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ONTOLOGY REPORT - ANNOTATIONS


Term:nuclear SCF ubiquitin ligase complex
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Accession:GO:0043224 term browser browse the term
Definition:A ubiquitin ligase complex, located in the nucleus, in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1).
Synonyms:exact_synonym: nuclear SCF complex;   nuclear Skp1/Cul1/F-box protein complex;   nuclear cullin complex


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  cellular_component 20609
    cellular anatomical entity 20358
      intracellular anatomical structure 14706
        ubiquitin ligase complex 309
          nuclear ubiquitin ligase complex 41
            nuclear SCF ubiquitin ligase complex 0
Path 2
Term Annotations click to browse term
  cellular_component 20609
    cellular anatomical entity 20358
      intracellular anatomical structure 14706
        intracellular organelle 12912
          intracellular membrane-bounded organelle 10704
            nucleus 7183
              nuclear ubiquitin ligase complex 41
                nuclear SCF ubiquitin ligase complex 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.