RGD Reference Report - Overexpression of pigment epithelium-derived factor inhibits retinal inflammation and neovascularization. - Rat Genome Database

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Overexpression of pigment epithelium-derived factor inhibits retinal inflammation and neovascularization.

Authors: Park, K  Jin, J  Hu, Y  Zhou, K  Ma, JX 
Citation: Park K, etal., Am J Pathol. 2011 Feb;178(2):688-98. doi: 10.1016/j.ajpath.2010.10.014.
RGD ID: 8554878
Pubmed: PMID:21281801   (View Abstract at PubMed)
PMCID: PMC3070578   (View Article at PubMed Central)
DOI: DOI:10.1016/j.ajpath.2010.10.014   (Journal Full-text)

Pigment epithelium-derived factor (PEDF) is a serine proteinase inhibitor with antiangiogenic activities. To investigate whether PEDF overexpression has an impact on ocular neovascularization in vivo, we generated PEDF transgenic (PEDF-Tg) mice that ubiquitously express human PEDF driven by the beta-actin promoter. The PEDF-Tg mice under normal conditions did not show any abnormalities in retinal histologic findings or visual function. In contrast, PEDF-Tg animals with oxygen-induced retinopathy (OIR) developed significantly less severe retinal neovascularization compared with wild-type (Wt) mice with OIR. In addition, PEDF-Tg mice with OIR had significantly lower vascular leakage in the retina but higher occludin levels than the Wt mice with OIR, suggesting a protective effect on the blood-retinal barrier. Furthermore, retinal levels of proinflammatory factors were significantly lower in PEDF-Tg mice with OIR than in the Wt mice with OIR. In the laser-induced choroidal neovascularization (CNV) model, the CNV area was significantly smaller in the PEDF-Tg mice than in the Wt mice. Also, the laser burn-induced overexpression of proangiogenic and inflammatory factors was observed in the retina and retinal pigment epithelium of Wt mice but not in PEDF-Tg mice. Taken together, these results suggest that overexpression of PEDF inhibits retinal inflammation and neovascularization in both the OIR and laser-induced CNV models. The PEDF-Tg mice provide a useful model for studying the roles of angiogenic inhibitors in neovascular disorders such as diabetic retinopathy.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Oxygen-Induced Retinopathy treatmentIMP 8554878human gene in a mouse modelRGD 
Oxygen-Induced Retinopathy treatmentISOSERPINF1 (Homo sapiens)8554878; 8554878human gene in a mouse modelRGD 

Objects Annotated

Genes (Rattus norvegicus)
Serpinf1  (serpin family F member 1)

Genes (Mus musculus)
Serpinf1  (serine (or cysteine) peptidase inhibitor, clade F, member 1)

Genes (Homo sapiens)
SERPINF1  (serpin family F member 1)


Additional Information