ONTOLOGY REPORT - ANNOTATIONS
Term: SCF ubiquitin ligase complex
Accession: GO:0019005
browse the term
Definition: A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1).
Synonyms: exact_synonym: CDL1 complex; CRL1 complex; Cul1-RING ubiquitin ligase complex; SCF complex; Skp1/Cul1/F-box protein complex; cullin-RING ligase 1
narrow_synonym: SCF complex substrate recognition subunit
xref: Wikipedia:SCF_complex
G
Amn1
antagonist of mitotic exit network 1 homolog
part_of
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 4:182,155,140...182,182,085
Ensembl chr 4:182,155,142...182,182,016
G
Arih1
ariadne RBR E3 ubiquitin protein ligase 1
located_in
ISO
(PMID:24076655), (PMID:27565346)
RGD
PMID:24076655 PMID:27565346
NCBI chr 8:59,777,378...59,879,762
Ensembl chr 8:59,777,379...59,880,245
G
Btrc
beta-transducin repeat containing E3 ubiquitin protein ligase
part_of
ISO
(PMID:12820959), (PMID:19966869)
RGD
PMID:12820959 PMID:19966869
NCBI chr 1:244,210,299...244,380,126
Ensembl chr 1:244,210,314...244,376,721
G
Cacybp
calcyclin binding protein
part_of
ISO IEA
(MGI:5882894|PMID:15996101) GO_REF:0000107
RGD Ensembl
PMID:15996101
GO_REF:0000107 MGI:5882894
NCBI chr13:72,437,485...72,447,810
Ensembl chr13:72,437,490...72,450,177
G
Ccnf
cyclin F
part_of
ISS ISO
GO_REF:0000024 (PMID:20596027)
UniProt RGD
PMID:20596027
GO_REF:0000024
NCBI chr10:13,253,073...13,279,140
Ensembl chr10:13,253,380...13,279,101
G
Cks1b
CDC28 protein kinase regulatory subunit 1B
part_of
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 2:174,833,025...174,837,614
Ensembl chr 2:174,833,050...174,837,636
G
Cks1l
CDC28 protein kinase regulatory subunit 1-like
part_of
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 5:106,982,443...106,983,182
Ensembl chr 5:106,982,882...106,983,121
G
Cul1
cullin 1
part_of
ISO IBA
(PMID:11956208), (PMID:15103331), (PMID:15145941), (PMID:16880511), (PMID:20596027), (PMID:21572392), (PMID:21725316), (PMID:23263282), (PMID:25585578), (PMID:28007894) GO_REF:0000033 (MGI:4821082|PMID:12140560), (MGI:5487698|PMID:23452856), (PMID:12665572)
RGD GO_Central
PMID:11956208 PMID:12140560 PMID:12665572 PMID:15103331 PMID:15145941 PMID:16880511 PMID:20596027 PMID:21572392 PMID:21725316 PMID:23263282 PMID:23452856 PMID:25585578 PMID:28007894 More...
GO_REF:0000033 MGI:4821082 MGI:5487698
NCBI chr 4:76,551,952...76,625,830
Ensembl chr 4:76,551,983...76,627,980
G
Cul2
cullin 2
part_of
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr17:54,169,093...54,210,197
Ensembl chr17:54,169,086...54,209,968
G
Cul5
cullin 5
part_of
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 8:54,012,963...54,066,751
Ensembl chr 8:54,016,006...54,066,666
G
Daw1
dynein assembly factor with WD repeats 1
part_of
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 9:84,435,552...84,472,632
Ensembl chr 9:84,435,552...84,472,635
G
Dmac2
distal membrane arm assembly component 2
part_of
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 1:81,128,760...81,134,810
Ensembl chr 1:81,128,857...81,134,812
G
Fbh1
F-box DNA helicase 1
part_of
ISO
(PMID:11956208), (PMID:19736316), (PMID:25585578)
RGD
PMID:11956208 PMID:19736316 PMID:25585578
NCBI chr17:66,749,506...66,787,590
Ensembl chr17:66,749,534...66,787,590
G
Fbxl15
F-box and leucine-rich repeat protein 15
part_of
ISO ISS IBA
(PMID:21572392) GO_REF:0000024 GO_REF:0000033
RGD UniProt GO_Central
PMID:21572392
GO_REF:0000024 GO_REF:0000033
NCBI chr 1:245,189,732...245,191,973
Ensembl chr 1:245,189,736...245,192,007
G
Fbxl16
F-box and leucine-rich repeat protein 16
part_of
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr10:14,829,453...14,841,739
Ensembl chr10:14,829,449...14,840,986
G
Fbxl17
F-box and leucine-rich repeat protein 17
part_of
ISO
(PMID:24035498)
RGD
PMID:24035498
NCBI chr 9:102,780,573...103,206,978
Ensembl chr 9:102,782,440...103,208,950
G
Fbxl18
F-box and leucine-rich repeat protein 18
part_of
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr12:11,674,538...11,701,317
Ensembl chr12:11,676,115...11,699,181
G
Fbxl18l1
F-box and leucine-rich repeat protein 18 like 1
part_of
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 5:95,460,480...95,464,873
Ensembl chr 5:95,462,188...95,465,129
G
Fbxl19
F-box and leucine-rich repeat protein 19
part_of
ISO
(PMID:22660580)
RGD
PMID:22660580
NCBI chr 1:182,356,899...182,380,839
Ensembl chr 1:182,360,830...182,380,083
G
Fbxl2
F-box and leucine-rich repeat protein 2
part_of
ISO IBA
(PMID:23604317), (PMID:26037928) GO_REF:0000033
RGD GO_Central
PMID:23604317 PMID:26037928
GO_REF:0000033
NCBI chr 8:113,916,660...113,965,137
Ensembl chr 8:113,913,373...113,965,066
G
Fbxl21
F-box and leucine-rich repeat protein 21
part_of
ISO IBA
(MGI:5470183|PMID:23452855), (MGI:5487698|PMID:23452856) GO_REF:0000033
RGD GO_Central
PMID:23452855 PMID:23452856
GO_REF:0000033 MGI:5470183 MGI:5487698
NCBI chr17:8,060,412...8,077,415
Ensembl chr17:8,060,414...8,073,359
G
Fbxl22
F-box and leucine-rich repeat protein 22
part_of
IDA IBA
PMID:22972877 GO_REF:0000033
GO_Central
PMID:22972877
GO_REF:0000033, RGD:10400868
NCBI chr 8:67,069,998...67,076,685
Ensembl chr 8:67,069,998...67,076,685
G
Fbxl3
F-box and leucine-rich repeat protein 3
part_of
ISO IBA
(PMID:17463251) GO_REF:0000033
RGD GO_Central
PMID:17463251
GO_REF:0000033
NCBI chr15:79,906,795...79,926,678
Ensembl chr15:79,906,795...79,927,867
G
Fbxl4
F-box and leucine-rich repeat protein 4
part_of
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 5:35,955,801...36,029,446
Ensembl chr 5:35,955,812...36,029,443
G
Fbxl5
F-box and leucine-rich repeat protein 5
part_of
ISO IBA
(PMID:19762596), (PMID:19762597) GO_REF:0000033
RGD GO_Central
PMID:19762596 PMID:19762597
GO_REF:0000033
NCBI chr14:67,305,109...67,347,383
Ensembl chr14:67,267,801...67,347,383
G
Fbxl6
F-box and leucine-rich repeat protein 6
part_of
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 7:108,259,097...108,262,528
Ensembl chr 7:108,257,160...108,262,513
G
Fbxl7
F-box and leucine-rich repeat protein 7
part_of
ISO IBA
(PMID:25778398) (MGI:5426128|PMID:22306998) GO_REF:0000033
RGD GO_Central
PMID:22306998 PMID:25778398
GO_REF:0000033 MGI:5426128
NCBI chr 2:77,139,775...77,509,223
Ensembl chr 2:77,140,826...77,509,223
G
Fbxl8
F-box and leucine-rich repeat protein 8
part_of
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr19:33,142,705...33,147,266
Ensembl chr19:33,142,715...33,147,262
G
Fbxo15
F-box protein 15
part_of
IBA ISO
GO_REF:0000033 (PMID:12665572)
GO_Central RGD
PMID:12665572
GO_REF:0000033
NCBI chr18:78,319,577...78,634,695
Ensembl chr18:78,319,534...78,390,765
G
Fbxo17
F-box protein 17
part_of
ISO ISS IBA
(PMID:18203720) GO_REF:0000024 GO_REF:0000033
RGD UniProt GO_Central
PMID:18203720
GO_REF:0000024 GO_REF:0000033
NCBI chr 1:84,002,276...84,024,455
Ensembl chr 1:84,002,267...84,024,453
G
Fbxo2
F-box protein 2
part_of
ISO IBA
(MGI:4821082|PMID:12140560) GO_REF:0000033
RGD GO_Central
PMID:12140560
GO_REF:0000033 MGI:4821082
NCBI chr 5:158,592,926...158,598,355
Ensembl chr 5:158,592,925...158,598,355
G
Fbxo25
F-box protein 25
part_of
ISS ISO IBA
GO_REF:0000024 (MGI:4821074|PMID:16714087) GO_REF:0000033
UniProt RGD GO_Central
PMID:16714087
GO_REF:0000024 GO_REF:0000033 MGI:4821074
NCBI chr16:75,666,062...75,701,770
Ensembl chr16:75,667,904...75,701,696
G
Fbxo27
F-box protein 27
part_of
ISO IBA
(PMID:18203720) GO_REF:0000033
RGD GO_Central
PMID:18203720
GO_REF:0000033
NCBI chr 1:83,965,426...83,987,781
Ensembl chr 1:83,965,986...83,987,778
G
Fbxo3
F-box protein 3
part_of
ISS ISO
GO_REF:0000024 (PMID:26037928)
UniProt RGD
PMID:26037928
GO_REF:0000024
NCBI chr 3:90,417,262...90,449,557
Ensembl chr 3:90,417,297...90,449,557
G
Fbxo31
F-box protein 31
part_of
ISO ISS IEA IBA
(PMID:19412162) GO_REF:0000024 GO_REF:0000107 GO_REF:0000033
RGD UniProt Ensembl GO_Central
PMID:19412162
GO_REF:0000024 GO_REF:0000033 GO_REF:0000107
NCBI chr19:49,624,813...49,656,052
Ensembl chr19:49,627,686...49,656,010
G
Fbxo32
F-box protein 32
part_of
IEA ISO IBA
GO_REF:0000107 (PMID:26753747) GO_REF:0000033
Ensembl RGD GO_Central
PMID:26753747
GO_REF:0000033 GO_REF:0000107
NCBI chr 7:89,731,428...89,764,997
Ensembl chr 7:89,730,232...89,765,436
G
Fbxo39
F-box protein 39
part_of
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr10:56,929,699...56,934,911
Ensembl chr10:56,932,297...56,934,906
G
Fbxo4
F-box protein 4
part_of
ISO IBA
(PMID:20181953) GO_REF:0000033 (PMID:21911473)
RGD GO_Central
PMID:20181953 PMID:21911473
GO_REF:0000033
NCBI chr 2:53,174,798...53,187,792
Ensembl chr 2:53,174,798...53,187,792
G
Fbxo42
F-box protein 42
part_of
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 5:153,451,162...153,509,564
Ensembl chr 5:153,451,153...153,506,342
G
Fbxo44
F-box protein 44
part_of
ISO IBA
(PMID:18203720) GO_REF:0000033
RGD GO_Central
PMID:18203720
GO_REF:0000033
NCBI chr 5:158,583,363...158,592,510
Ensembl chr 5:158,583,366...158,592,363
G
Fbxo45
F-box protein 45
part_of NOT|part_of
IBA ISO
GO_REF:0000033 (PMID:19398581)
GO_Central RGD
PMID:19398581
GO_REF:0000033
NCBI chr11:68,551,430...68,567,053
Ensembl chr11:68,551,122...68,566,800
G
Fbxo48
F-box protein 48
part_of
IEA
GO_REF:0000104
UniProt
GO_REF:0000104
NCBI chr14:91,380,857...91,382,314
Ensembl chr14:91,380,857...91,382,314
G
Fbxo6
F-box protein 6
part_of
ISS ISO IBA
GO_REF:0000024 (PMID:19716789) (MGI:2679753|PMID:12939278) GO_REF:0000033
UniProt RGD GO_Central
PMID:12939278 PMID:19716789
GO_REF:0000024 GO_REF:0000033 MGI:2679753
NCBI chr 5:158,576,729...158,582,520
Ensembl chr 5:158,576,759...158,582,525
G
Fbxo7
F-box protein 7
part_of
ISO
(PMID:15145941)
RGD
PMID:15145941
NCBI chr 7:17,809,224...17,837,549
Ensembl chr 7:17,809,231...17,837,530
G
Fbxo9
f-box protein 9
part_of
ISS ISO IEA IBA
GO_REF:0000024 (PMID:23263282) GO_REF:0000104 GO_REF:0000033
UniProt RGD GO_Central
PMID:23263282
GO_REF:0000024 GO_REF:0000033 GO_REF:0000104
NCBI chr 8:78,958,482...78,984,015
Ensembl chr 8:78,958,483...78,983,949
G
Fbxw11
F-box and WD repeat domain containing 11
part_of
ISO
(PMID:16880511), (PMID:20347421) (MGI:2176150|PMID:11896578)
RGD
PMID:11896578 PMID:16880511 PMID:20347421
MGI:2176150
NCBI chr10:17,232,735...17,330,574
Ensembl chr10:17,227,181...17,330,571
G
Fbxw4
F-box and WD repeat domain containing 4
part_of
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 1:244,426,892...244,514,188
Ensembl chr 1:244,426,896...244,514,163
G
Fbxw5
F-box and WD repeat domain containing 5
part_of
ISS ISO
GO_REF:0000024 (PMID:21725316) (MGI:5476881|PMID:23314863)
UniProt RGD
PMID:21725316 PMID:23314863
GO_REF:0000024 MGI:5476881
NCBI chr 3:8,322,543...8,327,092
Ensembl chr 3:8,322,543...8,327,092
G
Fbxw7
F-box and WD repeat domain containing 7
part_of
ISO ISS
(PMID:12628165), (PMID:15103331), (PMID:17434132) (PMID:28007894) GO_REF:0000024
RGD UniProt
PMID:12628165 PMID:15103331 PMID:17434132 PMID:28007894
GO_REF:0000024
NCBI chr 2:170,149,706...170,311,536
Ensembl chr 2:170,149,694...170,309,941
G
Fbxw8
F-box and WD repeat domain containing 8
part_of
IEA ISO
GO_REF:0000107 PR:Q9WTX5 (PMID:16880526)
Ensembl RGD
PMID:16880526
GO_REF:0000107
NCBI chr12:38,426,466...38,517,076
Ensembl chr12:38,426,444...38,516,424
G
LOC120102505
cyclin-dependent kinases regulatory subunit 2-like
part_of
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 4:144,220,612...144,220,990
Ensembl chr 4:144,220,751...144,220,990
G
Lrrc29
leucine rich repeat containing 29
part_of
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr19:33,181,713...33,203,583
Ensembl chr19:33,188,352...33,203,545
G
Nccrp1
NCCRP1, F-box associated domain containing
part_of
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 1:83,835,083...83,838,620
Ensembl chr 1:83,835,083...83,838,676
G
Pnkp
polynucleotide kinase 3'-phosphatase
part_of
ISO
(MGI:5780352|PMID:26774286)
RGD
PMID:26774286
MGI:5780352
NCBI chr 1:95,341,465...95,346,921
Ensembl chr 1:95,341,620...95,346,920
G
Prkn
parkin RBR E3 ubiquitin protein ligase
NOT|part_of
ISO
(PMID:12628165)
RGD
PMID:12628165
NCBI chr 1:48,688,651...49,882,520
Ensembl chr 1:48,690,556...49,882,555
G
Rbx1
ring-box 1
part_of
ISO
(PMID:11956208), (PMID:15103331), (PMID:21572392), (PMID:23263282), (PMID:25585578) PR:Q9WTX6 (MGI:4821082|PMID:12140560), (PMID:16880526)
RGD
PMID:11956208 PMID:12140560 PMID:15103331 PMID:16880526 PMID:21572392 PMID:23263282 PMID:25585578 More...
MGI:4821082
NCBI chr 7:112,976,863...113,001,051
Ensembl chr 7:112,990,835...113,001,051
G
Siah1
siah E3 ubiquitin protein ligase 1
part_of
ISO IEA
(MGI:5882894|PMID:15996101) GO_REF:0000107
RGD Ensembl
PMID:15996101
GO_REF:0000107 MGI:5882894
NCBI chr19:20,378,908...20,402,512
Ensembl chr19:20,378,439...20,403,808
G
Skp1
S-phase kinase-associated protein 1
part_of
ISS ISO IEA
GO_REF:0000024 (PMID:11956208), (PMID:12820959), (PMID:15103331), (PMID:15145941), (PMID:15996101), (PMID:16880511), (PMID:20347421), (PMID:20596027), (PMID:21572392), (PMID:21725316), (PMID:23263282), (PMID:25585578), (PMID:28007894) GO_REF:0000104 (MGI:4821082|PMID:12140560), (MGI:5487698|PMID:23452856), (PMID:12665572)
UniProt RGD
PMID:11956208 PMID:12140560 PMID:12665572 PMID:12820959 PMID:15103331 PMID:15145941 PMID:15996101 PMID:16880511 PMID:20347421 PMID:20596027 PMID:21572392 PMID:21725316 PMID:23263282 PMID:23452856 PMID:25585578 PMID:28007894 More...
GO_REF:0000024 GO_REF:0000104 MGI:4821082 MGI:5487698
NCBI chr10:36,401,987...36,417,066
Ensembl chr10:36,402,153...36,417,388
G
Skp2
S-phase kinase associated protein 2
part_of
IBA ISO
GO_REF:0000033 (PMID:16880511), (PMID:22464731) (MGI:5438910|PMID:22464731), (PMID:17785450)
GO_Central RGD
PMID:16880511 PMID:17785450 PMID:22464731
GO_REF:0000033 MGI:5438910
NCBI chr 2:58,161,226...58,189,293
Ensembl chr 2:58,161,229...58,189,338
G
Spsb1
splA/ryanodine receptor domain and SOCS box containing 1
part_of
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 5:160,358,292...160,418,541
Ensembl chr 5:160,358,308...160,418,468
G
Spsb2
splA/ryanodine receptor domain and SOCS box containing 2
part_of
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 4:157,613,404...157,615,293
Ensembl chr 4:157,613,401...157,615,284
G
Spsb3
splA/ryanodine receptor domain and SOCS box containing 3
part_of
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr10:13,907,175...13,912,841
Ensembl chr10:13,907,253...13,912,841
G
Spsb4
splA/ryanodine receptor domain and SOCS box containing 4
part_of
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 8:97,536,519...97,609,757
Ensembl chr 8:97,536,520...97,609,787
G
Tmem183a
transmembrane protein 183A
part_of
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr13:45,803,641...45,820,409
Ensembl chr13:45,803,639...45,820,375
G
Tmem249
transmembrane protein 249
part_of
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 7:108,256,535...108,259,429
Ensembl chr 7:108,257,160...108,262,513
G
Trim21
tripartite motif-containing 21
located_in
ISO
(PMID:16880511)
RGD
PMID:16880511
NCBI chr 1:156,964,896...156,987,504
Ensembl chr 1:156,964,913...156,987,440
G
Usp47
ubiquitin specific peptidase 47
part_of
ISO
(PMID:19966869)
RGD
PMID:19966869
NCBI chr 1:166,152,104...166,235,312
Ensembl chr 1:166,152,199...166,235,312
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all