RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: Oxygen-Induced Retinopathy
Accession: DOID:9002909
browse the term
Definition: A noninflammatory disorder of the retina, involving neuronal damage induced by hypoxic conditions, that is a widely used animal model of retinopathy of prematurity (ROP).
Synonyms: exact_synonym: OIP; OIR
primary_id: RDO:9000037
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ADIPOQ
adiponectin, C1Q and collagen domain containing
treatment
ISO
RGD
PMID:19342600
RGD:7394795
NCBI chr 3:186,842,710...186,858,463
Ensembl chr 3:186,842,704...186,858,463
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AMIGO2
adhesion molecule with Ig like domain 2
treatment
ISO
RGD
PMID:26553931
RGD:14392781
NCBI chr12:47,075,707...47,079,959
Ensembl chr12:47,075,707...47,079,959
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BCL2
BCL2 apoptosis regulator
ameliorates
ISO
RGD
PMID:35445044
RGD:329812014
NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128
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CASP3
caspase 3
ameliorates
ISO
RGD
PMID:35445044
RGD:329812014
NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062
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CCL2
C-C motif chemokine ligand 2
treatment
ISO
mRNA:increased expression:retina (mouse)
RGD
PMID:16710171 PMID:19038868
RGD:8548878 , RGD:11526145
NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208
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CCN1
cellular communication network factor 1
ameliorates
ISO
RGD
PMID:35445044
RGD:329812014
NCBI chr 1:85,580,761...85,583,950
Ensembl chr 1:85,580,761...85,584,589
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CSNK2A1
casein kinase 2 alpha 1
ISO
RGD
PMID:16651637
RGD:11565123
NCBI chr20:472,498...543,790
Ensembl chr20:472,498...543,835
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CSNK2A2
casein kinase 2 alpha 2
ISO
RGD
PMID:16651637
RGD:11565123
NCBI chr16:58,157,907...58,198,106
Ensembl chr16:58,157,907...58,198,106
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CSNK2B
casein kinase 2 beta
ISO
RGD
PMID:16651637
RGD:11565123
NCBI chr 6:31,666,080...31,670,067
Ensembl chr 6:31,665,227...31,670,343
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DLL4
delta like canonical Notch ligand 4
treatment
ISO
RGD
PMID:26670826
RGD:155663663
NCBI chr15:40,929,340...40,939,073
Ensembl chr15:40,929,340...40,939,073
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EFNB2
ephrin B2
ISO
mRNA:increased expression:retina
RGD
PMID:26670826
RGD:155663663
NCBI chr13:106,489,745...106,535,662
Ensembl chr13:106,489,745...106,535,662
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EPHB4
EPH receptor B4
treatment
ISO
RGD
PMID:26670826
RGD:155663663
NCBI chr 7:100,802,565...100,827,523
Ensembl chr 7:100,802,565...100,827,523
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FAS
Fas cell surface death receptor
ISO
mRNA:increased expression:retina
RGD
PMID:17102953
RGD:12903974
NCBI chr10:88,964,050...89,017,059
Ensembl chr10:88,953,813...89,029,605
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FASLG
Fas ligand
ISO
RGD
PMID:17102953
RGD:12903974
NCBI chr 1:172,659,103...172,666,876
Ensembl chr 1:172,659,103...172,666,876
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GHRL
ghrelin and obestatin prepropeptide
ISO
RGD
PMID:21642627
RGD:12904963
NCBI chr 3:10,285,666...10,292,947
Ensembl chr 3:10,285,666...10,292,947
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GHSR
growth hormone secretagogue receptor
treatment
ISO
RGD
PMID:21642627
RGD:12904963
NCBI chr 3:172,443,291...172,448,456
Ensembl chr 3:172,443,291...172,448,456
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HIF1A
hypoxia inducible factor 1 subunit alpha
treatment ameliorates
ISO
mRNA:increased expression:retina (mouse)
RGD
PMID:18087198 PMID:20220049 PMID:35445044
RGD:8695923 , RGD:9068455 , RGD:329812014
NCBI chr14:61,695,513...61,748,258
Ensembl chr14:61,695,513...61,748,259
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HMGB1
high mobility group box 1
treatment
ISO
RGD
PMID:24371837
RGD:10402057
NCBI chr13:30,456,704...30,617,597
Ensembl chr13:30,456,704...30,617,597
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IGF1
insulin like growth factor 1
ISO
protein:decreased expression:serum (rat)
RGD
PMID:18344903
RGD:12910457
NCBI chr12:102,395,874...102,481,839
Ensembl chr12:102,395,874...102,481,744
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IL1B
interleukin 1 beta
ameliorates
ISO
RGD
PMID:35445044
RGD:329812014
NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816
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KDR
kinase insert domain receptor
treatment
ISO
RGD
PMID:17349140 PMID:15951738
RGD:8549715 , RGD:1581593
NCBI chr 4:55,078,481...55,125,595
Ensembl chr 4:55,078,481...55,125,595
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MAPK8
mitogen-activated protein kinase 8
ISO
RGD
PMID:19433784
RGD:10412674
NCBI chr10:48,306,677...48,439,360
Ensembl chr10:48,306,639...48,439,360
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MIR126
microRNA 126
ameliorates
ISO
RGD
PMID:21586283
RGD:401850785
NCBI chr 9:136,670,602...136,670,686
Ensembl chr 9:136,670,602...136,670,686
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MIR145
microRNA 145
ameliorates
ISO
RGD
PMID:35445044
RGD:329812014
NCBI chr 5:149,430,646...149,430,733
Ensembl chr 5:149,430,646...149,430,733
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MOBP
myelin associated oligodendrocyte basic protein
ISO
mRNA:decreased expression:retina:
RGD
PMID:21350694
RGD:10401135
NCBI chr 3:39,467,680...39,529,497
Ensembl chr 3:39,467,198...39,529,479
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NDP
norrin cystine knot growth factor NDP
treatment
ISO
RGD
PMID:20053900
RGD:8694208
NCBI chr X:43,948,776...43,973,390
Ensembl chr X:43,948,776...43,973,395
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NTN1
netrin 1
treatment
ISO
RGD
PMID:26670826
RGD:155663663
NCBI chr17:9,003,087...9,244,000
Ensembl chr17:9,021,510...9,244,000
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PPARG
peroxisome proliferator activated receptor gamma
ISO
protein:decreased expression:retina (mouse)
RGD
PMID:18806296
RGD:2301844
NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356
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PTAFR
platelet activating factor receptor
treatment
ISO
RGD
PMID:12356842
RGD:10041062
NCBI chr 1:28,147,166...28,193,856
Ensembl chr 1:28,147,166...28,193,936
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PTGER3
prostaglandin E receptor 3
ISO
protein:increased expression:retina (rat)
RGD
PMID:12821538
RGD:9850261
NCBI chr 1:70,852,358...71,047,816
Ensembl chr 1:70,852,353...71,047,816
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SERPINE1
serpin family E member 1
severity treatment
ISO
mRNA, protein:increased expression:retina (mouse)
RGD
PMID:19443721 PMID:19443721 PMID:11133880
RGD:8547749 , RGD:8547749 , RGD:13208592
NCBI chr 7:101,127,104...101,139,247
Ensembl chr 7:101,127,104...101,139,247
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SERPINF1
serpin family F member 1
treatment susceptibility
IMP ISO
human gene in a mouse model mRNA, protein:decreased expression:retina (rat)
RGD
PMID:21281801 PMID:11916948
RGD:8554878 , RGD:8655544
NCBI chr17:1,762,060...1,777,565
Ensembl chr17:1,762,029...1,777,565
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SOD1
superoxide dismutase 1
ISO
RGD
PMID:16741961
RGD:8655606
NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,666...31,668,931
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STAT3
signal transducer and activator of transcription 3
ISO
RGD
PMID:16303927
RGD:8694296
NCBI chr17:42,313,324...42,388,442
Ensembl chr17:42,313,324...42,388,568
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TNF
tumor necrosis factor
ameliorates
ISO
RGD
PMID:15681845 PMID:19342600 PMID:35445044
RGD:7394799 , RGD:7394795 , RGD:329812014
NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
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TUG1
taurine up-regulated 1
ameliorates
ISO
RGD
PMID:35445044
RGD:329812014
NCBI chr22:30,969,265...30,979,395
Ensembl chr22:30,969,245...30,979,395
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VEGFA
vascular endothelial growth factor A
ameliorates
ISO
mRNA:increased expression:retina:
RGD
PMID:15303088 PMID:35445044
RGD:7483624 , RGD:329812014
NCBI chr 6:43,770,211...43,786,487
Ensembl chr 6:43,770,184...43,786,487
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