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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:olmesartan
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Accession:CHEBI:48416 term browser browse the term
Definition:A biphenylyltetrazole that has formula C24H26N6O3.
Synonyms:exact_synonym: 4-(1-hydroxy-1-methylethyl)-2-propyl-1-{[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl}-1H-imidazole-5-carboxylic acid
 related_synonym: 4-(1-hydroxy-1-methylethyl)-2-propyl-1-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazole-5-carboxylic acid;   4-(hydroxy-1-methylethyl)-2-propyl-1-{[2'-(1H-tetrazol-5-yl)-1,1'-biphenyl-4-yl]methyl}-1H-imidazole-5-carboxylic acid;   Formula=C24H26N6O3;   InChI=1S/C24H26N6O3/c1-4-7-19-25-21(24(2,3)33)20(23(31)32)30(19)14-15-10-12-16(13-11-15)17-8-5-6-9-18(17)22-26-28-29-27-22/h5-6,8-13,33H,4,7,14H2,1-3H3,(H,31,32)(H,26,27,28,29);   InChIKey=VTRAEEWXHOVJFV-UHFFFAOYSA-N;   SMILES=CCCc1nc(c(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1)C(C)(C)O
 alt_id: MESH:C437965
 xref: Beilstein:7502669;   CAS:144689-24-7;   DrugBank:DB00275;   LINCS:LSM-5893
 xref_mesh: MESH:C097933
 xref: Wikipedia:Olmesartan


show annotations for term's descendants           Sort by:
olmesartan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions
decreases activity		 ISO olmesartan inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
olmesartan results in decreased activity of ABCB11 protein		 CTD PMID:24014644 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 affects transport ISO ABCC2 protein affects the transport of olmesartan CTD PMID:19505989 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Ace2 angiotensin converting enzyme 2 increases expression EXP olmesartan results in increased expression of ACE2 mRNA; olmesartan results in increased expression of ACE2 protein CTD PMID:19171689 PMID:28656296 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977 		JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP olmesartan inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]; olmesartan inhibits the reaction [Fish Oils inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]] CTD PMID:24144775 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Agt angiotensinogen decreases expression
multiple interactions		 EXP
ISO		 olmesartan results in decreased expression of AGT protein modified form
[olmesartan co-treated with PD 123319] inhibits the reaction [AGT protein modified form results in increased abundance of Fatty Acids, Nonesterified]; [olmesartan co-treated with PD 123319] inhibits the reaction [AGT protein modified form results in increased secretion of and results in increased abundance of Triglycerides]		 CTD PMID:16003179 PMID:19171689 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a decreases activity ISO olmesartan results in decreased activity of AGTR1 protein CTD PMID:17208988 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP [Pravastatin co-treated with olmesartan] results in increased phosphorylation of AKT1 protein CTD PMID:17170375 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Alb albumin decreases oxidation ISO olmesartan results in decreased oxidation of ALB protein CTD PMID:17587751 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator decreases expression ISO olmesartan results in decreased expression of BAX protein CTD PMID:17208988 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO olmesartan results in decreased expression of and results in decreased activity of CASP3 protein CTD PMID:17208988 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Crp C-reactive protein decreases expression ISO olmesartan results in decreased expression of CRP protein CTD PMID:18360012 NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178 		JBrowse link
G Cyba cytochrome b-245 alpha chain decreases expression EXP olmesartan results in decreased expression of CYBA protein CTD PMID:17170375 NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721 		JBrowse link
G Daxx death-domain associated protein decreases expression ISO olmesartan results in decreased expression of DAXX protein CTD PMID:17208988 NCBI chr20:4,970,090...4,976,145
Ensembl chr20:4,970,092...4,975,843 		JBrowse link
G Dhfr dihydrofolate reductase increases expression EXP olmesartan results in increased expression of DHFR protein CTD PMID:17170375 NCBI chr 2:23,585,876...23,611,199
Ensembl chr 2:23,586,031...23,613,713 		JBrowse link
G Fas Fas cell surface death receptor decreases expression ISO olmesartan results in decreased expression of FAS protein CTD PMID:17208988 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Il18 interleukin 18 multiple interactions EXP olmesartan inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA] CTD PMID:18660453 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Il6 interleukin 6 decreases expression ISO olmesartan results in decreased expression of IL6 protein CTD PMID:18360012 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit decreases activity ISO olmesartan results in decreased activity of JUN protein CTD PMID:17208988 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 multiple interactions EXP Olmesartan inhibits the reaction [Angiotensin II increases phosphorylation of Map3k7 protein in the heart] RGD PMID:26706286 RGD:155791673 NCBI chr 5:46,356,973...46,415,597
Ensembl chr 5:46,357,931...46,415,597 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases expression ISO olmesartan results in increased expression of MAPK1 protein modified form CTD PMID:17208988 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases expression ISO olmesartan results in increased expression of MAPK3 protein modified form CTD PMID:17208988 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 decreases expression
decreases activity		 ISO olmesartan results in decreased expression of MAPK8 protein modified form
olmesartan results in decreased activity of MAPK8 protein		 CTD PMID:17208988 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 decreases expression
decreases activity		 ISO olmesartan results in decreased expression of MAPK9 protein modified form
olmesartan results in decreased activity of MAPK9 protein		 CTD PMID:17208988 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178 		JBrowse link
G Mas1 MAS1 proto-oncogene, G protein-coupled receptor increases expression EXP olmesartan results in increased expression of MAS1 mRNA; olmesartan results in increased expression of MAS1 protein CTD PMID:28656296 NCBI chr 1:47,879,956...47,911,500
Ensembl chr 1:47,880,309...47,911,709 		JBrowse link
G Mpo myeloperoxidase multiple interactions EXP olmesartan inhibits the reaction [Carbon Tetrachloride results in increased activity of MPO protein]; olmesartan inhibits the reaction [Fish Oils inhibits the reaction [Carbon Tetrachloride results in increased activity of MPO protein]] CTD PMID:24144775 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions EXP olmesartan promotes the reaction [NOS3 protein binds to NOS3 protein]; olmesartan results in increased activity of and results in increased phosphorylation of NOS3 protein; Pravastatin promotes the reaction [olmesartan results in increased activity of and results in increased phosphorylation of NOS3 protein] CTD PMID:17170375 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Nphs1 NPHS1 adhesion molecule, nephrin increases expression ISO Olmesartan increases expression of Nphs1 protein in kidney RGD PMID:17229913 RGD:38599164 NCBI chr 1:85,720,812...85,749,079
Ensembl chr 1:85,720,812...85,749,078 		JBrowse link
G Pdgfrb platelet derived growth factor receptor beta multiple interactions EXP olmesartan inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFRB protein]; olmesartan inhibits the reaction [Fish Oils inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFRB protein]] CTD PMID:24144775 NCBI chr18:54,499,962...54,538,840
Ensembl chr18:54,499,964...54,538,843 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP olmesartan inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]; olmesartan inhibits the reaction [Fish Oils inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]] CTD PMID:24144775 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
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Term Annotations click to browse term
  CHEBI ontology 19848
    role 19824
      application 19668
        pharmaceutical 19508
          drug 19508
            cardiovascular drug 8635
              antihypertensive agent 1946
                olmesartan 29
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  CHEBI ontology 19848
    subatomic particle 19846
      composite particle 19846
        hadron 19846
          baryon 19846
            nucleon 19846
              atomic nucleus 19846
                atom 19846
                  main group element atom 19796
                    p-block element atom 19796
                      carbon group element atom 19741
                        carbon atom 19737
                          organic molecular entity 19737
                            organic molecule 19690
                              organic cyclic compound 19501
                                organic heterocyclic compound 18878
                                  heteroarene 17137
                                    monocyclic heteroarene 14871
                                      azole 14375
                                        tetrazoles 365
                                          biphenylyltetrazole 332
                                            olmesartan 29
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