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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:galaxolide
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Accession:CHEBI:83784 term browser browse the term
Definition:An organic heterotricyclic compound that is 1,3,4,6,7,8-hexahydrocyclopenta[g]isochromene substituted by methyl groups at positions 4, 6, 6, 7, 8 and 8 respectively. It is a synthetic musk used as a fragrance in cosmetics.
Synonyms:exact_synonym: 4,6,6,7,8,8-hexamethyl-1,3,4,6,7,8-hexahydrocyclopenta[g]isochromene
 related_synonym: 1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethyl-cyclopenta-gamma-2-benzopyran;   1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethylindeno[5,6-c]pyran;   Formula=C18H26O;   InChI=1S/C18H26O/c1-11-9-19-10-13-7-15-16(8-14(11)13)18(5,6)12(2)17(15,3)4/h7-8,11-12H,9-10H2,1-6H3;   InChIKey=ONKNPOPIGWHAQC-UHFFFAOYSA-N;   SMILES=CC1C(C)(C)c2cc3COCC(C)c3cc2C1(C)C
 xref: CAS:1222-05-5
 xref_mesh: MESH:C033119
 xref: PMID:22489002;   PMID:24357097;   PMID:24659337;   PMID:24845313;   Patent:CN103784385;   Patent:CN103911214;   Reaxys:8147764;   Wikipedia:Galaxolide


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galaxolide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions ISO galaxolide binds to and results in decreased activity of AR protein; galaxolide inhibits the reaction [Metribolone results in increased activity of AR protein] CTD PMID:15537743 PMID:17762842 PMID:29427707 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Camk2d calcium/calmodulin-dependent protein kinase II delta increases expression EXP galaxolide results in increased expression of CAMK2D mRNA CTD PMID:37797914 NCBI chr 2:215,023,785...215,287,351
Ensembl chr 2:215,024,004...215,286,178 		JBrowse link
G Ces1d carboxylesterase 1D decreases activity ISO galaxolide results in decreased activity of CES1 protein CTD PMID:22489002 NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035 		JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 multiple interactions
decreases expression
increases activity
decreases activity		 ISO
EXP		 [galaxolide co-treated with Cyclic AMP] results in decreased activity of CYP17A1 protein; [galaxolide co-treated with Cyclic AMP] results in increased activity of CYP17A1 protein
galaxolide results in decreased expression of CYP17A1 mRNA
galaxolide results in increased activity of CYP17A1 protein
galaxolide results in decreased activity of CYP17A1 protein		 CTD PMID:23084589 PMID:37797914 NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573 		JBrowse link
G Dhcr7 7-dehydrocholesterol reductase decreases expression EXP galaxolide results in decreased expression of DHCR7 mRNA CTD PMID:37797914 NCBI chr 1:199,015,081...199,031,055
Ensembl chr 1:199,015,081...199,031,055 		JBrowse link
G Dmrtc1c1 DMRT-like family C1c1 increases expression EXP galaxolide results in increased expression of DMRTC1C1 mRNA CTD PMID:37797914 NCBI chr  X:67,896,973...67,904,182
Ensembl chr  X:67,896,974...67,904,182 		JBrowse link
G Dnajc19 DnaJ heat shock protein family (Hsp40) member C19 decreases expression EXP galaxolide results in decreased expression of DNAJC19 mRNA CTD PMID:37797914 NCBI chr 2:116,923,272...116,945,312
Ensembl chr 2:116,923,272...116,945,264 		JBrowse link
G Egfr epidermal growth factor receptor increases expression
multiple interactions		 ISO galaxolide results in increased expression of EGFR mRNA
[galaxolide co-treated with acetyl methyl tetramethyl tetralin] results in increased expression of EGFR mRNA		 CTD PMID:34687775 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO galaxolide binds to and results in increased activity of ESR1 protein CTD PMID:17762842 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO galaxolide binds to and results in decreased activity of ESR2 protein CTD PMID:15537743 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Fshb follicle stimulating hormone subunit beta increases expression EXP galaxolide results in increased expression of FSHB protein CTD PMID:37797914 NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370 		JBrowse link
G Fshr follicle stimulating hormone receptor increases expression EXP galaxolide results in increased expression of FSHR mRNA CTD PMID:37797914 NCBI chr 6:5,198,825...5,406,785
Ensembl chr 6:5,198,825...5,406,785 		JBrowse link
G Gnrhr gonadotropin releasing hormone receptor increases expression EXP galaxolide results in increased expression of GNRHR mRNA CTD PMID:37797914 NCBI chr14:21,856,871...21,874,861
Ensembl chr14:21,856,871...21,874,861 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases expression
multiple interactions		 ISO galaxolide results in increased expression of HIF1A mRNA
[galaxolide co-treated with acetyl methyl tetramethyl tetralin] results in increased expression of HIF1A mRNA; galaxolide inhibits the reaction [acetyl methyl tetramethyl tetralin results in increased expression of HIF1A mRNA]; galaxolide inhibits the reaction [acetyl methyl tetramethyl tetralin results in increased expression of HIF1A protein]		 CTD PMID:34687775 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hsd3b2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 multiple interactions
decreases expression		 ISO [galaxolide results in decreased expression of [HSD3B2 co-treated with CYP21A2]] which results in decreased chemical synthesis of Hydrocortisone; [galaxolide results in decreased expression of [HSD3B2 co-treated with CYP21A2]] which results in decreased chemical synthesis of Progesterone
galaxolide results in decreased expression of HSD3B2		 CTD PMID:23084589 NCBI chr 2:186,095,897...186,105,354
Ensembl chr 2:186,095,897...186,101,852 		JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions		 ISO galaxolide results in increased expression of IL6 mRNA
[galaxolide co-treated with acetyl methyl tetramethyl tetralin] results in increased expression of IL6 mRNA		 CTD PMID:34687775 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Jak2 Janus kinase 2 increases expression
multiple interactions		 ISO galaxolide results in increased expression of JAK2 mRNA
[galaxolide co-treated with acetyl methyl tetramethyl tetralin] results in increased expression of JAK2 mRNA		 CTD PMID:34687775 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189 		JBrowse link
G Kdr kinase insert domain receptor multiple interactions ISO [galaxolide co-treated with acetyl methyl tetramethyl tetralin] results in increased expression of KDR mRNA CTD PMID:34687775 NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018 		JBrowse link
G Lhb luteinizing hormone subunit beta increases expression EXP galaxolide results in increased expression of LHB protein CTD PMID:37797914 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972 		JBrowse link
G Map3k2 mitogen activated protein kinase kinase kinase 2 increases expression EXP galaxolide results in increased expression of MAP3K2 mRNA CTD PMID:37797914 NCBI chr18:23,807,218...23,879,722
Ensembl chr18:23,807,218...23,871,433 		JBrowse link
G Mir155 microRNA 155 multiple interactions ISO [galaxolide co-treated with acetyl methyl tetramethyl tetralin] results in increased expression of MIR155 mRNA; galaxolide inhibits the reaction [acetyl methyl tetramethyl tetralin results in increased expression of MIR155 mRNA] CTD PMID:34687775 NCBI chr11:23,774,654...23,774,718
Ensembl chr11:23,774,654...23,774,718 		JBrowse link
G Mir17 microRNA 17 decreases expression
multiple interactions		 ISO galaxolide results in decreased expression of MIR17 mRNA
[galaxolide co-treated with acetyl methyl tetramethyl tetralin] results in decreased expression of MIR17 mRNA		 CTD PMID:34687775 NCBI chr15:92,180,629...92,180,712
Ensembl chr15:92,180,629...92,180,712 		JBrowse link
G Mir19b1 microRNA 19b-1 decreases expression
multiple interactions		 ISO galaxolide results in decreased expression of MIR19B1 mRNA
[galaxolide co-treated with acetyl methyl tetramethyl tetralin] results in decreased expression of MIR19B1 mRNA		 CTD PMID:34687775 NCBI chr15:92,181,214...92,181,300
Ensembl chr15:92,181,214...92,181,300 		JBrowse link
G Mir20a microRNA 20a multiple interactions
decreases expression		 ISO [galaxolide co-treated with acetyl methyl tetramethyl tetralin] results in decreased expression of MIR20A mRNA
galaxolide results in decreased expression of MIR20A mRNA		 CTD PMID:34687775 NCBI chr15:92,181,084...92,181,168
Ensembl chr15:92,181,084...92,181,168 		JBrowse link
G Mir92a1 microRNA 92a-1 decreases expression
multiple interactions		 ISO galaxolide results in decreased expression of MIR92A1 mRNA
[galaxolide co-treated with acetyl methyl tetramethyl tetralin] results in decreased expression of MIR92A1 mRNA		 CTD PMID:34687775 NCBI chr15:92,181,336...92,181,413
Ensembl chr15:92,181,336...92,181,413 		JBrowse link
G Mir93 microRNA 93 multiple interactions ISO [galaxolide co-treated with acetyl methyl tetramethyl tetralin] results in increased expression of MIR93 mRNA; galaxolide promotes the reaction [acetyl methyl tetramethyl tetralin results in increased expression of MIR93 mRNA] CTD PMID:34687775 NCBI chr12:17,043,135...17,043,221
Ensembl chr12:17,043,135...17,043,221 		JBrowse link
G Mmp3 matrix metallopeptidase 3 increases expression
multiple interactions		 ISO galaxolide results in increased expression of MMP3 mRNA
[galaxolide co-treated with acetyl methyl tetramethyl tetralin] results in increased expression of MMP3 mRNA		 CTD PMID:34687775 NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
increases expression		 ISO [galaxolide co-treated with acetyl methyl tetramethyl tetralin] results in increased expression of MMP9 mRNA; [galaxolide co-treated with acetyl methyl tetramethyl tetralin] results in increased expression of MMP9 protein
galaxolide results in increased expression of MMP9 mRNA; galaxolide results in increased expression of MMP9 protein		 CTD PMID:34687775 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Pgr progesterone receptor multiple interactions ISO galaxolide binds to and results in decreased activity of PGR protein CTD PMID:15537743 NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344 		JBrowse link
G Snai1 snail family transcriptional repressor 1 increases expression
multiple interactions		 ISO galaxolide results in increased expression of SNAI1 mRNA
[galaxolide co-treated with acetyl methyl tetramethyl tetralin] results in increased expression of SNAI1 mRNA		 CTD PMID:34687775 NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969 		JBrowse link
G Snai2 snail family transcriptional repressor 2 multiple interactions
increases expression		 ISO [galaxolide co-treated with acetyl methyl tetramethyl tetralin] results in increased expression of SNAI2 mRNA; galaxolide promotes the reaction [acetyl methyl tetramethyl tetralin results in increased expression of SNAI2 mRNA]
galaxolide results in increased expression of SNAI2 mRNA		 CTD PMID:34687775 NCBI chr11:86,182,788...86,186,203
Ensembl chr11:86,181,909...86,186,200 		JBrowse link
G Srd5a2 steroid 5 alpha-reductase 2 decreases expression EXP galaxolide results in decreased expression of SRD5A2 mRNA CTD PMID:37797914 NCBI chr 6:21,426,225...21,465,727
Ensembl chr 6:21,426,215...21,462,112 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 increases expression
multiple interactions		 ISO galaxolide results in increased expression of STAT3 mRNA
[galaxolide co-treated with acetyl methyl tetramethyl tetralin] results in increased expression of STAT3 mRNA		 CTD PMID:34687775 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Tex14 testis expressed 14, intercellular bridge forming factor decreases expression EXP galaxolide results in decreased expression of TEX14 mRNA CTD PMID:37797914 NCBI chr10:72,231,766...72,356,938
Ensembl chr10:72,231,801...72,355,805 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions
increases expression		 ISO [galaxolide co-treated with acetyl methyl tetramethyl tetralin] results in increased expression of VEGFA mRNA; galaxolide inhibits the reaction [acetyl methyl tetramethyl tetralin results in increased expression of VEGFA protein]
galaxolide results in increased expression of VEGFA mRNA		 CTD PMID:34687775 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
G Vim vimentin multiple interactions
increases expression		 ISO [galaxolide co-treated with acetyl methyl tetramethyl tetralin] results in increased expression of VIM mRNA; galaxolide inhibits the reaction [acetyl methyl tetramethyl tetralin results in increased expression of VIM mRNA]
galaxolide results in increased expression of VIM mRNA		 CTD PMID:34687775 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187 		JBrowse link
G Zeb1 zinc finger E-box binding homeobox 1 multiple interactions
increases expression		 ISO acetyl methyl tetramethyl tetralin promotes the reaction [galaxolide results in increased expression of ZEB1 mRNA]; galaxolide promotes the reaction [acetyl methyl tetramethyl tetralin results in increased expression of ZEB1 mRNA] CTD PMID:34687775 NCBI chr17:51,948,948...52,116,018
Ensembl chr17:51,948,948...52,115,214 		JBrowse link
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  CHEBI ontology 19841
    role 19817
      application 19661
        fragrance 1000
          galaxolide 37
Path 2
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  CHEBI ontology 19841
    subatomic particle 19839
      composite particle 19839
        hadron 19839
          baryon 19839
            nucleon 19839
              atomic nucleus 19839
                atom 19839
                  main group element atom 19789
                    p-block element atom 19789
                      carbon group element atom 19737
                        carbon atom 19733
                          organic molecular entity 19733
                            organic molecule 19686
                              organic cyclic compound 19498
                                organic heterocyclic compound 18876
                                  oxacycle 17888
                                    benzopyran 11957
                                      2-benzopyran 1469
                                        isochromenes 1469
                                          galaxolide 37
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