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Genes search result for Mus musculus
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89 records found for search term Tox
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RGD IDSymbolNameDescriptionChrStartStopSpeciesAnnotationsMatchType
1321364Toxthymocyte selection-associated high mobility group boxEnables chromatin DNA binding activity. Involved in several processes, including alpha-beta T cell lineage commitment; cerebral cortex neuron differentiation; and regulation of positive thymic T cell selection. Acts upstream of or within hematopoietic or lymphoid organ development; lymphocyte differ466863536991557Mouse156symbol , old_gene_name , PhenoGen , descriptiongene, protein-coding, VALIDATED [RefSeq]
1619629Rhox8reproductive homeobox 8Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific. Acts upstream of or within regulation of gene expression and spermatogenesis. Located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]X3696365736979643Mouse29old_gene_name , old_gene_symbolgene, protein-coding, VALIDATED [RefSeq]
1550105Duox1dual oxidase 1Predicted to enable superoxide-generating NAD(P)H oxidase activity. Acts upstream of or within reactive oxygen species metabolic process. Located in plasma membrane. Is expressed in brain; placenta; and thyroid gland. Orthologous to human DUOX1 (dual oxidase 1). [provided by Alliance of Genome Resou2122143525122178454Mouse174old_gene_symbolgene, protein-coding, VALIDATED [RefSeq]
1332300Duox2dual oxidase 2Predicted to enable NAD(P)H oxidase H2O2-forming activity; calcium ion binding activity; and superoxide-generating NAD(P)H oxidase activity. Acts upstream of or within several processes, including bone mineralization; endocrine system development; and thyroid hormone metabolic process. Predicted to 2122109727122129221Mouse212old_gene_symbolgene, protein-coding, VALIDATED [RefSeq]
1625908Tox2TOX high mobility group box family member 2Predicted to enable RNA polymerase II-specific DNA-binding transcription factor binding activity; chromatin DNA binding activity; and transcription coactivator activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Pre2163045047163166092Mouse100symbol , PhenoGen , name , descriptiongene, protein-coding, VALIDATED [RefSeq]
1551816Tox3TOX high mobility group box family member 3Predicted to enable chromatin DNA binding activity; phosphoprotein binding activity; and protein homodimerization activity. Predicted to be involved in calcium-mediated signaling; negative regulation of neuron apoptotic process; and positive regulation of transcription by RNA polymerase II. Predicte89097366591075746Mouse141symbol , PhenoGen , name , descriptiongene, protein-coding, VALIDATED [RefSeq]
1553718Tox4TOX high mobility group box family member 4Predicted to enable chromatin DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in chromatin. Predicted to be part of PTW/PP1 phosphatase complex. Predicted to be active in nucleus. Predicted to colocalize with chromosome, tel145251660352532966Mouse92symbol , PhenoGen , name , descriptiongene, protein-coding, VALIDATED [RefSeq]
1316163Antxr1anthrax toxin receptor 1Predicted to enable actin filament binding activity; collagen binding activity; and transmembrane signaling receptor activity. Acts upstream of or within blood vessel development; negative regulation of extracellular matrix assembly; and positive regulation of metallopeptidase activity. Predicted to68711083587312757Mouse229namegene, protein-coding, VALIDATED [RefSeq]
1620775Antxr2anthrax toxin receptor 2Predicted to enable transmembrane signaling receptor activity. Acts upstream of or within collagen fibril organization; single fertilization; and uterus development. Located in external side of plasma membrane. Is expressed in cerebral cortex and retina. Human ortholog(s) of this gene implicated in 59803254798178876Mouse181namegene, protein-coding, VALIDATED [RefSeq]
1558486Antxrlanthrax toxin receptor-likePredicted to enable transmembrane signaling receptor activity. Predicted to be located in membrane. Predicted to be active in cell surface and plasma membrane. Is expressed in testis. Orthologous to human ANTXRL (ANTXR like). [provided by Alliance of Genome Resources, Jul 2025]143377462533798280Mouse19namegene, protein-coding, VALIDATED [RefSeq]
1620238Rpl15-ps2ribosomal protein L15, pseudogene 2INTERACTS WITH perfluorohexanesulfonic acid; T-2 toxin97196784371968902Mouse2descriptiongene, pseudo, INFERRED [RefSeq]
10217Atp7bATPase, copper transporting, beta polypeptideEnables P-type divalent copper transporter activity. Acts upstream of or within several processes, including copper ion transport; intracellular monoatomic cation homeostasis; and lactation. Located in membrane and trans-Golgi network. Is expressed in several structures, including alimentary system;82248279922550347Mouse447old_gene_namegene, protein-coding, VALIDATED [RefSeq]
1558479Tnfrsf19tumor necrosis factor receptor superfamily, member 19Predicted to enable signaling receptor activity. Acts upstream of or within hair follicle development and positive regulation of canonical NF-kappaB signal transduction. Predicted to be located in extracellular region. Predicted to be active in plasma membrane. Is expressed in several structures, in146120128361284304Mouse193old_gene_namegene, protein-coding, VALIDATED [RefSeq]
1552258Hbegfheparin-binding EGF-like growth factorEnables epidermal growth factor receptor binding activity; heparin binding activity; and signaling receptor activator activity. Involved in several processes, including ERBB2 signaling pathway; positive regulation of keratinocyte migration; and wound healing, spreading of epidermal cells. Acts upstr183663798036648858Mouse486old_gene_namegene, protein-coding, VALIDATED [RefSeq]
9644912Gm30083predicted gene, 30083Predicted to enable transmembrane signaling receptor activity. Predicted to be active in cell surface and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]143371037433738860Mouse7old_gene_namegene, protein-coding, VALIDATED [RefSeq]
731977CflarCASP8 and FADD-like apoptosis regulatorEnables peptidase activator activity. Involved in several processes, including negative regulation of myoblast fusion; positive regulation of NF-kappaB transcription factor activity; and skeletal muscle atrophy. Acts upstream of or within negative regulation of extrinsic apoptotic signaling pathway;15875035358798043Mouse476old_gene_namegene, protein-coding, VALIDATED [RefSeq]
736529Gucy2cguanylate cyclase 2cEnables guanylate cyclase activity. Acts upstream of or within regulation of cell population proliferation and response to toxic substance. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in plasma membrane. Is expressed in alim6136674282136758740Mouse136old_gene_name , descriptiongene, protein-coding, VALIDATED [RefSeq]
731800Kif1ckinesin family member 1CPredicted to enable ATP hydrolysis activity; microtubule binding activity; and plus-end-directed microtubule motor activity. Acts upstream of or within retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Located in Golgi apparatus. Is expressed in alimentary system; hindbrain meni117059117070622796Mouse108old_gene_namegene, protein-coding, VALIDATED [RefSeq]
1557600Dph1diphthamide biosynthesis 1Enables 2-(3-amino-3-carboxypropyl)histidine synthase activity. Involved in protein histidyl modification to diphthamide. Acts upstream of or within fibroblast proliferation. Part of 2-(3-amino-3-carboxypropyl)histidine synthase complex. Is expressed in several structures, including gonad; gut; hemo117506846975081309Mouse143old_gene_namegene, protein-coding, VALIDATED [RefSeq]
1623210Dph2DPH2 homologPredicted to enable 4 iron, 4 sulfur cluster binding activity. Predicted to contribute to 2-(3-amino-3-carboxypropyl)histidine synthase activity. Predicted to be involved in protein histidyl modification to diphthamide. Part of 2-(3-amino-3-carboxypropyl)histidine synthase complex. Is expressed in l4117745838117749220Mouse92old_gene_namegene, protein-coding, VALIDATED [RefSeq]
732106FaddFas associated via death domainEnables signaling adaptor activity. Involved in several processes, including hematopoietic or lymphoid organ development; positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation; and regulation of apoptotic process. Acts upstream of or wit7144132060144136178Mouse504old_gene_name , descriptiongene, protein-coding, VALIDATED [RefSeq]
1322414Slc47a1solute carrier family 47, member 1Enables polyspecific organic cation:proton antiporter activity. Involved in monoatomic cation transmembrane transport and xenobiotic transmembrane transport. Located in plasma membrane. Is expressed in several structures, including liver; lung; metanephros; nervous system; and spleen. Orthologous to116123422661269668Mouse312old_gene_namegene, protein-coding, VALIDATED [RefSeq]
1614799Slc47a2solute carrier family 47, member 2Enables organic cation transmembrane transporter activity and polyspecific organic cation:proton antiporter activity. Involved in organic cation transport. Located in plasma membrane. Is expressed in Harderian gland; esophagus; male reproductive gland or organ; and skin. Orthologous to human SLC47A1116119245361233686Mouse143old_gene_namegene, protein-coding, PROVISIONAL [RefSeq]
1614240Kti12KTI12 homolog, chromatin associatedPredicted to enable ATP binding activity. Predicted to be involved in tRNA wobble uridine modification. Is expressed in several structures, including adrenal gland; brain; genitourinary system; heart; and stomach. Orthologous to human KTI12 (KTI12 chromatin associated homolog). [provided by Alliance4108705054108706609Mouse51old_gene_namegene, protein-coding, VALIDATED [RefSeq]
1553531Rac1Rac family small GTPase 1Enables G protein activity; GTP binding activity; and GTP-dependent protein binding activity. Involved in several processes, including nervous system development; positive regulation of protein localization; and regulation of cell migration. Acts upstream of or within several processes, including ac5143491236143513786Mouse839old_gene_namegene, protein-coding, VALIDATED [RefSeq]
1316840Rac2Rac family small GTPase 2Enables GTPase activity and protein kinase regulator activity. Involved in several processes, including positive regulation of lamellipodium assembly; regulation of leukocyte chemotaxis; and regulation of mast cell degranulation. Acts upstream of or within several processes, including cell projectio157844336978456983Mouse321old_gene_namegene, protein-coding, VALIDATED [RefSeq]
1620652Rac3Rac family small GTPase 3Predicted to enable several functions, including GTP binding activity; GTPase activity; and calcium-dependent protein binding activity. Involved in regulation of postsynapse assembly. Acts upstream of or within several processes, including GABAergic synaptic transmission; neuron development; and reg11120612294120614795Mouse191old_gene_namegene, protein-coding, PROVISIONAL [RefSeq]
1312120Art1ADP-ribosyltransferase 1Enables NAD+ poly-ADP-ribosyltransferase activity. Located in cell surface and membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; limb; and sensory organ. Orthologous to human ART1 (ADP-ribosyltransferase 1). [provided by Alliance of Genome Resour7101750913101771410Mouse60old_gene_namegene, protein-coding, VALIDATED [RefSeq]
11210Art2aADP-ribosyltransferase 2aEnables NAD+-protein-arginine ADP-ribosyltransferase activity and hydrolase activity, acting on glycosyl bonds. Involved in NAD catabolic process. Located in external side of plasma membrane. Orthologous to human ART2P (ADP-ribosyltransferase 2, pseudogene). [provided by Alliance of Genome Resources7101201657101210072Mouse24old_gene_namegene, protein-coding, VALIDATED [RefSeq]
1553246Art2bADP-ribosyltransferase 2bEnables NAD+-protein-arginine ADP-ribosyltransferase activity and hydrolase activity, acting on glycosyl bonds. Involved in NAD catabolic process. Located in external side of plasma membrane. Orthologous to human ART2BP (ADP-ribosyltransferase 2B, pseudogene). [provided by Alliance of Genome Resourc7101224936101234790Mouse60old_gene_namegene, protein-coding, VALIDATED [RefSeq]
1320438Art3ADP-ribosyltransferase 3Predicted to enable NAD+ poly-ADP-ribosyltransferase activity. Predicted to be located in plasma membrane and side of membrane. Is expressed in 1-cell stage embryo; 2-cell stage embryo; facial ganglion; glossopharyngeal ganglion; and vestibulo-cochlear ganglion. Orthologous to human ART3 (ADP-ribosy59247965992562487Mouse108old_gene_namegene, protein-coding, VALIDATED [RefSeq]
1315085Art4ADP-ribosyltransferase 4Predicted to enable NAD+ poly-ADP-ribosyltransferase activity. Predicted to be located in plasma membrane and side of membrane. Is expressed in several structures, including cardiovascular system; genitourinary system; integumental system; liver; and sensory organ. Orthologous to human ART4 (ADP-rib6136825449136834598Mouse85old_gene_namegene, protein-coding, VALIDATED [RefSeq]
1550298Art5ADP-ribosyltransferase 5Predicted to enable NAD+ poly-ADP-ribosyltransferase activity. Predicted to be located in extracellular region and membrane. Is expressed in several structures, including heart; limb; male reproductive system; nose; and skeletal musculature. Orthologous to human ART5 (ADP-ribosyltransferase 5). [pro7101746086101752052Mouse62old_gene_namegene, protein-coding, VALIDATED [RefSeq]
1551988Parp1poly (ADP-ribose) polymerase family, member 1Enables chromatin binding activity and pentosyltransferase activity. Involved in several processes, including decidualization; negative regulation of adipose tissue development; and negative regulation of nucleobase-containing compound metabolic process. Acts upstream of or within several processes,1180396456180428564Mouse2367old_gene_namegene, protein-coding, VALIDATED [RefSeq]
1613887Parp14poly (ADP-ribose) polymerase family, member 14Enables NAD+ poly-ADP-ribosyltransferase activity. Involved in NAD catabolic process; negative regulation of type II interferon-mediated signaling pathway; and positive regulation of interleukin-4-mediated signaling pathway. Located in cytoplasm. Is expressed in hemolymphoid system; intestine; and u163565226235691904Mouse195old_gene_namegene, protein-coding, VALIDATED [RefSeq]
1553525Parp2poly (ADP-ribose) polymerase family, member 2Enables NAD+ poly-ADP-ribosyltransferase activity. Involved in decidualization. Acts upstream of or within base-excision repair and extrinsic apoptotic signaling pathway. Located in nucleolus and nucleoplasm. Is expressed in several structures, including central nervous system; gonad; liver; retina;145104534751058758Mouse208old_gene_namegene, protein-coding, VALIDATED [RefSeq]
1550140Parp3poly (ADP-ribose) polymerase family, member 3Predicted to enable pentosyltransferase activity. Involved in negative regulation of isotype switching. Acts upstream of or within double-strand break repair. Located in site of double-strand break. Is expressed in primordial germ cell of gonad. Orthologous to human PARP3 (poly(ADP-ribose) polymeras9106347521106354148Mouse138old_gene_namegene, protein-coding, VALIDATED [RefSeq]
1553510Parp4poly (ADP-ribose) polymerase family, member 4Predicted to enable NAD+ poly-ADP-ribosyltransferase activity; NAD+-protein mono-ADP-ribosyltransferase activity; and enzyme binding activity. Predicted to be involved in inflammatory response and protein modification process. Predicted to be located in cytosol; nucleoplasm; and spindle microtubule.145681298256897256Mouse105old_gene_namegene, protein-coding, VALIDATED [RefSeq]
1552550Parp9poly (ADP-ribose) polymerase family, member 9Predicted to enable several functions, including ADP-D-ribose binding activity; STAT family protein binding activity; and pentosyltransferase activity. Involved in positive regulation of type II interferon-mediated signaling pathway. Predicted to be located in several cellular components, including 163575936035792975Mouse206old_gene_namegene, protein-coding, VALIDATED [RefSeq]
1318757Tnkstankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerasePredicted to enable histone binding activity; pentosyltransferase activity; and zinc ion binding activity. Predicted to be involved in several processes, including positive regulation of canonical Wnt signaling pathway; post-translational protein modification; and regulation of chromosome organizati83529633335432844Mouse217old_gene_namegene, protein-coding, VALIDATED [RefSeq]
1552096Tnks2tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2Predicted to enable NAD+ poly-ADP-ribosyltransferase activity; NAD+-protein mono-ADP-ribosyltransferase activity; and enzyme binding activity. Acts upstream of or within regulation of growth. Predicted to be located in nuclear envelope; pericentriolar material; and perinuclear region of cytoplasm. P193681158336870877Mouse147old_gene_namegene, protein-coding, VALIDATED [RefSeq]
1550720Adgrl1adhesion G protein-coupled receptor L1Predicted to enable cell adhesion molecule binding activity; toxic substance binding activity; and transmembrane signaling receptor activity. Acts upstream of or within positive regulation of synapse assembly. Predicted to be located in growth cone and synapse. 88462659884668583Mouse164old_gene_name , descriptiongene, protein-coding, VALIDATED [RefSeq]
2311830Parp10poly (ADP-ribose) polymerase family, member 10Predicted to enable several functions, including K63-linked polyubiquitin modification-dependent protein binding activity; pentosyltransferase activity; and transcription corepressor activity. Predicted to be involved in several processes, including post-translational protein modification; regulatio157611719576127640Mouse122old_gene_namegene, protein-coding, VALIDATED [RefSeq]
1557039Parp11poly (ADP-ribose) polymerase family, member 11Predicted to enable NAD+ poly-ADP-ribosyltransferase activity and NAD+-protein mono-ADP-ribosyltransferase activity. Acts upstream of or within nuclear envelope organization. Predicted to be located in cytosol; nuclear body; and nuclear envelope. Predicted to be part of nuclear pore. Predicted to be6127423803127491200Mouse100old_gene_namegene, protein-coding, VALIDATED [RefSeq]
1551043Parp12poly (ADP-ribose) polymerase family, member 12Predicted to enable NAD+ poly-ADP-ribosyltransferase activity and NAD+-protein mono-ADP-ribosyltransferase activity. Predicted to be involved in protein auto-ADP-ribosylation. Predicted to be active in nucleus. Is expressed in early conceptus; gallbladder; genitourinary system; and gut. Orthologous 63906334639095283Mouse132old_gene_namegene, protein-coding, VALIDATED [RefSeq]
1551462Parp16poly (ADP-ribose) polymerase family, member 16Predicted to enable kinase binding activity; pentosyltransferase activity; and protein serine/threonine kinase activator activity. Acts upstream of or within cellular response to leukemia inhibitory factor. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic retic96512191865146502Mouse123old_gene_namegene, protein-coding, VALIDATED [RefSeq]
1553819Parp6poly (ADP-ribose) polymerase family, member 6Predicted to enable kinase binding activity; pentosyltransferase activity; and protein serine/threonine kinase activator activity. Predicted to be involved in endoplasmic reticulum unfolded protein response; positive regulation of dendrite morphogenesis; and protein auto-ADP-ribosylation. Predicted 95952447359557573Mouse87old_gene_namegene, protein-coding, VALIDATED [RefSeq]
1550781Parp8poly (ADP-ribose) polymerase family, member 8Predicted to enable kinase binding activity; pentosyltransferase activity; and protein serine/threonine kinase activator activity. Predicted to be involved in endoplasmic reticulum unfolded protein response and protein auto-ADP-ribosylation. Predicted to be active in endoplasmic reticulum tubular ne13116987378117162549Mouse105old_gene_namegene, protein-coding, VALIDATED [RefSeq]
1314637TiparpTCDD-inducible poly(ADP-ribose) polymeraseEnables NAD+ poly-ADP-ribosyltransferase activity. Acts upstream of or within several processes, including face morphogenesis; steroid metabolic process; and vasculogenesis. Predicted to be active in nucleus. Is expressed in bladder; reproductive system; telencephalon; and tongue. Orthologous to hum36543586865462939Mouse329old_gene_namegene, protein-coding, PROVISIONAL [RefSeq]
736107Zc3hav1zinc finger CCCH type, antiviral 1Predicted to enable DEAD/H-box RNA helicase binding activity; RNA binding activity; and identical protein binding activity. Acts upstream of or within cellular response to exogenous dsRNA and positive regulation of type I interferon production. Predicted to be located in cytosol. Predicted to be act63828222138332859Mouse174old_gene_namegene, protein-coding, VALIDATED [RefSeq]
10919Abcc1ATP-binding cassette, sub-family C member 1The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, G161417931714292743Mouse921descriptiongene, protein-coding, VALIDATED [RefSeq]
1551708Abtb2ankyrin repeat and BTB domain containing 2Predicted to enable protein heterodimerization activity. Acts upstream of or within cellular response to toxic substance. Is expressed in several structures, including central nervous system; hindlimb long bone; limb segment; respiratory system cartilage; and se2103396655103548768Mouse123descriptiongene, protein-coding, PROVISIONAL [RefSeq]
1553036Acy3aminoacylase 3This gene encodes a member of the aminoacylase family of enzymes. This enzyme specifically deacetylates N-acetyl aromatic amino acids and mercapturic acids. Action of this enzyme on metabolites of the environmental contaminant trichloroethylene leads to the generation of tox1940365704040007Mouse105descriptiongene, protein-coding, REVIEWED [RefSeq]
1557053Ahrraryl-hydrocarbon receptor repressorThis gene encodes a protein that represses aryl hydrocarbon receptor-dependent signaling. The encoded protein competes with the aryl hydrocarbon receptor transcription factor for heterodimerization with the aryl hydrocarbon receptor nuclear translocator protein and binding to xenobiotic response ele137435923774440450Mouse207descriptiongene, protein-coding, REVIEWED [RefSeq]
2313448Aqp10-psaquaporin 10, pseudogeneENCODES a pseudogene that exhibits glycerol channel activity (ortholog); water channel activity (ortholog); INVOLVED IN glycerol transmembrane transport (ortholog); protein homotetramerization (ortholog); response to toxic substance (ortholog); PARTICIPATES IN w38987075189877041Mouse39descriptiongene, pseudo, INFERRED [RefSeq]
733292As3mtarsenite methyltransferasePredicted to enable arsenite methyltransferase activity. Predicted to be involved in arsonoacetate metabolic process; methylation; and toxin metabolic process. Predicted to act upstream of or within response to arsenic-containing substance. Located in mitochondr194669512446729538Mouse251descriptiongene, protein-coding, VALIDATED [RefSeq]
736137Ass1argininosuccinate synthetase 1Predicted to enable several functions, including argininosuccinate synthase activity; identical protein binding activity; and toxic substance binding activity. Involved in circadian rhythm. Located in mitochondrion. Is expressed in several structures, including 23136028231410682Mouse516descriptiongene, protein-coding, VALIDATED [RefSeq]
736299Cnp2',3'-cyclic nucleotide 3' phosphodiesteraseEnables 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity. Acts upstream of or within adult locomotory behavior; neurogenesis; and response to toxic substance. Located in cytoplasm; membrane; and myelin sheath. Is expressed in adrenal gland; gut; nervous sys11100465765100472565Mouse385descriptiongene, protein-coding, VALIDATED [RefSeq]
10389Cps1carbamoyl-phosphate synthetase 1This gene encodes a protein localized to the inner mitochondrial matrix. The encoded protein plays a role in the detoxification of ammonia by catalyzing the first step in the urea cycle in which carbomyl-phosphate is synthesized from ammonia and bicarbonate. Car16715129467270426Mouse391descriptiongene, protein-coding, REVIEWED [RefSeq]
10436Cyp1a1cytochrome P450, family 1, subfamily a, polypeptide 1Enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen. Acts upstream of or within several processes, including hydrogen peroxide biosynthetic process; respons95759521157611107Mouse2930descriptiongene, protein-coding, VALIDATED [RefSeq]
733763Cyp2f2cytochrome P450, family 2, subfamily f, polypeptide 2Predicted to enable arachidonate epoxygenase activity; heme binding activity; and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen. Acts upstream of or within na72681938026833085Mouse212descriptiongene, protein-coding, VALIDATED [RefSeq]
10469Ddcdopa decarboxylaseEnables aromatic-L-amino-acid decarboxylase activity. Acts upstream of or within gene expression; kidney development; and response to toxic substance. Located in cytoplasm. Is expressed in several structures, including alimentary system; heart; nervous system; r111176410111848144Mouse392descriptiongene, protein-coding, VALIDATED [RefSeq]
10529Ephx1epoxide hydrolase 1, microsomalEnables oxysterol binding activity. Acts upstream of or within hydrocarbon catabolic process. Predicted to be located in intracellular membrane-bounded organelle and membrane. Is expressed in several structures, including brain ventricle and choroid plexus; exocrine system; integumental system; nerv1180817121180845134Mouse657descriptiongene, protein-coding, VALIDATED [RefSeq]
1623025Gjc2gap junction protein, gamma 2Enables gap junction channel activity. Acts upstream of or within cell-cell signaling and response to toxic substance. Located in gap junction and myelin sheath. Is expressed in brain; ovary; and spinal cord. Used to study hypomyelinating leukodystrophy 2. Human115906639059074039Mouse165descriptiongene, protein-coding, VALIDATED [RefSeq]
1320602Gsta4glutathione S-transferase, alpha 4Predicted to enable glutathione transferase activity and toxic substance binding activity. Acts upstream of or within response to caloric restriction. Located in mitochondrion. Is expressed in several structures, including alimentary system; brain; genitourinary97809924878116631Mouse337descriptiongene, protein-coding, VALIDATED [RefSeq]
736399Hspa1bheat shock protein 1BEnables protein folding chaperone. Involved in protein folding. Acts upstream of or within binding activity of sperm to zona pellucida; negative regulation of apoptotic process; and response to heat. Located in cell body and mitochondrion. Part of zona pellucida receptor complex. Is expressed in sev173517540535178214Mouse530descriptiongene, protein-coding, VALIDATED [RefSeq]
10746Htr1b5-hydroxytryptamine (serotonin) receptor 1BEnables G protein-coupled serotonin receptor activity and serotonin binding activity. Involved in negative regulation of serotonin secretion and phospholipase C-activating serotonin receptor signaling pathway. Acts upstream of or within adenylate cyclase-inhibiting G protein-coupled receptor signali98151034481515885Mouse244descriptiongene, protein-coding, VALIDATED [RefSeq]
10747Htr1d5-hydroxytryptamine (serotonin) receptor 1DEnables G protein-coupled serotonin receptor activity and serotonin binding activity. Acts upstream of or within response to toxic substance. Predicted to be active in several cellular components, including dendrite; glutamatergic synapse; and neuronal dense cor4136150835136171716Mouse116descriptiongene, protein-coding, VALIDATED [RefSeq]
1312374Lrp6low density lipoprotein receptor-related protein 6Enables Wnt-protein binding activity; apolipoprotein binding activity; and toxin transmembrane transporter activity. Involved in cell surface receptor signaling pathway; positive regulation of neuron projection development; and positive regulation of transcripti6134423439134543876Mouse546descriptiongene, protein-coding, VALIDATED [RefSeq]
1609862mt-Nd1NADH dehydrogenase 1, mitochondrialPredicted to enable NADH dehydrogenase (ubiquinone) activity. Predicted to contribute to NADH dehydrogenase activity. Predicted to be involved in mitochondrial electron transport, NADH to ubiquinone; mitochondrial respiratory chain complex I assembly; and response to hydroperoxide. Located in mitochMT27513707Mouse228descriptiongene, protein-coding, REVIEWED [RefSeq]
10970Nefmneurofilament, medium polypeptidePredicted to enable signaling receptor binding activity and toxic substance binding activity. Predicted to be a structural constituent of cytoskeleton. Acts upstream of or within axo-dendritic transport; cytoskeleton organization; and regulation of axon diameter146835699468362453Mouse275descriptiongene, protein-coding, VALIDATED [RefSeq]
735862Nptxrneuronal pentraxin receptorThis gene encodes a protein similar to the rat neuronal pentraxin receptor. The rat pentraxin receptor is an integral membrane protein that is thought to mediate neuronal uptake of the snake venom toxin, taipoxin, and its transport into the synapses. Studies in 157967055279688910Mouse102descriptiongene, protein-coding, REVIEWED [RefSeq]
1618391Phaxphosphorylated adaptor for RNA exportPredicted to enable mRNA cap binding complex binding activity and toxic substance binding activity. Acts upstream of or within snRNA export from nucleus. Located in cytoplasm and nucleus. Orthologous to human PHAX (phosphorylated adaptor for RNA export). [provid185669564156720784Mouse85descriptiongene, protein-coding, VALIDATED [RefSeq]
733240Pon1paraoxonase 1Enables arylesterase activity. Acts upstream of or within cholesterol metabolic process and response to toxic substance. Predicted to be part of spherical high-density lipoprotein particle. Predicted to be active in extracellular space. Is expressed in several s651681015193824Mouse683descriptiongene, protein-coding, VALIDATED [RefSeq]
1551394Pon2paraoxonase 2Predicted to enable acyl-L-homoserine-lactone lactonohydrolase activity; arylesterase activity; and protein homodimerization activity. Predicted to be involved in lactone catabolic process and response to toxic substance. Predicted to be located in plasma membra652646205298408Mouse219descriptiongene, protein-coding, VALIDATED [RefSeq]
11170Prh1proline rich protein HaeIII subfamily 1This gene encodes a member of the heterogeneous family of proline-rich salivary glycoproteins. The expression of this gene is dramatically induced in the parotid and submandibular glands of mice by beta-adrenergic stimulation. The encoded protein serves an important dental function by protecting mic6132546805132549364Mouse26descriptiongene, protein-coding, REVIEWED [RefSeq]
1312903Prp2proline rich protein 2This gene encodes a member of the heterogeneous family of proline-rich salivary glycoproteins. The expression of this gene is dramatically induced in the parotid and submandibular glands of mice by beta-adrenergic stimulation. The encoded protein serves an important dental function by protecting mic6132572874132577665Mouse15descriptiongene, protein-coding, REVIEWED [RefSeq]
737152Scn9asodium channel, voltage-gated, type IX, alphaPredicted to enable sodium ion binding activity and voltage-gated sodium channel activity. Involved in behavioral response to pain; circadian rhythm; and detection of stimulus involved in sensory perception. Acts upstream of or within inflammatory response; post-embryonic development; and response t26631042466465456Mouse209descriptiongene, protein-coding, VALIDATED [RefSeq]
1316584Serpinc1serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1Predicted to enable several functions, including heparin binding activity; identical protein binding activity; and serine-type endopeptidase inhibitor activity. Predicted to be involved in response to nutrient. Located in collagen-containing extracellular matrix. Is expressed in embryo; liver; neura1160806153160830113Mouse258descriptiongene, protein-coding, VALIDATED [RefSeq]
1552805Serping1serine (or cysteine) peptidase inhibitor, clade G, member 1Enables complement binding activity and serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of complement activation, lectin pathway. Located in extracellular space. Is expressed in several structures, including cerebral cortex; genitourinary system; notocho28459570484605748Mouse262descriptiongene, protein-coding, VALIDATED [RefSeq]
737198Sftpbsurfactant associated protein BPredicted to be involved in respiratory gaseous exchange by respiratory system and sphingolipid metabolic process. Located in cytoplasm. Is expressed in lung surfactant and respiratory system. Human ortholog(s) of this gene implicated in lung disease (multiple); respiratory syncytial virus infectiou67228159472291354Mouse272descriptiongene, protein-coding, VALIDATED [RefSeq]
732000Slc17a3solute carrier family 17 (sodium phosphate), member 3Predicted to enable several functions, including toxin transmembrane transporter activity; urate transmembrane transporter activity; and voltage-gated monoatomic anion channel activity. Predicted to be involved in urate metabolic process; urate transport; and xe132402090524044701Mouse131descriptiongene, protein-coding, VALIDATED [RefSeq]
11300Slc18a2solute carrier family 18 (vesicular monoamine), member 2Predicted to enable several functions, including amine transmembrane transporter activity; heat shock protein binding activity; and monoamine transmembrane transporter activity. Involved in histamine secretion by mast cell; neurotransmitter loading into synaptic vesicle; and serotonin secretion by m195924931059284444Mouse441descriptiongene, protein-coding, VALIDATED [RefSeq]
737278Slc22a1solute carrier family 22 (organic cation transporter), member 1Enables several functions, including organic cation transmembrane transporter activity; pyrimidine nucleoside transmembrane transporter activity; and toxin transmembrane transporter activity. Involved in several processes, including monoamine transport; quaterna171286776112894725Mouse517descriptiongene, protein-coding, PROVISIONAL [RefSeq]
735527Slc22a19solute carrier family 22 (organic anion transporter), member 19Enables organic anion transmembrane transporter activity and toxin transmembrane transporter activity. Acts upstream of or within organic anion transport. Predicted to be located in basolateral plasma membrane. Is expressed in metanephros. Human ortholog(s) of t1976504407688675Mouse134descriptiongene, protein-coding, VALIDATED [RefSeq]
62229Slc22a2solute carrier family 22 (organic cation transporter), member 2Enables several functions, including pyrimidine nucleoside transmembrane transporter activity; toxin transmembrane transporter activity; and xenobiotic transmembrane transporter activity. Involved in cellular detoxification 171280307612847376Mouse670descriptiongene, protein-coding, VALIDATED [RefSeq]
1558196Slc29a4solute carrier family 29 (nucleoside transporters), member 4Enables several functions, including monoamine transmembrane transporter activity; neurotransmitter transmembrane transporter activity; and toxin transmembrane transporter activity. Involved in several processes, including adenosine transport; monoamine transpor5142678226142708245Mouse177descriptiongene, protein-coding, VALIDATED [RefSeq]
62207Tfpitissue factor pathway inhibitorPredicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of blood coagulation. Located in extracellular space. Is expressed in several structures, including central nervous system; genitourinary system; hemolymphoid system; liver; and retina. 28426319984307119Mouse304descriptiongene, protein-coding, VALIDATED [RefSeq]
1620723Tmem181atransmembrane protein 181APredicted to enable toxic substance binding activity. Is expressed in several structures, including cardiovascular system; central nervous system; gut; reproductive system; and trachea. Orthologous to human TMEM181 (transmembrane protein 181). [provided by Allia1763070016358589Mouse57descriptiongene, protein-coding, VALIDATED [RefSeq]