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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61867
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp9
Name: caspase 9
Acc ID: CHEBI:65408
Term: andrographolide
Definition: A labdane diterpenoid isolated from the leaves and roots of Andrographis paniculata that exhibits anti-HIV, anti-inflammatory and antineoplastic properties.
Chemical ID: MESH:C030419
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp9multiple interactionsEXP 6480464CTDandrographolide inhibits the reaction [Copper Sulfate results in increased activity of CASP9 protein]; andrographolide promotes the reaction [Penicillamine inhibits the reaction [Copper Sulfate results in increased activity of CASP9 protein]]; Penicillamine promotes the reaction [andrographolide inhibits the reaction [Copper Sulfate results in increased activity of CASP9 protein]]PMID:20946909
Casp9increases activityISOCASP9 (Homo sapiens)6480464CTDandrographolide results in increased activity of CASP9 proteinPMID:19097688
Casp9increases expressionISOCASP9 (Homo sapiens)6480464CTDandrographolide results in increased expression of CASP9 mRNAPMID:24563380
Casp9multiple interactionsISOCASP9 (Homo sapiens)6480464CTD[andrographolide co-treated with Cisplatin] results in increased expression of CASP9 mRNA; CASP8 affects the reaction [Fluorouracil promotes the reaction [andrographolide results in increased activity of CASP9 protein]]; Fluorouracil promotes the reaction [andrographolide results in increased activity of CASP9 protein]PMID:19097688 PMID:24563380
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