Jak2 (Janus kinase 2) - Rat Genome Database

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Gene: Jak2 (Janus kinase 2) Rattus norvegicus
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Symbol: Jak2
Name: Janus kinase 2
RGD ID: 2939
Description: Enables several functions, including insulin receptor substrate binding activity; phosphatidylinositol 3-kinase binding activity; and signaling receptor binding activity. Involved in several processes, including cell surface receptor signaling pathway; positive regulation of biosynthetic process; and regulation of apoptotic process. Located in euchromatin. Is active in glutamatergic synapse and postsynapse. Used to study several diseases, including hyperuricemia; liver disease (multiple); retinal detachment; thrombocytosis; and transient cerebral ischemia. Biomarker of atherosclerosis; gastrointestinal system cancer (multiple); heart disease; liver cirrhosis; and obesity. Human ortholog(s) of this gene implicated in several diseases, including gastrointestinal system cancer (multiple); hematologic cancer (multiple); hepatic vascular disease (multiple); inflammatory bowel disease (multiple); and lung non-small cell carcinoma (multiple). Orthologous to human JAK2 (Janus kinase 2); PARTICIPATES IN aldosterone signaling pathway; angiotensin II signaling pathway; angiotensin II signaling pathway via AT1 receptor; INTERACTS WITH (4-oxo-3-\{[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]methyl\}-3,4-dihydrophthalazin-1-yl)acetic acid; (S)-colchicine; (S)-nicotine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: JAK-2; Janus kinase 2 (a protein tyrosine kinase); tyrosine-protein kinase JAK2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81236,408,905 - 236,468,769 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1236,408,662 - 236,468,762 (+)EnsemblGRCr8
mRatBN7.21226,995,334 - 227,054,381 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1226,995,334 - 227,054,189 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1235,396,988 - 235,455,863 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01242,326,646 - 242,385,527 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01235,144,413 - 235,203,184 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01247,398,667 - 247,457,521 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1247,398,598 - 247,458,509 (+)Ensemblrn6Rnor6.0
Rnor_5.01254,646,160 - 254,706,478 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41232,915,995 - 232,974,763 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1224,147,256 - 224,206,104 (+)NCBICelera
RGSC_v3.11233,080,017 - 233,138,786 (+)NCBI
Cytogenetic Map1q52NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
acute myeloid leukemia  (ISO)
alcoholic liver cirrhosis  (ISO)
Alzheimer's disease  (ISO)
anemia  (ISO)
ankylosing spondylitis  (ISO)
atherosclerosis  (IEP)
bacterial gastritis  (ISO)
Brain Injuries  (IMP)
Budd-Chiari syndrome  (ISO)
Cachexia  (ISO)
calcinosis  (ISO)
Cancer Pain  (IEP)
colon adenocarcinoma  (ISO)
colon cancer  (IEP)
colorectal carcinoma  (IEP)
COVID-19  (ISO)
Crohn's disease  (ISO)
Diabetic Nephropathies  (IDA)
esophageal carcinoma  (ISO)
esophagus squamous cell carcinoma  (ISO)
essential thrombocythemia  (ISO,ISS)
Experimental Arthritis  (IDA,ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Colitis  (IEP)
Experimental Liver Cirrhosis  (IEP,ISO)
Experimental Liver Neoplasms  (ISO)
familial erythrocytosis 1  (ISO)
familial erythrocytosis 2  (ISO)
Genetic Predisposition to Disease  (ISO)
glucose intolerance  (ISO)
Growth Disorders  (IEP)
heart disease  (IEP)
heart valve disease  (ISO)
hepatocellular carcinoma  (IDA,IEP,ISO)
hereditary breast ovarian cancer syndrome  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
Hyperalgesia  (IMP,ISO)
hyperuricemia  (IDA)
Inflammation  (ISO)
Intestinal Reperfusion Injury  (IMP)
leukemia  (ISO)
limited scleroderma  (ISO)
liver cancer  (IEP,IMP)
liver cirrhosis  (IEP)
Liver Injury  (IDA)
Liver Reperfusion Injury  (IDA)
lung adenocarcinoma  (ISO)
lung carcinoma  (ISO)
lung non-small cell carcinoma  (ISO)
mesenteric vascular occlusion  (ISO)
metabolic dysfunction-associated steatohepatitis  (ISO)
metabolic dysfunction-associated steatotic liver disease  (IDA,ISO)
myelofibrosis  (ISO,ISS)
myeloid neoplasm  (ISO)
myeloproliferative neoplasm  (ISS)
myocardial infarction  (IMP)
Myocardial Ischemia  (ISO)
Myocardial Reperfusion Injury  (IMP)
nasopharynx carcinoma  (ISO)
Neoplasm Metastasis  (ISO)
Neoplastic Cell Transformation  (ISO)
nephrotic syndrome  (ISO)
Niemann-Pick disease type C1  (ISO)
obesity  (IEP,ISO)
polycythemia  (ISO)
polycythemia vera  (ISO,ISS)
portal hypertension  (IMP)
Pregnancy Complications  (ISO)
primary biliary cholangitis  (IMP)
Prostatic Neoplasms  (ISO)
Reperfusion Injury  (ISO)
retinal detachment  (IDA)
rheumatoid arthritis  (ISO)
scrapie  (ISO)
Sepsis  (IDA)
Sepsis-Associated Encephalopathy  (IDA)
Spinal Cord Injuries  (IMP)
Spontaneous Abortions  (ISO)
steatotic liver disease  (ISO)
stomach cancer  (ISO)
stroke  (IMP)
systemic lupus erythematosus  (ISO)
Thrombocythemia 3  (ISO)
thrombocytosis  (IAGP,ISO)
Thromboembolism  (ISO)
thrombosis  (IAGP)
transient cerebral ischemia  (IDA)
ulcerative colitis  (ISO)
urinary bladder cancer  (ISO)
Uterine Cervical Neoplasms  (ISO)
Venous Thrombosis  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-Arctigenin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(4-oxo-3-\{[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]methyl\}-3,4-dihydrophthalazin-1-yl)acetic acid  (EXP)
(S)-colchicine  (EXP)
(S)-nicotine  (EXP,ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine  (EXP)
2-amino-2-deoxy-D-glucopyranose  (EXP,ISO)
2-ethoxyethanol  (EXP)
2-hydroxypropanoic acid  (ISO)
2-methoxyethanol  (EXP)
2-palmitoylglycerol  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-methyladenine  (ISO)
3-methylcholanthrene  (ISO)
3-nitropropanoic acid  (EXP)
3-phenylprop-2-enal  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
7,8-dihydroxycoumarin  (ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (EXP)
abamectin  (EXP)
acetamide  (EXP)
acetic acid  (EXP)
acetic acid [2-[[(5-nitro-2-thiazolyl)amino]-oxomethyl]phenyl] ester  (ISO)
acrylamide  (EXP,ISO)
actinomycin D  (EXP)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucosamine  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
aldosterone  (EXP)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (EXP)
aluminium hydroxide  (ISO)
amitrole  (EXP)
amlodipine  (ISO)
ammonium chloride  (EXP)
angiotensin II  (ISO)
antirheumatic drug  (ISO)
apocynin  (ISO)
arecoline  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
auranofin  (ISO)
baicalin  (ISO)
Bardoxolone methyl  (ISO)
baricitinib  (ISO)
benzo[a]pyrene  (ISO)
beta-D-glucosamine  (EXP,ISO)
beta-Elemonic acid  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Butylbenzyl phthalate  (EXP)
butyric acid  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calciol  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
cannabidiol  (ISO)
capillarisin  (ISO)
carbon nanotube  (ISO)
carvacrol  (EXP)
celastrol  (ISO)
ceruletide  (ISO)
chelerythrine  (EXP)
chloroquine  (ISO)
chlorpyrifos  (ISO)
Cirsimarin  (ISO)
cisplatin  (ISO)
clomiphene  (ISO)
clothianidin  (ISO)
clozapine  (EXP)
cocaine  (ISO)
coniferyl aldehyde  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
cordycepin  (ISO)
corticosterone  (EXP)
coumermycin A1  (ISO)
crocin-1  (ISO)
Cryptotanshinone  (ISO)
cucurbitacin I  (ISO)
Cuprizon  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP)
D-glucose  (EXP,ISO)
dapagliflozin  (EXP)
daunorubicin  (ISO)
decabromodiphenyl ether  (EXP)
delphinidin  (ISO)
deoxynivalenol  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dieldrin  (EXP)
diethylstilbestrol  (ISO)
dimethylarsinic acid  (EXP)
dioxygen  (ISO)
diquat  (ISO)
divanadium pentaoxide  (ISO)
doxorubicin  (ISO)
emodin  (ISO)
erianin  (ISO)
eriocitrin  (ISO)
erlotinib hydrochloride  (ISO)
estrone  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
flutamide  (EXP)
folic acid  (ISO)
fraxetin  (ISO)
fructose  (EXP)
fucoxanthin  (ISO)
fulvestrant  (ISO)
furan  (EXP)
galaxolide  (ISO)
Ganoderic acid A  (ISO)
genistein  (ISO)
Gingerenone A  (ISO)
Ginkgoic acid  (ISO)
glucose  (EXP,ISO)
glutathione  (ISO)
Goe 6976  (EXP,ISO)
gold atom  (ISO)
gold(0)  (ISO)
GSK-J4  (ISO)
hesperetin  (EXP)
hesperidin  (EXP)
hexadecanoic acid  (ISO)
hexestrol  (ISO)
hispidulin  (ISO)
hydrogen peroxide  (ISO)
ivermectin  (ISO)
kainic acid  (EXP,ISO)
ketamine  (EXP)
L-arginine  (ISO)
lactucin  (ISO)
lapatinib  (ISO)
limonin  (ISO)
linagliptin  (EXP,ISO)
linderalactone  (ISO)
lipopolysaccharide  (ISO)
loliolide  (ISO)
losartan  (ISO)
LY294002  (ISO)
lycorine  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
melittin  (ISO)
melphalan  (ISO)
mercury atom  (ISO)
mercury dichloride  (EXP,ISO)
mercury(0)  (ISO)
mesalamine  (EXP)
mestranol  (ISO)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
methyllycaconitine  (EXP)
methylmercury chloride  (ISO)
Methylthiouracil  (ISO)
mevalonic acid  (EXP)
microcystin-LR  (ISO)
mitomycin C  (ISO)
mitoxantrone  (ISO)
Monobutylphthalate  (ISO)
N-[2-(diethylamino)ethyl]-2-methoxy-5-methylsulfonylbenzamide  (EXP)
N-acetyl-L-cysteine  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
nickel atom  (ISO)
nickel dichloride  (EXP)
nicotine  (EXP,ISO)
nimesulide  (ISO)
nitric oxide  (ISO)
Nonylphenol  (ISO)
okadaic acid  (ISO)
olanzapine  (EXP)
oleic acid  (ISO)
ozone  (ISO)
pantoprazole  (ISO)
paracetamol  (ISO)
paroxetine  (ISO)
PD123319  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
Pervanadate  (ISO)
phenylpropanolamine  (EXP)
PhIP  (ISO)
phosphane  (EXP)
phosphatidic acid  (ISO)
pipoxolan  (ISO)
pirinixic acid  (ISO)
platycodin D  (ISO)
PNU-282987  (ISO)
ponatinib  (ISO)
Ponicidin  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
PRIM-O-GLUCOSYLCIMIFUGIN  (ISO)
progesterone  (ISO)
propofol  (ISO)
protosappanin A  (ISO)
pterostilbene  (ISO)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-glucofuranoside  (ISO)
quercetin 3-O-beta-D-glucopyranoside  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
reactive oxygen species  (ISO)
resveratrol  (ISO)
Rhynchophylline  (EXP)
rotenone  (ISO)
rutin  (EXP)
ruxolitinib  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
S3I-201  (ISO)
Salinomycin  (ISO)
selumetinib  (ISO)
silibinin  (ISO)
silicon dioxide  (ISO)
simvastatin  (EXP)
Sinomenine  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sphingosine 1-phosphate  (ISO)
spironolactone  (EXP)
stattic  (ISO)
streptozocin  (EXP)
succimer  (ISO)
sulfadimethoxine  (EXP)
sulfasalazine  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
T-2 toxin  (ISO)
tacrolimus hydrate  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone enanthate  (EXP)
tetrachloromethane  (ISO)
theobromine  (EXP)
thiamet G  (ISO)
thymoquinone  (ISO)
Tiron  (ISO)
titanium dioxide  (ISO)
tofacitinib  (ISO)
toosendanin  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
Triptolide  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
tropisetron  (EXP)
tyrphostin B42  (EXP,ISO)
umbelliferone  (EXP)
urethane  (ISO)
valproic acid  (ISO)
valsartan  (ISO)
verteporfin  (ISO)
vinclozolin  (EXP)
WP1066  (ISO)
zidovudine  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of Janus kinase activity  (ISO,ISS)
adaptive immune response  (IEA)
apoptotic signaling pathway  (IEA)
axon regeneration  (IMP)
cell adhesion  (IEA,ISO)
cell differentiation  (ISO)
cell surface receptor signaling pathway via JAK-STAT  (IBA,IDA,IEA,ISO)
cellular response to dexamethasone stimulus  (ISO)
cellular response to interleukin-3  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to steroid hormone stimulus  (IEA)
chromatin organization  (IEA)
chromatin remodeling  (IEA)
collagen-activated signaling pathway  (IEA,ISO)
cytokine-mediated signaling pathway  (IBA,IEA,ISO,ISS)
defense response to symbiont  (IEA,ISO)
enzyme-linked receptor protein signaling pathway  (ISO)
erythrocyte differentiation  (IBA,IEA,ISO,ISS)
erythropoietin-mediated signaling pathway  (IEA,ISO)
extrinsic apoptotic signaling pathway  (ISO)
granulocyte-macrophage colony-stimulating factor signaling pathway  (IEA,ISO)
growth hormone receptor signaling pathway  (IEA,ISO)
growth hormone receptor signaling pathway via JAK-STAT  (IBA,IDA,IEA,ISO,ISS)
hormone-mediated signaling pathway  (IDA)
immune system process  (IEA)
innate immune response  (IEA)
interleukin-12-mediated signaling pathway  (IEA,ISO)
interleukin-23-mediated signaling pathway  (IEA,ISO)
interleukin-3-mediated signaling pathway  (IEA,ISO)
interleukin-5-mediated signaling pathway  (IEA,ISO)
intracellular signal transduction  (IBA,IEA,ISO)
intrinsic apoptotic signaling pathway in response to oxidative stress  (IMP)
lipopolysaccharide-mediated signaling pathway  (IEA,ISO)
mammary gland epithelium development  (ISO)
microglial cell activation  (IEA,ISO)
modulation of chemical synaptic transmission  (IDA,IMP)
myeloid cell differentiation  (ISO)
negative regulation of apoptotic process  (IMP,ISO)
negative regulation of cardiac muscle cell apoptotic process  (IMP)
negative regulation of cell population proliferation  (ISO)
negative regulation of cell-cell adhesion  (IMP)
negative regulation of cytokine production involved in inflammatory response  (IEA,ISO)
negative regulation of neuron apoptotic process  (IMP)
negative regulation of protein localization to chromatin  (IEA,ISO)
nuclear receptor-mediated mineralocorticoid signaling pathway  (IMP)
obsolete positive regulation of DNA-binding transcription factor activity  (IMP)
peptidyl-tyrosine phosphorylation  (ISO)
platelet-derived growth factor receptor signaling pathway  (IMP)
positive regulation of apoptotic process  (IEA,IMP)
positive regulation of apoptotic signaling pathway  (ISO)
positive regulation of cell activation  (IEA,IMP)
positive regulation of cell differentiation  (IMP)
positive regulation of cell migration  (IMP)
positive regulation of cell population proliferation  (IEA,IMP)
positive regulation of cell-substrate adhesion  (IEA,ISO)
positive regulation of cold-induced thermogenesis  (IEA,ISO,ISS)
positive regulation of cytosolic calcium ion concentration  (IMP)
positive regulation of DNA binding  (IMP)
positive regulation of epithelial cell apoptotic process  (IMP)
positive regulation of growth factor dependent skeletal muscle satellite cell proliferation  (IMP)
positive regulation of growth hormone receptor signaling pathway  (IEA,ISO)
positive regulation of insulin secretion  (IMP)
positive regulation of interleukin-1 beta production  (IEA,IMP,ISO)
positive regulation of intracellular signal transduction  (IEA)
positive regulation of leukocyte proliferation  (IEA,ISO)
positive regulation of MAPK cascade  (IMP)
positive regulation of MHC class II biosynthetic process  (IEA,ISO)
positive regulation of nitric oxide biosynthetic process  (IEA,IMP)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA,ISO)
positive regulation of platelet activation  (ISO)
positive regulation of platelet aggregation  (ISO)
positive regulation of protein import into nucleus  (IMP)
positive regulation of SMAD protein signal transduction  (ISO)
positive regulation of T cell proliferation  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (IEA,IMP,ISO)
positive regulation of tumor necrosis factor production  (ISO)
positive regulation of tyrosine phosphorylation of STAT protein  (ISO,ISS)
positive regulation of vascular associated smooth muscle cell proliferation  (IMP)
post-embryonic hemopoiesis  (IEA,ISO)
post-translational protein modification  (IEA,ISO,ISS)
protein autophosphorylation  (IMP,ISO,ISS)
regulation of apoptotic process  (IBA)
regulation of cell-cell adhesion  (IEA)
regulation of inflammatory response  (IEA,ISO)
regulation of nitric oxide biosynthetic process  (IGI)
regulation of postsynapse to nucleus signaling pathway  (EXP,IDA)
response to antibiotic  (ISO)
response to hydroperoxide  (IMP)
response to interleukin-12  (IEA,ISO)
response to oxidative stress  (IMP)
response to tumor necrosis factor  (IEA,ISO)
signal transduction  (IEA,ISO,ISS)
symbiont-induced defense-related programmed cell death  (ISO)
thrombopoietin-mediated signaling pathway  (IEA,ISO)
tumor necrosis factor-mediated signaling pathway  (IEA,ISO)
type II interferon-mediated signaling pathway  (IMP)
tyrosine phosphorylation of STAT protein  (IMP,ISO)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Signal regulatory protein alpha ligation induces macrophage nitric oxide production through JAK/STAT- and phosphatidylinositol 3-kinase/Rac1/NAPDH oxidase/H2O2-dependent pathways. Alblas J, etal., Mol Cell Biol. 2005 Aug;25(16):7181-92. doi: 10.1128/MCB.25.16.7181-7192.2005.
2. Dependence on the motif YIPP for the physical association of Jak2 kinase with the intracellular carboxyl tail of the angiotensin II AT1 receptor. Ali MS, etal., J Biol Chem. 1997 Sep 12;272(37):23382-8.
3. An intracellular multi-effector complex mediates somatostatin receptor 1 activation of phospho-tyrosine phosphatase eta. Arena S, etal., Mol Endocrinol. 2007 Jan;21(1):229-46. Epub 2006 Oct 4.
4. Ngn3 expression during postnatal in vitro beta cell neogenesis induced by the JAK/STAT pathway. Baeyens L, etal., Cell Death Differ. 2006 Nov;13(11):1892-9. Epub 2006 Mar 3.
5. Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders. Baxter EJ, etal., Lancet. 2005 Mar 19-25;365(9464):1054-61.
6. Silibinin downregulates MMP2 expression via Jak2/STAT3 pathway and inhibits the migration and invasive potential in MDA-MB-231 cells. Byun HJ, etal., Oncol Rep. 2017 Jun;37(6):3270-3278. doi: 10.3892/or.2017.5588. Epub 2017 Apr 19.
7. Analysis of JAK2 and STAT3 polymorphisms in patients with ankylosing spondylitis in Chinese Han population. Chen C, etal., Clin Immunol. 2010 Sep;136(3):442-6. Epub 2010 Jun 2.
8. Sinomenine attenuates cancer-induced bone pain via suppressing microglial JAK2/STAT3 and neuronal CAMKII/CREB cascades in rat models. Chen SP, etal., Mol Pain. 2018 Jan-Dec;14:1744806918793232. doi: 10.1177/1744806918793232. Epub 2018 Jul 20.
9. Clinicopathologic and prognostic significance of VEGF, JAK2 and STAT3 in patients with nasopharyngeal carcinoma. Cheng JZ, etal., Cancer Cell Int. 2018 Aug 13;18:110. doi: 10.1186/s12935-018-0605-0. eCollection 2018.
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12. Adipocyte JAK2 mediates spontaneous metabolic liver disease and hepatocellular carcinoma. Corbit KC, etal., JCI Insight. 2019 Aug 8;5. pii: 131310. doi: 10.1172/jci.insight.131310.
13. JAK/STAT signaling pathway mediates cytokine-induced iNOS expression in primary astroglial cell cultures. Dell'Albani P, etal., J Neurosci Res. 2001 Sep 1;65(5):417-24.
14. JAK/STAT3 pathway is activated in spinal cord microglia after peripheral nerve injury and contributes to neuropathic pain development in rat. Dominguez E, etal., J Neurochem. 2008 Oct;107(1):50-60. Epub 2008 Jul 12.
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16. SH2-B promotes insulin receptor substrate 1 (IRS1)- and IRS2-mediated activation of the phosphatidylinositol 3-kinase pathway in response to leptin. Duan C, etal., J Biol Chem. 2004 Oct 15;279(42):43684-91. Epub 2004 Aug 16.
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18. Involvement of JAK2 upstream of the PI 3-kinase in cell-cell adhesion regulation by gastrin. Ferrand A, etal., Exp Cell Res. 2004 Dec 10;301(2):128-38.
19. Requirement of Ca(2+) and PKCdelta for Janus kinase 2 activation by angiotensin II: involvement of PYK2. Frank GD, etal., Mol Endocrinol 2002 Feb;16(2):367-77.
20. Blockade of Janus kinase-2 signaling ameliorates mouse liver damage due to ischemia and reperfusion. Freitas MC, etal., Liver Transpl. 2010 May;16(5):600-10.
21. JAK2 inhibition sensitizes resistant EGFR-mutant lung adenocarcinoma to tyrosine kinase inhibitors. Gao SP, etal., Sci Signal. 2016 Mar 29;9(421):ra33. doi: 10.1126/scisignal.aac8460.
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26. AG490 prevents cell death after exposure of rat astrocytes to hydrogen peroxide or proinflammatory cytokines: involvement of the Jak2/STAT pathway. Gorina R, etal., J Neurochem. 2005 Feb;92(3):505-18.
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31. Growth hormone receptor interaction with Jak proteins differs between tissues. Hellgren G, etal., J Interferon Cytokine Res. 2001 Feb;21(2):75-83.
32. Estrogen-sensitive PTPRO expression represses hepatocellular carcinoma progression by control of STAT3. Hou J, etal., Hepatology. 2013 Feb;57(2):678-88. doi: 10.1002/hep.25980. Epub 2012 Oct 30.
33. Attenuation of leptin and insulin signaling by SOCS proteins. Howard JK and Flier JS, Trends Endocrinol Metab. 2006 Nov;17(9):365-71. Epub 2006 Sep 28.
34. NVP-BSK805, an Inhibitor of JAK2 Kinase, Significantly Enhances the Radiosensitivity of Esophageal Squamous Cell Carcinoma in vitro and in vivo. Hua Y, etal., Drug Des Devel Ther. 2020 Feb 24;14:745-755. doi: 10.2147/DDDT.S203048. eCollection 2020.
35. A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera. James C, etal., Nature. 2005 Apr 28;434(7037):1144-8.
36. Angiotensin II induces angiogenic factors production partly via AT1/JAK2/STAT3/SOCS3 signaling pathway in MHCC97H cells. Ji Y, etal., Cell Physiol Biochem. 2012;29(5-6):863-74. doi: 10.1159/000171034. Epub 2012 May 11.
37. Amelioration of experimental autoimmune encephalomyelitis by plumbagin through down-regulation of JAK-STAT and NF-kappaB signaling pathways. Jia Y, etal., PLoS One. 2011;6(10):e27006. Epub 2011 Oct 31.
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48. Evidence that IL-6-type cytokine signaling in cardiomyocytes is inhibited by oxidative stress: parthenolide targets JAK1 activation by generating ROS. Kurdi M and Booz GW, J Cell Physiol. 2007 Aug;212(2):424-31.
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52. Therapeutic effect of 7, 3'-dimethoxy hesperetin on adjuvant arthritis in rats through inhibiting JAK2-STAT3 signal pathway. Li R, etal., Int Immunopharmacol. 2012 Oct;14(2):157-63. doi: 10.1016/j.intimp.2012.07.001. Epub 2012 Jul 15.
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69. 1Alpha,25-dihydroxyvitamin D3 inhibits GH-induced expression of SOCS-3 and CIS and prolongs growth hormone signaling via the Janus kinase (JAK2)/signal transducers and activators of transcription (STAT5) system in osteoblast-like cells. Morales O, etal., J Biol Chem 2002 Sep 20;277(38):34879-84.
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72. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
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85. Conditioning injury-induced spinal axon regeneration requires signal transducer and activator of transcription 3 activation. Qiu J, etal., J Neurosci. 2005 Feb 16;25(7):1645-53.
86. Novel 1,4-benzothazines obliterate COX-2 mediated JAK-2/STAT-3 signals with potential regulation of oxidative and metabolic stress during colorectal cancer. Rai A, etal., Pharmacol Res. 2018 Jun;132:188-203. doi: 10.1016/j.phrs.2017.12.010. Epub 2017 Dec 8.
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88. 5,7,3'-Triacetyl hesperetin suppresses adjuvant-induced arthritis in rats through modulating JAK2/STAT3 pathway. Ren DY, etal., Am J Chin Med. 2013;41(3):601-14. doi: 10.1142/S0192415X13500420.
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90. GOA pipeline RGD automated data pipeline
91. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
92. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
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95. Janus kinase 2, an early target of alpha 7 nicotinic acetylcholine receptor-mediated neuroprotection against Abeta-(1-42) amyloid. Shaw S, etal., J Biol Chem 2002 Nov 22;277(47):44920-4.
96. JAK2 promotes brown adipose tissue function and is required for diet- and cold-induced thermogenesis in mice. Shi SY, etal., Diabetologia. 2016 Jan;59(1):187-96. doi: 10.1007/s00125-015-3786-2. Epub 2015 Oct 29.
97. Hepatocyte-specific deletion of Janus kinase 2 (JAK2) protects against diet-induced steatohepatitis and glucose intolerance. Shi SY, etal., J Biol Chem. 2012 Mar 23;287(13):10277-88. Epub 2012 Jan 24.
98. Janus Kinase 2 (JAK2) Dissociates Hepatosteatosis from Hepatocellular Carcinoma in Mice. Shi SY, etal., J Biol Chem. 2017 Mar 3;292(9):3789-3799. doi: 10.1074/jbc.M116.752519. Epub 2017 Jan 18.
99. Oncopreventive effects of theanine and theobromine on dimethylhydrazine-induced colon cancer model. Shojaei-Zarghani S, etal., Biomed Pharmacother. 2021 Feb;134:111140. doi: 10.1016/j.biopha.2020.111140. Epub 2020 Dec 24.
100. Secretoneurin promotes neuroprotection and neuronal plasticity via the Jak2/Stat3 pathway in murine models of stroke. Shyu WC, etal., J Clin Invest. 2008 Jan;118(1):133-48.
101. Novel fused oxazepino-indoles (FOIs) attenuate liver carcinogenesis via IL-6/JAK2/STAT3 signaling blockade as evidenced through data-based mathematical modeling. Singh AK, etal., Life Sci. 2018 May 15;201:161-172. doi: 10.1016/j.lfs.2018.02.029. Epub 2018 Feb 24.
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103. High expression of Janus kinase 2 in background normal liver tissue of resected hepatocellular carcinoma is associated with worse prognosis. Sonohara F, etal., Oncol Rep. 2015 Feb;33(2):767-73. doi: 10.3892/or.2014.3621. Epub 2014 Nov 25.
104. A highly selective, orally active inhibitor of Janus kinase 2, CEP-33779, ablates disease in two mouse models of rheumatoid arthritis. Stump KL, etal., Arthritis Res Ther. 2011 Apr 21;13(2):R68.
105. Aldosterone induces angiotensin converting enzyme gene expression via a JAK2-dependent pathway in rat endothelial cells. Sugiyama T, etal., Endocrinology. 2005 Sep;146(9):3900-6. Epub 2005 Jun 2.
106. Apigetrin inhibits gastric cancer progression through inducing apoptosis and regulating ROS-modulated STAT3/JAK2 pathway. Sun Q, etal., Biochem Biophys Res Commun. 2018 Mar 25;498(1):164-170. doi: 10.1016/j.bbrc.2018.02.009. Epub 2018 Mar 5.
107. Inhibition of JAK2 signaling by TG101209 enhances radiotherapy in lung cancer models. Sun Y, etal., J Thorac Oncol. 2011 Apr;6(4):699-706. doi: 10.1097/JTO.0b013e31820d9d11.
108. Opposite effect of JAK2 on insulin-dependent activation of mitogen-activated protein kinases and Akt in muscle cells: possible target to ameliorate insulin resistance. Thirone AC, etal., Diabetes. 2006 Apr;55(4):942-51.
109. Epiphyseal growth plate growth hormone receptor signaling is decreased in chronic kidney disease-related growth retardation. Troib A, etal., Kidney Int. 2013 Nov;84(5):940-9. doi: 10.1038/ki.2013.196. Epub 2013 May 29.
110. Sequential activation of JAKs, STATs and xanthine dehydrogenase/oxidase by hypoxia in lung microvascular endothelial cells. Wang G, etal., Int J Biochem Cell Biol. 2008;40(3):461-70. Epub 2007 Aug 30.
111. Total glucosides of paeony regulates JAK2/STAT3 activation and macrophage proliferation in diabetic rat kidneys. Wang K, etal., Am J Chin Med. 2012;40(3):521-36.
112. N-Acetylcysteine and allopurinol up-regulated the Jak/STAT3 and PI3K/Akt pathways via adiponectin and attenuated myocardial postischemic injury in diabetes. Wang T, etal., Free Radic Biol Med. 2013 Oct;63:291-303. doi: 10.1016/j.freeradbiomed.2013.05.043. Epub 2013 Jun 6.
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115. Galantamine anti-colitic effect: Role of alpha-7 nicotinic acetylcholine receptor in modulating Jak/STAT3, NF-κB/HMGB1/RAGE and p-AKT/Bcl-2 pathways. Wazea SA, etal., Sci Rep. 2018 Mar 23;8(1):5110. doi: 10.1038/s41598-018-23359-6.
116. Ischemic postconditioning during reperfusion attenuates intestinal injury and mucosal cell apoptosis by inhibiting JAK/STAT signaling activation. Wen SH, etal., Shock. 2012 Oct;38(4):411-9. doi: 10.1097/SHK.0b013e3182662266.
117. Prevalence and clinical outcomes of the 46/1 haplotype, Janus kinase 2 mutations, and ten-eleven translocation 2 mutations in Budd-Chiari syndrome and their impact on thrombotic complications post liver transplantation. Westbrook RH, etal., Liver Transpl. 2012 Jul;18(7):819-27. doi: 10.1002/lt.23443.
118. Discovery of the macrocycle (9E)-15-(2-(pyrrolidin-1-yl)ethoxy)-7,12,25-trioxa-19,21,24-triaza-tetracyclo[18. 3.1.1(2,5).1(14,18)]hexacosa-1(24),2,4,9,14(26),15,17,20,22-nonaene (SB1578), a potent inhibitor of janus kinase 2/fms-like tyrosine kinase-3 (JAK2/FLT3) for the treatment of rheumatoid arthritis. William AD, etal., J Med Chem. 2012 Mar 22;55(6):2623-40. doi: 10.1021/jm201454n. Epub 2012 Mar 6.
119. Abrogated leptin-induced cardiac contractile response in ventricular myocytes under spontaneous hypertension: role of Jak/STAT pathway. Wold LE, etal., Hypertension 2002 Jan;39(1):69-74.
120. Da-Huang-Fu-Zi-Tang attenuates liver injury in rats with severe acute pancreatitis. Wu L, etal., J Ethnopharmacol. 2013 Dec 12;150(3):960-6. doi: 10.1016/j.jep.2013.09.051. Epub 2013 Oct 24.
121. Curcumin suppresses stem-like traits of lung cancer cells via inhibiting the JAK2/STAT3 signaling pathway. Wu L, etal., Oncol Rep. 2015 Dec;34(6):3311-7. doi: 10.3892/or.2015.4279. Epub 2015 Sep 16.
122. IL-6 secreted by cancer-associated fibroblasts promotes epithelial-mesenchymal transition and metastasis of gastric cancer via JAK2/STAT3 signaling pathway. Wu X, etal., Oncotarget. 2017 Mar 28;8(13):20741-20750. doi: 10.18632/oncotarget.15119.
123. Effects of supplemental erythropoietin on its receptor expression and signal transduction pathways in rat model of retinal detachment. Xie Z, etal., Curr Eye Res. 2012 Feb;37(2):138-44. doi: 10.3109/02713683.2011.647225.
124. The effect of JAK2 knockout on inhibition of liver tumor growth by inducing apoptosis, autophagy and anti-proliferation via STATs and PI3K/AKT signaling pathways. Xu Y and Lv SX, Biomed Pharmacother. 2016 Dec;84:1202-1212. doi: 10.1016/j.biopha.2016.09.040. Epub 2016 Oct 24.
125. Emulsified isoflurane induces postconditioning against myocardial infarction via JAK-STAT pathway. Yan L, etal., J Surg Res. 2012 Dec;178(2):578-85. doi: 10.1016/j.jss.2012.06.007. Epub 2012 Jun 21.
126. Janus kinase 2 polymorphisms are associated with risk in patients with gastric cancer in a Chinese population. Yang L, etal., PLoS One. 2013 May 24;8(5):e64628. doi: 10.1371/journal.pone.0064628. Print 2013.
127. JAK2/STAT3 activation by melatonin attenuates the mitochondrial oxidative damage induced by myocardial ischemia/reperfusion injury. Yang Y, etal., J Pineal Res. 2013 Oct;55(3):275-86. doi: 10.1111/jpi.12070. Epub 2013 Jun 25.
128. Prolactin promotes hepatocellular carcinoma through Janus kinase 2. Yeh YT, etal., World J Surg. 2012 May;36(5):1128-35. doi: 10.1007/s00268-012-1505-4.
129. Suppression of IL-1beta expression by the Jak 2 inhibitor AG490 in cerulein-stimulated pancreatic acinar cells. Yu JH, etal., Biochem Pharmacol. 2006 Nov 30;72(11):1555-62. Epub 2006 Aug 24.
130. JAK2/STAT3, not ERK1/2, mediates interleukin-6-induced activation of inducible nitric-oxide synthase and decrease in contractility of adult ventricular myocytes. Yu X, etal., J Biol Chem. 2003 May 2;278(18):16304-9. Epub 2003 Feb 20.
131. The association of the JAK2 46/1 haplotype with non-splanchnic venous thrombosis. Zerjavic K, etal., Thromb Res. 2013 Aug;132(2):e86-93. doi: 10.1016/j.thromres.2013.06.021. Epub 2013 Jul 9.
132. Protection of curcumin against fructose-induced hyperuricaemia and renal endothelial dysfunction involves NO-mediated JAK-STAT signalling in rats. Zhang DM, etal., Food Chem. 2012 Oct 15;134(4):2184-93. doi: 10.1016/j.foodchem.2012.04.026. Epub 2012 Apr 17.
133. Involvement of JAK2 and Src kinase tyrosine phosphorylation in human growth hormone-stimulated increases in cytosolic free Ca2+ and insulin secretion. Zhang F, etal., Am J Physiol Cell Physiol. 2006 Sep;291(3):C466-75. Epub 2006 Apr 5.
134. JAK2 inhibitor TG101348 overcomes erlotinib-resistance in non-small cell lung carcinoma cells with mutated EGF receptor. Zhang FQ, etal., Oncotarget. 2015 Jun 10;6(16):14329-43. doi: 10.18632/oncotarget.3685.
135. Inhibition of JAK2/STAT3 signaling pathway protects mice from the DDP-induced acute kidney injury in lung cancer. Zhang L, etal., Inflamm Res. 2019 Sep;68(9):751-760. doi: 10.1007/s00011-019-01258-4. Epub 2019 Jun 26.
136. Oxymatrine protects against myocardial injury via inhibition of JAK2/STAT3 signaling in rat septic shock. Zhang M, etal., Mol Med Rep. 2013 Apr;7(4):1293-9. doi: 10.3892/mmr.2013.1315. Epub 2013 Feb 8.
137. Amyloid-beta induces hepatic insulin resistance in vivo via JAK2. Zhang Y, etal., Diabetes. 2013 Apr;62(4):1159-66. doi: 10.2337/db12-0670. Epub 2012 Dec 6.
138. Suppression of JAK2/STAT3 signaling reduces end-to-end arterial anastomosis induced cell proliferation in common carotid arteries of rats. Zhao J, etal., PLoS One. 2013;8(3):e58730. doi: 10.1371/journal.pone.0058730. Epub 2013 Mar 14.
139. Activation of JAK2/STAT pathway in cerebral cortex after experimental traumatic brain injury of rats. Zhao JB, etal., Neurosci Lett. 2011 Jul 8;498(2):147-52. Epub 2011 May 10.
140. [Effects of puerarin on expressions of leptin receptor mRNA, phosphorylated Janus kinase 2/phosphorylated signal transducers and activators of transcription 3 proteins in the liver of rats with non-alcoholic fatty liver]. Zheng PY, etal., Zhong Xi Yi Jie He Xue Bao. 2008 Sep;6(9):921-7.
141. Recombinant human erythropoietin attenuates neuronal apoptosis and cognitive defects via JAK2/STAT3 signaling in experimental endotoxemia. Zhou TF and Yu JG, J Surg Res. 2013 Jul;183(1):304-12. doi: 10.1016/j.jss.2012.11.035. Epub 2012 Dec 6.
142. Elevated retinol binding protein 4 levels are associated with atherosclerosis in diabetic rats via JAK2/STAT3 signaling pathway. Zhou W, etal., World J Diabetes. 2021 Apr 15;12(4):466-479. doi: 10.4239/wjd.v12.i4.466.
143. SMND-309, a novel derivative of salvianolic acid B, protects rat brains ischemia and reperfusion injury by targeting the JAK2/STAT3 pathway. Zhu H, etal., Eur J Pharmacol. 2013 Aug 15;714(1-3):23-31. doi: 10.1016/j.ejphar.2013.05.043. Epub 2013 Jun 11.
Additional References at PubMed
PMID:7527668   PMID:7528775   PMID:7538110   PMID:7782332   PMID:7961995   PMID:8022486   PMID:8378315   PMID:8400282   PMID:8609418   PMID:8923468   PMID:9111318   PMID:9727029  
PMID:10600756   PMID:10822380   PMID:10872802   PMID:10925297   PMID:11201744   PMID:11489994   PMID:11493922   PMID:11821424   PMID:12040017   PMID:12147240   PMID:12388746   PMID:12426001  
PMID:12538627   PMID:12777386   PMID:12941779   PMID:12960006   PMID:14522994   PMID:14678947   PMID:15012602   PMID:15065871   PMID:15143187   PMID:15156153   PMID:15159394   PMID:15354294  
PMID:15591245   PMID:15746188   PMID:15958724   PMID:16025117   PMID:16280321   PMID:16297319   PMID:17332060   PMID:17496209   PMID:17519522   PMID:17526654   PMID:17565041   PMID:17607690  
PMID:17726028   PMID:17728251   PMID:17761766   PMID:18006272   PMID:18499741   PMID:18582595   PMID:18611343   PMID:18798867   PMID:19063868   PMID:19276765   PMID:19350281   PMID:19435852  
PMID:19625377   PMID:19665053   PMID:19748527   PMID:19781194   PMID:19783980   PMID:19888448   PMID:20122990   PMID:20304997   PMID:20492356   PMID:20530874   PMID:20724918   PMID:20817061  
PMID:20848345   PMID:20976841   PMID:20979831   PMID:21036157   PMID:21470923   PMID:21502705   PMID:21509626   PMID:21536676   PMID:21606371   PMID:21808064   PMID:21813872   PMID:21841788  
PMID:21929289   PMID:22125600   PMID:22466958   PMID:22561747   PMID:22697788   PMID:22820988   PMID:22948409   PMID:23061660   PMID:23449887   PMID:23544085   PMID:24013029   PMID:24018979  
PMID:24463190   PMID:24965138   PMID:25129435   PMID:25380525   PMID:25500624   PMID:25537973   PMID:25559502   PMID:25731682   PMID:25986861   PMID:26227742   PMID:26261556   PMID:26527061  
PMID:26802935   PMID:26884823   PMID:27003918   PMID:27057278   PMID:27301615   PMID:27337676   PMID:27450794   PMID:27573711   PMID:27717845   PMID:28334068   PMID:28385490   PMID:28782583  
PMID:28782829   PMID:29032602   PMID:29061394   PMID:29174854   PMID:29210652   PMID:29550470   PMID:29580751   PMID:30552029   PMID:31264277   PMID:31406138   PMID:31454541   PMID:31545485  
PMID:31564534   PMID:31703282   PMID:31746349   PMID:31841394   PMID:31982878   PMID:32016456   PMID:32647179   PMID:33002365   PMID:33522063   PMID:33729996   PMID:34081793   PMID:34516361  
PMID:35042436   PMID:35122774   PMID:36446389   PMID:37232379   PMID:37338759   PMID:37641874   PMID:37759514   PMID:38154546   PMID:38306778   PMID:38796983  


Genomics

Comparative Map Data
Jak2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81236,408,905 - 236,468,769 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1236,408,662 - 236,468,762 (+)EnsemblGRCr8
mRatBN7.21226,995,334 - 227,054,381 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1226,995,334 - 227,054,189 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1235,396,988 - 235,455,863 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01242,326,646 - 242,385,527 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01235,144,413 - 235,203,184 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01247,398,667 - 247,457,521 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1247,398,598 - 247,458,509 (+)Ensemblrn6Rnor6.0
Rnor_5.01254,646,160 - 254,706,478 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41232,915,995 - 232,974,763 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1224,147,256 - 224,206,104 (+)NCBICelera
RGSC_v3.11233,080,017 - 233,138,786 (+)NCBI
Cytogenetic Map1q52NCBI
JAK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3894,984,390 - 5,129,948 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl94,984,390 - 5,129,948 (+)Ensemblhg38GRCh38
GRCh3794,984,390 - 5,129,948 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3694,975,245 - 5,117,995 (+)NCBIBuild 36Build 36hg18NCBI36
Build 3494,975,244 - 5,117,995NCBI
Celera94,910,860 - 5,053,802 (+)NCBICelera
Cytogenetic Map9p24.1NCBI
HuRef94,940,783 - 5,083,727 (+)NCBIHuRef
CHM1_194,985,470 - 5,128,355 (+)NCBICHM1_1
T2T-CHM13v2.094,989,498 - 5,135,022 (+)NCBIT2T-CHM13v2.0
Jak2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391929,229,006 - 29,290,495 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1929,229,228 - 29,290,480 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381929,251,803 - 29,313,095 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1929,251,828 - 29,313,080 (+)Ensemblmm10GRCm38
MGSCv371929,326,318 - 29,387,570 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361929,318,452 - 29,377,979 (+)NCBIMGSCv36mm8
Celera1930,028,576 - 30,089,642 (+)NCBICelera
Cytogenetic Map19C1NCBI
cM Map1923.73NCBI
Jak2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554349,227,595 - 9,341,208 (+)Ensembl
ChiLan1.0NW_0049554349,227,897 - 9,341,208 (+)NCBIChiLan1.0ChiLan1.0
JAK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v211119,420,003 - 119,589,890 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan19119,425,950 - 119,595,837 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v094,820,303 - 4,971,867 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.195,006,271 - 5,156,626 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl95,006,271 - 5,156,626 (+)EnsemblpanPan2panpan1.1
JAK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1193,321,055 - 93,438,898 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl193,142,635 - 93,435,997 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha193,730,062 - 93,844,204 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0193,940,875 - 93,989,640 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl193,877,224 - 93,990,814 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1193,507,891 - 93,622,032 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0193,232,417 - 93,346,624 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0193,996,654 - 94,110,963 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Jak2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947140,931,052 - 141,061,286 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936503110,963 - 241,867 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936503111,722 - 243,627 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JAK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1216,848,689 - 217,002,148 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11216,849,744 - 217,002,310 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21242,696,921 - 242,837,407 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JAK2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11274,421,243 - 74,566,766 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1274,421,016 - 74,566,710 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603862,818,134 - 62,927,470 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Jak2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247369,724,369 - 9,830,365 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247369,724,876 - 9,827,364 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Jak2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1229,327,717 - 29,387,231 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Jak2
561 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:118
Count of miRNA genes:88
Interacting mature miRNAs:101
Transcripts:ENSRNOT00000021217
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8693637Alc29Alcohol consumption QTL 292.70.258drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)1217412367243666627Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1160111531262090437Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
1357335Bw39Body weight QTL 393.3body mass (VT:0001259)body weight (CMO:0000012)1207243873252243873Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1186658830266453731Rat
2293674Bss39Bone structure and strength QTL 397.10.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)1210980612255980612Rat
61455Niddm7Non-insulin dependent diabetes mellitus QTL 75.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1223964326248681945Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1226175591270518180Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1205233991267096252Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1218829748263829748Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1186658830266453731Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1176288899270518180Rat
631838Niddm36Non-insulin dependent diabetes mellitus QTL 360.01insulin secretion trait (VT:0003564)calculated pancreatic islet insulin release measurement (CMO:0001217)1193964073238964073Rat
8693661Alc34Alcohol consumption QTL 342.20.611drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)1217412367238041033Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1132966869252856240Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
2293694Bss38Bone structure and strength QTL 387.050.0001femur strength trait (VT:0010010)femur stiffness (CMO:0001674)1210980612255980612Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1160111531262090437Rat
1300145Rf7Renal function QTL 72.96urine creatinine amount (VT:0010540)urine creatinine level (CMO:0000125)1194575422239575422Rat
8655655Arrd2Age-related retinal degeneration QTL 27.79retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1193400541238400541Rat
734767Niddm57Non-insulin dependent diabetes mellitus QTL 57body mass (VT:0001259)body weight (CMO:0000012)1233480549270108840Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1200449456256003563Rat
631215Stl8Serum triglyceride level QTL 89.270.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1234540191270518180Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1146080545243492863Rat
631843Bw116Body weight QTL 1164.10.016abdominal adipose amount (VT:1000220)abdominal fat pad weight (CMO:0000088)1233480549270108840Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1207163993269633915Rat
2300175Bmd40Bone mineral density QTL 4015.40.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)1210980612255980612Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
724538Kidm1Kidney mass QTL 13.2kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1223134011262090599Rat
2293655Bss36Bone structure and strength QTL 3610.660.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1210980612255980612Rat
1298084Thym4Thymus enlargement QTL 410.68thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1207243873252243873Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1160111426262090599Rat
2314011Gluco56Glucose level QTL 56blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1209203273254203273Rat
8552891Epfw5Epididymal fat weight QTL 54.4epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1202543537247543537Rat
734769Niddm58Non-insulin dependent diabetes mellitus QTL 58body mass (VT:0001259)body weight (CMO:0000012)1225108840270108840Rat
724533Rf51Renal function QTL 515.30.0002kidney plasma flow trait (VT:0005524)renal plasma flow (CMO:0001914)1228180370266453608Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
1358292Cm37Cardiac mass QTL 376.28e-07heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1205674651250674651Rat
61376Bp42Blood pressure QTL 4223.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1207243873252243873Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1208479811269633915Rat
70211Niddm24Non-insulin dependent diabetes mellitus QTL 243.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1224633915269633915Rat
724552Glom2Glomerulus QTL 23.30.0001kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)1232312773270518180Rat
1358916Kidm22Kidney mass QTL 223.32kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1212738576257738576Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1194786607262083703Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1188241285250779312Rat
2292218Kidm35Kidney mass QTL 35kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1208798288253798288Rat
61400Niddm1Non-insulin dependent diabetes mellitus QTL 111blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1228180243255849249Rat
1300168Bp170Blood pressure QTL 1702.76arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1192995199237995199Rat
61403Niddm4Non-insulin dependent diabetes mellitus QTL 4blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1201464383246464383Rat
1641926Teswt2Testicular weight QTL 22.82testis mass (VT:1000644)both testes wet weight (CMO:0000175)1203675682248675682Rat
631658Cm7Cardiac mass QTL 75.320.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)1205674651250674651Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
2293700Bmd27Bone mineral density QTL 276.60.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1210980612255980612Rat
2293701Bmd34Bone mineral density QTL 348.30.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)1210980612255980612Rat
7387289Uae45Urinary albumin excretion QTL 452.860.0021urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1233204160270518180Rat
8655855Arrd3Age-related retinal degeneration QTL 33.07lens clarity trait (VT:0001304)cataract incidence/prevalence measurement (CMO:0001585)1193400541238400541Rat
1600374Mcs17Mammary carcinoma susceptibility QTL 173mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1207099883252099883Rat
6480786Bw97Body weight QTL 975.03body mass (VT:0001259)body weight (CMO:0000012)1234540191237018045Rat
1600363Hc6Hypercalciuria QTL 62.7urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1210980612255980612Rat
8693618Alc25Alcohol consumption QTL 2530.28drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)1217412367238041033Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1185857683270518180Rat
2302040Pia35Pristane induced arthritis QTL 353.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1226175591270518180Rat
631669Iddm9Insulin dependent diabetes mellitus QTL 92.80.039blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1233349180270518180Rat
7394701Uae46Urinary albumin excretion QTL 463.60.0056urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1210980612255980612Rat
1598821Rf55Renal function QTL 556.3renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1228174566270518180Rat

Markers in Region
D1Bda61  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21227,053,939 - 227,054,173 (+)MAPPERmRatBN7.2
Rnor_6.01247,457,272 - 247,457,505NCBIRnor6.0
Rnor_5.01254,705,185 - 254,705,418UniSTSRnor5.0
RGSC_v3.41232,974,514 - 232,974,747UniSTSRGSC3.4
Celera1224,205,855 - 224,206,088UniSTS
Cytogenetic Map1q51-q53UniSTS
RH141418  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21227,054,207 - 227,054,407 (+)MAPPERmRatBN7.2
Rnor_6.01247,457,540 - 247,457,739NCBIRnor6.0
Rnor_5.01254,705,453 - 254,705,652UniSTSRnor5.0
RGSC_v3.41232,974,782 - 232,974,981UniSTSRGSC3.4
Celera1224,206,123 - 224,206,322UniSTS
Cytogenetic Map1q51-q53UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 92 59 6 356 192 11 142 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000087011   ⟹   ENSRNOP00000071877
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1236,408,662 - 236,468,762 (+)Ensembl
mRatBN7.2 Ensembl1226,995,334 - 227,054,189 (+)Ensembl
Rnor_6.0 Ensembl1247,398,598 - 247,458,509 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000103558   ⟹   ENSRNOP00000081122
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1227,021,067 - 227,054,189 (+)Ensembl
RefSeq Acc Id: NM_031514   ⟹   NP_113702
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81236,408,905 - 236,467,759 (+)NCBI
mRatBN7.21226,995,334 - 227,054,189 (+)NCBI
Rnor_6.01247,398,667 - 247,457,521 (+)NCBI
Rnor_5.01254,646,160 - 254,706,478 (+)NCBI
RGSC_v3.41232,915,995 - 232,974,763 (+)RGD
Celera1224,147,256 - 224,206,104 (+)RGD
Sequence:
RefSeq Acc Id: XM_039097313   ⟹   XP_038953241
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81236,443,747 - 236,468,769 (+)NCBI
mRatBN7.21227,030,176 - 227,054,381 (+)NCBI
Protein Sequences
Protein RefSeqs NP_113702 (Get FASTA)   NCBI Sequence Viewer  
  XP_038953241 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA79911 (Get FASTA)   NCBI Sequence Viewer  
  CAA04188 (Get FASTA)   NCBI Sequence Viewer  
  EDM13086 (Get FASTA)   NCBI Sequence Viewer  
  EDM13087 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000071877
  ENSRNOP00000071877.1
GenBank Protein Q62689 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_113702   ⟸   NM_031514
- UniProtKB: Q62689 (UniProtKB/Swiss-Prot),   A6I0V5 (UniProtKB/TrEMBL),   A0A8I5ZSC0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000071877   ⟸   ENSRNOT00000087011
RefSeq Acc Id: XP_038953241   ⟸   XM_039097313
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000081122   ⟸   ENSRNOT00000103558
Protein Domains
FERM   FERM F1 lobe ubiquitin-like   Protein kinase   SH2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62689-F1-model_v2 AlphaFold Q62689 1-1132 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2939 AgrOrtholog
BioCyc Gene G2FUF-55973 BioCyc
Ensembl Genes ENSRNOG00000059968 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000087011 ENTREZGENE
  ENSRNOT00000087011.2 UniProtKB/Swiss-Prot
Gene3D-CATH 2.30.29.30 UniProtKB/Swiss-Prot
  3.30.505.10 UniProtKB/Swiss-Prot
  Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
InterPro Band_41_domain UniProtKB/Swiss-Prot
  FERM_2 UniProtKB/Swiss-Prot
  FERM_central UniProtKB/Swiss-Prot
  FERM_domain UniProtKB/Swiss-Prot
  FERM_F1 UniProtKB/Swiss-Prot
  FERM_F2 UniProtKB/Swiss-Prot
  JAK UniProtKB/Swiss-Prot
  Jak1_PHL_dom UniProtKB/Swiss-Prot
  JAK2_FERM_C-lobe UniProtKB/Swiss-Prot
  JAK2_SH2 UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  PH-like_dom_sf UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  PTK_Jak2_rpt1 UniProtKB/Swiss-Prot
  PTKc_Jak2_rpt2 UniProtKB/Swiss-Prot
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot
  SH2 UniProtKB/Swiss-Prot
  SH2_dom_sf UniProtKB/Swiss-Prot
  Tyr_kinase_AS UniProtKB/Swiss-Prot
  Tyr_kinase_cat_dom UniProtKB/Swiss-Prot
  Tyr_kinase_non-rcpt_Jak/Tyk2 UniProtKB/Swiss-Prot
  Tyr_kinase_non-rcpt_Jak2 UniProtKB/Swiss-Prot
KEGG Report rno:24514 UniProtKB/Swiss-Prot
NCBI Gene 24514 ENTREZGENE
PANTHER TYROSINE-PROTEIN KINASE HOPSCOTCH UniProtKB/Swiss-Prot
  TYROSINE-PROTEIN KINASE JAK2 UniProtKB/Swiss-Prot
Pfam FERM_F1 UniProtKB/Swiss-Prot
  FERM_F2 UniProtKB/Swiss-Prot
  Jak1_Phl UniProtKB/Swiss-Prot
  Pkinase_Tyr UniProtKB/Swiss-Prot
  SH2_1 UniProtKB/Swiss-Prot
PharmGKB JAK2 RGD
PhenoGen Jak2 PhenoGen
PIRSF TyrPK_Jak UniProtKB/Swiss-Prot
PRINTS JANUSKINASE UniProtKB/Swiss-Prot
  JANUSKINASE2 UniProtKB/Swiss-Prot
  TYRKINASE UniProtKB/Swiss-Prot
PROSITE FERM_3 UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_TYR UniProtKB/Swiss-Prot
  SH2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000059968 RatGTEx
SMART B41 UniProtKB/Swiss-Prot
  SH2 UniProtKB/Swiss-Prot
  TyrKc UniProtKB/Swiss-Prot
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot
  SSF47031 UniProtKB/Swiss-Prot
  SSF55550 UniProtKB/Swiss-Prot
  SSF56112 UniProtKB/Swiss-Prot
UniProt A0A8I5ZSC0 ENTREZGENE
  A6I0V5 ENTREZGENE, UniProtKB/TrEMBL
  A6I0V6_RAT UniProtKB/TrEMBL
  JAK2_RAT UniProtKB/Swiss-Prot
  O35804_RAT UniProtKB/TrEMBL
  Q62689 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Jak2  Janus kinase 2 (a protein tyrosine kinase)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains two tandem protein kinase related domain 633059
gene_expression mRNA expressed in brain and spleen 633059
gene_homology 93.4% nucleotide and 97.1% amino acid homology with murine Jak2 633059
gene_product member of Janus family; non receptor protein tyrosine kinase 633059