Elane (elastase, neutrophil expressed) - Rat Genome Database

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Gene: Elane (elastase, neutrophil expressed) Rattus norvegicus
Analyze
Symbol: Elane
Name: elastase, neutrophil expressed
RGD ID: 1307968
Description: Predicted to enable several functions, including heparin binding activity; serine-type endopeptidase activity; and transcription corepressor activity. Involved in leukocyte migration involved in inflammatory response and positive regulation of leukocyte tethering or rolling. Predicted to be located in cell surface and secretory granule. Predicted to be part of transcription repressor complex. Predicted to be active in extracellular space. Used to study several diseases, including cerebrovascular disease (multiple); lung disease (multiple); mucositis; pleurisy; and polycythemia vera. Biomarker of suppurative periapical periodontitis. Human ortholog(s) of this gene implicated in cyclic hematopoiesis; periodontitis; severe congenital neutropenia; and severe congenital neutropenia 1. Orthologous to human ELANE (elastase, neutrophil expressed); PARTICIPATES IN systemic lupus erythematosus pathway; INTERACTS WITH amphetamine; andrographolide; anilines.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Ela2; elastase 2, neutrophil; LOC299606; neutrophil elastase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8710,467,877 - 10,469,725 (-)NCBIGRCr8
mRatBN7.279,817,251 - 9,819,174 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl79,817,252 - 9,819,100 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx712,699,238 - 12,701,086 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0714,574,555 - 14,576,403 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0712,435,754 - 12,437,602 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0712,638,320 - 12,640,168 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl712,638,322 - 12,640,232 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0712,808,042 - 12,809,890 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4711,329,642 - 11,331,490 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1711,329,643 - 11,331,467 (-)NCBI
Celera77,992,002 - 7,993,850 (-)NCBICelera
Cytogenetic Map7q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Mice lacking neutrophil elastase reveal impaired host defense against gram negative bacterial sepsis. Belaaouaj A, etal., Nat Med. 1998 May;4(5):615-8.
2. Neutrophil elastase inhibitor (ONO-5046) attenuates reperfusion-induced hepatic microcirculatory derangement, energy depletion and lipid peroxidation in rats. Chen HM, etal., Shock. 1999 Dec;12(6):462-7.
3. Different clinical phenotypes in familial severe congenital neutropenia cases with same mutation of the ELANE gene. Cho HK and Jeon IS, J Korean Med Sci. 2014 Mar;29(3):452-5. doi: 10.3346/jkms.2014.29.3.452. Epub 2014 Feb 27.
4. Neutrophil elastase and syndecan shedding contribute to antithrombin depletion in murine anthrax. Chung MC, etal., FEMS Immunol Med Microbiol. 2008 Dec;54(3):309-18. doi: 10.1111/j.1574-695X.2008.00480.x.
5. Role of neutrophil depletion and elastase inhibition in modifying skeletal muscle reperfusion injury. Crinnion JN, etal., Cardiovasc Surg. 1994 Dec;2(6):749-53.
6. Inflammation Profiling of Critically Ill Coronavirus Disease 2019 Patients. Fraser DD, etal., Crit Care Explor. 2020 Jun 22;2(6):e0144. doi: 10.1097/CCE.0000000000000144. eCollection 2020 Jun.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Neutrophil elastase inhibitor (ONO-5046) prevents lung hemorrhage induced by lipopolysaccharide in rat model of cerulein pancreatitis. Guo L, etal., Dig Dis Sci. 1995 Oct;40(10):2177-83.
10. Role of neutrophil elastase in development of pulmonary vascular injury and septic shock in rats. Harada N, etal., Shock. 2008 Oct;30(4):379-87. doi: 10.1097/SHK.0b013e3181673e2c.
11. Disseminated intravascular coagulation at an early phase of trauma is associated with consumption coagulopathy and excessive fibrinolysis both by plasmin and neutrophil elastase. Hayakawa M, etal., Surgery. 2011 Feb;149(2):221-30. doi: 10.1016/j.surg.2010.06.010. Epub 2010 Jul 23.
12. Benefical effect of neutrophil elastase inhibitor on renal warm ischemia-reperfusion injury in the rat. Hayama T, etal., Transplant Proc. 2006 Sep;38(7):2201-2.
13. Mac-1 (CD11b/CD18) links inflammation and thrombosis after glomerular injury. Hirahashi J, etal., Circulation. 2009 Sep 29;120(13):1255-65. Epub 2009 Sep 14.
14. Beneficial effect of an inhibitor of leukocyte elastase (EPI-hNE-4) in presence of repeated lung injuries. Honore S, etal., Shock. 2004 Aug;22(2):131-6.
15. Mutations in ELA2, encoding neutrophil elastase, define a 21-day biological clock in cyclic haematopoiesis. Horwitz M, etal., Nat Genet. 1999 Dec;23(4):433-6.
16. The effects of a new human leukocyte elastase inhibitor (recombinant guamerin) on cerulein-induced pancreatitis in rats. Jo YJ, etal., Int Immunopharmacol. 2008 Jul;8(7):959-66. doi: 10.1016/j.intimp.2008.02.014. Epub 2008 Mar 27.
17. Neutrophil elastase is needed for neutrophil emigration into lungs in ventilator-induced lung injury. Kaynar AM, etal., Am J Respir Cell Mol Biol. 2008 Jul;39(1):53-60. doi: 10.1165/rcmb.2007-0315OC. Epub 2008 Feb 14.
18. Neutrophil elastase inhibitor, sivelestat sodium hydrate prevents ischemia-reperfusion injury in the rat bladder. Kono T, etal., Mol Cell Biochem. 2008 Apr;311(1-2):87-92. doi: 10.1007/s11010-007-9698-9. Epub 2007 Dec 30.
19. A novel oral neutrophil elastase inhibitor (ONO-6818) inhibits human neutrophil elastase-induced emphysema in rats. Kuraki T, etal., Am J Respir Crit Care Med. 2002 Aug 15;166(4):496-500.
20. Four novel ELANE mutations in patients with congenital neutropenia. Kurnikova M, etal., Pediatr Blood Cancer. 2011 Aug;57(2):332-5. doi: 10.1002/pbc.23104. Epub 2011 Mar 21.
21. Role of neutrophil elastase in stress-induced gastric mucosal injury in rats. Liu W, etal., J Lab Clin Med. 1998 Nov;132(5):432-9.
22. Association between promoter polymorphisms of the nicastrin gene and sporadic Alzheimer's disease in North Chinese Han population. Ma Z, etal., Neurosci Lett. 2009 Jul 24;458(3):136-9. doi: 10.1016/j.neulet.2009.04.048. Epub 2009 Apr 24.
23. Thrombin generation and activated protein C resistance in patients with essential thrombocythemia and polycythemia vera. Marchetti M, etal., Blood. 2008 Nov 15;112(10):4061-8. doi: 10.1182/blood-2008-06-164087. Epub 2008 Sep 3.
24. Neutrophil elastase inhibitor attenuates hippocampal neuronal damage after transient forebrain ischemia in rats. Matayoshi H, etal., Brain Res. 2009 Mar 9;1259:98-106. doi: 10.1016/j.brainres.2008.12.070. Epub 2009 Jan 10.
25. Addition of a neutrophil elastase inhibitor to the organ flushing solution decreases lung reperfusion injury in rat lung transplantation. Mori H, etal., Eur J Cardiothorac Surg. 2007 Nov;32(5):791-5. Epub 2007 Sep 20.
26. Effect of plant neutrophil elastase inhibitor on leucocyte migration, adhesion and cytokine release in inflammatory conditions. Oliveira C, etal., Br J Pharmacol. 2010 Oct;161(4):899-910. doi: 10.1111/j.1476-5381.2010.00924.x.
27. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
28. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
29. Oxidative burst and neutrophil elastase contribute to clearance of Aspergillus fumigatus pneumonia in mice. Prufer S, etal., Immunobiology. 2014 Feb;219(2):87-96. doi: 10.1016/j.imbio.2013.08.010. Epub 2013 Aug 30.
30. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
31. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
32. Comprehensive gene review and curation RGD comprehensive gene curation
33. Neutrophil elastase inhibition reduces cerebral ischemic damage in the middle cerebral artery occlusion. Shimakura A, etal., Brain Res. 2000 Mar 6;858(1):55-60.
34. Neutrophil elastase is severely down-regulated in severe congenital neutropenia independent of ELA2 or HAX1 mutations but dependent on LEF-1. Skokowa J, etal., Blood. 2009 Oct 1;114(14):3044-51. doi: 10.1182/blood-2008-11-188755. Epub 2009 Jul 20.
35. Effects of elastase inhibitor on the epithelial cell apoptosis in bleomycin-induced pulmonary fibrosis. Song JS, etal., Exp Lung Res. 2009 Dec;35(10):817-29. doi: 10.3109/01902140902912527.
36. Neutrophil elastase may play a key role in developing symptomatic disseminated intravascular coagulation and multiple organ failure in patients with head injury. Takahasi H, etal., J Trauma. 2000 Jul;49(1):86-91.
37. Role of neutrophil elastase in compression-induced spinal cord injury in rats. Taoka Y, etal., Brain Res. 1998 Jul 20;799(2):264-9.
38. A neutrophil elastase inhibitor, sivelestat, ameliorates lung injury after hemorrhagic shock in rats. Toda Y, etal., Int J Mol Med. 2007 Feb;19(2):237-43.
39. Histochemical localization of neutral proteases released during development of rat periradicular lesion. Tsuji M, etal., Arch Oral Biol. 2009 Dec;54(12):1128-35. doi: 10.1016/j.archoralbio.2009.10.003. Epub 2009 Nov 12.
40. Effects of lecithinized superoxide dismutase and a neutrophil elastase inhibitor (ONO-5046) on hyperoxic lung injury in rat. Yamamoto H, etal., Eur J Pharmacol. 2000 Dec 8;409(2):179-83.
41. The involvement of nitric oxide, nitric oxide synthase, neutrophil elastase, myeloperoxidase and proinflammatory cytokines in the acute lung injury caused by phorbol myristate acetate. Yang YL, etal., J Biomed Sci. 2008 Jul;15(4):499-507. doi: 10.1007/s11373-008-9238-y. Epub 2008 Feb 19.
42. Mutations in the ELANE gene are associated with development of periodontitis in patients with severe congenital neutropenia. Ye Y, etal., J Clin Immunol. 2011 Dec;31(6):936-45. doi: 10.1007/s10875-011-9572-0. Epub 2011 Jul 29.
Additional References at PubMed
PMID:6980881   PMID:10714686   PMID:11907569   PMID:11928814   PMID:12114510   PMID:12223522   PMID:12393522   PMID:12887060   PMID:14705961   PMID:14730209   PMID:15010259   PMID:15034066  
PMID:16473861   PMID:17878334   PMID:19056867   PMID:19506020   PMID:20411049   PMID:20421939   PMID:20828556   PMID:21576245   PMID:22206666   PMID:23533145   PMID:25645918   PMID:25915831  
PMID:27430552   PMID:31640144   PMID:37393835  


Genomics

Comparative Map Data
Elane
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8710,467,877 - 10,469,725 (-)NCBIGRCr8
mRatBN7.279,817,251 - 9,819,174 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl79,817,252 - 9,819,100 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx712,699,238 - 12,701,086 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0714,574,555 - 14,576,403 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0712,435,754 - 12,437,602 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0712,638,320 - 12,640,168 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl712,638,322 - 12,640,232 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0712,808,042 - 12,809,890 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4711,329,642 - 11,331,490 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1711,329,643 - 11,331,467 (-)NCBI
Celera77,992,002 - 7,993,850 (-)NCBICelera
Cytogenetic Map7q11NCBI
ELANE
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3819852,303 - 856,243 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl19851,014 - 856,247 (+)EnsemblGRCh38hg38GRCh38
GRCh3719852,303 - 856,243 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3619803,291 - 807,246 (+)NCBINCBI36Build 36hg18NCBI36
Build 3419803,290 - 807,244NCBI
Celera19777,442 - 781,374 (+)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef19621,154 - 625,109 (+)NCBIHuRef
CHM1_119851,692 - 855,840 (+)NCBICHM1_1
T2T-CHM13v2.019806,810 - 812,352 (+)NCBIT2T-CHM13v2.0
Elane
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391079,722,146 - 79,724,050 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1079,722,081 - 79,724,049 (+)EnsemblGRCm39 Ensembl
GRCm381079,886,312 - 79,888,216 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1079,886,247 - 79,888,215 (+)EnsemblGRCm38mm10GRCm38
MGSCv371079,349,057 - 79,350,961 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361079,289,464 - 79,291,246 (+)NCBIMGSCv36mm8
Celera1080,901,123 - 80,903,026 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
LOC102018844
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554956,964,667 - 6,967,106 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554956,964,577 - 6,967,208 (-)NCBIChiLan1.0ChiLan1.0
ELANE
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2205,180,943 - 5,186,287 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1194,419,710 - 4,427,623 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v019276,499 - 280,598 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.119820,455 - 828,181 (+)NCBIpanpan1.1PanPan1.1panPan2
ELANE
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12057,789,044 - 57,790,932 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2057,788,062 - 57,790,932 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2057,591,060 - 57,592,948 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02058,531,328 - 58,533,216 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2058,531,329 - 58,533,196 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12057,586,105 - 57,588,011 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02058,065,758 - 58,067,646 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02058,268,788 - 58,270,676 (-)NCBIUU_Cfam_GSD_1.0
LOC101961846
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118217,487,292 - 217,490,154 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936588345,678 - 347,413 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936588345,678 - 347,420 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ELANE
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl277,509,344 - 77,516,027 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1277,513,769 - 77,516,118 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2277,480,250 - 77,485,906 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ELANE
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.16599,392 - 604,925 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl6601,217 - 604,725 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660818,311,933 - 8,315,809 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
LOC101715199
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248287,720,020 - 7,722,842 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:29
Count of miRNA genes:28
Interacting mature miRNAs:28
Transcripts:ENSRNOT00000014981
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7127829089Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7131962314Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7131962314Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134000259Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7135342956Rat
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7144782185Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)766427026029351Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
10755438Coatc9Coat color QTL 90coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7352928048529280Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7532901950329019Rat
10755440Coatc10Coat color QTL 100coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7749649952496499Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7757398552573985Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)7946224658265113Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 14 14 2 14
Low 16 8 17 8 3
Below cutoff 1 9 10 6 6 2 2 1 11 15 4 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000014981   ⟹   ENSRNOP00000014981
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl79,817,252 - 9,819,100 (-)Ensembl
Rnor_6.0 Ensembl712,638,322 - 12,640,232 (-)Ensembl
RefSeq Acc Id: NM_001106767   ⟹   NP_001100237
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8710,467,877 - 10,469,725 (-)NCBI
mRatBN7.279,817,252 - 9,819,100 (-)NCBI
Rnor_6.0712,638,320 - 12,640,168 (-)NCBI
Rnor_5.0712,808,042 - 12,809,890 (-)NCBI
RGSC_v3.4711,329,642 - 11,331,490 (-)RGD
Celera77,992,002 - 7,993,850 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001100237 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL89378 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000014981
  ENSRNOP00000014981.4
Reference Protein Sequences
RefSeq Acc Id: NP_001100237   ⟸   NM_001106767
- Peptide Label: precursor
- UniProtKB: D4A488 (UniProtKB/TrEMBL),   A6K8V8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000014981   ⟸   ENSRNOT00000014981
Protein Domains
Peptidase S1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A488-F1-model_v2 AlphaFold D4A488 1-271 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307968 AgrOrtholog
BioCyc Gene G2FUF-34895 BioCyc
Ensembl Genes ENSRNOG00000033685 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000014981 ENTREZGENE
  ENSRNOT00000014981.6 UniProtKB/TrEMBL
Gene3D-CATH 2.40.10.10 UniProtKB/TrEMBL
InterPro Peptidase_S1/S6_AS UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/TrEMBL
  Peptidase_S1_S6 UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/TrEMBL
  Ser/Cys_Pept_Trypsin-like UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/TrEMBL
KEGG Report rno:299606 UniProtKB/TrEMBL
NCBI Gene 299606 ENTREZGENE
PANTHER CHYMOTRYPSIN-LIKE ELASTASE FAMILY MEMBER UniProtKB/TrEMBL
  NEUTROPHIL ELASTASE UniProtKB/TrEMBL
Pfam Trypsin UniProtKB/TrEMBL
PharmGKB ELA2 RGD
PhenoGen Elane PhenoGen
PRINTS CHYMOTRYPSIN UniProtKB/TrEMBL
PROSITE TRYPSIN_DOM UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/TrEMBL
RatGTEx ENSRNOG00000033685 RatGTEx
SMART Tryp_SPc UniProtKB/TrEMBL
Superfamily-SCOP Pept_Ser_Cys UniProtKB/TrEMBL
UniProt A6K8V8 ENTREZGENE, UniProtKB/TrEMBL
  D4A488 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2009-05-18 Elane  elastase, neutrophil expressed  Ela2  elastase 2, neutrophil   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Ela2  elastase 2, neutrophil   Ela2_predicted  elastase 2, neutrophil (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Ela2_predicted  elastase 2, neutrophil (predicted)      Symbol and Name status set to approved 70820 APPROVED