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Ontology Browser

Term:
cytoplasmic SCF ubiquitin ligase complex (GO:0043223)
Annotations: Rat: (0) Mouse: (0) Human: (0) Chinchilla: (0) Bonobo: (0) Dog: (0) Squirrel: (0) Pig: (0)
Parent Terms Term With Siblings Child Terms
cytoplasmic SCF ubiquitin ligase complex 
A ubiquitin ligase complex, located in the cytoplasm, in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1).
ER ubiquitin ligase complex +   
nuclear SCF ubiquitin ligase complex 
SCF-Cdc4 ubiquitin ligase complex 
SCF-Ctf13 ubiquitin ligase complex 
SCF-Das1 ubiquitin ligase complex 
SCF-Dia2/Pof3 ubiquitin ligase complex 
SCF-Grr1/Pof2 ubiquitin ligase complex 
SCF-Hrt3/Pof7 ubiquitin ligase complex 
SCF-Mdm30 ubiquitin ligase complex 
SCF-Met30/Pof1 ubiquitin ligase complex 
SCF-Pof5 ubiquitin ligase complex 
SCF-Rcy1/Pof6 ubiquitin ligase complex 
SCF-Saf1/Pof9 ubiquitin ligase complex 
SCF-Skp2 ubiquitin ligase complex 
SCF-Ucc1 ubiquitin ligase complex 
SCF-Ufo1/Pof10 ubiquitin ligase complex 
SCF-YDR131C ubiquitin ligase complex 
SCF-YLR352W ubiquitin ligase complex 
VCB complex  

Synonyms
Exact Synonyms: cytoplasmic SCF complex ;   cytoplasmic Skp1/Cul1/F-box protein complex ;   cytoplasmic cullin complex
Definition Sources: PMID:15571813, PMID:15688063

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.