Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

Ontology Browser

Term:
SCF ubiquitin ligase complex (GO:0019005)
Annotations: Rat: (70) Mouse: (67) Human: (67) Chinchilla: (39) Bonobo: (38) Dog: (64) Squirrel: (39) Pig: (62)
Parent Terms Term With Siblings Child Terms
anaphase-promoting complex  
Cul2-RING ubiquitin ligase complex  
Cul3-RING ubiquitin ligase complex  
Cul4-RING E3 ubiquitin ligase complex +   
Cul5-RING ubiquitin ligase complex  
Cul7-RING ubiquitin ligase complex  
Cul8-RING ubiquitin ligase complex 
SCF ubiquitin ligase complex +   
A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1).

Synonyms
Exact Synonyms: CDL1 complex ;   CRL1 complex ;   Cul1-RING ubiquitin ligase complex ;   SCF complex ;   Skp1/Cul1/F-box protein complex ;   cullin-RING ligase 1
Narrow Synonyms: SCF complex substrate recognition subunit
Xrefs: Wikipedia:SCF_complex
Definition Sources: PMID:15571813, PMID:15688063

paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.