |
PMID:33423118 |
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NCBI chr15:53,673,850...53,705,325
Ensembl chr15:53,673,877...53,705,445
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