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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Oxygen-Induced Retinopathy
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Accession:DOID:9002909 term browser browse the term
Definition:A noninflammatory disorder of the retina, involving neuronal damage induced by hypoxic conditions, that is a widely used animal model of retinopathy of prematurity (ROP).
Synonyms:exact_synonym: OIP;   OIR
 primary_id: RDO:9000037


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Oxygen-Induced Retinopathy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADIPOQ adiponectin, C1Q and collagen domain containing treatment ISO RGD PMID:19342600 RGD:7394795 NCBI chr 3:186,842,710...186,858,463
Ensembl chr 3:186,842,704...186,858,463 		JBrowse link
G AMIGO2 adhesion molecule with Ig like domain 2 treatment ISO RGD PMID:26553931 RGD:14392781 NCBI chr12:47,075,707...47,079,959
Ensembl chr12:47,075,707...47,079,959 		JBrowse link
G BCL2 BCL2 apoptosis regulator ameliorates ISO RGD PMID:35445044 RGD:329812014 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128 		JBrowse link
G CASP3 caspase 3 ameliorates ISO RGD PMID:35445044 RGD:329812014 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062 		JBrowse link
G CCL2 C-C motif chemokine ligand 2 treatment ISO mRNA:increased expression:retina (mouse) RGD PMID:16710171 PMID:19038868 RGD:8548878, RGD:11526145 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208 		JBrowse link
G CCN1 cellular communication network factor 1 ameliorates ISO RGD PMID:35445044 RGD:329812014 NCBI chr 1:85,580,761...85,583,950
Ensembl chr 1:85,580,761...85,584,589 		JBrowse link
G CSNK2A1 casein kinase 2 alpha 1 ISO RGD PMID:16651637 RGD:11565123 NCBI chr20:472,498...543,790
Ensembl chr20:472,498...543,835 		JBrowse link
G CSNK2A2 casein kinase 2 alpha 2 ISO RGD PMID:16651637 RGD:11565123 NCBI chr16:58,157,907...58,198,106
Ensembl chr16:58,157,907...58,198,106 		JBrowse link
G CSNK2B casein kinase 2 beta ISO RGD PMID:16651637 RGD:11565123 NCBI chr 6:31,666,080...31,670,067
Ensembl chr 6:31,665,227...31,670,343 		JBrowse link
G DLL4 delta like canonical Notch ligand 4 treatment ISO RGD PMID:26670826 RGD:155663663 NCBI chr15:40,929,340...40,939,073
Ensembl chr15:40,929,340...40,939,073 		JBrowse link
G EFNB2 ephrin B2 ISO mRNA:increased expression:retina RGD PMID:26670826 RGD:155663663 NCBI chr13:106,489,745...106,535,662
Ensembl chr13:106,489,745...106,535,662 		JBrowse link
G EPHB4 EPH receptor B4 treatment ISO RGD PMID:26670826 RGD:155663663 NCBI chr 7:100,802,565...100,827,523
Ensembl chr 7:100,802,565...100,827,523 		JBrowse link
G FAS Fas cell surface death receptor ISO mRNA:increased expression:retina RGD PMID:17102953 RGD:12903974 NCBI chr10:88,964,050...89,017,059
Ensembl chr10:88,953,813...89,029,605 		JBrowse link
G FASLG Fas ligand ISO RGD PMID:17102953 RGD:12903974 NCBI chr 1:172,659,103...172,666,876
Ensembl chr 1:172,659,103...172,666,876 		JBrowse link
G GHRL ghrelin and obestatin prepropeptide ISO RGD PMID:21642627 RGD:12904963 NCBI chr 3:10,285,666...10,292,947
Ensembl chr 3:10,285,666...10,292,947 		JBrowse link
G GHSR growth hormone secretagogue receptor treatment ISO RGD PMID:21642627 RGD:12904963 NCBI chr 3:172,443,291...172,448,456
Ensembl chr 3:172,443,291...172,448,456 		JBrowse link
G HIF1A hypoxia inducible factor 1 subunit alpha treatment
ameliorates		 ISO mRNA:increased expression:retina (mouse) RGD PMID:18087198 PMID:35445044 PMID:20220049 RGD:8695923, RGD:329812014, RGD:9068455 NCBI chr14:61,695,513...61,748,258
Ensembl chr14:61,695,513...61,748,259 		JBrowse link
G HMGB1 high mobility group box 1 treatment ISO RGD PMID:24371837 RGD:10402057 NCBI chr13:30,456,704...30,617,597
Ensembl chr13:30,456,704...30,617,597 		JBrowse link
G IGF1 insulin like growth factor 1 ISO protein:decreased expression:serum (rat) RGD PMID:18344903 RGD:12910457 NCBI chr12:102,395,874...102,481,839
Ensembl chr12:102,395,874...102,481,744 		JBrowse link
G IL1B interleukin 1 beta ameliorates ISO RGD PMID:35445044 RGD:329812014 NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816 		JBrowse link
G KDR kinase insert domain receptor treatment ISO RGD PMID:17349140 PMID:15951738 RGD:8549715, RGD:1581593 NCBI chr 4:55,078,481...55,125,595
Ensembl chr 4:55,078,481...55,125,595 		JBrowse link
G MAPK8 mitogen-activated protein kinase 8 ISO RGD PMID:19433784 RGD:10412674 NCBI chr10:48,306,677...48,439,360
Ensembl chr10:48,306,639...48,439,360 		JBrowse link
G MIR126 microRNA 126 ameliorates ISO RGD PMID:21586283 RGD:401850785 NCBI chr 9:136,670,602...136,670,686
Ensembl chr 9:136,670,602...136,670,686 		JBrowse link
G MIR145 microRNA 145 ameliorates ISO RGD PMID:35445044 RGD:329812014 NCBI chr 5:149,430,646...149,430,733
Ensembl chr 5:149,430,646...149,430,733 		JBrowse link
G MOBP myelin associated oligodendrocyte basic protein ISO mRNA:decreased expression:retina: RGD PMID:21350694 RGD:10401135 NCBI chr 3:39,467,680...39,529,497
Ensembl chr 3:39,467,198...39,529,479 		JBrowse link
G NDP norrin cystine knot growth factor NDP treatment ISO RGD PMID:20053900 RGD:8694208 NCBI chr  X:43,948,776...43,973,390
Ensembl chr  X:43,948,776...43,973,395 		JBrowse link
G NTN1 netrin 1 treatment ISO RGD PMID:26670826 RGD:155663663 NCBI chr17:9,003,087...9,244,000
Ensembl chr17:9,021,510...9,244,000 		JBrowse link
G PPARG peroxisome proliferator activated receptor gamma ISO protein:decreased expression:retina (mouse) RGD PMID:18806296 RGD:2301844 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356 		JBrowse link
G PTAFR platelet activating factor receptor treatment ISO RGD PMID:12356842 RGD:10041062 NCBI chr 1:28,147,166...28,193,856
Ensembl chr 1:28,147,166...28,193,936 		JBrowse link
G PTGER3 prostaglandin E receptor 3 ISO protein:increased expression:retina (rat) RGD PMID:12821538 RGD:9850261 NCBI chr 1:70,852,358...71,047,816
Ensembl chr 1:70,852,353...71,047,816 		JBrowse link
G SERPINE1 serpin family E member 1 treatment
severity		 ISO mRNA, protein:increased expression:retina (mouse) RGD PMID:19443721 PMID:11133880 PMID:19443721 RGD:8547749, RGD:13208592, RGD:8547749 NCBI chr 7:101,127,104...101,139,247
Ensembl chr 7:101,127,104...101,139,247 		JBrowse link
G SERPINF1 serpin family F member 1 treatment
susceptibility		 IMP
ISO		 human gene in a mouse model
mRNA, protein:decreased expression:retina (rat)		 RGD PMID:21281801 PMID:11916948 RGD:8554878, RGD:8655544 NCBI chr17:1,762,060...1,777,565
Ensembl chr17:1,762,029...1,777,565 		JBrowse link
G SOD1 superoxide dismutase 1 ISO RGD PMID:16741961 RGD:8655606 NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,666...31,668,931 		JBrowse link
G STAT3 signal transducer and activator of transcription 3 ISO RGD PMID:16303927 RGD:8694296 NCBI chr17:42,313,324...42,388,442
Ensembl chr17:42,313,324...42,388,568 		JBrowse link
G TNF tumor necrosis factor ameliorates ISO RGD PMID:15681845 PMID:35445044 PMID:19342600 RGD:7394799, RGD:329812014, RGD:7394795 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G TUG1 taurine up-regulated 1 ameliorates ISO RGD PMID:35445044 RGD:329812014 NCBI chr22:30,969,265...30,979,395
Ensembl chr22:30,969,245...30,979,395 		JBrowse link
G VEGFA vascular endothelial growth factor A ameliorates ISO mRNA:increased expression:retina: RGD PMID:15303088 PMID:35445044 RGD:7483624, RGD:329812014 NCBI chr 6:43,770,211...43,786,487
Ensembl chr 6:43,770,184...43,786,487 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 41189
    sensory system disease 9730
      eye disease 4942
        retinal disease 2030
          retinopathy of prematurity 56
            Oxygen-Induced Retinopathy 37
Path 2
Term Annotations click to browse term
  disease 41189
    disease of anatomical entity 32344
      nervous system disease 26233
        Neurologic Manifestations 15387
          sensory system disease 9730
            eye disease 4942
              retinal disease 2030
                retinopathy of prematurity 56
                  Oxygen-Induced Retinopathy 37
paths to the root