Fbxo7 (F-box protein 7) - Rat Genome Database

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Gene: Fbxo7 (F-box protein 7) Rattus norvegicus
Analyze
Symbol: Fbxo7
Name: F-box protein 7
RGD ID: 1305648
Description: Predicted to enable several functions, including enzyme binding activity; protein heterodimerization activity; and ubiquitin-like ligase-substrate adaptor activity. Involved in positive regulation of mitophagy. Predicted to be located in several cellular components, including Lewy body core; Lewy body corona; and Lewy neurite. Predicted to be part of SCF ubiquitin ligase complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Parkinson's disease and Parkinson's disease 15. Orthologous to human FBXO7 (F-box protein 7); PARTICIPATES IN Parkinson's disease pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: F-box only protein 7; LOC366854
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8719,696,951 - 19,725,180 (-)NCBIGRCr8
mRatBN7.2717,809,224 - 17,837,549 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl717,809,231 - 17,837,530 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx719,771,322 - 19,799,547 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0721,928,523 - 21,956,738 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0721,710,970 - 21,739,195 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0723,815,246 - 23,843,505 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl723,815,245 - 23,843,634 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0723,964,601 - 23,993,030 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4719,947,498 - 19,975,730 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1719,960,416 - 19,988,648 (-)NCBI
Celera715,042,489 - 15,070,722 (-)NCBICelera
Cytogenetic Map7q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
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Reference
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Source
Original Reference(s)
Fbxo7RatParkinson's disease  ISOFBXO7 (Homo sapiens)10450518 RGD 
Object Symbol
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Reference
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Original Reference(s)
Fbxo7Ratgenetic disease  ISOFBXO7 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:25741868 and PMID:28492532
Fbxo7Ratglucose-galactose malabsorption  ISOFBXO7 (Homo sapiens)8554872ClinVar Annotator: match by term: Congenital glucose-galactose malabsorptionClinVarPMID:28492532
Fbxo7Ratmuscular dystrophy-dystroglycanopathy type B6  ISOFBXO7 (Homo sapiens)8554872ClinVar Annotator: match by term: Muscular dystrophy-dystroglycanopathy type B6ClinVarPMID:28492532
Fbxo7RatParkinson's disease  ISOFBXO7 (Homo sapiens)8554872ClinVar Annotator: match by term: Parkinson Disease and RecessiveClinVarPMID:25741868
Fbxo7RatParkinson's disease 15  ISOFBXO7 (Homo sapiens)8554872ClinVar Annotator: match by term: Parkinsonian-pyramidal syndromeClinVarPMID:16199547 more ...
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Original Reference(s)
Fbxo7RatParkinson's disease 15  ISOFBXO7 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25029497
Object Symbol
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Original Reference(s)
Fbxo7RatParkinson's disease 15  ISOFBXO7 (Homo sapiens)7240710 OMIM 

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Original Reference(s)
Fbxo7Rat1,1-dichloroethene decreases expressionISOFbxo7 (Mus musculus)6480464vinylidene chloride results in decreased expression of FBXO7 mRNACTDPMID:26682919
Fbxo7Rat2,2',4,4'-Tetrabromodiphenyl ether decreases expressionISOFBXO7 (Homo sapiens)64804642 more ...CTDPMID:31675489
Fbxo7Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOFbxo7 (Mus musculus)6480464Tetrachlorodibenzodioxin results in decreased expression of FBXO7 mRNACTDPMID:19465110 and PMID:21354282
Fbxo7Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of FBXO7 mRNACTDPMID:33387578
Fbxo7Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOFbxo7 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of FBXO7 mRNACTDPMID:21570461
Fbxo7Rat2,4,6-tribromophenol decreases expressionISOFBXO7 (Homo sapiens)64804642 more ...CTDPMID:31675489
Fbxo7Rat3,3',5,5'-tetrabromobisphenol A decreases expressionISOFBXO7 (Homo sapiens)6480464tetrabromobisphenol A results in decreased expression of FBXO7 proteinCTDPMID:31675489
Fbxo7Rat4,4'-sulfonyldiphenol multiple interactionsEXP 6480464[bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of FBXO7 mRNACTDPMID:36041667
Fbxo7Ratazoxystrobin decreases expressionISOFBXO7 (Homo sapiens)6480464azoxystrobin results in decreased expression of FBXO7 mRNACTDPMID:33512557
Fbxo7Ratbenzo[a]pyrene increases expressionISOFbxo7 (Mus musculus)6480464Benzo(a)pyrene results in increased expression of FBXO7 mRNACTDPMID:21715664 and PMID:22228805
Fbxo7Ratbisphenol A increases expressionEXP 6480464bisphenol A results in increased expression of FBXO7 mRNACTDPMID:25181051
Fbxo7Ratbisphenol A multiple interactionsEXP 6480464[bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of FBXO7 mRNACTDPMID:36041667
Fbxo7Ratbisphenol A decreases expressionISOFBXO7 (Homo sapiens)6480464bisphenol A results in decreased expression of FBXO7 proteinCTDPMID:31675489
Fbxo7Ratbisphenol F multiple interactionsISOFBXO7 (Homo sapiens)6480464[bisphenol F co-treated with Fulvestrant] results in increased methylation of FBXO7 geneCTDPMID:31601247
Fbxo7Ratbisphenol F multiple interactionsEXP 6480464[bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of FBXO7 mRNACTDPMID:36041667
Fbxo7RatCGP 52608 multiple interactionsISOFBXO7 (Homo sapiens)6480464CGP 52608 promotes the reaction [RORA protein binds to FBXO7 gene]CTDPMID:28238834
Fbxo7Ratchlorpyrifos increases expressionISOFbxo7 (Mus musculus)6480464Chlorpyrifos results in increased expression of FBXO7 mRNACTDPMID:37019170
Fbxo7Ratdecabromodiphenyl ether decreases expressionISOFBXO7 (Homo sapiens)6480464decabromobiphenyl ether results in decreased expression of FBXO7 proteinCTDPMID:31675489
Fbxo7RatDibutyl phosphate affects expressionISOFBXO7 (Homo sapiens)6480464di-n-butylphosphoric acid affects the expression of FBXO7 mRNACTDPMID:37042841
Fbxo7Ratdioxygen multiple interactionsISOFbxo7 (Mus musculus)6480464Oxygen inhibits the reaction [Oxygen deficiency results in increased expression of FBXO7 mRNA]CTDPMID:22629407

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Biological Process
1 to 20 of 38 rows

  
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Original Reference(s)
Fbxo7Ratautophagy of mitochondrion involved_inISSUniProtKB:Q9Y3I11600115GO_REF:0000024UniProtGO_REF:0000024
Fbxo7Ratautophagy of mitochondrion involved_inIEAUniProtKB:Q9Y3I1 and ensembl:ENSP000002660871600115GO_REF:0000107EnsemblGO_REF:0000107
Fbxo7Ratautophagy of mitochondrion involved_inISOFBXO7 (Homo sapiens)1624291 PMID:23933751RGDPMID:23933751
Fbxo7Ratbiological_process  ND 159840712/2020: no relevant rat dataRGD 
Fbxo7Ratlymphocyte differentiation acts_upstream_ofISOFbxo7 (Mus musculus)1624291MGI:4434927 more ...RGDPMID:21652635
Fbxo7Ratlymphocyte differentiation acts_upstream_ofIEAUniProtKB:Q3U7U3 and ensembl:ENSMUSP000001208401600115GO_REF:0000107EnsemblGO_REF:0000107
Fbxo7Ratnegative regulation of cyclin-dependent protein serine/threonine kinase activity acts_upstream_of_or_withinISOFbxo7 (Mus musculus)1624291 PMID:21652635RGDPMID:21652635
Fbxo7Ratnegative regulation of G1/S transition of mitotic cell cycle acts_upstream_of_or_withinISOFbxo7 (Mus musculus)1624291 PMID:21652635RGDPMID:21652635
Fbxo7Ratnegative regulation of G1/S transition of mitotic cell cycle acts_upstream_of_or_withinIEAUniProtKB:Q3U7U3 and ensembl:ENSMUSP000001208401600115GO_REF:0000107EnsemblGO_REF:0000107
Fbxo7Ratnegative regulation of lymphocyte differentiation acts_upstream_of_or_withinIEAUniProtKB:Q3U7U3 and ensembl:ENSMUSP000001208401600115GO_REF:0000107EnsemblGO_REF:0000107
Fbxo7Ratnegative regulation of lymphocyte differentiation acts_upstream_of_or_withinISOFbxo7 (Mus musculus)1624291MGI:4434927 more ...RGDPMID:21652635
Fbxo7Ratnegative regulation of neuron apoptotic process acts_upstream_ofIMP 11536096PMID:26310625ParkinsonsUK-UCL 
Fbxo7Ratnegative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway involved_inISOFBXO7 (Homo sapiens)1624291 PMID:25029497RGDPMID:25029497
Fbxo7Ratnegative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway acts_upstream_ofIEAUniProtKB:Q9Y3I1 and ensembl:ENSP000002660871600115GO_REF:0000107EnsemblGO_REF:0000107
Fbxo7Ratnegative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway acts_upstream_ofISOFBXO7 (Homo sapiens) and UniProtKB:Q9Y3I1-21624291 PMID:26310625RGDPMID:26310625
Fbxo7Ratpositive regulation of autophagy of mitochondrion involved_inIBAPANTHER:PTN001036668 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Fbxo7Ratpositive regulation of mitophagy involved_inIEAUniProtKB:Q9Y3I1 and ensembl:ENSP000002660871600115GO_REF:0000107EnsemblGO_REF:0000107
Fbxo7Ratpositive regulation of mitophagy involved_inISOFBXO7 (Homo sapiens)1624291 PMID:26310625RGDPMID:26310625
Fbxo7Ratpositive regulation of mitophagy involved_inIMP 11536096PMID:26310625ParkinsonsUK-UCL 
Fbxo7Ratproteasome-mediated ubiquitin-dependent protein catabolic process involved_inIEAUniProtKB:Q9Y3I1 and ensembl:ENSP000002660871600115GO_REF:0000107EnsemblGO_REF:0000107
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Cellular Component
1 to 20 of 45 rows

  
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Original Reference(s)
Fbxo7Ratclassical Lewy body located_inISOFBXO7 (Homo sapiens)1624291 PMID:23656991RGDPMID:23656991
Fbxo7Ratclassical Lewy body located_inIEAUniProtKB:Q9Y3I1 and ensembl:ENSP000002660871600115GO_REF:0000107EnsemblGO_REF:0000107
Fbxo7Ratcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Fbxo7Ratcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
Fbxo7Ratcytoplasm located_inIEAUniProtKB:Q9Y3I1 and ensembl:ENSP000002660871600115GO_REF:0000107EnsemblGO_REF:0000107
Fbxo7Ratcytoplasm located_inISOFBXO7 (Homo sapiens)1624291 PMID:16510124 more ...RGDPMID:16510124 more ...
Fbxo7Ratcytoplasm located_inISOFBXO7 (Homo sapiens) and UniProtKB:Q9Y3I1-21624291 PMID:21347293RGDPMID:21347293
Fbxo7Ratcytosol located_inISOFBXO7 (Homo sapiens)1624291 PMID:18495667 and PMID:23933751RGDPMID:18495667 and PMID:23933751
Fbxo7Ratcytosol located_inIEAUniProtKB:Q9Y3I1 and ensembl:ENSP000002660871600115GO_REF:0000107EnsemblGO_REF:0000107
Fbxo7Ratcytosol located_inISSUniProtKB:Q9Y3I11600115GO_REF:0000024UniProtGO_REF:0000024
Fbxo7Ratcytosol located_inISOFBXO7 (Homo sapiens) and UniProtKB:Q9Y3I1-11624291 RGDGO_REF:0000052
Fbxo7Ratcytosol located_inIEAUniProtKB-SubCell:SL-00911600115GO_REF:0000044UniProtGO_REF:0000044
Fbxo7Ratglial cytoplasmic inclusion located_inISOFBXO7 (Homo sapiens)1624291 PMID:23656991RGDPMID:23656991
Fbxo7Ratglial cytoplasmic inclusion located_inIEAUniProtKB:Q9Y3I1 and ensembl:ENSP000002660871600115GO_REF:0000107EnsemblGO_REF:0000107
Fbxo7RatLewy body core located_inISOFBXO7 (Homo sapiens)1624291 PMID:23656991RGDPMID:23656991
Fbxo7RatLewy body core located_inIEAUniProtKB:Q9Y3I1 and ensembl:ENSP000002660871600115GO_REF:0000107EnsemblGO_REF:0000107
Fbxo7RatLewy body corona located_inISOFBXO7 (Homo sapiens)1624291 PMID:23656991RGDPMID:23656991
Fbxo7RatLewy body corona located_inIEAUniProtKB:Q9Y3I1 and ensembl:ENSP000002660871600115GO_REF:0000107EnsemblGO_REF:0000107
Fbxo7RatLewy neurite located_inISOFBXO7 (Homo sapiens)1624291 PMID:23656991RGDPMID:23656991
Fbxo7RatLewy neurite located_inIEAUniProtKB:Q9Y3I1 and ensembl:ENSP000002660871600115GO_REF:0000107EnsemblGO_REF:0000107
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Molecular Function
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Original Reference(s)
Fbxo7Ratprotein binding enablesISOFBXO7 (Homo sapiens)1624291UniProtKB:O14980 more ...RGDPMID:15145941 more ...
Fbxo7Ratprotein binding enablesISOFBXO7 (Homo sapiens) and UniProtKB:Q9Y3I1-11624291UniProtKB:O60260 more ...RGDPMID:23933751
Fbxo7Ratprotein heterodimerization activity enablesISOFBXO7 (Homo sapiens)1624291UniProtKB:Q92530 and PMID:18495667RGDPMID:18495667
Fbxo7Ratprotein heterodimerization activity enablesIEAUniProtKB:Q9Y3I1 and ensembl:ENSP000002660871600115GO_REF:0000107EnsemblGO_REF:0000107
Fbxo7Ratprotein kinase binding enablesISOFBXO7 (Homo sapiens)1624291UniProtKB:Q00534 and PMID:18495667RGDPMID:18495667
Fbxo7Ratprotein kinase binding enablesIEAUniProtKB:Q9Y3I1 and ensembl:ENSP000002660871600115GO_REF:0000107EnsemblGO_REF:0000107
Fbxo7Ratprotein kinase binding enablesIEAUniProtKB:Q3U7U3 and ensembl:ENSMUSP000001208401600115GO_REF:0000107EnsemblGO_REF:0000107
Fbxo7Ratprotein kinase binding enablesIBAMGI:1917004 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Fbxo7Ratprotein kinase binding enablesISOFbxo7 (Mus musculus)1624291PR:Q64261 PMID:21652635RGDPMID:21652635
Fbxo7Ratprotein kinase binding enablesIEAInterPro:IPR0471181600115GO_REF:0000002InterProGO_REF:0000002
Fbxo7Ratubiquitin binding enablesISOFBXO7 (Homo sapiens)1624291 PMID:25029497RGDPMID:25029497
Fbxo7Ratubiquitin binding enablesIEAUniProtKB:Q9Y3I1 and ensembl:ENSP000002660871600115GO_REF:0000107EnsemblGO_REF:0000107
Fbxo7Ratubiquitin protein ligase binding enablesISOFBXO7 (Homo sapiens)1624291UniProtKB:Q13490 and PMID:16510124RGDPMID:16510124
Fbxo7Ratubiquitin protein ligase binding enablesIEAUniProtKB:Q9Y3I1 and ensembl:ENSP000002660871600115GO_REF:0000107EnsemblGO_REF:0000107
Fbxo7Ratubiquitin-like ligase-substrate adaptor activity enablesISOFBXO7 (Homo sapiens)1624291 PMID:15145941 and PMID:36646384RGDPMID:15145941 and PMID:36646384
Fbxo7Ratubiquitin-like ligase-substrate adaptor activity enablesIEAUniProtKB:Q9Y3I1 and ensembl:ENSP000002660871600115GO_REF:0000107EnsemblGO_REF:0000107
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RGD Manual Annotations


  
Object Symbol
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Reference
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Original Reference(s)
Fbxo7RatParkinson's disease pathway   ISOFBXO7 (Homo sapiens)10450518 RGD 

#
Reference Title
Reference Citation
1. Genes associated with Parkinson's disease: regulation of autophagy and beyond. Beilina A and Cookson MR, J Neurochem. 2015 Jul 30. doi: 10.1111/jnc.13266.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Comprehensive gene review and curation RGD comprehensive gene curation
8. F-box protein 7 mutations promote protein aggregation in mitochondria and inhibit mitophagy. Zhou ZD, etal., Hum Mol Genet. 2015 Nov 15;24(22):6314-30. doi: 10.1093/hmg/ddv340. Epub 2015 Aug 26.
PMID:12477932   PMID:15145941   PMID:16510124   PMID:18495667   PMID:19028597   PMID:21347293   PMID:21378169   PMID:21652635   PMID:23656991   PMID:23933751   PMID:25029497  



Fbxo7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8719,696,951 - 19,725,180 (-)NCBIGRCr8
mRatBN7.2717,809,224 - 17,837,549 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl717,809,231 - 17,837,530 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx719,771,322 - 19,799,547 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0721,928,523 - 21,956,738 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0721,710,970 - 21,739,195 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0723,815,246 - 23,843,505 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl723,815,245 - 23,843,634 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0723,964,601 - 23,993,030 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4719,947,498 - 19,975,730 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1719,960,416 - 19,988,648 (-)NCBI
Celera715,042,489 - 15,070,722 (-)NCBICelera
Cytogenetic Map7q13NCBI
FBXO7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382232,474,811 - 32,498,829 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2232,474,676 - 32,498,829 (+)EnsemblGRCh38hg38GRCh38
GRCh372232,870,798 - 32,894,816 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362231,200,707 - 31,224,818 (+)NCBINCBI36Build 36hg18NCBI36
Build 342231,195,263 - 31,219,369NCBI
Celera2216,672,879 - 16,696,990 (+)NCBICelera
Cytogenetic Map22q12.3NCBI
HuRef2215,827,931 - 15,852,000 (+)NCBIHuRef
CHM1_12232,830,063 - 32,854,178 (+)NCBICHM1_1
T2T-CHM13v2.02232,938,705 - 32,962,724 (+)NCBIT2T-CHM13v2.0
Fbxo7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391085,856,313 - 85,887,737 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1085,857,836 - 85,887,737 (+)EnsemblGRCm39 Ensembl
GRCm381086,020,449 - 86,051,873 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1086,021,972 - 86,051,873 (+)EnsemblGRCm38mm10GRCm38
MGSCv371085,484,674 - 85,511,073 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361085,451,796 - 85,478,128 (+)NCBIMGSCv36mm8
Celera1087,995,701 - 88,022,106 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1041.91NCBI
Fbxo7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540541,433,082 - 41,453,909 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540541,429,421 - 41,449,670 (+)NCBIChiLan1.0ChiLan1.0
FBXO7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22342,411,197 - 42,435,546 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12245,111,484 - 45,135,854 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02213,481,255 - 13,505,301 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12231,335,423 - 31,359,224 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2231,335,423 - 31,359,224 (+)Ensemblpanpan1.1panPan2
FBXO7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11030,928,059 - 30,948,858 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1030,928,329 - 30,948,977 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1030,910,928 - 30,931,963 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01031,770,136 - 31,791,111 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1031,770,138 - 31,791,130 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11031,510,102 - 31,530,961 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01031,799,411 - 31,820,248 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01031,985,722 - 32,006,997 (-)NCBIUU_Cfam_GSD_1.0
Fbxo7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494514,251,029 - 14,266,764 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364927,261,009 - 7,276,943 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364927,261,442 - 7,276,779 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FBXO7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl512,505,654 - 12,526,232 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1512,505,646 - 12,526,206 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2512,291,445 - 12,313,045 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FBXO7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11915,300,135 - 15,324,256 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1915,300,158 - 15,323,956 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666045110,683,150 - 110,707,342 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fbxo7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247501,977,761 - 1,997,231 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247501,977,666 - 1,997,408 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Fbxo7
166 total Variants


Assembly: RGSC_v3.4
Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain Variant Page
7 19975667 19975668 T G snv SS/JrHsdMcwi (MCW), FHL/EurMcwi (MCW) View more Information

Predicted Target Of
Summary Value
Count of predictions:37
Count of miRNA genes:31
Interacting mature miRNAs:35
Transcripts:ENSRNOT00000006366
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 21 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
2317059Aia15Adjuvant induced arthritis QTL 152.46joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)71700459862004598Rat
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7144782185Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)766427026029351Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7532901950329019Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)7986646760460686Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
10755438Coatc9Coat color QTL 90coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7352928048529280Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7131962314Rat

1 to 10 of 21 rows
D7Rat185  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8719,701,509 - 19,701,674 (+)Marker Load Pipeline
mRatBN7.2717,813,789 - 17,813,954 (+)MAPPERmRatBN7.2
Rnor_6.0723,819,835 - 23,819,999NCBIRnor6.0
Rnor_5.0723,969,360 - 23,969,524UniSTSRnor5.0
RGSC_v3.4719,952,059 - 19,952,224RGDRGSC3.4
RGSC_v3.4719,952,060 - 19,952,224UniSTSRGSC3.4
RGSC_v3.1719,964,977 - 19,965,142RGD
Celera715,047,048 - 15,047,212UniSTS
SHRSP x BN Map76.87UniSTS
SHRSP x BN Map76.87RGD
Cytogenetic Map7q13UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000006366   ⟹   ENSRNOP00000006366
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl717,809,231 - 17,837,530 (-)Ensembl
Rnor_6.0 Ensembl723,815,263 - 23,843,505 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000077577   ⟹   ENSRNOP00000070310
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl717,809,422 - 17,837,528 (-)Ensembl
Rnor_6.0 Ensembl723,815,245 - 23,843,634 (-)Ensembl
RefSeq Acc Id: NM_001012222   ⟹   NP_001012222
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8719,696,951 - 19,725,180 (-)NCBI
mRatBN7.2717,809,231 - 17,837,460 (-)NCBI
Rnor_6.0723,815,253 - 23,843,505 (-)NCBI
Rnor_5.0723,964,601 - 23,993,030 (-)NCBI
RGSC_v3.4719,947,498 - 19,975,730 (-)RGD
Celera715,042,489 - 15,070,722 (-)RGD
Sequence:
RefSeq Acc Id: XM_006241166   ⟹   XP_006241228
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8719,696,951 - 19,725,057 (-)NCBI
mRatBN7.2717,809,224 - 17,837,438 (-)NCBI
Rnor_6.0723,815,246 - 23,843,344 (-)NCBI
Rnor_5.0723,964,601 - 23,993,030 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006241167   ⟹   XP_006241229
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8719,696,951 - 19,724,957 (-)NCBI
mRatBN7.2717,809,224 - 17,837,334 (-)NCBI
Rnor_6.0723,815,246 - 23,843,379 (-)NCBI
Rnor_5.0723,964,601 - 23,993,030 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039079673   ⟹   XP_038935601
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8719,696,951 - 19,725,166 (-)NCBI
mRatBN7.2717,809,224 - 17,837,549 (-)NCBI
RefSeq Acc Id: XM_039079674   ⟹   XP_038935602
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8719,696,951 - 19,724,782 (-)NCBI
mRatBN7.2717,809,224 - 17,837,075 (-)NCBI
1 to 10 of 10 rows
Protein RefSeqs NP_001012222 (Get FASTA)   NCBI Sequence Viewer  
  XP_006241228 (Get FASTA)   NCBI Sequence Viewer  
  XP_006241229 (Get FASTA)   NCBI Sequence Viewer  
  XP_038935601 (Get FASTA)   NCBI Sequence Viewer  
  XP_038935602 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH79382 (Get FASTA)   NCBI Sequence Viewer  
  EDM17120 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000006366
  ENSRNOP00000006366.5
GenBank Protein Q68FS3 (Get FASTA)   NCBI Sequence Viewer  
1 to 10 of 10 rows
RefSeq Acc Id: NP_001012222   ⟸   NM_001012222
- UniProtKB: Q68FS3 (UniProtKB/Swiss-Prot),   A6IFC7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006241229   ⟸   XM_006241167
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_006241228   ⟸   XM_006241166
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000006366   ⟸   ENSRNOT00000006366
Ensembl Acc Id: ENSRNOP00000070310   ⟸   ENSRNOT00000077577
F-box

Name Modeler Protein Id AA Range Protein Structure
AF-Q68FS3-F1-model_v2 AlphaFold Q68FS3 1-522 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13695092
Promoter ID:EPDNEW_R5617
Type:initiation region
Name:Fbxo7_1
Description:F-box protein 7
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0723,843,523 - 23,843,583EPDNEW


1 to 26 of 26 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-34642 BioCyc
Ensembl Genes ENSRNOG00000004637 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000006366 ENTREZGENE
  ENSRNOT00000006366.8 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1280.50 UniProtKB/Swiss-Prot
  3.40.1000.30 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7111095 IMAGE-MGC_LOAD
InterPro F-box-like_dom_sf UniProtKB/Swiss-Prot
  F-box_dom UniProtKB/Swiss-Prot
  Fbxo7 UniProtKB/Swiss-Prot
  PI31_Prot_N UniProtKB/Swiss-Prot
KEGG Report rno:366854 UniProtKB/Swiss-Prot
MGC_CLONE MGC:94890 IMAGE-MGC_LOAD
NCBI Gene 366854 ENTREZGENE
PANTHER F-BOX ONLY PROTEIN 7 UniProtKB/Swiss-Prot
  F-BOX ONLY PROTEIN 7 UniProtKB/Swiss-Prot
Pfam F-box-like UniProtKB/Swiss-Prot
  PI31_Prot_N UniProtKB/Swiss-Prot
PhenoGen Fbxo7 PhenoGen
PROSITE FBOX UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000004637 RatGTEx
Superfamily-SCOP SSF81383 UniProtKB/Swiss-Prot
UniProt A0A0G2JXK7_RAT UniProtKB/TrEMBL
  A6IFC7 ENTREZGENE, UniProtKB/TrEMBL
  A6IFC8 ENTREZGENE, UniProtKB/TrEMBL
  FBX7_RAT UniProtKB/Swiss-Prot, ENTREZGENE
1 to 26 of 26 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-04 Fbxo7  F-box protein 7  Fbxo7  F-box only protein 7  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Fbxo7  F-box only protein 7  Fbxo7_predicted  F-box only protein 7 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Fbxo7_predicted  F-box only protein 7 (predicted)      Symbol and Name status set to approved 70820 APPROVED