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ONTOLOGY REPORT - ANNOTATIONS


Term:immunological synapse
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Accession:GO:0001772 term browser browse the term
Definition:An area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell formed through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and the target cell and facilitating activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction.
Synonyms:exact_synonym: supramolecular activation cluster
 narrow_synonym: c-SMAC
 xref: Wikipedia:Immunological_synapse



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immunological synapse term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alcam activated leukocyte cell adhesion molecule located_in ISO
ISS
(PMID:15294938)
GO_REF:0000024
RGD
UniProt
PMID:15294938 GO_REF:0000024 NCBI chr11:48,336,123...48,536,296
Ensembl chr11:48,336,169...48,537,954
JBrowse link
G Arhgdia Rho GDP dissociation inhibitor alpha located_in ISO (MGI:3510555|PMID:11728336) RGD PMID:11728336 MGI:3510555 NCBI chr10:105,854,526...105,858,020
Ensembl chr10:105,854,533...105,858,023
JBrowse link
G Atp2b1 ATPase plasma membrane Ca2+ transporting 1 located_in ISS
ISO
GO_REF:0000024
(MGI:6114568|PMID:28827723)
UniProt
RGD
PMID:28827723 GO_REF:0000024 MGI:6114568 NCBI chr 7:33,735,595...33,845,226
Ensembl chr 7:33,735,871...33,843,295
JBrowse link
G Bcl10 BCL10, immune signaling adaptor located_in ISO (MGI:3032475|PMID:14724296) RGD PMID:14724296 MGI:3032475 NCBI chr 2:234,840,880...234,850,520
Ensembl chr 2:234,840,858...234,850,523
JBrowse link
G Card11 caspase recruitment domain family, member 11 located_in ISO (MGI:5544872|PMID:23793062) RGD PMID:23793062 MGI:5544872 NCBI chr12:13,620,979...13,758,115
Ensembl chr12:13,621,087...13,758,112
JBrowse link
G Carmil2 capping protein regulator and myosin 1 linker 2 located_in ISO (MGI:5544872|PMID:23793062) RGD PMID:23793062 MGI:5544872 NCBI chr19:33,571,255...33,586,783
Ensembl chr19:33,574,257...33,586,965
JBrowse link
G Cd28 Cd28 molecule located_in IEA
ISO
GO_REF:0000107
(MGI:5544872|PMID:23793062)
Ensembl
RGD
PMID:23793062 GO_REF:0000107 MGI:5544872 NCBI chr 9:62,166,324...62,194,674
Ensembl chr 9:62,166,192...62,194,685
JBrowse link
G Cd37 CD37 molecule located_in ISO
IEA
(PMID:21930792)
GO_REF:0000107
RGD
Ensembl
PMID:21930792 GO_REF:0000107 NCBI chr 1:95,719,171...95,724,662
Ensembl chr 1:95,719,190...95,724,648
JBrowse link
G Cd3e CD3e molecule located_in ISO (MGI:3041667|PMID:15064761), (MGI:3044274|PMID:14635057) RGD PMID:14635057 PMID:15064761 MGI:3041667 MGI:3044274 NCBI chr 8:45,303,848...45,315,297
Ensembl chr 8:45,303,852...45,315,022
JBrowse link
G Cd53 Cd53 molecule located_in ISO (PMID:21930792) RGD PMID:21930792 NCBI chr 2:194,352,139...194,399,668
Ensembl chr 2:194,352,139...194,399,657
JBrowse link
G Cd6 Cd6 molecule located_in ISO (PMID:15294938) RGD PMID:15294938 NCBI chr 1:207,442,873...207,481,703
Ensembl chr 1:207,442,877...207,481,634
JBrowse link
G Cd81 Cd81 molecule located_in ISO
IEA
ISS
(PMID:21930792), (PMID:23858057)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:21930792 PMID:23858057 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:198,235,861...198,251,660
Ensembl chr 1:198,241,484...198,251,660
JBrowse link
G Coro1a coronin 1A located_in ISO (PMID:24760828)
(MGI:3773559|PMID:18199416)
RGD PMID:18199416 PMID:24760828 MGI:3773559 NCBI chr 1:181,295,561...181,300,566
Ensembl chr 1:181,295,562...181,300,534
JBrowse link
G Cracr2a calcium release activated channel regulator 2A located_in ISO (PMID:27016526) RGD PMID:27016526 NCBI chr 4:160,428,987...160,517,427
Ensembl chr 4:160,408,077...160,518,107
JBrowse link
G Crtam cytotoxic and regulatory T cell molecule located_in ISO (MGI:3834299|PMID:18329370) RGD PMID:18329370 MGI:3834299 NCBI chr 8:41,340,117...41,377,343
Ensembl chr 8:41,340,837...41,377,343
JBrowse link
G Dlg1 discs large MAGUK scaffold protein 1 located_in ISO
IEA
(PMID:20551903)
GO_REF:0000107
(MGI:3528803|PMID:15699074)
RGD
Ensembl
PMID:15699074 PMID:20551903 GO_REF:0000107 MGI:3528803 NCBI chr11:68,911,883...69,103,230
Ensembl chr11:68,911,883...69,102,689
JBrowse link
G Dusp3 dual specificity phosphatase 3 located_in ISO (PMID:12447358) RGD PMID:12447358 NCBI chr10:86,920,014...86,933,739
Ensembl chr10:86,920,014...86,933,962
JBrowse link
G Ezr ezrin colocalizes_with
located_in
ISO (PMID:17911601)
(PMID:20551903)
RGD PMID:17911601 PMID:20551903 NCBI chr 1:46,967,961...47,011,505
Ensembl chr 1:46,967,658...47,011,505
JBrowse link
G Fyb2 FYN binding protein 2 located_in ISO (PMID:27335501) RGD PMID:27335501 NCBI chr 5:119,677,116...119,800,911 JBrowse link
G Havcr2 hepatitis A virus cellular receptor 2 located_in ISO (MGI:5705214|PMID:24337741) RGD PMID:24337741 MGI:5705214 NCBI chr10:30,882,484...30,914,018
Ensembl chr10:30,882,606...30,909,137
JBrowse link
G Icam1 intercellular adhesion molecule 1 located_in ISO (MGI:3038342|PMID:14973438) RGD PMID:14973438 MGI:3038342 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Il4i1 interleukin 4 induced 1 located_in ISO (PMID:28891065) RGD PMID:28891065 NCBI chr 1:95,299,457...95,324,564
Ensembl chr 1:95,295,601...95,324,562
JBrowse link
G Itgal integrin subunit alpha L located_in ISO (MGI:3041667|PMID:15064761) RGD PMID:15064761 MGI:3041667 NCBI chr 1:181,918,183...181,955,735
Ensembl chr 1:181,918,183...181,955,732
JBrowse link
G Lat linker for activation of T cells located_in
is_active_in
ISO
IBA
(PMID:12646565)
PMID:21873635
(MGI:3044274|PMID:14635057)
RGD PMID:12646565 PMID:14635057 PMID:21873635 MGI:3044274, RGD:13792537 NCBI chr 1:180,936,536...180,941,561
Ensembl chr 1:180,936,534...180,941,578
JBrowse link
G Lck LCK proto-oncogene, Src family tyrosine kinase located_in ISO
IEA
(PMID:20007709)
GO_REF:0000107
RGD
Ensembl
PMID:20007709 GO_REF:0000107 NCBI chr 5:141,888,319...141,916,992
Ensembl chr 5:141,888,326...141,903,794
JBrowse link
G Lgals3 galectin 3 located_in
is_active_in
ISO
IBA
IEA
(PMID:19706535)
PMID:21873635
(MGI:4355752|PMID:19706535)
GO_REF:0000107
RGD
Ensembl
PMID:19706535 PMID:21873635 GO_REF:0000107 MGI:4355752, RGD:13792537 NCBI chr15:20,620,083...20,632,019
Ensembl chr15:20,607,692...20,632,025
JBrowse link
G Myh9 myosin, heavy chain 9 located_in ISO (MGI:3041667|PMID:15064761)
(PMID:15064761)
RGD PMID:15064761 MGI:3041667 NCBI chr 7:109,343,718...109,424,457
Ensembl chr 7:109,343,706...109,424,457
JBrowse link
G Nptn neuroplastin located_in ISS
ISO
GO_REF:0000024
(MGI:6114568|PMID:28827723)
UniProt
RGD
PMID:28827723 GO_REF:0000024 MGI:6114568 NCBI chr 8:58,996,876...59,063,402
Ensembl chr 8:58,996,887...59,063,401
JBrowse link
G Pdcd6ip programmed cell death 6 interacting protein located_in ISO (PMID:19706535) RGD PMID:19706535 NCBI chr 8:113,590,998...113,646,795
Ensembl chr 8:113,590,998...113,646,773
JBrowse link
G Prkar1a protein kinase cAMP-dependent type I regulatory subunit alpha colocalizes_with ISO (PMID:17911601) RGD PMID:17911601 NCBI chr10:94,621,042...94,639,534
Ensembl chr10:94,620,039...94,639,041
JBrowse link
G Prkcq protein kinase C, theta located_in IEA
ISO
GO_REF:0000107
(MGI:3039643|PMID:12867038), (MGI:3041758|PMID:15128768), (MGI:3510555|PMID:11728336), (MGI:3510556|PMID:15117976), (MGI:5544872|PMID:23793062)
Ensembl
RGD
PMID:11728336 PMID:12867038 PMID:15117976 PMID:15128768 PMID:23793062 GO_REF:0000107 MGI:3039643 MGI:3041758 MGI:3510555 MGI:3510556 MGI:5544872 NCBI chr17:67,246,394...67,379,049
Ensembl chr17:67,246,394...67,378,704
JBrowse link
G Ptprj protein tyrosine phosphatase, receptor type, J located_in ISO (PMID:12913111)
(MGI:4942249|PMID:12913111)
RGD PMID:12913111 MGI:4942249 NCBI chr 3:76,405,917...76,561,842
Ensembl chr 3:76,405,927...76,562,260
JBrowse link
G Rhoh ras homolog family member H located_in ISO (MGI:3686961|PMID:17028588) RGD PMID:17028588 MGI:3686961 NCBI chr14:42,341,135...42,371,971
Ensembl chr14:42,337,751...42,386,369
JBrowse link
G RT1-Da RT1 class II, locus Da located_in ISO (PMID:15322540), (PMID:29884618) RGD PMID:15322540 PMID:29884618 NCBI chr20:4,513,464...4,518,457
Ensembl chr20:4,512,911...4,518,455
JBrowse link
G RT1-Db1 RT1 class II, locus Db1 located_in ISO (PMID:15322540), (PMID:29884618) RGD PMID:15322540 PMID:29884618 NCBI chr20:4,548,664...4,558,237
Ensembl chr20:4,548,666...4,558,258
JBrowse link
G Scimp SLP adaptor and CSK interacting membrane protein located_in
is_active_in
ISO
IBA
(PMID:21930792)
PMID:21873635
RGD PMID:21930792 PMID:21873635 RGD:13792537 NCBI chr10:55,507,593...55,528,288
Ensembl chr10:55,507,519...55,528,171
JBrowse link
G Scrib scribble planar cell polarity protein located_in ISO (MGI:3834299|PMID:18329370) RGD PMID:18329370 MGI:3834299 NCBI chr 7:107,759,343...107,782,364
Ensembl chr 7:107,759,343...107,782,331
JBrowse link
G Skap1 src kinase associated phosphoprotein 1 located_in ISO (PMID:12652296) RGD PMID:12652296 NCBI chr10:81,425,472...81,732,651
Ensembl chr10:81,425,525...81,732,650
JBrowse link
G Snx27 sorting nexin 27 located_in ISS
ISO
IEA
GO_REF:0000024
(PMID:17644068)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:17644068 GO_REF:0000024 GO_REF:0000107 NCBI chr 2:182,135,904...182,218,906
Ensembl chr 2:182,135,905...182,218,906
JBrowse link
G Socs6 suppressor of cytokine signaling 6 located_in ISO (PMID:20007709) RGD PMID:20007709 NCBI chr18:82,111,866...82,139,193
Ensembl chr18:82,111,827...82,139,219
JBrowse link
G Stoml2 stomatin like 2 colocalizes_with ISO
ISS
(PMID:22623988)
GO_REF:0000024
RGD
UniProt
PMID:22623988 GO_REF:0000024 NCBI chr 5:57,256,227...57,259,824
Ensembl chr 5:57,256,220...57,259,920
JBrowse link
G Stx7 syntaxin 7 located_in ISO (PMID:21438968) RGD PMID:21438968 NCBI chr 1:21,197,075...21,237,320
Ensembl chr 1:21,197,075...21,237,279
JBrowse link
G Vav3 vav guanine nucleotide exchange factor 3 part_of ISO (PMID:15708849) RGD PMID:15708849 NCBI chr 2:197,011,901...197,354,321
Ensembl chr 2:197,011,831...197,354,321
JBrowse link
G Zap70 zeta chain of T cell receptor associated protein kinase 70 located_in ISO (MGI:3686961|PMID:17028588) RGD PMID:17028588 MGI:3686961 NCBI chr 9:38,989,750...39,011,701
Ensembl chr 9:38,989,750...39,011,700
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 19969
    cellular anatomical entity 19676
      immunological synapse 44
Path 2
Term Annotations click to browse term
  cellular_component 19969
    cellular anatomical entity 19676
      membrane 9945
        plasma membrane 6245
          immunological synapse 44
paths to the root