RGD Reference Report - Cyclooxygenase-2 in human and experimental ischemic proliferative retinopathy. - Rat Genome Database

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Cyclooxygenase-2 in human and experimental ischemic proliferative retinopathy.

Authors: Sennlaub, F  Valamanesh, F  Vazquez-Tello, A  El-Asrar, AM  Checchin, D  Brault, S  Gobeil, F  Beauchamp, MH  Mwaikambo, B  Courtois, Y  Geboes, K  Varma, DR  Lachapelle, P  Ong, H  Behar-Cohen, F  Chemtob, S 
Citation: Sennlaub F, etal., Circulation. 2003 Jul 15;108(2):198-204. Epub 2003 Jun 23.
RGD ID: 9850261
Pubmed: PMID:12821538   (View Abstract at PubMed)
DOI: DOI:10.1161/01.CIR.0000080735.93327.00   (Journal Full-text)

BACKGROUND: Intravitreal neovascular diseases, as in ischemic retinopathies, are a major cause of blindness. Because inflammatory mechanisms influence vitreal neovascularization and cyclooxygenase (COX)-2 promotes tumor angiogenesis, we investigated the role of COX-2 in ischemic proliferative retinopathy. METHODS AND RESULTS: We describe here that COX-2 is induced in retinal astrocytes in human diabetic retinopathy, in the murine and rat model of ischemic proliferative retinopathy in vivo, and in hypoxic astrocytes in vitro. Specific COX-2 but not COX-1 inhibitors prevented intravitreal neovascularization, whereas prostaglandin E2, mainly via its prostaglandin E receptor 3 (EP3), exacerbated neovascularization. COX-2 inhibition induced an upregulation of thrombospondin-1 and its CD36 receptor, consistent with the observed antiangiogenic effects of COX-2 inhibition; EP3 stimulation reversed effects of COX-2 inhibitors on thrombospondin-1 and CD36. CONCLUSIONS: These findings point to an important role for COX-2 in ischemic proliferative retinopathy, as in diabetes.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
PTGER3HumanOxygen-Induced Retinopathy  ISOPtger3 (Rattus norvegicus)protein:increased expression:retina (rat)RGD 
Ptger3RatOxygen-Induced Retinopathy  IEP protein:increased expression:retina (rat)RGD 
Ptger3MouseOxygen-Induced Retinopathy  ISOPtger3 (Rattus norvegicus)protein:increased expression:retina (rat)RGD 
PTGER4Humanretinal ischemia  ISOPtger4 (Rattus norvegicus)protein:decreased expression:retina (rat)RGD 
Ptger4Ratretinal ischemia  IEP protein:decreased expression:retina (rat)RGD 
Ptger4Mouseretinal ischemia  ISOPtger4 (Rattus norvegicus)protein:decreased expression:retina (rat)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ptger3  (prostaglandin E receptor 3)
Ptger4  (prostaglandin E receptor 4)

Genes (Mus musculus)
Ptger3  (prostaglandin E receptor 3 (subtype EP3))
Ptger4  (prostaglandin E receptor 4 (subtype EP4))

Genes (Homo sapiens)
PTGER3  (prostaglandin E receptor 3)
PTGER4  (prostaglandin E receptor 4)


Additional Information