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ONTOLOGY REPORT - ANNOTATIONS


Term:immunological synapse
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Accession:GO:0001772 term browser browse the term
Definition:An area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell formed through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and the target cell and facilitating activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction.
Synonyms:exact_synonym: supramolecular activation cluster
 narrow_synonym: c-SMAC
 xref: Wikipedia:Immunological_synapse


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immunological synapse term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alcam activated leukocyte cell adhesion molecule ISO
ISS
(PMID:15294938)
GO_REF:0000024
RGD
UniProt
PMID:15294938 GO_REF:0000024 NCBI chr11:50,780,735...50,985,083
Ensembl chr11:50,781,127...50,985,083
JBrowse link
G Arhgdia Rho GDP dissociation inhibitor alpha ISO (MGI:3510555|PMID:11728336) RGD PMID:11728336 MGI:3510555 NCBI chr10:109,754,012...109,757,506
Ensembl chr10:109,754,004...109,757,550
JBrowse link
G Atp2b1 ATPase plasma membrane Ca2+ transporting 1 ISS
ISO
GO_REF:0000024
(MGI:6114568|PMID:28827723)
UniProt
RGD
PMID:28827723 GO_REF:0000024, MGI:6114568 NCBI chr 7:41,114,606...41,223,138
Ensembl chr 7:41,114,697...41,220,579
JBrowse link
G Bcl10 BCL10, immune signaling adaptor ISO (MGI:3032475|PMID:14724296) RGD PMID:14724296 MGI:3032475 NCBI chr 2:251,805,392...251,814,957
Ensembl chr 2:251,805,392...251,814,957
JBrowse link
G Card11 caspase recruitment domain family, member 11 ISO (MGI:5544872|PMID:23793062) RGD PMID:23793062 MGI:5544872 NCBI chr12:15,700,600...15,844,512
Ensembl chr12:15,700,825...15,844,512
JBrowse link
G Carmil2 capping protein regulator and myosin 1 linker 2 ISO (MGI:5544872|PMID:23793062) RGD PMID:23793062 MGI:5544872 NCBI chr19:37,652,383...37,665,333
Ensembl chr19:37,652,969...37,668,019
JBrowse link
G Cd28 Cd28 molecule IEA
ISO
GO_REF:0000107
(MGI:5544872|PMID:23793062)
Ensembl
RGD
PMID:23793062 GO_REF:0000107, MGI:5544872 NCBI chr 9:67,546,408...67,573,858
Ensembl chr 9:67,546,408...67,571,871
JBrowse link
G Cd37 CD37 molecule IEA
ISO
GO_REF:0000107
(PMID:21930792)
Ensembl
RGD
PMID:21930792 GO_REF:0000107 NCBI chr 1:101,230,470...101,236,061
Ensembl chr 1:101,230,533...101,236,065
JBrowse link
G Cd3e CD3e molecule ISO (MGI:3041667|PMID:15064761), (MGI:3044274|PMID:14635057) RGD PMID:14635057, PMID:15064761 MGI:3041667, MGI:3044274 NCBI chr 8:49,297,604...49,309,370
Ensembl chr 8:49,297,608...49,308,806
JBrowse link
G Cd53 Cd53 molecule ISO (PMID:21930792) RGD PMID:21930792 NCBI chr 2:209,489,279...209,537,098
Ensembl chr 2:209,489,279...209,537,087
JBrowse link
G Cd6 Cd6 molecule ISO (PMID:15294938) RGD PMID:15294938 NCBI chr 1:226,848,399...226,887,259
Ensembl chr 1:226,848,403...226,887,156
JBrowse link
G Cd81 Cd81 molecule IEA
ISO
ISS
GO_REF:0000107
(PMID:21930792), (PMID:23858057)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:21930792, PMID:23858057 GO_REF:0000024, GO_REF:0000107 NCBI chr 1:216,237,663...216,253,460
Ensembl chr 1:216,237,697...216,253,311
JBrowse link
G Coro1a coronin 1A ISO (PMID:24760828)
(MGI:3773559|PMID:18199416)
RGD PMID:18199416, PMID:24760828 MGI:3773559 NCBI chr 1:198,123,883...198,128,890
Ensembl chr 1:198,123,884...198,128,857
JBrowse link
G Crtam cytotoxic and regulatory T cell molecule ISO (MGI:3834299|PMID:18329370) RGD PMID:18329370 MGI:3834299 NCBI chr 8:45,152,584...45,216,082
Ensembl chr 8:45,153,308...45,215,974
JBrowse link
G Dlg1 discs large MAGUK scaffold protein 1 IEA
ISO
GO_REF:0000107
(MGI:3528803|PMID:15699074)
(PMID:20551903)
Ensembl
RGD
PMID:15699074, PMID:20551903 GO_REF:0000107, MGI:3528803 NCBI chr11:72,164,566...72,378,895
Ensembl chr11:72,163,749...72,378,895
JBrowse link
G Dusp3 dual specificity phosphatase 3 ISO (PMID:12447358) RGD PMID:12447358 NCBI chr10:89,904,578...89,918,296
Ensembl chr10:89,904,560...89,918,427
JBrowse link
G Ezr ezrin colocalizes_with ISO (PMID:20551903)
(PMID:17911601)
RGD PMID:17911601, PMID:20551903 NCBI chr 1:47,287,872...47,331,412
Ensembl chr 1:47,287,874...47,331,412
JBrowse link
G Fyb2 FYN binding protein 2 ISO (PMID:27335501) RGD PMID:27335501 NCBI chr 5:124,442,386...124,561,766 JBrowse link
G Havcr2 hepatitis A virus cellular receptor 2 ISO (MGI:5705214|PMID:24337741) RGD PMID:24337741 MGI:5705214 NCBI chr10:31,561,838...31,590,624
Ensembl chr10:31,561,895...31,588,943
JBrowse link
G Icam1 intercellular adhesion molecule 1 ISO (MGI:3038342|PMID:14973438) RGD PMID:14973438 MGI:3038342 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Itgal integrin subunit alpha L ISO (MGI:3041667|PMID:15064761) RGD PMID:15064761 MGI:3041667 NCBI chr 1:198,744,053...198,781,745
Ensembl chr 1:198,744,050...198,781,750
JBrowse link
G Lat linker for activation of T cells ISO
IBA
(PMID:12646565)
(MGI:3044274|PMID:14635057)
PMID:21873635
RGD PMID:12646565, PMID:14635057, PMID:21873635 MGI:3044274, RGD:13792537 NCBI chr 1:197,765,644...197,770,669
Ensembl chr 1:197,765,644...197,770,669
JBrowse link
G Lck LCK proto-oncogene, Src family tyrosine kinase ISO
IEA
(PMID:20007709)
GO_REF:0000107
RGD
Ensembl
PMID:20007709 GO_REF:0000107 NCBI chr 5:147,750,976...147,779,627
Ensembl chr 5:147,750,973...147,761,983
JBrowse link
G Lgals3 galectin 3 ISO
IBA
IEA
(PMID:19706535)
(MGI:4355752|PMID:19706535)
PMID:21873635
GO_REF:0000107
RGD
Ensembl
PMID:19706535, PMID:21873635 GO_REF:0000107, MGI:4355752, RGD:13792537 NCBI chr15:24,153,602...24,165,537
Ensembl chr15:24,141,651...24,165,537
JBrowse link
G Myh9 myosin, heavy chain 9 colocalizes_with ISO (PMID:15064761)
(MGI:3041667|PMID:15064761)
RGD PMID:15064761 MGI:3041667 NCBI chr 7:118,740,005...118,792,507
Ensembl chr 7:118,741,110...118,792,625
JBrowse link
G Nptn neuroplastin ISS
ISO
GO_REF:0000024
(MGI:6114568|PMID:28827723)
UniProt
RGD
PMID:28827723 GO_REF:0000024, MGI:6114568 NCBI chr 8:63,379,062...63,445,694
Ensembl chr 8:63,379,087...63,445,686
JBrowse link
G Pdcd6ip programmed cell death 6 interacting protein ISO (PMID:19706535) RGD PMID:19706535 NCBI chr 8:121,916,233...121,973,145
Ensembl chr 8:121,916,185...121,973,125
JBrowse link
G Prkar1a protein kinase cAMP-dependent type I regulatory subunit alpha colocalizes_with ISO (PMID:17911601) RGD PMID:17911601 NCBI chr10:97,940,705...97,959,199
Ensembl chr10:97,940,705...97,957,336
JBrowse link
G Prkcq protein kinase C, theta IEA
ISO
GO_REF:0000107
(MGI:3039643|PMID:12867038), (MGI:3041758|PMID:15128768), (MGI:3510555|PMID:11728336), (MGI:3510556|PMID:15117976), (MGI:5544872|PMID:23793062)
Ensembl
RGD
PMID:11728336, PMID:12867038, PMID:15117976, PMID:15128768, PMID:23793062 GO_REF:0000107, MGI:3039643, MGI:3041758, MGI:3510555, MGI:3510556, MGI:5544872 NCBI chr17:70,971,915...71,105,286
Ensembl chr17:70,971,915...71,105,286
JBrowse link
G Ptprj protein tyrosine phosphatase, receptor type, J ISO (PMID:12913111)
(MGI:4942249|PMID:12913111)
RGD PMID:12913111 MGI:4942249 NCBI chr 3:79,233,519...79,390,956
Ensembl chr 3:79,233,525...79,390,956
JBrowse link
G Rhoh ras homolog family member H ISO (MGI:3686961|PMID:17028588) RGD PMID:17028588 MGI:3686961 NCBI chr14:43,961,756...43,992,587
Ensembl chr14:43,961,756...43,992,587
JBrowse link
G Scimp SLP adaptor and CSK interacting membrane protein ISO
IBA
(PMID:21930792)
PMID:21873635
RGD PMID:21930792, PMID:21873635 RGD:13792537 NCBI chr10:57,415,429...57,436,412
Ensembl chr10:57,415,832...57,436,368
JBrowse link
G Scrib scribble planar cell polarity protein ISO (MGI:3834299|PMID:18329370) RGD PMID:18329370 MGI:3834299 NCBI chr 7:117,105,810...117,128,802
Ensembl chr 7:117,105,810...117,128,798
JBrowse link
G Skap1 src kinase associated phosphoprotein 1 ISO (PMID:12652296) RGD PMID:12652296 NCBI chr10:84,309,379...84,619,051
Ensembl chr10:84,309,430...84,619,050
JBrowse link
G Snx27 sorting nexin 27 IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:17644068)
Ensembl
UniProt
RGD
PMID:17644068 GO_REF:0000024, GO_REF:0000107 NCBI chr 2:195,738,613...195,821,608
Ensembl chr 2:195,738,619...195,821,608
JBrowse link
G Socs6 suppressor of cytokine signaling 6 ISO (PMID:20007709) RGD PMID:20007709 NCBI chr18:85,962,729...85,981,125
Ensembl chr18:85,962,729...85,980,833
JBrowse link
G Stoml2 stomatin like 2 colocalizes_with ISO
ISS
(PMID:22623988)
GO_REF:0000024
RGD
UniProt
PMID:22623988 GO_REF:0000024 NCBI chr 5:58,472,561...58,476,158
Ensembl chr 5:58,472,550...58,476,251
JBrowse link
G Stx7 syntaxin 7 ISO (PMID:21438968) RGD PMID:21438968 NCBI chr 1:22,241,655...22,281,850
Ensembl chr 1:22,241,661...22,281,788
JBrowse link
G Vav3 vav guanine nucleotide exchange factor 3 ISO (PMID:15708849) RGD PMID:15708849 NCBI chr 2:212,247,061...212,585,818
Ensembl chr 2:212,247,451...212,585,818
JBrowse link
G Zap70 zeta chain of T cell receptor associated protein kinase 70 ISO (MGI:3686961|PMID:17028588) RGD PMID:17028588 MGI:3686961 NCBI chr 9:43,331,149...43,353,097
Ensembl chr 9:43,331,155...43,353,113
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20602
    cellular anatomical entity 20292
      immunological synapse 40
Path 2
Term Annotations click to browse term
  cellular_component 20602
    cellular anatomical entity 20292
      membrane 10190
        plasma membrane 6308
          immunological synapse 40
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.