biphenylyltetrazole - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	biphenylyltetrazole	go back to main search page
Accession:	CHEBI:48420	browse the term
Definition:	A member of the class of biphenyls that consists of a biphenyl ring system substituted by a tetrazole ring at an unspecified position.
Synonyms:	related_synonym:	biphenylyltetrazoles

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Genes (333)

candesartan

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

angiotensin I converting enzyme

affects expression

candesartan affects the expression of ACE mRNA

NCBI chr10:91,410,129...91,430,246
Ensembl chr10:90,910,316...90,931,131

G

angiotensin converting enzyme 2

decreases expression

candesartan results in decreased expression of ACE2 mRNA

NCBI chr X:33,925,458...33,972,851
Ensembl chr X:30,293,589...30,340,977

G

adiponectin, C1Q and collagen domain containing

multiple interactions
decreases expression
increases expression

[candesartan co-treated with Fenofibrate] results in increased expression of ADIPOQ protein; candesartan promotes the reaction [Ramipril results in increased expression of ADIPOQ]; Ramipril promotes the reaction [candesartan results in increased expression of ADIPOQ]
candesartan results in decreased expression of ADIPOQ
candesartan results in increased expression of ADIPOQ; candesartan results in increased expression of ADIPOQ protein

PMID:16443859 PMID:17483542 PMID:19059660

NCBI chr11:91,226,524...91,240,244
Ensembl chr11:77,721,912...77,735,564

G

angiotensinogen

multiple interactions

candesartan inhibits the reaction [[AGT co-treated with REN] results in increased abundance of Aldosterone]; candesartan inhibits the reaction [AGT protein results in increased chemical synthesis of Nitric Oxide]; candesartan inhibits the reaction [AGT protein results in increased chemical synthesis of Reactive Oxygen Species]
candesartan inhibits the reaction [AGT protein inhibits the reaction [Glycochenodeoxycholic Acid results in increased activity of CASP3 protein]]; candesartan inhibits the reaction [AGT protein promotes the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]]; candesartan inhibits the reaction [AGT protein results in increased expression of ENG mRNA]; candesartan inhibits the reaction [AGT protein results in increased expression of ENG protein]; candesartan inhibits the reaction [AGT protein results in increased expression of IL6 protein]; candesartan inhibits the reaction [AGT protein results in increased expression of PTHLH mRNA]; candesartan inhibits the reaction [AGT protein results in increased expression of PTHLH protein]; candesartan inhibits the reaction [AGT protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; candesartan inhibits the reaction [AGT protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]; candesartan inhibits the reaction [Folic Acid results in increased localization of [AGT protein binds to AGTR1A protein]]
candesartan inhibits the reaction [AGT protein modified form results in increased expression of COL1A2 protein]; candesartan inhibits the reaction [AGT results in increased expression of NOS3 protein]; candesartan inhibits the reaction [AGT results in increased expression of PTGS2 protein]; candesartan inhibits the reaction [AGT results in increased expression of VEGFA protein]

PMID:10525314 PMID:11729239 PMID:12065685 PMID:15539634 PMID:15728788 More...

NCBI chr19:69,426,540...69,447,017
Ensembl chr19:52,529,185...52,540,977

G

angiotensin II receptor, type 1a

multiple interactions
decreases expression

candesartan binds to and results in decreased activity of AGTR1 protein
candesartan inhibits the reaction [Folic Acid results in increased localization of [AGT protein binds to AGTR1A protein]]
candesartan results in decreased expression of AGTR1A mRNA

PMID:15728788 PMID:18796534 PMID:21474964

NCBI chr17:34,383,397...34,435,523
Ensembl chr17:34,174,429...34,226,946

G

angiotensin II receptor, type 2

multiple interactions
decreases expression

[PD 123319 binds to and results in decreased activity of AGTR2 protein] inhibits the reaction [candesartan results in increased expression of NOS3 protein]
candesartan results in decreased expression of AGTR2 mRNA

PMID:18551021 PMID:18796534

NCBI chr X:116,914,320...116,918,504
Ensembl chr X:112,120,228...112,124,057

G

A-kinase anchoring protein 11

increases expression

candesartan results in increased expression of AKAP11 mRNA

NCBI chr15:60,320,839...60,365,480
Ensembl chr15:53,911,657...53,941,605

G

aldo-keto reductase family 1 member B1

decreases expression

candesartan results in decreased expression of AKR1B1 mRNA

NCBI chr 4:63,899,222...63,913,315
Ensembl chr 4:62,932,031...62,946,157

G

AKT serine/threonine kinase 1

decreases phosphorylation

candesartan results in decreased phosphorylation of AKT1 protein

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921

G

autophagy related 5

multiple interactions

candesartan inhibits the reaction [Galactose results in decreased expression of ATG5 mRNA]

NCBI chr20:49,380,835...49,471,826
Ensembl chr20:47,798,290...47,889,209

G

ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2

multiple interactions

candesartan inhibits the reaction [Isoproterenol results in decreased expression of ATP2A2 protein]

NCBI chr12:39,733,519...39,782,942
Ensembl chr12:34,072,683...34,122,101

G

BCL2 associated X, apoptosis regulator

increases expression

candesartan results in increased expression of BAX mRNA; candesartan results in increased expression of BAX protein

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368

G

bradykinin receptor B2

decreases expression

candesartan results in decreased expression of BDKRB2 mRNA

NCBI chr 6:130,237,055...130,267,205
Ensembl chr 6:124,472,566...124,502,497

G

beclin 1

multiple interactions

candesartan inhibits the reaction [Galactose results in decreased expression of BECN1 mRNA]

NCBI chr10:86,731,649...86,747,002
Ensembl chr10:86,231,388...86,246,742

G

carbonic anhydrase 1

decreases activity

candesartan results in decreased activity of CA1 protein

NCBI chr 2:88,550,681...88,593,454
Ensembl chr 2:86,861,897...86,872,208

G

caspase 3

multiple interactions

[candesartan co-treated with epigallocatechin gallate] inhibits the reaction [Gentamicins results in increased expression of CASP3 protein]; candesartan inhibits the reaction [AGT protein inhibits the reaction [Glycochenodeoxycholic Acid results in increased activity of CASP3 protein]]; candesartan inhibits the reaction [Gentamicins results in increased expression of CASP3 protein]

PMID:23300732 PMID:30368989

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648

G

catalase

multiple interactions

candesartan inhibits the reaction [Galactose results in decreased activity of CAT protein]

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478

G

cellular communication network factor 2

decreases expression

candesartan results in decreased expression of CCN2 mRNA

NCBI chr 1:22,621,498...22,624,614
Ensembl chr 1:20,802,199...20,805,734

G

CD36 molecule

multiple interactions
decreases expression
increases expression

T 0070907 inhibits the reaction [candesartan results in increased expression of CD36 mRNA]
candesartan results in decreased expression of CD36 mRNA

PMID:14871019 PMID:22124178

NCBI chr 4:18,209,088...18,302,142
Ensembl chr 4:17,354,466...17,513,903

G

CD40 ligand

multiple interactions
decreases expression

candesartan promotes the reaction [Fenofibrate results in decreased expression of CD40LG protein]; Fenofibrate promotes the reaction [candesartan results in decreased expression of CD40LG protein]

NCBI chr X:140,164,341...140,176,057
Ensembl chr X:135,126,969...135,138,306

G

collagen type I alpha 2 chain

multiple interactions

candesartan inhibits the reaction [AGT protein modified form results in increased expression of COL1A2 protein]

NCBI chr 4:33,518,557...33,553,484
Ensembl chr 4:32,563,381...32,598,867

G

cysteine-rich secretory protein LCCL domain containing 2

decreases expression

candesartan results in decreased expression of CRISPLD2 mRNA

NCBI chr19:64,961,764...65,020,099
Ensembl chr19:48,053,287...48,110,465

G

C-reactive protein

multiple interactions
decreases expression

candesartan promotes the reaction [Fenofibrate results in decreased expression of CRP protein]; Fenofibrate promotes the reaction [candesartan results in decreased expression of CRP protein]

PMID:14620923 PMID:16443859

NCBI chr13:87,694,062...87,695,978
Ensembl chr13:85,124,977...85,175,178

G

C-X-C motif chemokine ligand 1

multiple interactions

candesartan inhibits the reaction [Indomethacin results in increased expression of CXCL1 protein]

NCBI chr14:17,477,542...17,479,321
Ensembl chr14:17,193,365...17,195,215

G

cytochrome b-245 alpha chain

decreases expression
multiple interactions

candesartan results in decreased expression of CYBA protein
candesartan results in decreased expression of CYBA; candesartan results in decreased expression of CYBA mRNA
Amlodipine promotes the reaction [candesartan results in decreased expression of CYBA]; candesartan inhibits the reaction [Streptozocin results in increased expression of CYBA mRNA]; Hydrochlorothiazide promotes the reaction [candesartan results in decreased expression of CYBA]

PMID:16139267 PMID:16685210 PMID:18551021 PMID:21107329

NCBI chr19:67,396,143...67,404,214
Ensembl chr19:50,487,597...50,495,721

G

cytochrome b-245 beta chain

multiple interactions
decreases expression

Amlodipine promotes the reaction [candesartan results in decreased expression of CYBB]; Hydrochlorothiazide promotes the reaction [candesartan results in decreased expression of CYBB]
candesartan results in decreased expression of CYBB; candesartan results in decreased expression of CYBB mRNA

PMID:16685210 PMID:21107329

NCBI chr X:16,030,596...16,065,065
Ensembl chr X:13,359,430...13,392,586

G

cytochrome P450, family 11, subfamily b, polypeptide 3

affects response to substance
decreases expression

CYP11B2 protein polymorphism affects the susceptibility to candesartan
candesartan results in decreased expression of CYP11B2 mRNA

PMID:12065207 PMID:18796534

NCBI chr 7:108,689,319...108,694,808
Ensembl chr 7:106,808,559...106,814,048

G

endoglin

multiple interactions

candesartan inhibits the reaction [AGT protein results in increased expression of ENG mRNA]; candesartan inhibits the reaction [AGT protein results in increased expression of ENG protein]

NCBI chr 3:36,332,190...36,370,324
Ensembl chr 3:15,934,518...15,973,230

G

Fas ligand

multiple interactions

candesartan inhibits the reaction [Daunorubicin results in increased expression of FASLG protein]

NCBI chr13:76,680,885...76,706,042
Ensembl chr13:74,154,954...74,162,215

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions

candesartan inhibits the reaction [[Acetaldehyde co-treated with Cyanamide] results in increased expression of FOS protein]; candesartan inhibits the reaction [Acetaldehyde promotes the reaction [Cyanamide results in increased expression of FOS protein]]

NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:105,121,170...105,124,036

G

forkhead box O1

multiple interactions

[GCG protein co-treated with candesartan] inhibits the reaction [Palmitic Acid results in decreased phosphorylation of FOXO1 protein]; candesartan inhibits the reaction [Palmitic Acid results in decreased phosphorylation of FOXO1 protein]

NCBI chr 2:138,462,974...138,541,420
Ensembl chr 2:136,312,168...136,387,790

G

glucagon

multiple interactions

[GCG protein co-treated with candesartan] inhibits the reaction [Palmitic Acid results in decreased phosphorylation of FOXO1 protein]; [GCG protein co-treated with candesartan] inhibits the reaction [Palmitic Acid results in decreased phosphorylation of IRS2 protein]

NCBI chr 3:67,522,489...67,531,533
Ensembl chr 3:47,113,914...47,122,929

G

glial cell derived neurotrophic factor

multiple interactions

candesartan inhibits the reaction [Galactose results in decreased expression of GDNF mRNA]

NCBI chr 2:58,621,327...58,647,242
Ensembl chr 2:56,895,010...56,917,209

G

heat shock protein family E (Hsp10) member 1

decreases expression

candesartan results in decreased expression of HSPE1 mRNA

NCBI chr 9:64,084,327...64,087,415
Ensembl chr 9:56,589,789...56,593,089

G

intercellular adhesion molecule 1

multiple interactions

candesartan inhibits the reaction [Streptozocin results in increased expression of ICAM1 protein]

NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:19,553,645...19,565,438

G

inhibitor of DNA binding 1

decreases expression

candesartan results in decreased expression of ID1 mRNA

NCBI chr 3:161,671,525...161,672,691
Ensembl chr 3:141,211,267...141,212,419

G

interleukin 1 beta

multiple interactions

[candesartan co-treated with epigallocatechin gallate] inhibits the reaction [Gentamicins results in increased expression of IL1B protein]; candesartan inhibits the reaction [Gentamicins results in increased expression of IL1B protein]

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

multiple interactions

candesartan inhibits the reaction [AGT protein promotes the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]]; candesartan inhibits the reaction [AGT protein results in increased expression of IL6 protein]

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178

G

insulin receptor substrate 2

multiple interactions

[GCG protein co-treated with candesartan] inhibits the reaction [Palmitic Acid results in decreased phosphorylation of IRS2 protein]; candesartan inhibits the reaction [Palmitic Acid results in decreased phosphorylation of IRS2 protein]

NCBI chr16:85,190,310...85,214,543
Ensembl chr16:78,485,045...78,512,482

G

potassium calcium-activated channel subfamily N member 4

decreases expression

candesartan decreases expression of KCNN4 mRNA and protein in CD4-positive, alpha-beta T cell

RGD

NCBI chr 1:89,084,306...89,102,279
Ensembl chr 1:79,959,322...79,974,340

G

kallikrein 1

decreases expression

candesartan results in decreased expression of KLK1 mRNA

NCBI chr 1:103,779,152...103,783,270
Ensembl chr 1:94,642,687...94,646,754

G

leptin

multiple interactions
increases response to substance
decreases expression

candesartan promotes the reaction [Ramipril results in increased expression of LEP]; Ramipril promotes the reaction [candesartan results in increased expression of LEP]
LEP protein results in increased susceptibility to candesartan
candesartan results in decreased expression of LEP

PMID:17483542 PMID:19059660 PMID:21287150

NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:57,661,131...57,675,262

G

mitogen activated protein kinase 1

multiple interactions

candesartan inhibits the reaction [AGT protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions

candesartan inhibits the reaction [AGT protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863

G

mitogen-activated protein kinase 8

multiple interactions

candesartan inhibits the reaction [Isoproterenol results in increased phosphorylation of MAPK8 protein]

NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,638,924...8,721,981

G

matrix metallopeptidase 13

increases expression

candesartan results in increased expression of MMP13 protein

NCBI chr 8:12,782,829...12,793,108
Ensembl chr 8:4,497,960...4,508,239

G

matrix metallopeptidase 15

increases expression

candesartan results in increased expression of MMP15 mRNA

NCBI chr19:9,669,506...9,691,000
Ensembl chr19:9,663,449...9,684,943

G

matrix metallopeptidase 9

decreases expression

candesartan results in decreased expression of MMP9 mRNA; candesartan results in decreased expression of MMP9 protein

NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:153,683,858...153,692,120

G

myeloperoxidase

multiple interactions

candesartan inhibits the reaction [Indomethacin results in increased activity of MPO protein]

NCBI chr10:73,092,124...73,102,057
Ensembl chr10:72,594,661...72,604,819

G

nitric oxide synthase 2

multiple interactions

candesartan inhibits the reaction [Streptozocin results in increased expression of NOS2 protein]

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210

G

nitric oxide synthase 3

multiple interactions

[PD 123319 binds to and results in decreased activity of AGTR2 protein] inhibits the reaction [candesartan results in increased expression of NOS3 protein]
candesartan inhibits the reaction [Streptozocin results in increased expression of NOS3 mRNA]; candesartan inhibits the reaction [Streptozocin results in increased expression of NOS3 protein]
candesartan inhibits the reaction [AGT results in increased expression of NOS3 protein]

PMID:12065685 PMID:16139267 PMID:18551021

NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:10,793,834...10,814,166

G

NADPH oxidase 1

multiple interactions
decreases expression

Amlodipine promotes the reaction [candesartan results in decreased expression of NOX1]; Hydrochlorothiazide promotes the reaction [candesartan results in decreased expression of NOX1]

NCBI chr X:101,572,338...101,625,571
Ensembl chr X:97,279,056...97,302,236

G

NADPH oxidase 4

decreases expression
multiple interactions

candesartan results in decreased expression of NOX4 protein
Amlodipine promotes the reaction [candesartan results in decreased expression of NOX4]; Hydrochlorothiazide promotes the reaction [candesartan results in decreased expression of NOX4]

PMID:18551021 PMID:21107329

NCBI chr 1:150,313,736...150,491,480
Ensembl chr 1:140,901,097...141,077,406

G

natriuretic peptide A

increases expression
increases secretion

candesartan results in increased expression of NPPA mRNA; candesartan results in increased expression of NPPA protein
candesartan results in increased secretion of NPPA protein

NCBI chr 5:163,712,184...163,713,493
Ensembl chr 5:158,429,042...158,430,351

G

nuclear receptor subfamily 3, group C, member 2

affects expression

candesartan affects the expression of NR3C2 mRNA

NCBI chr19:47,619,853...47,964,089
Ensembl chr19:30,715,648...31,059,885

G

phospholamban

multiple interactions

candesartan inhibits the reaction [Isoproterenol results in decreased phosphorylation of PLN protein]

NCBI chr20:33,166,512...33,182,241

G

pro-melanin-concentrating hormone

decreases expression

candesartan results in decreased expression of PMCH mRNA

NCBI chr 7:24,399,404...24,400,720
Ensembl chr 7:22,511,934...22,513,250

G

prostaglandin I2 synthase

decreases expression

candesartan results in decreased expression of PTGIS mRNA

NCBI chr 3:176,347,589...176,383,251
Ensembl chr 3:155,916,412...155,965,451

G

prostaglandin-endoperoxide synthase 2

multiple interactions

candesartan inhibits the reaction [AGT results in increased expression of PTGS2 protein]

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188

G

parathyroid hormone-like hormone

multiple interactions

candesartan inhibits the reaction [AGT protein results in increased expression of PTHLH mRNA]; candesartan inhibits the reaction [AGT protein results in increased expression of PTHLH protein]

NCBI chr 4:181,919,400...181,930,454
Ensembl chr 4:180,188,792...180,199,847

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

[candesartan co-treated with epigallocatechin gallate] inhibits the reaction [Gentamicins results in increased phosphorylation of RELA protein]; candesartan inhibits the reaction [Gentamicins results in increased phosphorylation of RELA protein]

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484

G

renin

multiple interactions
increases expression
decreases activity

candesartan inhibits the reaction [[AGT co-treated with REN] results in increased abundance of Aldosterone]
candesartan results in increased expression of REN mRNA
candesartan results in decreased activity of REN protein

PMID:18679781 PMID:18796534 PMID:19047581

NCBI chr13:47,348,312...47,359,539
Ensembl chr13:44,796,091...44,807,489

G

ryanodine receptor 2

multiple interactions

candesartan inhibits the reaction [Isoproterenol results in increased phosphorylation of RYR2 protein]

NCBI chr17:63,081,527...63,667,141
Ensembl chr17:58,389,925...58,975,142

G

solute carrier family 22, member 25

multiple interactions

candesartan inhibits the reaction [SLC22A9 protein results in increased uptake of estrone sulfate]

NCBI chr 1:214,767,837...214,956,535
Ensembl chr 1:205,338,699...205,433,085

G

SMAD family member 3

multiple interactions

[benazepril co-treated with candesartan] results in decreased expression of SMAD3 protein

NCBI chr 8:73,022,204...73,132,324
Ensembl chr 8:64,110,039...64,236,960

G

transforming growth factor, beta 1

multiple interactions

[benazepril co-treated with candesartan] results in decreased expression of TGFB1 protein; candesartan inhibits the reaction [Nitric Oxide deficiency results in increased expression of TGFB1 mRNA]

PMID:16778335 PMID:19487956

NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847

G

thrombomodulin

multiple interactions

candesartan inhibits the reaction [Nitric Oxide deficiency results in decreased expression of THBD protein]

NCBI chr 3:156,316,526...156,320,178
Ensembl chr 3:135,862,835...135,867,193

G

TIMP metallopeptidase inhibitor 2

decreases expression

candesartan results in decreased expression of TIMP2 mRNA

NCBI chr10:104,041,604...104,089,214
Ensembl chr10:103,531,505...103,590,611

G

TIMP metallopeptidase inhibitor 3

decreases expression

candesartan results in decreased expression of TIMP3 mRNA

NCBI chr 7:19,408,539...19,459,558
Ensembl chr 7:17,521,919...17,571,839

G

tumor necrosis factor

multiple interactions
decreases expression

candesartan inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; candesartan inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; T 0070907 inhibits the reaction [candesartan inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]
candesartan results in decreased expression of TNF mRNA
[candesartan co-treated with epigallocatechin gallate] inhibits the reaction [Gentamicins results in increased expression of TNF protein]; candesartan inhibits the reaction [Galactose results in increased expression of TNF mRNA]; candesartan inhibits the reaction [Gentamicins results in increased expression of TNF protein]

PMID:22124178 PMID:30368989 PMID:34906534

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629

G

tumor protein p53

increases expression

candesartan results in increased expression of TP53 mRNA; candesartan results in increased expression of TP53 protein

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524

G

uncoupling protein 2

decreases expression
multiple interactions

candesartan results in decreased expression of UCP2 mRNA
candesartan inhibits the reaction [Palmitic Acid results in increased expression of UCP2 mRNA]

PMID:16685210 PMID:20667613

NCBI chr 1:164,251,373...164,257,742
Ensembl chr 1:154,839,209...154,845,611

G

vascular cell adhesion molecule 1

multiple interactions

candesartan inhibits the reaction [Streptozocin results in increased expression of VCAM1 protein]

NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:204,038,114...204,057,958

G

vascular endothelial growth factor A

decreases expression
multiple interactions

candesartan results in decreased expression of VEGFA
candesartan inhibits the reaction [VEGFA protein results in increased expression of VEGFA mRNA]
candesartan inhibits the reaction [AGT results in increased expression of VEGFA protein]

PMID:12065685 PMID:16202860 PMID:16675585

NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:14,955,300...14,970,641

G

Y box binding protein 3

decreases expression

candesartan results in decreased expression of YBX3 mRNA

NCBI chr 4:166,861,180...166,884,532
Ensembl chr 4:165,129,758...165,153,161

irbesartan

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 11

decreases activity

irbesartan results in decreased activity of ABCB11 protein

NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:54,017,127...54,112,730

G

angiotensin converting enzyme 2

affects response to substance

ACE2 gene polymorphism affects the susceptibility to irbesartan

NCBI chr X:33,925,458...33,972,851
Ensembl chr X:30,293,589...30,340,977

G

actin alpha 2, smooth muscle

multiple interactions

[irbesartan co-treated with benazepril] results in decreased expression of ACTA2 protein

NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:231,746,548...231,759,554

G

angiotensinogen

affects response to substance
multiple interactions
increases expression

AGT gene polymorphism affects the susceptibility to irbesartan; AGT gene SNP affects the susceptibility to irbesartan
irbesartan inhibits the reaction [AGT protein inhibits the reaction [Glycochenodeoxycholic Acid results in increased activity of CASP3 protein]]
irbesartan inhibits the reaction [AGT protein modified form results in increased susceptibility to Phenylephrine]
irbesartan results in increased expression of AGT protein
Cholesterol inhibits the reaction [irbesartan results in increased expression of AGT protein]

PMID:10082498 PMID:11910301 PMID:14639093 PMID:15614026 PMID:16794485 More...

NCBI chr19:69,426,540...69,447,017
Ensembl chr19:52,529,185...52,540,977

G

angiotensin II receptor, type 1a

affects response to substance
multiple interactions

AGTR1 gene polymorphism affects the susceptibility to irbesartan
Cholesterol inhibits the reaction [irbesartan results in increased expression of AGTR1 mRNA]
irbesartan binds to and results in decreased activity of AGTR1 protein

PMID:11910301 PMID:12022239 PMID:19028402

NCBI chr17:34,383,397...34,435,523
Ensembl chr17:34,174,429...34,226,946

G

AKT serine/threonine kinase 1

multiple interactions

Cholesterol inhibits the reaction [irbesartan results in increased expression of AKT1 protein]

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921

G

albumin

multiple interactions

Irbesartan inhibits the reaction [Acetaminophen results in increased expression of ALB protein]

NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,607,381...17,622,836

G

apolipoprotein B

affects response to substance

APOB gene SNP affects the susceptibility to irbesartan

PMID:15453913 PMID:15614026

NCBI chr 6:36,563,704...36,603,300
Ensembl chr 6:30,844,368...30,892,497

G

BCL2 associated X, apoptosis regulator

multiple interactions

irbesartan inhibits the reaction [ioversol results in increased expression of BAX mRNA]
Irbesartan inhibits the reaction [Acetaminophen results in increased expression of BAX protein]

PMID:16828304 PMID:31967706

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

multiple interactions

irbesartan inhibits the reaction [ioversol results in decreased expression of BCL2 mRNA]
Irbesartan inhibits the reaction [Acetaminophen results in decreased expression of BCL2 protein]

PMID:16828304 PMID:31967706

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

bradykinin receptor B2

affects response to substance

BDKRB2 exon polymorphism affects the susceptibility to irbesartan

NCBI chr 6:130,237,055...130,267,205
Ensembl chr 6:124,472,566...124,502,497

G

carbonic anhydrase 1

decreases activity

irbesartan results in decreased activity of CA1 protein

NCBI chr 2:88,550,681...88,593,454
Ensembl chr 2:86,861,897...86,872,208

G

caspase 3

multiple interactions

Irbesartan inhibits the reaction [AGT protein inhibits the reaction [Glycochenodeoxycholic Acid results in increased activity of CASP3 protein]]; Irbesartan inhibits the reaction [Indomethacin results in increased expression of CASP3 mRNA]
Irbesartan inhibits the reaction [Acetaminophen results in increased expression of CASP3 protein]

PMID:23300732 PMID:29523851 PMID:31967706

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648

G

C-C motif chemokine ligand 2

multiple interactions

Cholesterol inhibits the reaction [irbesartan results in increased expression of CCL2 mRNA]; Cholesterol inhibits the reaction [irbesartan results in increased expression of CCL2 protein]

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,005,424...67,007,226

G

cyclin-dependent kinase inhibitor 1A

multiple interactions

Irbesartan inhibits the reaction [KRAS protein mutant form results in increased expression of CDKN1A protein]

NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585

G

cyclin-dependent kinase inhibitor 2A

multiple interactions

Irbesartan inhibits the reaction [KRAS protein mutant form results in increased expression of CDKN2A protein]

NCBI chr 5:109,100,763...109,114,448
Ensembl chr 5:103,984,949...104,003,149

G

cytochrome P450, family 11, subfamily b, polypeptide 3

increases response to substance

CYP11B2 gene SNP results in increased susceptibility to irbesartan

NCBI chr 7:108,689,319...108,694,808
Ensembl chr 7:106,808,559...106,814,048

G

cytochrome P450, family 2, subfamily c, polypeptide 79

decreases activity

irbesartan results in decreased activity of CYP2C8 protein

G

cytochrome P450, family 2, subfamily e, polypeptide 1

multiple interactions

Irbesartan inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 protein]

NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:195,840,058...195,864,023

G

dimethylarginine dimethylaminohydrolase 1

multiple interactions

Irbesartan inhibits the reaction [Indomethacin results in decreased expression of DDAH1 mRNA]

NCBI chr 2:237,327,812...237,460,624
Ensembl chr 2:234,667,491...234,799,339

G

endothelin 1

affects response to substance

EDN1 gene polymorphism affects the susceptibility to irbesartan

NCBI chr17:22,660,799...22,666,687
Ensembl chr17:22,454,420...22,460,885

G

epidermal growth factor receptor

multiple interactions

Irbesartan inhibits the reaction [Indomethacin results in increased expression of EGFR mRNA]

NCBI chr14:95,378,626...95,551,358
Ensembl chr14:91,177,067...91,344,382

G

endoplasmic reticulum aminopeptidase 1

affects response to substance

ERAP1 gene polymorphism affects the susceptibility to irbesartan

NCBI chr 2:5,666,337...5,705,256
Ensembl chr 2:3,931,904...3,972,447

G

coagulation factor III, tissue factor

multiple interactions

[irbesartan co-treated with carvedilol] results in decreased expression of F3 mRNA; [irbesartan co-treated with carvedilol] results in decreased expression of F3 protein

NCBI chr 2:212,511,675...212,523,375
Ensembl chr 2:209,826,959...209,838,668

G

glutamic--pyruvic transaminase

multiple interactions

Irbesartan inhibits the reaction [Acetaminophen results in increased expression of GPT protein]

NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:108,416,642...108,419,494

G

interferon gamma

decreases expression

irbesartan results in decreased expression of IFNG protein

NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:53,903,337...53,907,375

G

interleukin 6

multiple interactions

Cholesterol inhibits the reaction [irbesartan results in increased expression of IL6 mRNA]; Cholesterol inhibits the reaction [irbesartan results in increased expression of IL6 protein]

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178

G

KRAS proto-oncogene, GTPase

multiple interactions

Irbesartan inhibits the reaction [KRAS protein mutant form results in increased expression of CDKN2A protein]
Irbesartan inhibits the reaction [KRAS protein mutant form results in increased expression of CDKN1A protein]

NCBI chr 4:179,916,255...179,949,613

G

matrix metallopeptidase 9

multiple interactions

Irbesartan inhibits the reaction [Indomethacin results in increased expression of MMP9 protein]

NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:153,683,858...153,692,120

G

neutrophil cytosolic factor 1

multiple interactions

Cholesterol inhibits the reaction [irbesartan results in increased expression of NCF1 mRNA]; Cholesterol inhibits the reaction [irbesartan results in increased expression of NCF1 protein]

NCBI chr12:28,121,816...28,131,080
Ensembl chr12:22,485,451...22,494,646

G

nuclear factor kappa B subunit 1

multiple interactions

Cholesterol inhibits the reaction [irbesartan results in increased expression of NFKB1 protein]

NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:224,016,214...224,110,404

G

NFKB inhibitor beta

multiple interactions

Cholesterol inhibits the reaction [irbesartan results in increased phosphorylation of NFKBIB protein]

NCBI chr 1:93,173,817...93,181,387
Ensembl chr 1:84,046,295...84,053,862

G

natriuretic peptide A

increases expression

irbesartan results in increased expression of NPPA protein

NCBI chr 5:163,712,184...163,713,493
Ensembl chr 5:158,429,042...158,430,351

G

prostaglandin-endoperoxide synthase 2

multiple interactions

Irbesartan inhibits the reaction [Indomethacin results in increased expression of PTGS2 mRNA]

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188

G

Rac family small GTPase 1

multiple interactions

Cholesterol inhibits the reaction [irbesartan results in increased expression of RAC1 mRNA]

NCBI chr12:16,150,411...16,170,864
Ensembl chr12:11,036,698...11,057,251

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

Cholesterol inhibits the reaction [irbesartan results in increased expression of RELA protein]

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484

G

renin

increases expression

irbesartan results in increased expression of REN protein

NCBI chr13:47,348,312...47,359,539
Ensembl chr13:44,796,091...44,807,489

G

ret proto-oncogene

increases expression

irbesartan results in increased expression of RET protein

NCBI chr 4:152,998,344...153,040,556
Ensembl chr 4:151,326,431...151,368,176

G

SMAD family member 2

multiple interactions
affects expression

[benazepril co-treated with irbesartan] affects the expression of SMAD2 mRNA; [benazepril co-treated with irbesartan] affects the expression of SMAD2 protein
irbesartan affects the expression of SMAD2 mRNA; irbesartan affects the expression of SMAD2 protein

NCBI chr18:72,124,792...72,193,345
Ensembl chr18:69,850,377...69,912,323

G

SMAD family member 3

multiple interactions
affects expression

[benazepril co-treated with irbesartan] affects the expression of SMAD3 mRNA; [benazepril co-treated with irbesartan] affects the expression of SMAD3 protein
irbesartan affects the expression of SMAD3 mRNA; irbesartan affects the expression of SMAD3 protein

NCBI chr 8:73,022,204...73,132,324
Ensembl chr 8:64,110,039...64,236,960

G

tissue factor pathway inhibitor

multiple interactions

[irbesartan co-treated with carvedilol] results in decreased expression of TFPI mRNA; [irbesartan co-treated with carvedilol] results in decreased expression of TFPI protein

NCBI chr 3:89,939,862...89,989,253
Ensembl chr 3:69,533,156...69,576,880

G

transforming growth factor, beta 1

affects response to substance
multiple interactions
affects expression
decreases expression

TGFB1 gene SNP affects the susceptibility to irbesartan
[benazepril co-treated with irbesartan] affects the expression of TGFB1 mRNA
irbesartan affects the expression of TGFB1 mRNA
irbesartan results in decreased expression of TGFB1 mRNA

PMID:11352773 PMID:15049387 PMID:16635409

NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847

G

tumor necrosis factor

decreases expression
multiple interactions

irbesartan results in decreased expression of TNF protein
Irbesartan inhibits the reaction [Indomethacin results in increased expression of TNF protein]
Cholesterol inhibits the reaction [Irbesartan results in increased expression of TNF mRNA]; Cholesterol inhibits the reaction [Irbesartan results in increased expression of TNF protein]; Irbesartan inhibits the reaction [Acetaminophen results in increased expression of TNF protein]

PMID:15210574 PMID:19028402 PMID:29523851 PMID:31967706

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629

G

vascular cell adhesion molecule 1

multiple interactions

Cholesterol inhibits the reaction [irbesartan results in increased expression of VCAM1 mRNA]; Cholesterol inhibits the reaction [irbesartan results in increased expression of VCAM1 protein]

NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:204,038,114...204,057,958

losartan

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 11

decreases activity
multiple interactions

Losartan results in decreased activity of ABCB11 protein
Losartan inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]

PMID:23956101 PMID:24014644

NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:54,017,127...54,112,730

G

angiotensin I converting enzyme

multiple interactions
decreases expression

Losartan inhibits the reaction [AGT protein results in increased expression of ACE mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of ACE protein]; Losartan inhibits the reaction [Oxygen deficiency results in increased expression of ACE protein]; Losartan inhibits the reaction [Silicon Dioxide results in increased expression of ACE mRNA]; Losartan inhibits the reaction [Silicon Dioxide results in increased expression of ACE protein]
Losartan inhibits the reaction [Testosterone results in increased activity of ACE protein]
Losartan results in decreased expression of ACE protein

PMID:25511041 PMID:25655897 PMID:25673179 PMID:28091615 PMID:28578904 More...

NCBI chr10:91,410,129...91,430,246
Ensembl chr10:90,910,316...90,931,131

G

angiotensin converting enzyme 2

multiple interactions
increases activity
increases expression

Losartan inhibits the reaction [AGT protein results in decreased expression of ACE2 mRNA]; Losartan inhibits the reaction [AGT protein results in decreased expression of ACE2 protein]; Losartan inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of ACE2 protein]
Losartan results in increased activity of ACE2 protein
Losartan results in increased expression of ACE2 protein
Losartan results in increased expression of ACE2 mRNA; Losartan results in increased expression of ACE2 protein
Losartan inhibits the reaction [AGT protein results in decreased expression of ACE2 mRNA]; Losartan inhibits the reaction [AGT protein results in decreased expression of ACE2 protein]; Losartan inhibits the reaction [Oxygen deficiency results in decreased expression of ACE2 protein]; Losartan inhibits the reaction [Silicon Dioxide results in decreased expression of ACE2 protein]

PMID:15897343 PMID:16176966 PMID:16221218 PMID:20178811 PMID:22009550 More...

NCBI chr X:33,925,458...33,972,851
Ensembl chr X:30,293,589...30,340,977

G

actin alpha 2, smooth muscle

decreases expression
multiple interactions

Losartan results in decreased expression of ACTA2 mRNA; Losartan results in decreased expression of ACTA2 protein
Losartan inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]; Losartan inhibits the reaction [Silicon Dioxide results in increased expression of ACTA2 protein]

PMID:15100363 PMID:28091615 PMID:28578904 PMID:33007385

NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:231,746,548...231,759,554

G

actin gamma 2, smooth muscle

decreases expression

Losartan results in decreased expression of ACTG2 mRNA

NCBI chr 4:117,579,513...117,604,379
Ensembl chr 4:116,021,832...116,046,465

G

adiponectin, C1Q and collagen domain containing

increases expression

Losartan results in increased expression of ADIPOQ mRNA

NCBI chr11:91,226,524...91,240,244
Ensembl chr11:77,721,912...77,735,564

G

adrenoceptor beta 2

affects expression

Losartan affects the expression of ADRB2 protein

NCBI chr18:57,912,760...57,914,802
Ensembl chr18:55,502,903...55,644,512

G

alpha-fetoprotein

multiple interactions

Losartan inhibits the reaction [Diethylnitrosamine results in increased expression of AFP protein]

NCBI chr14:17,857,584...17,875,645
Ensembl chr14:17,573,412...17,591,480

G

advanced glycosylation end product-specific receptor

multiple interactions

Losartan inhibits the reaction [Glucose promotes the reaction [Linoleic Acid promotes the reaction [Azoxymethane results in increased expression of AGER protein]]]; Losartan inhibits the reaction [Linoleic Acid promotes the reaction [Glucose promotes the reaction [Azoxymethane results in increased expression of AGER protein]]]

NCBI chr20:4,152,758...4,155,956
Ensembl chr20:4,147,890...4,151,078

G

angiotensinogen

multiple interactions
increases secretion
decreases activity
decreases response to substance
increases expression
decreases expression

[Losartan co-treated with ICG 001] inhibits the reaction [AGT protein results in decreased expression of NPHS2 protein]; [Losartan co-treated with ICG 001] inhibits the reaction [AGT protein results in increased expression of S100A4 protein]; [Losartan results in decreased activity of AGTR1 protein] which results in increased expression of AGT protein alternative form; ICG 001 promotes the reaction [Losartan inhibits the reaction [AGT protein results in increased expression of MMP7 protein]]; ICG 001 promotes the reaction [Losartan inhibits the reaction [AGT protein results in increased expression of SNAI1 protein]]; Losartan inhibits the reaction [[AGT protein modified form co-treated with Ascorbic Acid co-treated with Copper Sulfate] results in increased chemical synthesis of [4-hydroxy-2-nonenal binds to AGT protein modified form]]; Losartan inhibits the reaction [[AGT protein modified form co-treated with Ascorbic Acid co-treated with Copper Sulfate] results in increased chemical synthesis of [pyruvamide binds to AGT protein modified form]]; Losartan inhibits the reaction [AGT protein affects the localization of CTNNB1 protein]; Losartan inhibits the reaction [AGT protein modified form promotes the reaction [[Shiga Toxin 1 co-treated with TNF protein] results in increased activity of F3 protein]]; Losartan inhibits the reaction [AGT protein modified form results in decreased secretion of Nitric Oxide]; Losartan inhibits the reaction [AGT protein modified form results in increased expression of EDN1 protein]; Losartan inhibits the reaction [AGT protein promotes the reaction [[Medroxyprogesterone Acetate co-treated with Bucladesine] results in increased secretion of PRL protein]]; Losartan inhibits the reaction [AGT protein results in decreased expression of CDH1 protein]; Losartan inhibits the reaction [AGT protein results in decreased expression of HMOX1 protein]; Losartan inhibits the reaction [AGT protein results in decreased expression of NFE2L2 protein]; Losartan inhibits the reaction [AGT protein results in increased abundance of Aldosterone]; Losartan inhibits the reaction [AGT protein results in increased expression of ACE protein]; Losartan inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of AGT protein]; Losartan inhibits the reaction [AGT protein results in increased expression of AGTR1A protein]; Losartan inhibits the reaction [AGT protein results in increased expression of and results in increased activity of CTNNB1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of CCL2 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of COL3A1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of CTNNB1 mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of MMP7 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of PTGS2 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of REN protein]; Losartan inhibits the reaction [AGT protein results in increased expression of S100A4 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of SNAI1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of TWIST1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of VIM protein]; Losartan inhibits the reaction [AGT protein results in increased expression of WNT1 mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of WNT1 protein]; Losartan inhibits the reaction [AGT protein results in increased secretion of CXCL8 protein]; Losartan inhibits the reaction [AGT protein results in increased secretion of ICAM1 protein]; Losartan inhibits the reaction [AGT protein results in increased secretion of MMP2 protein]; Losartan promotes the reaction [AGT protein results in increased expression of VEGFA mRNA]; Losartan promotes the reaction [AGT protein results in increased secretion of VEGFA protein]; Losartan promotes the reaction [ICG 001 inhibits the reaction [AGT protein results in increased expression of COL3A1 protein]]; Losartan promotes the reaction [ICG 001 inhibits the reaction [AGT protein results in increased expression of MMP7 protein]]; Losartan promotes the reaction [ICG 001 inhibits the reaction [AGT protein results in increased expression of SNAI1 protein]]
Losartan results in increased secretion of AGT protein; Losartan results in increased secretion of AGT protein alternative form
[Losartan results in decreased activity of AGT protein] which results in decreased activity of TGFB1 protein; Losartan results in decreased activity of AGT protein
Losartan results in decreased susceptibility to AGT protein modified form
Losartan results in increased expression of AGT protein
Losartan results in decreased activity of AGT protein; Losartan results in decreased activity of AGT protein modified form
Losartan results in decreased expression of AGT protein; Losartan results in decreased expression of AGT protein alternative form; Losartan results in decreased expression of AGT protein modified form
[Lisinopril co-treated with Losartan] results in increased expression of AGT mRNA; [Losartan co-treated with Carvedilol] results in decreased susceptibility to AGT protein modified form; Carvedilol inhibits the reaction [Losartan results in decreased susceptibility to AGT protein modified form]; Losartan inhibits the reaction [[AGT protein binds to and results in increased localization of AGTR1A protein] which results in increased expression of PTGS2 protein]; Losartan inhibits the reaction [[AGT protein binds to and results in increased localization of AGTR1A protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Losartan inhibits the reaction [[AGT protein binds to and results in increased localization of AGTR1A protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Losartan inhibits the reaction [[Phenylephrine results in increased expression of AGT protein] which results in increased activity of MMP2 protein]; Losartan inhibits the reaction [AGT protein affects the abundance of Cholesterol]; Losartan inhibits the reaction [AGT protein affects the localization of Calcium]; Losartan inhibits the reaction [AGT protein affects the localization of Lipids]; Losartan inhibits the reaction [AGT protein alternative form results in increased expression of PDGFA mRNA alternative form]; Losartan inhibits the reaction [AGT protein inhibits the reaction [Glycochenodeoxycholic Acid results in increased activity of CASP3 protein]]; Losartan inhibits the reaction [AGT protein modified form results in increased expression of BAX protein]; Losartan inhibits the reaction [AGT protein modified form results in increased expression of S1PR1 mRNA]; Losartan inhibits the reaction [AGT protein modified form results in increased expression of S1PR1 protein]; Losartan inhibits the reaction [AGT protein modified form results in increased phosphorylation of GSK3B protein]; Losartan inhibits the reaction [AGT protein modified form results in increased phosphorylation of MAPT protein]; Losartan inhibits the reaction [AGT protein results in decreased abundance of NADP]; Losartan inhibits the reaction [AGT protein results in decreased expression of ACE2 mRNA]; Losartan inhibits the reaction [AGT protein results in decreased expression of ACE2 protein]; Losartan inhibits the reaction [AGT protein results in decreased expression of CPT1A mRNA]; Losartan inhibits the reaction [AGT protein results in increased abundance of Fatty Acids, Nonesterified]; Losartan inhibits the reaction [AGT protein results in increased abundance of Glycerol]; Losartan inhibits the reaction [AGT protein results in increased abundance of Norepinephrine]; Losartan inhibits the reaction [AGT protein results in increased abundance of Triglycerides]; Losartan inhibits the reaction [AGT protein results in increased activity of CREB1 protein]; Losartan inhibits the reaction [AGT protein results in increased cleavage of SREBF1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of ATP1A1 mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of CYBA mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of ENG mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of ENG protein]; Losartan inhibits the reaction [AGT protein results in increased expression of FASN mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of FOS protein]; Losartan inhibits the reaction [AGT protein results in increased expression of HMGCR mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of HSPA5 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of MYLK protein]; Losartan inhibits the reaction [AGT protein results in increased expression of NCF2 mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of PARP1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of PDGFB mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of PDGFD mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of PDGFRB mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of POSTN mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of PPARA mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of PPARG mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of PPARGC1A mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of PTHLH mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of PTHLH protein]; Losartan inhibits the reaction [AGT protein results in increased expression of REG3G mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of SREBF1 mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of TSC22D1 mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of UCP2 mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of UCP3 mRNA]; Losartan inhibits the reaction [AGT protein results in increased phosphorylation of EIF2S1 protein]; Losartan inhibits the reaction [AGT protein results in increased phosphorylation of MAPK1 protein]; Losartan inhibits the reaction [AGT protein results in increased phosphorylation of MAPK3 protein]; Losartan inhibits the reaction [AGT protein results in increased phosphorylation of SREBF1 protein]; Losartan inhibits the reaction [AGT protein results in increased secretion of COL3A1 protein]; Losartan inhibits the reaction [AGT protein results in increased secretion of PRL protein]; Losartan inhibits the reaction [bisphenol A results in increased expression of AGT protein]; Losartan inhibits the reaction [Carvedilol results in decreased susceptibility to AGT protein modified form]; Losartan inhibits the reaction [Ethanol results in increased secretion of AGT protein alternative form]; Losartan inhibits the reaction [Folic Acid results in increased localization of [AGT protein binds to AGTR1A protein]]; Losartan inhibits the reaction [Folic Acid results in increased localization of AGT protein]; Losartan inhibits the reaction [Isoproterenol results in increased expression of AGT protein]; Losartan inhibits the reaction [Sodium Chloride results in increased expression of AGT protein]; Losartan inhibits the reaction [Tobacco Smoke Pollution results in increased expression of AGT protein]; Losartan promotes the reaction [AGTR2 protein binds to AGT protein]; Losartan promotes the reaction [Isoproterenol results in increased expression of AGT protein]
Losartan inhibits the reaction [AGT protein affects the localization of CTNNB1 protein]; Losartan inhibits the reaction [AGT protein results in decreased abundance of angiotensin I (1-7)]; Losartan inhibits the reaction [AGT protein results in decreased expression of ACE2 mRNA]; Losartan inhibits the reaction [AGT protein results in decreased expression of ACE2 protein]; Losartan inhibits the reaction [AGT protein results in decreased expression of CDH1 protein]; Losartan inhibits the reaction [AGT protein results in decreased expression of MAS1 protein]; Losartan inhibits the reaction [AGT protein results in decreased expression of NFE2L2 protein]; Losartan inhibits the reaction [AGT protein results in decreased expression of NPHS1 protein]; Losartan inhibits the reaction [AGT protein results in decreased expression of PODXL protein]; Losartan inhibits the reaction [AGT protein results in decreased expression of WT1 protein]; Losartan inhibits the reaction [AGT protein results in increased activity of PARP1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of ACE mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of ACE protein]; Losartan inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of AGT protein]; Losartan inhibits the reaction [AGT protein results in increased expression of AGTR1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of AGTR1A protein]; Losartan inhibits the reaction [AGT protein results in increased expression of AKT2 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of CCL2 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of COL3A1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of CTNNB1 mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of CTNNB1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of DES protein]; Losartan inhibits the reaction [AGT protein results in increased expression of FOS protein]; Losartan inhibits the reaction [AGT protein results in increased expression of MMP7 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of PTGS2 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of RELA protein]; Losartan inhibits the reaction [AGT protein results in increased expression of REN1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of SOD3 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of TWIST1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of VIM protein]; Losartan inhibits the reaction [AGT protein results in increased expression of WNT1 mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of WNT1 protein]; Losartan inhibits the reaction [Silicon Dioxide results in decreased expression of AGT protein alternative form]; Losartan inhibits the reaction [Silicon Dioxide results in increased expression of AGT protein]

PMID:1387008 PMID:7965263 PMID:8403307 PMID:8952583 PMID:9124547 More...

NCBI chr19:69,426,540...69,447,017
Ensembl chr19:52,529,185...52,540,977

G

angiotensin II receptor, type 1a

multiple interactions
decreases expression
increases expression
decreases activity

[Losartan results in decreased activity of AGTR1 protein] which results in decreased abundance of Aldosterone; [Losartan results in decreased activity of AGTR1 protein] which results in increased expression of AGT protein alternative form; [Losartan results in decreased activity of AGTR1 protein] which results in increased expression of REN protein; Losartan binds to and results in decreased activity of AGTR1 protein; Losartan inhibits the reaction [AGT protein results in increased expression of AGTR1A protein]
Losartan binds to and results in decreased activity of AGTR1A protein; Losartan inhibits the reaction [AGT protein results in increased expression of AGTR1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of AGTR1A protein]; Losartan inhibits the reaction [Hydrogen Peroxide results in increased expression of AGTR1A mRNA]; Losartan inhibits the reaction [Oxygen deficiency results in increased expression of AGTR1 protein]; Losartan inhibits the reaction [Silicon Dioxide results in increased expression of AGTR1 protein]
Losartan results in decreased expression of AGTR1 protein; Losartan results in decreased expression of AGTR1A mRNA; Losartan results in decreased expression of AGTR1A protein
Losartan results in increased expression of AGTR1 mRNA; Losartan results in increased expression of AGTR1A mRNA
[Cilazapril co-treated with Losartan] promotes the reaction [Doxorubicin results in increased expression of AGTR1 mRNA]; Losartan binds to and results in decreased activity of AGTR1 protein; Losartan binds to and results in decreased activity of AGTR1A protein; Losartan inhibits the reaction [[AGT protein binds to and results in increased localization of AGTR1A protein] which results in increased expression of PTGS2 protein]; Losartan inhibits the reaction [[AGT protein binds to and results in increased localization of AGTR1A protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Losartan inhibits the reaction [[AGT protein binds to and results in increased localization of AGTR1A protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Losartan inhibits the reaction [Carbon Tetrachloride results in increased expression of AGTR1A mRNA]; Losartan inhibits the reaction [Carbon Tetrachloride results in increased expression of AGTR1A protein]; Losartan inhibits the reaction [Doxorubicin results in increased expression of AGTR1 mRNA]; Losartan inhibits the reaction [Doxorubicin results in increased expression of AGTR1 protein]; Losartan inhibits the reaction [Folic Acid results in increased localization of [AGT protein binds to AGTR1A protein]]

PMID:9124547 PMID:9533614 PMID:10821809 PMID:11893553 PMID:12930639 More...

NCBI chr17:34,383,397...34,435,523
Ensembl chr17:34,174,429...34,226,946

G

angiotensin II receptor, type 2

multiple interactions
increases expression
decreases expression

[Losartan co-treated with Cilazapril] inhibits the reaction [Doxorubicin results in decreased expression of AGTR2 mRNA]; Losartan inhibits the reaction [Doxorubicin results in decreased expression of AGTR2 mRNA]; Losartan promotes the reaction [AGTR2 protein binds to AGT protein]
Losartan inhibits the reaction [Oxygen deficiency results in decreased expression of AGTR2 protein]
Losartan results in increased expression of AGTR2 protein
Losartan results in decreased expression of AGTR2 mRNA

PMID:9336375 PMID:11967826 PMID:15331931 PMID:18300857 PMID:25511041

NCBI chr X:116,914,320...116,918,504
Ensembl chr X:112,120,228...112,124,057

G

AKT serine/threonine kinase 2

multiple interactions

Losartan inhibits the reaction [AGT protein results in increased expression of AKT2 protein]

NCBI chr 1:92,004,705...92,061,420
Ensembl chr 1:82,883,547...82,933,817

G

albumin

affects binding

Losartan binds to ALB protein; Losartan binds to ALB protein modified form

NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,607,381...17,622,836

G

arachidonate 15-lipoxygenase

decreases expression

Losartan results in decreased expression of ALOX15 mRNA; Losartan results in decreased expression of ALOX15 protein

NCBI chr10:55,559,060...55,567,535
Ensembl chr10:55,060,412...55,068,874

G

arachidonate 5-lipoxygenase

decreases expression

Losartan results in decreased expression of ALOX5 protein

NCBI chr 4:151,203,948...151,251,126
Ensembl chr 4:149,531,515...149,578,743

G

alpha-1-microglobulin/bikunin precursor

decreases expression
multiple interactions

Losartan results in decreased expression of AMBP protein
benazepril promotes the reaction [Losartan results in decreased expression of AMBP protein]; Losartan promotes the reaction [benazepril results in decreased expression of AMBP protein]

NCBI chr 5:81,583,621...81,593,938
Ensembl chr 5:76,568,094...76,578,331

G

ATPase Na+/K+ transporting subunit alpha 1

multiple interactions

Losartan inhibits the reaction [AGT protein results in increased expression of ATP1A1 mRNA]

NCBI chr 2:191,709,311...191,737,414
Ensembl chr 2:189,020,722...189,048,837

G

ATPase Na+/K+ transporting subunit alpha 2

increases expression

Losartan results in increased expression of ATP1A2 mRNA; Losartan results in increased expression of ATP1A2 protein

NCBI chr13:87,261,964...87,286,911
Ensembl chr13:84,729,601...84,754,544

G

ATPase Na+/K+ transporting subunit alpha 3

decreases expression

Losartan results in decreased expression of ATP1A3 mRNA; Losartan results in decreased expression of ATP1A3 protein

NCBI chr 1:89,700,645...89,729,782
Ensembl chr 1:80,572,796...80,601,918

G

BCL2-antagonist/killer 1

multiple interactions

Losartan inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of BAK1 mRNA]

NCBI chr20:5,102,334...5,111,615
Ensembl chr20:5,100,480...5,109,264

G

BCL2 associated X, apoptosis regulator

multiple interactions
increases expression
decreases expression

Losartan inhibits the reaction [AGT protein modified form results in increased expression of BAX protein]; Losartan inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of BAX mRNA]
Losartan results in increased expression of BAX protein
Losartan results in decreased expression of BAX mRNA

PMID:12623880 PMID:12845756 PMID:15502641 PMID:17784886 PMID:19298698

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

multiple interactions
affects expression
increases expression
decreases expression

Losartan promotes the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of BCL2 mRNA]
Losartan affects the expression of BCL2 protein
Losartan results in increased expression of BCL2 protein
Losartan results in decreased expression of BCL2 protein

PMID:12623880 PMID:15502641 PMID:19298698 PMID:21153712 PMID:22000973

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

bone morphogenetic protein 2

multiple interactions

Losartan affects the reaction [[Warfarin co-treated with Vitamin K 1] affects the expression of BMP2 mRNA]; Losartan affects the reaction [[Warfarin co-treated with Vitamin K 1] affects the expression of BMP2 protein]

NCBI chr 3:141,264,648...141,275,416
Ensembl chr 3:120,812,882...120,821,397

G

calcium/calmodulin-dependent protein kinase II alpha

multiple interactions

[KN 93 co-treated with Losartan] inhibits the reaction [bisphenol A results in increased phosphorylation of CAMK2A protein]; Losartan inhibits the reaction [bisphenol A results in increased phosphorylation of CAMK2A protein]

NCBI chr18:56,648,779...56,711,505
Ensembl chr18:54,378,784...54,438,994

G

caspase 3

increases cleavage
decreases activity
multiple interactions

Losartan results in increased cleavage of CASP3 protein
Losartan results in decreased activity of CASP3 protein
Losartan inhibits the reaction [AGT protein inhibits the reaction [Glycochenodeoxycholic Acid results in increased activity of CASP3 protein]]; Losartan inhibits the reaction [Testosterone results in increased activity of CASP3 protein]

PMID:12623880 PMID:23300732 PMID:23875703 PMID:25673179

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648

G

caspase 8

decreases activity

Losartan results in decreased activity of CASP8 protein

NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:60,264,075...60,312,542

G

caspase 9

increases cleavage

Losartan results in increased cleavage of CASP9 protein

Ensembl chr 5:154,109,046...154,126,626

G

catalase

decreases expression
multiple interactions

Losartan results in decreased expression of CAT protein
Losartan inhibits the reaction [Streptozocin results in decreased activity of CAT protein]

PMID:23875703 PMID:30958922

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478

G

C-C motif chemokine ligand 2

multiple interactions
decreases expression

Losartan inhibits the reaction [Estrogens deficiency results in increased expression of CCL2 protein]; Losartan inhibits the reaction [Ethylene Glycol results in increased expression of CCL2 protein]; Losartan inhibits the reaction [glyoxylic acid results in increased expression of CCL2 protein]
Losartan inhibits the reaction [AGT protein results in increased expression of CCL2 protein]
Losartan results in decreased expression of CCL2 mRNA; Losartan results in decreased expression of CCL2 protein

PMID:10925121 PMID:16284884 PMID:17922026 PMID:19553526 PMID:28578904 More...

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,005,424...67,007,226

G

C-C motif chemokine ligand 3

multiple interactions

Losartan inhibits the reaction [Estrogens deficiency results in increased expression of CCL3 protein]

NCBI chr10:68,948,889...68,950,439
Ensembl chr10:68,451,388...68,452,938

G

C-C motif chemokine ligand 5

multiple interactions

Losartan inhibits the reaction [Ethylene Glycol results in increased expression of CCL5 protein]

NCBI chr10:68,820,330...68,824,906
Ensembl chr10:68,322,829...68,327,377

G

cyclin D1

multiple interactions

Losartan inhibits the reaction [Diethylnitrosamine results in increased expression of CCND1 mRNA]

NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:200,089,002...200,098,602

G

C-C motif chemokine receptor 2

decreases expression

Losartan results in decreased expression of CCR2 mRNA

NCBI chr 8:132,611,883...132,619,106
Ensembl chr 8:123,734,430...123,742,100

G

CD36 molecule

increases expression
decreases expression
multiple interactions

Losartan results in increased expression of CD36 mRNA
Losartan results in decreased expression of CD36 mRNA
Losartan promotes the reaction [[Dietary Fats co-treated with Cholesterol] results in increased expression of CD36 mRNA]
T 0070907 inhibits the reaction [Losartan results in increased expression of CD36 mRNA]

PMID:18302760 PMID:22124178

NCBI chr 4:18,209,088...18,302,142
Ensembl chr 4:17,354,466...17,513,903

G

CD44 molecule

multiple interactions

Losartan inhibits the reaction [glyoxylic acid results in increased expression of CD44 protein]

NCBI chr 3:109,610,824...109,699,776
Ensembl chr 3:89,157,058...89,244,620

G

CD74 molecule

decreases expression

Losartan results in decreased expression of CD74 mRNA

NCBI chr18:56,527,071...56,536,406
Ensembl chr18:54,256,778...54,266,003

G

cadherin 1

multiple interactions

Losartan inhibits the reaction [AGT protein results in decreased expression of CDH1 protein]
Losartan inhibits the reaction [AGT protein results in decreased expression of CDH1 protein]; Losartan inhibits the reaction [Silicon Dioxide results in decreased expression of CDH1 protein]

PMID:28578904 PMID:33007385

NCBI chr19:51,402,178...51,471,572
Ensembl chr19:34,492,371...34,561,775

G

cyclin-dependent kinase inhibitor 1A

multiple interactions

Losartan inhibits the reaction [KRAS protein mutant form results in increased expression of CDKN1A protein]

NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585

G

cyclin-dependent kinase inhibitor 2A

multiple interactions

Losartan inhibits the reaction [KRAS protein mutant form results in increased expression of CDKN2A protein]

NCBI chr 5:109,100,763...109,114,448
Ensembl chr 5:103,984,949...104,003,149

G

collagen type I alpha 1 chain

decreases expression
multiple interactions

Losartan results in decreased expression of COL1A1 mRNA
Losartan inhibits the reaction [Lipopolysaccharides results in increased expression of COL1A1 mRNA]

PMID:15100363 PMID:18300870 PMID:23585870

NCBI chr10:80,380,458...80,397,461
Ensembl chr10:79,883,622...79,900,624

G

collagen type III alpha 1 chain

decreases expression
multiple interactions

Losartan results in decreased expression of COL3A1 mRNA
Losartan inhibits the reaction [AGT protein results in increased expression of COL3A1 protein]; Losartan promotes the reaction [ICG 001 inhibits the reaction [AGT protein results in increased expression of COL3A1 protein]]
Losartan inhibits the reaction [AGT protein results in increased expression of COL3A1 protein]; Losartan inhibits the reaction [Lipopolysaccharides results in increased expression of COL3A1 mRNA]; Losartan inhibits the reaction [Silicon Dioxide results in increased expression of COL3A1 protein]
Losartan inhibits the reaction [AGT protein results in increased secretion of COL3A1 protein]; Losartan inhibits the reaction [Paraquat results in increased expression of COL3A1 protein]

PMID:15100363 PMID:16539842 PMID:23585870 PMID:25233898 PMID:28578904 More...

NCBI chr 9:54,866,646...54,902,578
Ensembl chr 9:47,374,593...47,410,547

G

collagen type IV alpha 1 chain

decreases expression

Losartan results in decreased expression of COL4A1 mRNA

NCBI chr16:84,885,597...84,996,482
Ensembl chr16:78,183,533...78,294,412

G

carnitine palmitoyltransferase 1A

multiple interactions

Losartan inhibits the reaction [AGT protein results in decreased expression of CPT1A mRNA]

NCBI chr 1:209,993,881...210,056,329
Ensembl chr 1:200,565,613...200,627,055

G

cAMP responsive element binding protein 1

multiple interactions

Losartan inhibits the reaction [AGT protein results in increased activity of CREB1 protein]; Losartan inhibits the reaction [Folic Acid results in increased activity of CREB1 protein]

NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:65,903,547...65,970,816

G

C-reactive protein

multiple interactions

Dexamethasone promotes the reaction [Losartan inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CRP protein]]; Losartan inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CRP protein]

NCBI chr13:87,694,062...87,695,978
Ensembl chr13:85,124,977...85,175,178

G

catenin beta 1

multiple interactions

Losartan inhibits the reaction [AGT protein affects the localization of CTNNB1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of CTNNB1 mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of CTNNB1 protein]
Losartan inhibits the reaction [AGT protein affects the localization of CTNNB1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of and results in increased activity of CTNNB1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of CTNNB1 mRNA]

NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:120,639,995...120,667,111

G

cubilin

multiple interactions

Losartan inhibits the reaction [Cadmium results in decreased expression of CUBN protein]

NCBI chr17:81,293,619...81,501,694
Ensembl chr17:76,385,060...76,593,231

G

C-X-C motif chemokine ligand 1

multiple interactions

Losartan inhibits the reaction [Estrogens deficiency results in increased expression of CXCL1 protein]

NCBI chr14:17,477,542...17,479,321
Ensembl chr14:17,193,365...17,195,215

G

cytochrome b-245 alpha chain

multiple interactions

Losartan inhibits the reaction [AGT protein results in increased expression of CYBA mRNA]

NCBI chr19:67,396,143...67,404,214
Ensembl chr19:50,487,597...50,495,721

G

cytochrome c, somatic

increases expression

Losartan results in increased expression of CYCS protein

NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases expression

Losartan results in increased expression of CYP1A1 mRNA

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:58,096,077...58,102,125

G

decorin

decreases expression

Losartan results in decreased expression of DCN mRNA

NCBI chr 7:34,167,973...34,208,004
Ensembl chr 7:32,281,252...32,321,270

G

desmin

multiple interactions

Losartan inhibits the reaction [AGT protein results in increased expression of DES protein]

NCBI chr 9:84,299,626...84,307,344
Ensembl chr 9:76,850,982...76,858,699

G

endothelin 1

decreases expression
multiple interactions

Losartan results in decreased expression of EDN1 protein
Losartan results in decreased expression of EDN1 mRNA; Losartan results in decreased expression of EDN1 protein
Losartan inhibits the reaction [Nitroglycerin results in increased expression of EDN1 protein]
Losartan inhibits the reaction [AGT protein modified form results in increased expression of EDN1 protein]

PMID:11369837 PMID:12901495 PMID:16191423 PMID:17666345 PMID:18971572

NCBI chr17:22,660,799...22,666,687
Ensembl chr17:22,454,420...22,460,885

G

endothelin receptor type A

multiple interactions
decreases expression

Atorvastatin promotes the reaction [Losartan results in decreased expression of EDNRA mRNA]; Losartan promotes the reaction [Atorvastatin results in decreased expression of EDNRA mRNA]

NCBI chr19:47,137,360...47,207,961
Ensembl chr19:30,233,571...30,297,049

G

eukaryotic translation initiation factor 2 subunit alpha

multiple interactions

Losartan inhibits the reaction [AGT protein results in increased phosphorylation of EIF2S1 protein]

NCBI chr 6:103,405,880...103,430,549
Ensembl chr 6:97,672,766...97,706,225

G

elastin

decreases expression

Losartan results in decreased expression of ELN mRNA

NCBI chr12:27,604,983...27,648,413
Ensembl chr12:21,968,544...22,011,928

G

endoglin

multiple interactions
increases expression

Losartan inhibits the reaction [AGT protein results in increased expression of ENG mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of ENG protein]
Losartan results in increased expression of ENG mRNA; Losartan results in increased expression of ENG protein

PMID:15539634 PMID:32947957

NCBI chr 3:36,332,190...36,370,324
Ensembl chr 3:15,934,518...15,973,230

G

coagulation factor III, tissue factor

decreases expression
multiple interactions

Losartan results in decreased expression of F3 mRNA; Losartan results in decreased expression of F3 protein
Losartan inhibits the reaction [[Shiga Toxin 1 co-treated with TNF protein] results in increased activity of F3 protein]; Losartan inhibits the reaction [AGT protein modified form promotes the reaction [[Shiga Toxin 1 co-treated with TNF protein] results in increased activity of F3 protein]]

PMID:18060435 PMID:22188725

NCBI chr 2:212,511,675...212,523,375
Ensembl chr 2:209,826,959...209,838,668

G

Fas ligand

decreases expression

Losartan results in decreased expression of FASLG mRNA

NCBI chr13:76,680,885...76,706,042
Ensembl chr13:74,154,954...74,162,215

G

fatty acid synthase

multiple interactions

Losartan inhibits the reaction [AGT protein results in increased expression of FASN mRNA]

NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,072,091...106,090,261

G

Fms related receptor tyrosine kinase 1

decreases expression

Losartan results in decreased expression of FLT1 mRNA; Losartan results in decreased expression of FLT1 protein

NCBI chr12:12,333,050...12,504,750
Ensembl chr12:7,297,292...7,468,626

G

Fms related receptor tyrosine kinase 4

decreases expression

Losartan results in decreased expression of FLT4 mRNA

NCBI chr10:34,414,834...34,455,878
Ensembl chr10:33,913,608...33,954,770

G

fibronectin 1

decreases expression

Losartan results in decreased expression of FN1 mRNA; Losartan results in decreased expression of FN1 protein

NCBI chr 9:80,645,507...80,714,200
Ensembl chr 9:73,196,044...73,264,678

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions

Losartan inhibits the reaction [AGT protein results in increased expression of FOS protein]; Losartan inhibits the reaction [Furosemide results in increased expression of FOS protein]; Losartan inhibits the reaction [Polyethylene Glycols results in increased expression of FOS protein]

PMID:11463773 PMID:15528393

NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:105,121,170...105,124,036

G

gap junction protein, alpha 1

increases expression

Losartan results in increased expression of GJA1 protein

NCBI chr20:36,302,490...36,315,010
Ensembl chr20:35,755,991...35,768,582

G

glutamic--pyruvic transaminase

multiple interactions

Losartan inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]
Losartan inhibits the reaction [Diethylnitrosamine results in increased activity of GPT protein]

PMID:15573910 PMID:29859236

NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:108,416,642...108,419,494

G

glycogen synthase kinase 3 beta

multiple interactions

Losartan inhibits the reaction [AGT protein modified form results in increased phosphorylation of GSK3B protein]

NCBI chr11:76,004,502...76,154,665
Ensembl chr11:62,504,316...62,648,646

G

hepatitis A virus cellular receptor 1

multiple interactions

Losartan inhibits the reaction [Cadmium results in increased expression of HAVCR1]

NCBI chr10:31,619,914...31,652,955
Ensembl chr10:31,119,088...31,151,698

G

3-hydroxy-3-methylglutaryl-CoA reductase

multiple interactions

Losartan inhibits the reaction [AGT protein results in increased expression of HMGCR mRNA]

NCBI chr 2:29,732,163...29,754,276
Ensembl chr 2:27,997,525...28,019,703

G

heme oxygenase 1

increases activity
multiple interactions
increases expression

Losartan results in increased activity of HMOX1 protein
Losartan inhibits the reaction [AGT protein results in decreased expression of HMOX1 protein]
Losartan results in increased expression of HMOX1 mRNA
cobaltiprotoporphyrin promotes the reaction [Losartan results in increased activity of HMOX1 protein]; cobaltiprotoporphyrin promotes the reaction [Losartan results in increased expression of HMOX1 mRNA]

PMID:19804535 PMID:28578904

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079

G

heat shock protein family A (Hsp70) member 5

multiple interactions

Losartan inhibits the reaction [AGT protein results in increased expression of HSPA5 protein]

NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:18,055,405...18,059,891

G

intercellular adhesion molecule 1

multiple interactions
decreases secretion

Losartan inhibits the reaction [AGT protein results in increased secretion of ICAM1 protein]
Dexamethasone promotes the reaction [Losartan inhibits the reaction [Tobacco Smoke Pollution results in increased expression of ICAM1 protein]]; Losartan inhibits the reaction [Tobacco Smoke Pollution results in increased expression of ICAM1 protein]
Losartan results in decreased secretion of ICAM1 protein

PMID:10517737 PMID:32812458

NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:19,553,645...19,565,438

G

interferon gamma

increases expression
multiple interactions

Losartan results in increased expression of IFNG protein
[Losartan co-treated with Vitamin D] inhibits the reaction [Amiodarone results in decreased expression of IFNG protein]; Losartan inhibits the reaction [Amiodarone results in decreased expression of IFNG protein]

PMID:23875703 PMID:34590760

NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:53,903,337...53,907,375

G

interleukin 10

increases expression

Losartan results in increased expression of IL10 mRNA

NCBI chr13:45,024,921...45,029,586
Ensembl chr13:42,472,839...42,477,313

G

interleukin 1 alpha

multiple interactions
decreases expression

Losartan inhibits the reaction [IL1A protein results in increased expression of VEGFA mRNA]; Losartan inhibits the reaction [IL1A protein results in increased expression of VEGFA protein]
Losartan results in decreased expression of IL1A protein

PMID:17299153 PMID:23875703

NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 4

multiple interactions

[Vitamin D co-treated with Losartan] inhibits the reaction [Amiodarone results in increased expression of IL4 protein]; Losartan inhibits the reaction [Amiodarone results in increased expression of IL4 protein]

NCBI chr10:38,272,003...38,277,549
Ensembl chr10:37,771,203...37,776,750

G

interleukin 6

decreases expression
increases expression
multiple interactions

Losartan results in decreased expression of IL6 mRNA
Losartan results in increased expression of IL6 protein
[Losartan co-treated with Vitamin D] inhibits the reaction [Amiodarone results in increased expression of IL6 protein]; Losartan inhibits the reaction [Amiodarone results in increased expression of IL6 protein]; Losartan inhibits the reaction [bisphenol A results in increased expression of IL6 mRNA]; Losartan inhibits the reaction [bisphenol A results in increased expression of IL6 protein]; Losartan inhibits the reaction [Ethylene Glycol results in increased expression of IL6 protein]

PMID:16284884 PMID:21479465 PMID:23875703 PMID:30677511 PMID:32947957 More...

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178

G

integrin subunit alpha 3

decreases expression

Losartan results in decreased expression of ITGA3 protein

NCBI chr10:80,486,998...80,522,548
Ensembl chr10:79,990,161...80,022,118

G

integrin subunit alpha 6

decreases expression

Losartan results in decreased expression of ITGA6 protein

NCBI chr 3:77,012,168...77,097,076
Ensembl chr 3:56,617,268...56,689,428

G

inositol 1,4,5-trisphosphate receptor, type 1

multiple interactions

Losartan inhibits the reaction [Calcium Oxalate results in increased expression of ITPR1 protein]

NCBI chr 4:142,743,401...143,066,505
Ensembl chr 4:141,187,418...141,510,491

G

inositol 1,4,5-trisphosphate receptor, type 2

multiple interactions

Losartan inhibits the reaction [Calcium Oxalate results in increased expression of ITPR2 protein]

NCBI chr 4:180,759,325...181,165,361
Ensembl chr 4:179,027,281...179,404,164

G

Janus kinase 2

multiple interactions

losartan inhibits the reaction [Angiotensin II increases phosphorylation of JAK2 protein in liver]

RGD

NCBI chr 1:236,408,905...236,468,769
Ensembl chr 1:226,995,334...227,054,189

G

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions

[Losartan co-treated with Vitamin D] inhibits the reaction [Amiodarone results in increased phosphorylation of JUN protein]; Losartan inhibits the reaction [Amiodarone results in increased phosphorylation of JUN protein]

NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:109,893,145...109,897,656

G

kinase insert domain receptor

multiple interactions

Losartan inhibits the reaction [Cyclosporine results in increased expression of KDR mRNA]

NCBI chr14:32,572,031...32,615,204
Ensembl chr14:32,217,871...32,261,018

G

kininogen 1

multiple interactions

Losartan inhibits the reaction [bisphenol A results in increased expression of KNG1 protein]

NCBI chr11:91,317,354...91,340,148
Ensembl chr11:77,812,752...77,835,555

G

KRAS proto-oncogene, GTPase

multiple interactions

Losartan inhibits the reaction [KRAS protein mutant form results in increased expression of CDKN1A protein]; Losartan inhibits the reaction [KRAS protein mutant form results in increased expression of CDKN2A protein]

NCBI chr 4:179,916,255...179,949,613

G

lysyl oxidase

decreases expression

Losartan results in decreased expression of LOX mRNA

NCBI chr18:48,162,889...48,175,640
Ensembl chr18:45,967,343...46,041,477

G

lumican

decreases expression

Losartan results in decreased expression of LUM mRNA

NCBI chr 7:34,245,323...34,252,510
Ensembl chr 7:32,358,614...32,365,793

G

mitogen activated protein kinase 1

multiple interactions
increases phosphorylation
increases activity

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Losartan results in increased phosphorylation of MAPK1 protein]; [Losartan co-treated with Vitamin D] inhibits the reaction [Amiodarone results in increased phosphorylation of MAPK1 protein]; Losartan inhibits the reaction [[AGT protein binds to and results in increased localization of AGTR1A protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Losartan inhibits the reaction [AGT protein results in increased phosphorylation of MAPK1 protein]; Losartan inhibits the reaction [Amiodarone results in increased phosphorylation of MAPK1 protein]
Losartan results in increased activity of MAPK1 protein
Losartan inhibits the reaction [Particulate Matter results in increased phosphorylation of MAPK1 protein]

PMID:11711055 PMID:16079071 PMID:18267125 PMID:18511912 PMID:20056918 More...

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 14

decreases expression
multiple interactions

Losartan results in decreased expression of MAPK14 protein
[Losartan co-treated with Vitamin D] inhibits the reaction [Amiodarone results in increased phosphorylation of MAPK14 protein]; Losartan inhibits the reaction [Amiodarone results in increased phosphorylation of MAPK14 protein]

PMID:28091615 PMID:34590760

NCBI chr20:6,751,288...6,812,294
Ensembl chr20:6,749,670...6,810,589

G

mitogen activated protein kinase 3

multiple interactions
increases phosphorylation
increases activity

Losartan inhibits the reaction [Particulate Matter results in increased phosphorylation of MAPK3 protein]
Losartan results in increased phosphorylation of MAPK3 protein
Losartan results in increased activity of MAPK3 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Losartan results in increased phosphorylation of MAPK3 protein]; [Losartan co-treated with Vitamin D] inhibits the reaction [Amiodarone results in increased phosphorylation of MAPK3 protein]; Losartan inhibits the reaction [[AGT protein binds to and results in increased localization of AGTR1A protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Losartan inhibits the reaction [AGT protein results in increased phosphorylation of MAPK3 protein]; Losartan inhibits the reaction [Amiodarone results in increased phosphorylation of MAPK3 protein]

PMID:11711055 PMID:16079071 PMID:18267125 PMID:18511912 PMID:20056918 More...

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863

G

microtubule-associated protein tau

multiple interactions

Losartan inhibits the reaction [AGT protein modified form results in increased phosphorylation of MAPT protein]

NCBI chr10:89,638,618...89,736,108
Ensembl chr10:89,138,627...89,236,129

G

MAS1 proto-oncogene, G protein-coupled receptor

multiple interactions

Losartan inhibits the reaction [AGT protein results in decreased expression of MAS1 protein]; Losartan inhibits the reaction [Silicon Dioxide results in decreased expression of MAS1 protein]

NCBI chr 1:50,428,064...50,459,537
Ensembl chr 1:47,880,309...47,911,709

G

matrix Gla protein

decreases expression

Losartan results in decreased expression of MGP mRNA

NCBI chr 4:171,497,472...171,500,888
Ensembl chr 4:169,766,279...169,769,667

G

matrix metallopeptidase 2

multiple interactions

Losartan inhibits the reaction [[Phenylephrine results in increased expression of AGT protein] which results in increased activity of MMP2 protein]; Losartan inhibits the reaction [Carbon Tetrachloride results in increased activity of MMP2 protein]
Losartan inhibits the reaction [AGT protein results in increased secretion of MMP2 protein]
Losartan inhibits the reaction [Diethylnitrosamine results in increased expression of MMP2 protein]; Losartan inhibits the reaction [Lipopolysaccharides results in increased expression of MMP2 mRNA]

PMID:12930639 PMID:16251426 PMID:23585870 PMID:29859236 PMID:36682589

NCBI chr19:30,327,643...30,355,856
Ensembl chr19:14,154,657...14,182,870

G

matrix metallopeptidase 23

decreases expression

Losartan results in decreased expression of MMP23 mRNA

NCBI chr 5:171,521,905...171,525,007
Ensembl chr 5:166,239,644...166,242,433

G

matrix metallopeptidase 7

multiple interactions

ICG 001 promotes the reaction [Losartan inhibits the reaction [AGT protein results in increased expression of MMP7 protein]]; Losartan inhibits the reaction [AGT protein results in increased expression of MMP7 protein]; Losartan promotes the reaction [ICG 001 inhibits the reaction [AGT protein results in increased expression of MMP7 protein]]

NCBI chr 8:13,133,043...13,140,761
Ensembl chr 8:4,848,186...4,855,902

G

matrix metallopeptidase 9

decreases expression
multiple interactions

Losartan results in decreased expression of MMP9 mRNA
Dexamethasone promotes the reaction [Losartan inhibits the reaction [Tobacco Smoke Pollution results in increased expression of MMP9 protein]]; Losartan inhibits the reaction [Paraquat results in increased expression of MMP9 mRNA]; Losartan inhibits the reaction [Tobacco Smoke Pollution results in increased expression of MMP9 protein]
Losartan inhibits the reaction [Lipopolysaccharides results in increased expression of MMP9 mRNA]

PMID:18971572 PMID:23585870 PMID:25233898 PMID:32812458

NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:153,683,858...153,692,120

G

MYC proto-oncogene, bHLH transcription factor

affects expression

Losartan affects the expression of MYC protein

NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:93,593,705...93,598,630

G

myosin heavy chain 11

decreases expression

Losartan results in decreased expression of MYH11 mRNA

NCBI chr10:1,250,554...1,345,681
Ensembl chr10:743,685...838,459

G

myosin heavy chain 6

multiple interactions

Losartan inhibits the reaction [Streptozocin results in decreased expression of MYH6 mRNA]; Losartan inhibits the reaction [Streptozocin results in decreased expression of MYH6 protein]

NCBI chr15:32,388,102...32,413,663
Ensembl chr15:28,417,616...28,441,720

G

myosin heavy chain 7

multiple interactions

Losartan inhibits the reaction [Streptozocin results in increased expression of MYH7 mRNA]; Losartan inhibits the reaction [Streptozocin results in increased expression of MYH7 protein]

NCBI chr15:32,416,525...32,439,851
Ensembl chr15:28,446,550...28,468,217

G

myosin light chain kinase

multiple interactions

Losartan inhibits the reaction [AGT protein results in increased expression of MYLK protein]

NCBI chr11:79,288,243...79,535,450
Ensembl chr11:65,783,008...66,030,261

G

neutrophil cytosolic factor 1

multiple interactions

Losartan inhibits the reaction [Hydrogen Peroxide results in increased expression of NCF1 mRNA]
Losartan inhibits the reaction [Ethanol affects the localization of NCF1 protein]

PMID:22306536 PMID:22497828 PMID:22982071

NCBI chr12:28,121,816...28,131,080
Ensembl chr12:22,485,451...22,494,646

G

neutrophil cytosolic factor 2

multiple interactions

Losartan inhibits the reaction [AGT protein results in increased expression of NCF2 mRNA]

NCBI chr13:67,505,492...67,536,015
Ensembl chr13:64,955,503...64,986,277

G

N-deacetylase and N-sulfotransferase 1

multiple interactions

Losartan inhibits the reaction [Streptozocin results in decreased expression of NDST1 protein]

NCBI chr18:56,407,308...56,470,007
Ensembl chr18:54,140,779...54,178,191

G

NFE2 like bZIP transcription factor 2

decreases expression
multiple interactions

Losartan results in decreased expression of NFE2L2 mRNA
Losartan inhibits the reaction [AGT protein results in decreased expression of NFE2L2 protein]

PMID:18765277 PMID:28578904

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:60,594,242...60,621,737

G

nuclear factor kappa B subunit 1

multiple interactions

Losartan inhibits the reaction [Ethylene Glycol results in increased expression of NFKB1 protein]
Losartan inhibits the reaction [Diethylnitrosamine results in decreased expression of NFKB1 protein]

PMID:16284884 PMID:29859236

NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:224,016,214...224,110,404

G

nitric oxide synthase 1

increases phosphorylation
multiple interactions

Losartan results in increased phosphorylation of NOS1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Losartan results in increased phosphorylation of NOS1 protein]

NCBI chr12:44,276,011...44,456,371
Ensembl chr12:38,626,714...38,710,945

G

nitric oxide synthase 2

affects expression
decreases expression
increases expression

Losartan affects the expression of NOS2 mRNA
Losartan results in decreased expression of NOS2 mRNA; Losartan results in decreased expression of NOS2 protein
Losartan results in increased expression of NOS2 protein

PMID:12198324 PMID:16191423 PMID:18390819 PMID:21377515

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210

G

nitric oxide synthase 3

affects expression
increases expression
multiple interactions
increases phosphorylation

Losartan affects the expression of NOS3 mRNA
Losartan results in increased expression of NOS3 mRNA
[Losartan co-treated with Atorvastatin] results in increased expression of NOS3 mRNA; Losartan inhibits the reaction [Sodium Chloride results in decreased expression of NOS3 protein]
Losartan results in increased phosphorylation of NOS3 protein

PMID:12198324 PMID:18390819 PMID:18971572 PMID:20232302 PMID:23091284

NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:10,793,834...10,814,166

G

NPHS1 adhesion molecule, nephrin

multiple interactions

Losartan inhibits the reaction [AGT protein results in decreased expression of NPHS1 protein]

NCBI chr 1:94,848,261...94,876,522
Ensembl chr 1:85,720,812...85,749,078

G

NPHS2 stomatin family member, podocin

multiple interactions

[Losartan co-treated with ICG 001] inhibits the reaction [AGT protein results in decreased expression of NPHS2 protein]

NCBI chr13:68,448,720...68,461,312
Ensembl chr13:68,448,926...68,461,313

G

natriuretic peptide A

multiple interactions
decreases expression

Losartan inhibits the reaction [Nitric Oxide deficiency results in increased expression of NPPA mRNA]
Losartan results in decreased expression of NPPA protein

NCBI chr 5:163,712,184...163,713,493
Ensembl chr 5:158,429,042...158,430,351

G

natriuretic peptide B

multiple interactions
decreases expression

[Atenolol co-treated with Losartan co-treated with Doxazosin] results in decreased expression of NPPB mRNA; [Losartan co-treated with Doxazosin] results in decreased expression of NPPB mRNA; [Losartan co-treated with Nifedipine] results in decreased expression of NPPB mRNA; Losartan inhibits the reaction [Nitric Oxide deficiency results in increased expression of NPPB mRNA]
Losartan results in decreased expression of NPPB mRNA; Losartan results in decreased expression of NPPB protein

PMID:12198334 PMID:15969258 PMID:17666919

NCBI chr 5:163,699,955...163,701,314
Ensembl chr 5:158,416,866...158,418,168

G

natriuretic peptide receptor 1

affects response to substance

NPR1 protein mutant form affects the susceptibility to Losartan

NCBI chr 2:178,231,766...178,247,591
Ensembl chr 2:175,934,181...175,949,505

G

nuclear receptor subfamily 1, group H, member 3

increases expression

Losartan results in increased expression of NR1H3 protein

NCBI chr 3:97,614,616...97,632,053
Ensembl chr 3:77,158,808...77,168,722

G

nuclear respiratory factor 1

increases expression

Losartan results in increased expression of NRF1 mRNA

NCBI chr 4:59,632,366...59,738,166
Ensembl chr 4:58,664,957...58,825,328

G

poly (ADP-ribose) polymerase 1

multiple interactions

Losartan inhibits the reaction [AGT protein results in increased expression of PARP1 protein]
Losartan inhibits the reaction [AGT protein results in increased activity of PARP1 protein]

PMID:15502880 PMID:21613793

NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404

G

platelet derived growth factor subunit A

multiple interactions

Losartan inhibits the reaction [AGT protein alternative form results in increased expression of PDGFA mRNA alternative form]

NCBI chr12:20,759,366...20,780,337
Ensembl chr12:15,645,541...15,666,497

G

platelet derived growth factor subunit B

multiple interactions

Losartan inhibits the reaction [AGT protein results in increased expression of PDGFB mRNA]; Losartan inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFB protein]

PMID:12930639 PMID:17043664

NCBI chr 7:113,419,882...113,438,343
Ensembl chr 7:111,540,345...111,557,984

G

platelet derived growth factor D

multiple interactions

Losartan inhibits the reaction [AGT protein results in increased expression of PDGFD mRNA]

NCBI chr 8:11,773,335...12,007,277
Ensembl chr 8:3,488,423...3,722,395

G

platelet derived growth factor receptor beta

multiple interactions

Losartan inhibits the reaction [AGT protein results in increased expression of PDGFRB mRNA]

NCBI chr18:56,770,348...56,809,228
Ensembl chr18:54,499,964...54,538,843

G

PDZ and LIM domain 3

decreases expression

Losartan results in decreased expression of PDLIM3 mRNA

NCBI chr16:53,085,020...53,116,495
Ensembl chr16:46,352,467...46,383,657

G

platelet and endothelial cell adhesion molecule 1

decreases expression

Losartan results in decreased expression of PECAM1 mRNA

NCBI chr10:92,090,263...92,152,002
Ensembl chr10:91,590,521...91,652,116

G

plasminogen activator, tissue type

decreases expression

Losartan results in decreased expression of PLAT mRNA

NCBI chr16:75,943,061...76,022,037
Ensembl chr16:69,240,585...69,268,223

G

podocalyxin-like

multiple interactions

Losartan inhibits the reaction [AGT protein results in decreased expression of PODXL protein]

NCBI chr 4:61,102,434...61,149,131
Ensembl chr 4:60,135,109...60,181,899

G

periostin

multiple interactions
decreases expression

Losartan inhibits the reaction [AGT protein results in increased expression of POSTN mRNA]
Losartan results in decreased expression of POSTN mRNA

PMID:15121739 PMID:21641384 PMID:32947957

NCBI chr 2:140,677,774...140,709,304
Ensembl chr 2:138,527,696...138,559,099

G

peroxisome proliferator activated receptor alpha

multiple interactions

Losartan inhibits the reaction [AGT protein results in increased expression of PPARA mRNA]

NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:116,832,756...116,895,346

G

peroxisome proliferator-activated receptor gamma

multiple interactions

Losartan inhibits the reaction [AGT protein results in increased expression of PPARG mRNA]
Losartan inhibits the reaction [[Dietary Fats co-treated with Cholesterol] results in increased expression of PPARG mRNA]

PMID:18302760 PMID:19109942

NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:148,423,194...148,548,468

G

PPARG coactivator 1 alpha

multiple interactions
increases expression

Losartan inhibits the reaction [AGT protein results in increased expression of PPARGC1A mRNA]
Losartan results in increased expression of PPARGC1A mRNA

PMID:18765277 PMID:18971572 PMID:19109942

NCBI chr14:63,073,505...63,729,215
Ensembl chr14:58,861,144...59,512,656

G

protein kinase C, beta

multiple interactions

Losartan inhibits the reaction [Ethanol results in increased expression of PRKCB protein]

NCBI chr 1:186,263,397...186,594,743
Ensembl chr 1:176,832,226...177,163,536

G

prolactin

multiple interactions

Losartan inhibits the reaction [AGT protein results in increased secretion of PRL protein]
Losartan inhibits the reaction [AGT protein promotes the reaction [[Medroxyprogesterone Acetate co-treated with Bucladesine] results in increased secretion of PRL protein]]

PMID:14722030 PMID:36682589

NCBI chr17:38,287,355...38,298,234
Ensembl chr17:37,860,007...37,870,062

G

prostaglandin-endoperoxide synthase 2

multiple interactions
decreases expression

Losartan inhibits the reaction [[AGT protein binds to and results in increased localization of AGTR1A protein] which results in increased expression of PTGS2 protein]; Losartan inhibits the reaction [Phenylephrine results in increased expression of PTGS2 mRNA]; Losartan inhibits the reaction [Phenylephrine results in increased expression of PTGS2 protein]
Losartan inhibits the reaction [AGT protein results in increased expression of PTGS2 protein]
Losartan results in decreased expression of PTGS2 mRNA; Losartan results in decreased expression of PTGS2 protein

PMID:17244722 PMID:18267125 PMID:21377515 PMID:28578904

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188

G

parathyroid hormone 1 receptor

multiple interactions

Losartan inhibits the reaction [Folic Acid results in decreased expression of PTH1R protein]; Losartan inhibits the reaction [Gentamicins results in decreased expression of PTH1R protein]

NCBI chr 8:119,572,295...119,597,405
Ensembl chr 8:110,697,485...110,719,729

G

parathyroid hormone-like hormone

multiple interactions

Losartan inhibits the reaction [AGT protein results in increased expression of PTHLH mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of PTHLH protein]; Losartan inhibits the reaction [Folic Acid results in increased expression of PTHLH mRNA]; Losartan inhibits the reaction [Folic Acid results in increased expression of PTHLH protein]; Losartan inhibits the reaction [Gentamicins results in increased expression of PTHLH protein]

NCBI chr 4:181,919,400...181,930,454
Ensembl chr 4:180,188,792...180,199,847

G

regenerating family member 3 gamma

multiple interactions

Losartan inhibits the reaction [AGT protein results in increased expression of REG3G mRNA]

NCBI chr 4:112,482,183...112,484,738
Ensembl chr 4:110,924,168...110,926,723

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

Dexamethasone promotes the reaction [Losartan inhibits the reaction [Tobacco Smoke Pollution results in increased expression of RELA protein]]; Losartan inhibits the reaction [Doxorubicin results in increased expression of RELA mRNA]; Losartan inhibits the reaction [Tobacco Smoke Pollution results in increased expression of RELA protein]
Losartan inhibits the reaction [AGT protein results in increased expression of RELA protein]; Losartan inhibits the reaction [Diethylnitrosamine results in increased phosphorylation of RELA protein]

PMID:15157388 PMID:28578904 PMID:29859236 PMID:32812458

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484

G

renin

multiple interactions
increases expression
increases activity

[Losartan results in decreased activity of AGTR1 protein] which results in increased expression of REN protein; Losartan inhibits the reaction [AGT protein results in increased expression of REN protein]; Losartan promotes the reaction [Hydrochlorothiazide results in increased expression of REN protein]
Losartan inhibits the reaction [AGT protein results in increased expression of REN1 protein]
Losartan results in increased expression of REN mRNA; Losartan results in increased expression of REN protein
Losartan results in increased activity of REN protein
[Lisinopril co-treated with Losartan] results in increased expression of REN mRNA; Losartan inhibits the reaction [Ethanol results in increased activity of REN protein]; Losartan promotes the reaction [Isoproterenol results in increased expression of REN protein]

PMID:1387008 PMID:7965263 PMID:8382237 PMID:8403307 PMID:9124547 More...

NCBI chr13:47,348,312...47,359,539
Ensembl chr13:44,796,091...44,807,489

G

RT1 class II, locus Da

decreases expression

Losartan results in decreased expression of RT1-DA mRNA

NCBI chr20:4,515,393...4,520,387
Ensembl chr20:4,512,911...4,518,455

G

RT1 class Ib, locus S3

decreases expression

Losartan results in decreased expression of RT1-S3 mRNA

NCBI chr20:2,675,463...2,680,229
Ensembl chr20:2,670,709...2,675,411

G

RUNX family transcription factor 2

multiple interactions

Losartan affects the reaction [[Warfarin co-treated with Vitamin K 1] affects the expression of RUNX2 mRNA]; Losartan affects the reaction [[Warfarin co-treated with Vitamin K 1] affects the expression of RUNX2 protein]

NCBI chr 9:23,661,278...23,990,248
Ensembl chr 9:16,167,482...16,492,167

G

S100 calcium-binding protein A4

multiple interactions

[Losartan co-treated with ICG 001] inhibits the reaction [AGT protein results in increased expression of S100A4 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of S100A4 protein]

NCBI chr 2:178,388,529...178,390,838
Ensembl chr 2:176,091,804...176,093,254

G

sphingosine-1-phosphate receptor 1

multiple interactions

Losartan inhibits the reaction [AGT protein modified form results in increased expression of S1PR1 mRNA]; Losartan inhibits the reaction [AGT protein modified form results in increased expression of S1PR1 protein]

NCBI chr 2:206,309,715...206,314,070
Ensembl chr 2:203,621,587...203,629,681

G

scavenger receptor class B, member 1

multiple interactions

Losartan inhibits the reaction [[Dietary Fats co-treated with Cholesterol] results in decreased expression of SCARB1 mRNA]

NCBI chr12:36,957,302...37,023,982
Ensembl chr12:31,296,156...31,362,647

G

syndecan 2

decreases expression

Losartan results in decreased expression of SDC2 mRNA; Losartan results in decreased expression of SDC2 protein

NCBI chr 7:66,012,405...66,125,101
Ensembl chr 7:64,127,110...64,241,081

G

selectin P

multiple interactions

Losartan inhibits the reaction [Estrogens deficiency results in increased expression of SELP protein]

NCBI chr13:79,009,379...79,044,994
Ensembl chr13:76,476,295...76,511,845

G

secreted frizzled-related protein 2

decreases response to substance

SFRP2 protein results in decreased susceptibility to Losartan

NCBI chr 2:171,387,536...171,395,081
Ensembl chr 2:169,089,517...169,097,063

G

solute carrier family 22 member 12

decreases activity
affects response to substance
decreases expression
multiple interactions

Losartan results in decreased activity of SLC22A12 protein
SLC22A12 protein affects the susceptibility to Losartan
Losartan results in decreased expression of SLC22A12 mRNA
[Losartan results in decreased activity of SLC22A12 protein] which results in decreased abundance of Uric Acid

PMID:18670416 PMID:20486468

NCBI chr 1:203,845,039...203,852,496
Ensembl chr 1:203,845,048...203,853,555

G

solute carrier family 22, member 25

multiple interactions

Losartan inhibits the reaction [SLC22A9 protein results in increased uptake of estrone sulfate]

NCBI chr 1:214,767,837...214,956,535
Ensembl chr 1:205,338,699...205,433,085

G

solute carrier family 2 member 9

multiple interactions

Losartan inhibits the reaction [SLC2A9 protein results in increased uptake of Uric Acid]

NCBI chr14:76,540,649...76,674,277
Ensembl chr14:72,328,320...72,461,981

G

solute carrier family 9 member A3

multiple interactions

Losartan inhibits the reaction [Ammonium Chloride results in increased expression of NHE3 protein]

NCBI chr 1:30,953,215...30,996,209
Ensembl chr 1:29,124,674...29,167,417

G

snail family transcriptional repressor 1

multiple interactions

ICG 001 promotes the reaction [Losartan inhibits the reaction [AGT protein results in increased expression of SNAI1 protein]]; Losartan inhibits the reaction [AGT protein results in increased expression of SNAI1 protein]; Losartan promotes the reaction [ICG 001 inhibits the reaction [AGT protein results in increased expression of SNAI1 protein]]

NCBI chr 3:176,667,476...176,671,965
Ensembl chr 3:156,248,485...156,252,969

G

superoxide dismutase 2

decreases activity

Losartan results in decreased activity of SOD2 protein

NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:47,636,528...47,645,189

G

superoxide dismutase 3

multiple interactions

Losartan inhibits the reaction [AGT protein results in increased expression of SOD3 protein]

NCBI chr14:62,822,865...62,828,602
Ensembl chr14:58,609,958...58,615,990

G

secreted protein acidic and cysteine rich

decreases expression

Losartan results in decreased expression of SPARC mRNA

NCBI chr10:40,017,065...40,038,816
Ensembl chr10:39,516,406...39,538,396

G

secreted phosphoprotein 1

multiple interactions

Losartan inhibits the reaction [glyoxylic acid results in increased expression of SPP1 protein]

NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,308,885...5,315,162

G

sterol regulatory element binding transcription factor 1

multiple interactions

Losartan inhibits the reaction [AGT protein results in increased cleavage of SREBF1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of SREBF1 mRNA]; Losartan inhibits the reaction [AGT protein results in increased phosphorylation of SREBF1 protein]

PMID:19109942 PMID:25398788

NCBI chr10:45,507,152...45,529,164
Ensembl chr10:45,007,637...45,029,650

G

signal transducer and activator of transcription 3

decreases phosphorylation

Losartan results in decreased phosphorylation of STAT3 protein

NCBI chr10:86,311,528...86,363,513
Ensembl chr10:85,811,218...85,863,057

G

transforming growth factor, beta 1

decreases secretion
multiple interactions
decreases activity
decreases expression
increases expression

Losartan results in decreased secretion of TGFB1 protein
Losartan inhibits the reaction [Diethylnitrosamine results in increased expression of TGFB1 protein]
[Losartan results in decreased activity of AGT protein] which results in decreased activity of TGFB1 protein
Losartan results in decreased expression of TGFB1 mRNA; Losartan results in decreased expression of TGFB1 protein
Losartan results in decreased expression of TGFB1 mRNA; Losartan results in decreased expression of TGFB1 protein; Losartan results in decreased expression of TGFB1 protein modified form
Losartan results in increased expression of TGFB1 protein
[Losartan co-treated with Cilazapril] inhibits the reaction [Doxorubicin results in increased expression of TGFB1 protein]; [Losartan co-treated with Nifedipine] results in decreased expression of TGFB1 mRNA; [Losartan co-treated with Vitamin D] inhibits the reaction [Amiodarone results in increased expression of TGFB1 protein]; Losartan inhibits the reaction [Amiodarone results in increased expression of TGFB1 protein]; Losartan inhibits the reaction [bisphenol A results in increased expression of TGFB1 protein]; Losartan inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]; Losartan inhibits the reaction [Carbon Tetrachloride results in increased secretion of TGFB1 protein]; Losartan inhibits the reaction [Doxorubicin results in increased expression of TGFB1 protein]; Losartan inhibits the reaction [Paraquat results in increased expression of TGFB1 mRNA]

PMID:11369837 PMID:12930639 PMID:12937228 PMID:15331931 PMID:15573910 More...

NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847

G

TIMP metallopeptidase inhibitor 1

multiple interactions
decreases expression

Losartan inhibits the reaction [Paraquat results in increased expression of TIMP1 mRNA]; Losartan inhibits the reaction [Simvastatin results in decreased expression of TIMP1 mRNA]; Simvastatin inhibits the reaction [Losartan results in decreased expression of TIMP1 mRNA]

PMID:20137537 PMID:25233898

NCBI chr X:3,766,509...3,772,578
Ensembl chr X:1,212,972...1,217,664

G

TIMP metallopeptidase inhibitor 2

decreases expression
multiple interactions

Losartan results in decreased expression of TIMP2 mRNA
Losartan inhibits the reaction [Simvastatin results in decreased expression of TIMP2 mRNA]; Simvastatin inhibits the reaction [Losartan results in decreased expression of TIMP2 mRNA]

NCBI chr10:104,041,604...104,089,214
Ensembl chr10:103,531,505...103,590,611

G

tight junction protein 1

decreases expression

Losartan results in decreased expression of TJP1 protein

NCBI chr 1:128,260,330...128,505,018
Ensembl chr 1:118,849,838...119,094,432

G

tenascin C

decreases expression

Losartan results in decreased expression of TNC mRNA

PMID:15100363 PMID:32947957

NCBI chr 5:82,391,340...82,476,197
Ensembl chr 5:77,375,851...77,460,624

G

tumor necrosis factor

multiple interactions
decreases expression

Losartan affects the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Losartan inhibits the reaction [[Shiga Toxin 1 co-treated with TNF protein] results in increased activity of F3 protein]; Losartan inhibits the reaction [AGT protein modified form promotes the reaction [[Shiga Toxin 1 co-treated with TNF protein] results in increased activity of F3 protein]]; Losartan inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Losartan inhibits the reaction [TNF protein results in increased expression of VEGFA mRNA]; Losartan inhibits the reaction [TNF protein results in increased expression of VEGFA protein]; T 0070907 inhibits the reaction [Losartan inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]
Losartan inhibits the reaction [Diethylnitrosamine results in increased expression of TNF protein]
Losartan results in decreased expression of TNF protein
[Losartan co-treated with Vitamin D] inhibits the reaction [Amiodarone results in increased expression of TNF protein]; Losartan inhibits the reaction [Amiodarone results in increased expression of TNF protein]; Losartan inhibits the reaction [bisphenol A results in increased expression of TNF mRNA]; Losartan inhibits the reaction [bisphenol A results in increased expression of TNF protein]; Losartan inhibits the reaction [Carbon Tetrachloride results in increased secretion of TNF protein]; Losartan inhibits the reaction [Testosterone results in increased expression of TNF protein]

PMID:15573910 PMID:17299153 PMID:18060435 PMID:22124178 PMID:23875703 More...

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629

G

translocase of outer mitochondrial membrane 20

decreases expression

Losartan results in decreased expression of TOMM20 mRNA

NCBI chr19:71,822,429...71,832,420
Ensembl chr19:54,923,402...54,935,198

G

tumor protein p53

affects expression

Losartan affects the expression of TP53 protein

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524

G

TSC22 domain family, member 1

multiple interactions

Losartan inhibits the reaction [AGT protein results in increased expression of TSC22D1 mRNA]

NCBI chr15:58,159,612...58,260,244
Ensembl chr15:51,749,510...51,850,958

G

twist family bHLH transcription factor 1

multiple interactions

Losartan inhibits the reaction [AGT protein results in increased expression of TWIST1 protein]

NCBI chr 6:56,402,309...56,404,303
Ensembl chr 6:50,674,678...50,677,653

G

uncoupling protein 2

decreases expression
multiple interactions

Losartan results in decreased expression of UCP2 mRNA; Losartan results in decreased expression of UCP2 protein
Losartan inhibits the reaction [AGT protein results in increased expression of UCP2 mRNA]

PMID:17508912 PMID:19109942

NCBI chr 1:164,251,373...164,257,742
Ensembl chr 1:154,839,209...154,845,611

G

uncoupling protein 3

multiple interactions

Losartan inhibits the reaction [AGT protein results in increased expression of UCP3 mRNA]

NCBI chr 1:164,227,910...164,240,893
Ensembl chr 1:154,815,777...154,828,762

G

vascular cell adhesion molecule 1

multiple interactions

Losartan inhibits the reaction [Estrogens deficiency results in increased expression of VCAM1 protein]

NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:204,038,114...204,057,958

G

vascular endothelial growth factor A

multiple interactions
decreases expression

Losartan inhibits the reaction [IL1A protein results in increased expression of VEGFA mRNA]; Losartan inhibits the reaction [IL1A protein results in increased expression of VEGFA protein]; Losartan inhibits the reaction [TNF protein results in increased expression of VEGFA mRNA]; Losartan inhibits the reaction [TNF protein results in increased expression of VEGFA protein]; Losartan promotes the reaction [AGT protein results in increased expression of VEGFA mRNA]; Losartan promotes the reaction [AGT protein results in increased secretion of VEGFA protein]
Losartan inhibits the reaction [Diethylnitrosamine results in increased expression of VEGFA protein]; Losartan inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA protein]
Losartan inhibits the reaction [Cyclosporine results in increased expression of VEGFA protein]
Losartan results in decreased expression of VEGFA mRNA; Losartan results in decreased expression of VEGFA protein

PMID:12110003 PMID:17299153 PMID:17481528 PMID:22188725 PMID:25511041 More...

NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:14,955,300...14,970,641

G

vascular endothelial growth factor C

decreases expression

Losartan results in decreased expression of VEGFC mRNA

NCBI chr16:44,445,293...44,560,887
Ensembl chr16:37,712,262...37,827,848

G

vimentin

multiple interactions

Losartan inhibits the reaction [AGT protein results in increased expression of VIM protein]
Losartan inhibits the reaction [AGT protein results in increased expression of VIM protein]; Losartan inhibits the reaction [Silicon Dioxide results in increased expression of VIM protein]

PMID:28578904 PMID:33007385

NCBI chr17:81,577,261...81,585,746
Ensembl chr17:76,668,647...76,677,187

G

Wnt family member 1

multiple interactions

Losartan inhibits the reaction [AGT protein results in increased expression of WNT1 mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of WNT1 protein]

NCBI chr 7:131,817,558...131,821,605
Ensembl chr 7:129,938,604...129,942,651

G

WT1 transcription factor

multiple interactions

Losartan inhibits the reaction [AGT protein results in decreased expression of WT1 protein]

NCBI chr 3:112,019,721...112,068,454
Ensembl chr 3:91,567,001...91,613,643

losartan carboxylic acid

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

solute carrier family 22, member 25

multiple interactions

losartan carboxylic acid inhibits the reaction [SLC22A9 protein results in increased uptake of estrone sulfate]

NCBI chr 1:214,767,837...214,956,535
Ensembl chr 1:205,338,699...205,433,085

olmesartan

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 11

multiple interactions
decreases activity

olmesartan inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
olmesartan results in decreased activity of ABCB11 protein

NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:54,017,127...54,112,730

G

ATP binding cassette subfamily C member 2

affects transport

ABCC2 protein affects the transport of olmesartan

NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:242,664,657...242,723,238

G

angiotensin converting enzyme 2

increases expression

olmesartan results in increased expression of ACE2 mRNA; olmesartan results in increased expression of ACE2 protein

PMID:19171689 PMID:28656296

NCBI chr X:33,925,458...33,972,851
Ensembl chr X:30,293,589...30,340,977

G

actin alpha 2, smooth muscle

multiple interactions

olmesartan inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]; olmesartan inhibits the reaction [Fish Oils inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]]

NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:231,746,548...231,759,554

G

angiotensinogen

decreases expression
multiple interactions

olmesartan results in decreased expression of AGT protein modified form
[olmesartan co-treated with PD 123319] inhibits the reaction [AGT protein modified form results in increased abundance of Fatty Acids, Nonesterified]; [olmesartan co-treated with PD 123319] inhibits the reaction [AGT protein modified form results in increased secretion of and results in increased abundance of Triglycerides]

PMID:16003179 PMID:19171689

NCBI chr19:69,426,540...69,447,017
Ensembl chr19:52,529,185...52,540,977

G

angiotensin II receptor, type 1a

decreases activity

olmesartan results in decreased activity of AGTR1 protein

NCBI chr17:34,383,397...34,435,523
Ensembl chr17:34,174,429...34,226,946

G

AKT serine/threonine kinase 1

multiple interactions

[Pravastatin co-treated with olmesartan] results in increased phosphorylation of AKT1 protein

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921

G

albumin

decreases oxidation

olmesartan results in decreased oxidation of ALB protein

NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,607,381...17,622,836

G

BCL2 associated X, apoptosis regulator

decreases expression

olmesartan results in decreased expression of BAX protein

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368

G

caspase 3

multiple interactions

olmesartan results in decreased expression of and results in decreased activity of CASP3 protein

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648

G

C-reactive protein

decreases expression

olmesartan results in decreased expression of CRP protein

NCBI chr13:87,694,062...87,695,978
Ensembl chr13:85,124,977...85,175,178

G

cytochrome b-245 alpha chain

decreases expression

olmesartan results in decreased expression of CYBA protein

NCBI chr19:67,396,143...67,404,214
Ensembl chr19:50,487,597...50,495,721

G

death-domain associated protein

decreases expression

olmesartan results in decreased expression of DAXX protein

NCBI chr20:4,971,973...4,978,062
Ensembl chr20:4,970,092...4,975,843

G

dihydrofolate reductase

increases expression

olmesartan results in increased expression of DHFR protein

NCBI chr 2:25,320,895...25,346,004
Ensembl chr 2:23,586,031...23,613,713

G

Fas cell surface death receptor

decreases expression

olmesartan results in decreased expression of FAS protein

NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:231,798,960...231,832,591

G

interleukin 18

multiple interactions

olmesartan inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA]

NCBI chr 8:59,802,072...59,829,275
Ensembl chr 8:50,906,960...50,932,887

G

interleukin 6

decreases expression

olmesartan results in decreased expression of IL6 protein

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178

G

Jun proto-oncogene, AP-1 transcription factor subunit

decreases activity

olmesartan results in decreased activity of JUN protein

NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:109,893,145...109,897,656

G

mitogen activated protein kinase kinase kinase 7

multiple interactions

Olmesartan inhibits the reaction [Angiotensin II increases phosphorylation of Map3k7 protein in the heart]

RGD

NCBI chr 5:51,149,524...51,212,012
Ensembl chr 5:46,357,931...46,415,597

G

mitogen activated protein kinase 1

increases expression

olmesartan results in increased expression of MAPK1 protein modified form

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

increases expression

olmesartan results in increased expression of MAPK3 protein modified form

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863

G

mitogen-activated protein kinase 8

decreases expression
decreases activity

olmesartan results in decreased expression of MAPK8 protein modified form
olmesartan results in decreased activity of MAPK8 protein

NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,638,924...8,721,981

G

mitogen-activated protein kinase 9

decreases expression
decreases activity

olmesartan results in decreased expression of MAPK9 protein modified form
olmesartan results in decreased activity of MAPK9 protein

NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,169,675...34,210,178

G

MAS1 proto-oncogene, G protein-coupled receptor

increases expression

olmesartan results in increased expression of MAS1 mRNA; olmesartan results in increased expression of MAS1 protein

NCBI chr 1:50,428,064...50,459,537
Ensembl chr 1:47,880,309...47,911,709

G

myeloperoxidase

multiple interactions

olmesartan inhibits the reaction [Carbon Tetrachloride results in increased activity of MPO protein]; olmesartan inhibits the reaction [Fish Oils inhibits the reaction [Carbon Tetrachloride results in increased activity of MPO protein]]

NCBI chr10:73,092,124...73,102,057
Ensembl chr10:72,594,661...72,604,819

G

nitric oxide synthase 3

multiple interactions

olmesartan promotes the reaction [NOS3 protein binds to NOS3 protein]; olmesartan results in increased activity of and results in increased phosphorylation of NOS3 protein; Pravastatin promotes the reaction [olmesartan results in increased activity of and results in increased phosphorylation of NOS3 protein]

NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:10,793,834...10,814,166

G

NPHS1 adhesion molecule, nephrin

increases expression

Olmesartan increases expression of Nphs1 protein in kidney

RGD

NCBI chr 1:94,848,261...94,876,522
Ensembl chr 1:85,720,812...85,749,078

G

platelet derived growth factor receptor beta

multiple interactions

olmesartan inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFRB protein]; olmesartan inhibits the reaction [Fish Oils inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFRB protein]]

NCBI chr18:56,770,348...56,809,228
Ensembl chr18:54,499,964...54,538,843

G

transforming growth factor, beta 1

multiple interactions

olmesartan inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]; olmesartan inhibits the reaction [Fish Oils inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]]

NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847

valsartan

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily C member 4

multiple interactions

[adefovir co-treated with Probenecid co-treated with Valsartan] affects the expression of ABCC4 protein; Valsartan inhibits the reaction [Purines analog results in decreased expression of MRP4 protein]

PMID:35114312 PMID:36464070

NCBI chr15:101,948,387...102,182,912
Ensembl chr15:95,542,315...95,774,283

G

ATP binding cassette subfamily G member 2

multiple interactions

Valsartan inhibits the reaction [Purines analog results in decreased expression of ABCG2 protein]

NCBI chr 4:89,006,056...89,132,915
Ensembl chr 4:87,745,319...87,802,409

G

angiotensin I converting enzyme

multiple interactions
decreases expression

Valsartan inhibits the reaction [Streptozocin results in increased expression of ACE mRNA]; Valsartan inhibits the reaction [Streptozocin results in increased expression of ACE protein]
Valsartan results in decreased expression of ACE mRNA

PMID:23733546 PMID:31023080

NCBI chr10:91,410,129...91,430,246
Ensembl chr10:90,910,316...90,931,131

G

angiotensin converting enzyme 2

multiple interactions

Valsartan inhibits the reaction [AGT protein results in decreased expression of ACE2 mRNA]
Valsartan inhibits the reaction [Glucose results in decreased expression of ACE2 protein]

PMID:16176966 PMID:29266779

NCBI chr X:33,925,458...33,972,851
Ensembl chr X:30,293,589...30,340,977

G

actin alpha 2, smooth muscle

multiple interactions

Valsartan inhibits the reaction [[adefovir co-treated with Probenecid] results in increased expression of ACTA2 protein]

NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:231,746,548...231,759,554

G

ADAM metallopeptidase with thrombospondin type 1 motif, 1

multiple interactions

Valsartan inhibits the reaction [AGT protein results in increased expression of ADAMTS1 mRNA]

NCBI chr11:38,418,565...38,427,384
Ensembl chr11:24,931,761...24,941,103

G

angiotensinogen

multiple interactions
increases expression

[benazepril co-treated with Valsartan] results in decreased expression of AGT protein modified form; [Valsartan co-treated with benidipine] inhibits the reaction [AGT protein results in increased abundance of Aldosterone]; [Valsartan co-treated with Simvastatin] inhibits the reaction [AGT protein results in increased expression of KLF10 mRNA]; [Valsartan co-treated with Simvastatin] inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased expression of CCL2 mRNA]]; [Valsartan co-treated with Simvastatin] inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased expression of LIF mRNA]]; Valsartan inhibits the reaction [AGT protein affects the localization of STAT1 protein]; Valsartan inhibits the reaction [AGT protein affects the localization of STAT3 protein]; Valsartan inhibits the reaction [AGT protein results in decreased expression of APOE protein]; Valsartan inhibits the reaction [AGT protein results in decreased expression of BMP4 mRNA]; Valsartan inhibits the reaction [AGT protein results in decreased expression of CDKN1B mRNA]; Valsartan inhibits the reaction [AGT protein results in decreased expression of FZD2 mRNA]; Valsartan inhibits the reaction [AGT protein results in decreased expression of ID2 mRNA]; Valsartan inhibits the reaction [AGT protein results in decreased expression of IER2 mRNA]; Valsartan inhibits the reaction [AGT protein results in decreased expression of MN1 mRNA]; Valsartan inhibits the reaction [AGT protein results in decreased expression of PPP1R3C mRNA]; Valsartan inhibits the reaction [AGT protein results in increased abundance of Aldosterone]; Valsartan inhibits the reaction [AGT protein results in increased activity of STAT1 protein]; Valsartan inhibits the reaction [AGT protein results in increased activity of STAT3 protein]; Valsartan inhibits the reaction [AGT protein results in increased expression of ADAMTS1 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of CCL2 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of CCL2 protein]; Valsartan inhibits the reaction [AGT protein results in increased expression of CYBB mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of CYBB protein]; Valsartan inhibits the reaction [AGT protein results in increased expression of DUSP5 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of DYRK2 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of EGR1 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of FGF5 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of FILIP1L mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of FOSL1 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of HBEGF mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of HDAC9 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of HIVEP1 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of IER3 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of INHBA mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of KDR mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of KLF10 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of KLF9 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of LIF mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of MAFF mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of NFIL3 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of NUP98 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of PLAUR mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of PTGS2 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of RCAN1 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of RGS3 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of SLC25A32 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of SNN mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of SPRY2 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of TGIF1 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of TIMP1 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of TIMP1 protein]; Valsartan inhibits the reaction [AGT protein results in increased phosphorylation of STAT1 protein]; Valsartan inhibits the reaction [AGT protein results in increased phosphorylation of STAT3 protein]; Valsartan inhibits the reaction [AGT protein results in increased secretion of SERPINE1 protein]; Valsartan inhibits the reaction [benazepril results in decreased expression of AGT protein]; Valsartan inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased expression of CCL2 mRNA]]; Valsartan inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased expression of EGR1 mRNA]]; Valsartan inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased expression of KLF10 mRNA]]; Valsartan inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased expression of LIF mRNA]]; Valsartan inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased phosphorylation of JAK2 protein]]
Valsartan results in increased expression of AGT protein; Valsartan results in increased expression of AGT protein modified form
[Probenecid co-treated with Valsartan co-treated with adefovir] results in increased expression of AGT protein; Dactinomycin promotes the reaction [Valsartan inhibits the reaction [AGT protein results in increased expression of CTF1 mRNA]]; Valsartan inhibits the reaction [AGT protein affects the localization of ELAVL1 protein]; Valsartan inhibits the reaction [AGT protein inhibits the reaction [Glycochenodeoxycholic Acid results in increased activity of CASP3 protein]]; Valsartan inhibits the reaction [AGT protein results in decreased export of Sodium]; Valsartan inhibits the reaction [AGT protein results in decreased expression of ACE2 mRNA]; Valsartan inhibits the reaction [AGT protein results in decreased expression of SYP protein]; Valsartan inhibits the reaction [AGT protein results in increased abundance of Nitric Oxide]; Valsartan inhibits the reaction [AGT protein results in increased abundance of Oxygen]; Valsartan inhibits the reaction [AGT protein results in increased abundance of Prostaglandins E]; Valsartan inhibits the reaction [AGT protein results in increased activity of SERPINE1 protein]; Valsartan inhibits the reaction [AGT protein results in increased expression of AGTR2 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of AGTR2 protein]; Valsartan inhibits the reaction [AGT protein results in increased expression of ANGPT1 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of ANGPT1 protein]; Valsartan inhibits the reaction [AGT protein results in increased expression of ANGPT2 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of CTF1 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of ENG mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of ENG protein]; Valsartan inhibits the reaction [AGT protein results in increased expression of KDR mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of POSTN mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of PTGS2 protein]; Valsartan inhibits the reaction [AGT protein results in increased expression of SERPINE1 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of SERPINE1 protein]; Valsartan inhibits the reaction [AGT protein results in increased expression of SPP1 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of SPP1 protein]; Valsartan inhibits the reaction [AGT protein results in increased expression of TEK mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of VEGFA mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of VEGFA protein]; Valsartan inhibits the reaction [AGT protein results in increased secretion of Nitric Oxide]; Valsartan inhibits the reaction [AGT protein results in increased ubiquitination of SYP protein]; Valsartan inhibits the reaction [Dimethylnitrosamine results in increased expression of AGT protein]; Valsartan inhibits the reaction [Oxygen deficiency promotes the reaction [AGT protein results in increased expression of NOS3 protein]]; Valsartan inhibits the reaction [Oxygen deficiency promotes the reaction [AGT protein results in increased expression of VEGFA protein]]; Valsartan inhibits the reaction [Purines analog results in increased secretion of AGT protein]; Valsartan promotes the reaction [AGT protein promotes the reaction [PTPN6 protein binds to MTUS1 protein]]; Valsartan promotes the reaction [AGT protein results in increased expression of FOS mRNA]; Valsartan promotes the reaction [AGT protein results in increased expression of JUN mRNA]; Valsartan promotes the reaction [AGT protein results in increased expression of MAP2 protein]; Valsartan promotes the reaction [AGT protein results in increased expression of TUBB3 protein]; Valsartan promotes the reaction [AGT protein results in increased expression of UBE2V2 protein]; Valsartan promotes the reaction [Glucose results in increased expression of AGT protein]; Valsartan promotes the reaction [Particulate Matter results in increased expression of AGT protein modified form]
[Valsartan co-treated with AGT protein] results in increased activity of LPL protein; Valsartan inhibits the reaction [AGT protein results in increased activity of ALOX15 protein]; Valsartan inhibits the reaction [AGT protein results in increased expression of CXCL10 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of CXCL10 protein]; Valsartan inhibits the reaction [AGT protein results in increased phosphorylation of MAPK1 protein]; Valsartan inhibits the reaction [AGT protein results in increased phosphorylation of MAPK3 protein]; Valsartan inhibits the reaction [AGT protein results in increased phosphorylation of OSR1 protein]; Valsartan inhibits the reaction [AGT protein results in increased phosphorylation of SLC12A3 protein]; Valsartan inhibits the reaction [Streptozocin results in decreased abundance of AGT protein modified form]; Valsartan promotes the reaction [AGT protein results in increased expression of UBE2V2 mRNA]; Valsartan promotes the reaction [AGT protein results in increased expression of UBE2V2 protein]; Valsartan promotes the reaction [Streptozocin results in increased expression of AGT protein]

PMID:9261183 PMID:10082498 PMID:11115077 PMID:11244025 PMID:11403356 More...

NCBI chr19:69,426,540...69,447,017
Ensembl chr19:52,529,185...52,540,977

G

angiotensin II receptor, type 1a

decreases expression
multiple interactions

Valsartan results in decreased expression of AGTR1A mRNA
Valsartan promotes the reaction [Streptozocin results in increased expression of AGTR1 protein]
Valsartan binds to and results in decreased activity of AGTR1 protein

PMID:18403896 PMID:28973481 PMID:29266779

NCBI chr17:34,383,397...34,435,523
Ensembl chr17:34,174,429...34,226,946

G

angiotensin II receptor, type 2

affects response to substance
multiple interactions
increases expression
decreases expression

AGTR2 affects the susceptibility to Valsartan
Valsartan inhibits the reaction [Streptozocin results in increased expression of AGTR2 protein]
Valsartan results in increased expression of AGTR2 protein
Valsartan results in decreased expression of AGTR2 mRNA
[PD 123319 results in decreased activity of AGTR2 protein] inhibits the reaction [Valsartan results in increased abundance of Cyclic GMP]; [PD 123319 results in decreased activity of AGTR2 protein] which results in decreased susceptibility to Valsartan; Valsartan inhibits the reaction [AGT protein results in increased expression of AGTR2 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of AGTR2 protein]

PMID:11403356 PMID:12215461 PMID:16982965 PMID:18403896 PMID:29266779

NCBI chr X:116,914,320...116,918,504
Ensembl chr X:112,120,228...112,124,057

G

AKT serine/threonine kinase 1

multiple interactions

Valsartan inhibits the reaction [Isoproterenol results in increased phosphorylation of AKT1 protein]

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921

G

albumin

multiple interactions
decreases export

Valsartan inhibits the reaction [Carbon Tetrachloride results in decreased expression of ALB protein]
Valsartan results in decreased export of ALB protein

PMID:16872305 PMID:17664856

NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,607,381...17,622,836

G

arachidonate 15-lipoxygenase

multiple interactions

Valsartan inhibits the reaction [AGT protein results in increased activity of ALOX15 protein]

NCBI chr10:55,559,060...55,567,535
Ensembl chr10:55,060,412...55,068,874

G

angiogenin

decreases expression

Valsartan results in decreased expression of ANG mRNA

NCBI chr15:26,786,233...26,796,883

G

angiopoietin 1

multiple interactions

Valsartan inhibits the reaction [AGT protein results in increased expression of ANGPT1 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of ANGPT1 protein]

NCBI chr 7:75,415,959...75,668,696
Ensembl chr 7:73,531,486...73,784,067

G

angiopoietin 2

multiple interactions

Valsartan inhibits the reaction [AGT protein results in increased expression of ANGPT2 mRNA]

NCBI chr16:77,790,760...77,841,241
Ensembl chr16:71,088,364...71,138,804

G

amyloid P component, serum

decreases expression

Valsartan results in decreased expression of APCS protein

NCBI chr13:87,905,532...87,906,508
Ensembl chr13:85,373,220...85,374,298

G

apolipoprotein B

multiple interactions

[Valsartan co-treated with benazepril] results in decreased expression of APOB protein; fluvastatin promotes the reaction [[Valsartan co-treated with benazepril] results in decreased expression of APOB protein]

NCBI chr 6:36,563,704...36,603,300
Ensembl chr 6:30,844,368...30,892,497

G

apolipoprotein E

multiple interactions

[Bezafibrate co-treated with Enalapril co-treated with Dipyridamole co-treated with Atorvastatin co-treated with Valsartan] results in decreased expression of APOE protein; Valsartan inhibits the reaction [AGT protein results in decreased expression of APOE protein]

PMID:17785354 PMID:19603250

NCBI chr 1:88,481,889...88,485,816
Ensembl chr 1:79,353,916...79,357,932

G

aquaporin 1

multiple interactions

Valsartan inhibits the reaction [Glucose results in increased expression of AQP1 mRNA]

NCBI chr 4:85,812,784...85,824,964
Ensembl chr 4:84,482,512...84,494,690

G

aquaporin 4

multiple interactions

Valsartan inhibits the reaction [Glucose results in increased expression of AQP4 mRNA]

NCBI chr18:6,782,389...6,799,034
Ensembl chr18:6,507,903...6,524,856

G

ATPase H+ transporting accessory protein 2

multiple interactions

Valsartan inhibits the reaction [Streptozocin results in increased expression of ATP6AP2 mRNA]; Valsartan inhibits the reaction [Streptozocin results in increased expression of ATP6AP2 protein]

NCBI chr X:12,856,708...12,883,670
Ensembl chr X:10,183,068...10,210,918

G

BCL2 associated X, apoptosis regulator

multiple interactions

Valsartan inhibits the reaction [Cyclophosphamide results in increased expression of BAX protein]; Valsartan inhibits the reaction [Doxorubicin results in increased expression of BAX protein]
Valsartan inhibits the reaction [Glucose results in increased expression of BAX protein]; Valsartan inhibits the reaction [Streptozocin results in increased expression of BAX protein]

PMID:29266779 PMID:32197949 PMID:34273911

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368

G

Bcl-2 binding component 3

multiple interactions

Valsartan inhibits the reaction [Cyclophosphamide results in increased expression of BBC3 mRNA]

NCBI chr 1:86,141,450...86,150,666
Ensembl chr 1:77,014,543...77,022,509

G

BCL2, apoptosis regulator

multiple interactions

Valsartan inhibits the reaction [Cyclophosphamide results in decreased expression of BCL2 protein]; Valsartan inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]
Valsartan inhibits the reaction [Streptozocin results in decreased expression of BCL2 protein]

PMID:29266779 PMID:32197949 PMID:34273911

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Bcl2-like 11

multiple interactions

Valsartan inhibits the reaction [Cyclophosphamide results in increased expression of BCL2L11 mRNA]

NCBI chr 3:135,820,042...135,857,330
Ensembl chr 3:115,366,646...115,404,068

G

bradykinin receptor B1

multiple interactions

[bradykinin, Leu(8)-des-Arg(9)- results in decreased activity of BDKRB1 protein] inhibits the reaction [Valsartan results in increased abundance of Cyclic GMP]; [bradykinin, Leu(8)-des-Arg(9)- results in decreased activity of BDKRB1 protein] which results in decreased susceptibility to Valsartan

NCBI chr 6:130,275,631...130,284,968
Ensembl chr 6:124,510,870...124,513,747

G

bradykinin receptor B2

multiple interactions

[icatibant results in decreased activity of BDKRB2 protein] inhibits the reaction [Valsartan results in increased abundance of Cyclic GMP]; [icatibant results in decreased activity of BDKRB2 protein] which results in decreased susceptibility to Valsartan

NCBI chr 6:130,237,055...130,267,205
Ensembl chr 6:124,472,566...124,502,497

G

bone morphogenetic protein 4

multiple interactions

Valsartan inhibits the reaction [AGT protein results in decreased expression of BMP4 mRNA]

NCBI chr15:22,098,191...22,113,145
Ensembl chr15:19,618,542...19,623,306

G

bone morphogenetic protein 7

multiple interactions

Valsartan inhibits the reaction [Tacrolimus results in decreased expression of BMP7 protein]

NCBI chr 3:182,059,318...182,135,273
Ensembl chr 3:161,516,462...161,716,788

G

calcium/calmodulin-dependent protein kinase II delta

affects splicing

valsartan affects alternative mRNA splicing of camk2d protein in left ventricle of 2k1c rats with renovascular hypertension

RGD

NCBI chr 2:217,698,324...217,961,898
Ensembl chr 2:215,024,004...215,286,178

G

caspase 3

multiple interactions

Valsartan inhibits the reaction [AGT protein inhibits the reaction [Glycochenodeoxycholic Acid results in increased activity of CASP3 protein]]; Valsartan inhibits the reaction [Cyclophosphamide results in increased activity of CASP3 protein]

PMID:23300732 PMID:32197949

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648

G

caspase 4

multiple interactions

Valsartan inhibits the reaction [Cyclophosphamide results in increased cleavage of CASP4 protein]

NCBI chr 8:10,883,817...10,919,978
Ensembl chr 8:2,598,876...2,635,092

G

catalase

multiple interactions
decreases activity

Fluorouracil promotes the reaction [Valsartan results in decreased activity of CAT protein]; Valsartan promotes the reaction [Fluorouracil results in decreased activity of CAT protein]

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478

G

C-C motif chemokine ligand 2

multiple interactions
decreases expression

[Valsartan co-treated with Simvastatin] inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased expression of CCL2 mRNA]]; Valsartan inhibits the reaction [AGT protein results in increased expression of CCL2 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of CCL2 protein]; Valsartan inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased expression of CCL2 mRNA]]; Valsartan inhibits the reaction [sodium arsenite results in increased secretion of CCL2 protein]
Valsartan results in decreased expression of CCL2 mRNA
Valsartan inhibits the reaction [Streptozocin results in increased expression of CCL2 mRNA]; Valsartan inhibits the reaction [Streptozocin results in increased expression of CCL2 protein]
Fluorouracil promotes the reaction [Valsartan results in decreased expression of CCL2 mRNA]; Valsartan inhibits the reaction [Oxygen deficiency results in increased expression of CCL2 mRNA]; Valsartan inhibits the reaction [Streptozocin results in increased expression of CCL2 protein]; Valsartan promotes the reaction [Fluorouracil results in decreased expression of CCL2 mRNA]

PMID:15284299 PMID:16705055 PMID:17624267 PMID:18436887 PMID:19225232 More...

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,005,424...67,007,226

G

CD163 molecule

decreases expression

Valsartan results in decreased expression of CD163 mRNA

NCBI chr 4:158,770,751...158,804,146
Ensembl chr 4:157,085,093...157,117,878

G

CD34 molecule

decreases expression

Valsartan results in decreased expression of CD34 mRNA

NCBI chr13:109,008,786...109,029,317
Ensembl chr13:106,480,043...106,499,832

G

Cd68 molecule

decreases expression

Valsartan results in decreased expression of CD68 mRNA

NCBI chr10:54,880,562...54,882,441
Ensembl chr10:54,381,815...54,383,697

G

cyclin-dependent kinase inhibitor 1B

multiple interactions

Valsartan inhibits the reaction [AGT protein results in decreased expression of CDKN1B mRNA]

NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:167,760,181...167,764,982

G

CCAAT/enhancer binding protein alpha

decreases expression

Valsartan results in decreased expression of CEBPA mRNA

NCBI chr 1:96,896,584...96,899,256
Ensembl chr 1:87,759,433...87,762,412

G

collagen type I alpha 1 chain

multiple interactions
decreases expression

Fluorouracil promotes the reaction [Valsartan results in decreased expression of COL1A1 mRNA]; Valsartan inhibits the reaction [Isoproterenol results in increased expression of COL1A1 mRNA]; Valsartan inhibits the reaction [Isoproterenol results in increased expression of COL1A1 protein]; Valsartan promotes the reaction [Fluorouracil results in decreased expression of COL1A1 mRNA]

PMID:31009642 PMID:35235860

NCBI chr10:80,380,458...80,397,461
Ensembl chr10:79,883,622...79,900,624

G

collagen type III alpha 1 chain

multiple interactions

Valsartan inhibits the reaction [Glucose results in increased expression of COL3A1 protein]; Valsartan inhibits the reaction [Isoproterenol results in increased expression of COL3A1 mRNA]; Valsartan inhibits the reaction [Isoproterenol results in increased expression of COL3A1 protein]; Valsartan inhibits the reaction [Streptozocin results in increased expression of COL3A1 protein]

PMID:29266779 PMID:31009642

NCBI chr 9:54,866,646...54,902,578
Ensembl chr 9:47,374,593...47,410,547

G

collagen type IV alpha 4 chain

multiple interactions

Valsartan inhibits the reaction [Streptozocin results in increased expression of COL4A4 mRNA]

NCBI chr 9:91,281,324...91,323,577
Ensembl chr 9:83,755,515...83,875,876

G

cAMP responsive element modulator

decreases expression

Valsartan results in decreased expression of CREM mRNA

NCBI chr17:58,932,011...59,001,160
Ensembl chr17:54,239,030...54,305,989

G

cystatin C

multiple interactions

[Probenecid co-treated with Valsartan co-treated with adefovir] results in increased expression of CST3 protein; [Probenecid co-treated with Valsartan] inhibits the reaction [adefovir results in increased expression of CST3 protein]

NCBI chr 3:156,790,061...156,794,116
Ensembl chr 3:136,336,920...136,340,822

G

cardiotrophin 1

multiple interactions

Dactinomycin promotes the reaction [Valsartan inhibits the reaction [AGT protein results in increased expression of CTF1 mRNA]]; Valsartan inhibits the reaction [AGT protein results in increased expression of CTF1 mRNA]; Valsartan inhibits the reaction [Isoproterenol results in increased expression of CTF1 mRNA]; Valsartan inhibits the reaction [Isoproterenol results in increased expression of CTF1 protein]

NCBI chr 1:191,758,512...191,771,259
Ensembl chr 1:182,328,090...182,333,335

G

cathepsin S

decreases expression

Valsartan results in decreased expression of CTSS mRNA

NCBI chr 2:185,775,316...185,803,440
Ensembl chr 2:183,086,437...183,114,483

G

CXADR, Ig-like cell adhesion molecule

decreases expression

Valsartan results in decreased expression of CXADR mRNA; Valsartan results in decreased expression of CXADR protein

NCBI chr11:30,469,778...30,516,990
Ensembl chr11:16,982,860...17,030,046

G

C-X-C motif chemokine ligand 10

multiple interactions

Valsartan inhibits the reaction [AGT protein results in increased expression of CXCL10 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of CXCL10 protein]

NCBI chr14:15,989,066...15,991,263
Ensembl chr14:15,704,758...15,706,975

G

cytochrome b-245 beta chain

multiple interactions

Valsartan inhibits the reaction [AGT protein results in increased expression of CYBB mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of CYBB protein]

NCBI chr X:16,030,596...16,065,065
Ensembl chr X:13,359,430...13,392,586

G

cytochrome P450, family 11, subfamily b, polypeptide 3

decreases expression

Valsartan results in decreased expression of CYP11B2 mRNA; Valsartan results in decreased expression of CYP11B2 protein

NCBI chr 7:108,689,319...108,694,808
Ensembl chr 7:106,808,559...106,814,048

G

cytochrome P450, family 3, subfamily a, polypeptide 9

affects response to substance

CYP3A5 gene affects the susceptibility to Valsartan

NCBI chr12:21,919,955...21,960,160
Ensembl chr12:16,806,207...16,846,422

G

DNA-damage inducible transcript 3

multiple interactions

Valsartan inhibits the reaction [Cyclophosphamide results in increased expression of DDIT3 mRNA]; Valsartan inhibits the reaction [Cyclophosphamide results in increased expression of DDIT3 protein]

NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:63,116,380...63,121,201

G

desmin

multiple interactions

Valsartan inhibits the reaction [Streptozocin results in increased expression of DES protein]

NCBI chr 9:84,299,626...84,307,344
Ensembl chr 9:76,850,982...76,858,699

G

dual specificity phosphatase 5

multiple interactions

Valsartan inhibits the reaction [AGT protein results in increased expression of DUSP5 mRNA]

NCBI chr 1:262,543,774...262,557,201
Ensembl chr 1:252,538,449...252,551,818

G

dual specificity tyrosine phosphorylation regulated kinase 1A

decreases expression

valsartan inhibits the reaction [renovascular hypertension and cardiomegaly increases expression of dyrk1a protein in left ventricle of 2k1c rats]

RGD

NCBI chr11:47,360,824...47,479,033
Ensembl chr11:33,890,490...34,009,420

G

dual specificity tyrosine phosphorylation regulated kinase 2

multiple interactions

Valsartan inhibits the reaction [AGT protein results in increased expression of DYRK2 mRNA]

NCBI chr 7:56,235,276...56,265,741
Ensembl chr 7:54,349,610...54,380,106

G

endothelin 1

multiple interactions

[Valsartan co-treated with benazepril] results in decreased expression of EDN1 protein

NCBI chr17:22,660,799...22,666,687
Ensembl chr17:22,454,420...22,460,885

G

endothelin receptor type A

decreases expression

Valsartan results in decreased expression of EDNRA mRNA

NCBI chr19:47,137,360...47,207,961
Ensembl chr19:30,233,571...30,297,049

G

early growth response 1

multiple interactions

Valsartan inhibits the reaction [AGT protein results in increased expression of EGR1 mRNA]; Valsartan inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased expression of EGR1 mRNA]]

NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,462,981...26,466,766

G

eukaryotic translation initiation factor 2 alpha kinase 3

multiple interactions

Valsartan inhibits the reaction [Cyclophosphamide results in increased phosphorylation of EIF2AK3 protein]

NCBI chr 4:104,363,838...104,425,271
Ensembl chr 4:102,805,510...102,866,911

G

ELAV like RNA binding protein 1

multiple interactions

Valsartan inhibits the reaction [AGT protein affects the localization of ELAVL1 protein]

NCBI chr12:7,441,699...7,482,625
Ensembl chr12:2,645,061...2,684,784

G

endoglin

multiple interactions

Valsartan inhibits the reaction [AGT protein results in increased expression of ENG mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of ENG protein]

NCBI chr 3:36,332,190...36,370,324
Ensembl chr 3:15,934,518...15,973,230

G

endoplasmic reticulum to nucleus signaling 1

multiple interactions

Valsartan inhibits the reaction [Cyclophosphamide results in increased phosphorylation of ERN1 protein]

NCBI chr10:91,826,663...91,920,976
Ensembl chr10:91,330,654...91,421,029

G

fatty acid binding protein 4

decreases expression

Valsartan results in decreased expression of FABP4 mRNA

NCBI chr 2:93,488,251...93,492,961
Ensembl chr 2:91,580,885...91,585,578

G

Fas cell surface death receptor

multiple interactions

benazepril promotes the reaction [Valsartan inhibits the reaction [Doxorubicin results in increased expression of FAS protein]]; Valsartan inhibits the reaction [Doxorubicin results in increased expression of FAS protein]; Valsartan promotes the reaction [benazepril inhibits the reaction [Doxorubicin results in increased expression of FAS protein]]

NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:231,798,960...231,832,591

G

Fas ligand

multiple interactions

benazepril promotes the reaction [Valsartan inhibits the reaction [Doxorubicin results in increased expression of FASLG protein]]; Valsartan inhibits the reaction [Doxorubicin results in increased expression of FASLG protein]; Valsartan promotes the reaction [benazepril inhibits the reaction [Doxorubicin results in increased expression of FASLG protein]]

NCBI chr13:76,680,885...76,706,042
Ensembl chr13:74,154,954...74,162,215

G

fibroblast growth factor 5

multiple interactions

Valsartan inhibits the reaction [AGT protein results in increased expression of FGF5 mRNA]

NCBI chr14:11,627,906...11,650,243
Ensembl chr14:11,325,334...11,345,997

G

filamin A interacting protein 1-like

multiple interactions

Valsartan inhibits the reaction [AGT protein results in increased expression of FILIP1L mRNA]

NCBI chr11:56,403,467...56,646,422
Ensembl chr11:42,940,467...43,177,415

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions

Valsartan promotes the reaction [AGT protein results in increased expression of FOS mRNA]

PMID:18619357 PMID:18846332

NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:105,121,170...105,124,036

G

FOS like 1, AP-1 transcription factor subunit

multiple interactions

Valsartan inhibits the reaction [AGT protein results in increased expression of FOSL1 mRNA]

NCBI chr 1:212,183,885...212,192,391
Ensembl chr 1:202,754,529...202,764,930

G

follicle stimulating hormone subunit beta

multiple interactions

Valsartan inhibits the reaction [Cyclophosphamide results in decreased secretion of FSHB protein]

NCBI chr 3:114,003,262...114,007,072
Ensembl chr 3:93,548,560...93,552,370

G

frizzled class receptor 2

multiple interactions

Valsartan inhibits the reaction [AGT protein results in decreased expression of FZD2 mRNA]

NCBI chr10:88,061,988...88,063,898
Ensembl chr10:87,561,326...87,565,334

G

glutathione peroxidase 1

multiple interactions

Valsartan inhibits the reaction [Purines analog results in decreased expression of GPX1 protein]

NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:109,026,905...109,028,024

G

glycogen synthase kinase 3 beta

multiple interactions

Valsartan inhibits the reaction [Isoproterenol results in increased phosphorylation of GSK3B protein]

NCBI chr11:76,004,502...76,154,665
Ensembl chr11:62,504,316...62,648,646

G

heparin-binding EGF-like growth factor

multiple interactions

Valsartan inhibits the reaction [AGT protein results in increased expression of HBEGF mRNA]

NCBI chr18:28,380,337...28,390,220
Ensembl chr18:28,105,760...28,116,441

G

histone deacetylase 2

multiple interactions

Valsartan inhibits the reaction [Isoproterenol results in increased phosphorylation of HDAC2 protein]

NCBI chr20:42,101,815...42,126,486
Ensembl chr20:40,548,250...40,571,609

G

histone deacetylase 9

multiple interactions

Valsartan inhibits the reaction [AGT protein results in increased expression of HDAC9 mRNA]

NCBI chr 6:56,489,472...57,351,654
Ensembl chr 6:50,763,590...51,625,333

G

hepatocyte growth factor

multiple interactions

Valsartan inhibits the reaction [Bleomycin results in decreased expression of HGF mRNA]; Valsartan inhibits the reaction [Bleomycin results in decreased expression of HGF protein]

NCBI chr 4:19,628,902...19,700,467
Ensembl chr 4:18,677,101...18,745,409

G

HIVEP zinc finger 1

multiple interactions

Valsartan inhibits the reaction [AGT protein results in increased expression of HIVEP1 mRNA]

NCBI chr17:22,585,016...22,714,517
Ensembl chr17:22,585,016...22,711,956

G

heme oxygenase 1

multiple interactions

Valsartan inhibits the reaction [Cyclophosphamide results in decreased expression of HMOX1 protein]

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079

G

intercellular adhesion molecule 1

multiple interactions

Valsartan inhibits the reaction [Streptozocin results in increased expression of ICAM1 mRNA]
Valsartan inhibits the reaction [sodium arsenite results in increased secretion of ICAM1 protein modified form]

PMID:17724226 PMID:28973481

NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:19,553,645...19,565,438

G

inhibitor of DNA binding 2

multiple interactions

Valsartan inhibits the reaction [AGT protein results in decreased expression of ID2 mRNA]

NCBI chr 6:47,469,162...47,470,995
Ensembl chr 6:41,728,946...41,744,400

G

immediate early response 2

multiple interactions

Valsartan inhibits the reaction [AGT protein results in decreased expression of IER2 mRNA]

NCBI chr19:40,399,373...40,400,897
Ensembl chr19:23,494,184...23,499,211

G

immediate early response 3

multiple interactions

Valsartan inhibits the reaction [AGT protein results in increased expression of IER3 mRNA]

NCBI chr20:2,933,173...2,934,377
Ensembl chr20:2,928,378...2,929,583

G

interleukin 1 beta

decreases expression

Valsartan results in decreased expression of IL1B mRNA

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

multiple interactions
decreases secretion

[Tacrolimus co-treated with Valsartan] results in decreased expression of IL6 protein; [Tacrolimus co-treated with Valsartan] results in increased expression of IL6 protein
Valsartan results in decreased secretion of IL6 protein
Fluorouracil promotes the reaction [Valsartan results in decreased secretion of IL6 protein]; Valsartan inhibits the reaction [Streptozocin results in increased expression of IL6 protein]

PMID:16549154 PMID:29266779 PMID:35235860

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178

G

inhibin subunit beta A

multiple interactions

Valsartan inhibits the reaction [AGT protein results in increased expression of INHBA mRNA]

NCBI chr17:53,787,159...53,810,942
Ensembl chr17:49,095,920...49,108,982

G

Janus kinase 2

multiple interactions

Valsartan inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased phosphorylation of JAK2 protein]]

NCBI chr 1:236,408,905...236,468,769
Ensembl chr 1:226,995,334...227,054,189

G

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions

Valsartan promotes the reaction [AGT protein results in increased expression of JUN mRNA]

PMID:18619357 PMID:18846332

NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:109,893,145...109,897,656

G

kinase insert domain receptor

multiple interactions

Valsartan inhibits the reaction [AGT protein results in increased expression of KDR mRNA]

PMID:14638905 PMID:15005273

NCBI chr14:32,572,031...32,615,204
Ensembl chr14:32,217,871...32,261,018

G

Klotho

increases expression

Valsartan results in increased expression of KL mRNA; Valsartan results in increased expression of KL protein

NCBI chr12:5,326,003...5,367,016
Ensembl chr12:490,399...530,080

G

KLF transcription factor 10

multiple interactions

[Valsartan co-treated with Simvastatin] inhibits the reaction [AGT protein results in increased expression of KLF10 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of KLF10 mRNA]; Valsartan inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased expression of KLF10 mRNA]]

NCBI chr 7:71,352,612...71,358,680
Ensembl chr 7:69,465,619...69,473,994

G

KLF transcription factor 9

multiple interactions

Valsartan inhibits the reaction [AGT protein results in increased expression of KLF9 mRNA]

NCBI chr 1:230,126,646...230,151,641
Ensembl chr 1:220,700,108...220,725,037

G

kininogen 1

increases expression
multiple interactions

Valsartan results in increased expression of KNG1 protein modified form
benazepril promotes the reaction [Valsartan results in increased expression of KNG1 protein modified form]; PD 123319 inhibits the reaction [benazepril promotes the reaction [Valsartan results in increased expression of KNG1 protein modified form]]; PD 123319 inhibits the reaction [Valsartan promotes the reaction [benazepril results in increased expression of KNG1 protein modified form]]; Valsartan promotes the reaction [benazepril results in increased expression of KNG1 protein modified form]

NCBI chr11:91,317,354...91,340,148
Ensembl chr11:77,812,752...77,835,555

G

luteinizing hormone subunit beta

multiple interactions

Valsartan inhibits the reaction [Cyclophosphamide results in decreased secretion of LHB protein]

NCBI chr 1:105,037,457...105,038,446
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972

G

LIF, interleukin 6 family cytokine

multiple interactions

[Valsartan co-treated with Simvastatin] inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased expression of LIF mRNA]]; Valsartan inhibits the reaction [AGT protein results in increased expression of LIF mRNA]; Valsartan inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased expression of LIF mRNA]]

NCBI chr14:83,354,602...83,364,053
Ensembl chr14:79,134,574...79,140,482

G

lipoprotein lipase

multiple interactions
increases activity

[Valsartan co-treated with AGT protein] results in increased activity of LPL protein
Valsartan results in increased activity of LPL protein

NCBI chr16:25,596,205...25,621,928
Ensembl chr16:20,829,465...20,855,249

G

MAF bZIP transcription factor F

multiple interactions

Valsartan inhibits the reaction [AGT protein results in increased expression of MAFF mRNA]

NCBI chr 7:112,792,787...112,804,139
Ensembl chr 7:110,912,499...110,923,851

G

microtubule-associated protein 2

multiple interactions

Valsartan promotes the reaction [AGT protein results in increased expression of MAP2 protein]

NCBI chr 9:75,173,038...75,431,606
Ensembl chr 9:67,723,371...67,979,809

G

mitogen activated protein kinase 1

multiple interactions

Valsartan inhibits the reaction [AGT protein results in increased phosphorylation of MAPK1 protein]

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions

Valsartan inhibits the reaction [AGT protein results in increased phosphorylation of MAPK3 protein]

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863

G

matrix metallopeptidase 2

multiple interactions
decreases activity

Fluorouracil promotes the reaction [Valsartan results in decreased activity of MMP2 protein]; Valsartan inhibits the reaction [Glucose results in decreased expression of and results in decreased activity of MMP2 protein]; Valsartan inhibits the reaction [Streptozocin results in decreased expression of MMP2 protein]; Valsartan promotes the reaction [Fluorouracil results in decreased activity of MMP2 protein]

PMID:29266779 PMID:35235860

NCBI chr19:30,327,643...30,355,856
Ensembl chr19:14,154,657...14,182,870

G

matrix metallopeptidase 9

multiple interactions
decreases activity
decreases expression

[Valsartan co-treated with Fosinopril] results in decreased expression of MMP9 mRNA; [Valsartan co-treated with Fosinopril] results in decreased expression of MMP9 protein
Valsartan results in decreased activity of MMP9 protein
Fluorouracil promotes the reaction [Valsartan results in decreased activity of MMP9 protein]
Valsartan results in decreased expression of MMP9 mRNA; Valsartan results in decreased expression of MMP9 protein

PMID:21051829 PMID:35235860

NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:153,683,858...153,692,120

G

MN1 proto-oncogene, transcriptional regulator

multiple interactions

Valsartan inhibits the reaction [AGT protein results in decreased expression of MN1 mRNA]

NCBI chr12:50,841,632...50,880,795
Ensembl chr12:45,183,085...45,221,651

G

mannose receptor, C type 1

decreases expression

Valsartan results in decreased expression of MRC1 mRNA

NCBI chr17:82,157,725...82,239,411
Ensembl chr17:77,249,187...77,330,857

G

microtubule associated scaffold protein 1

multiple interactions

Valsartan promotes the reaction [AGT protein promotes the reaction [PTPN6 protein binds to MTUS1 protein]]

NCBI chr16:57,905,991...58,051,466
Ensembl chr16:51,253,562...51,347,793

G

myosin heavy chain 6

multiple interactions
increases expression

[Valsartan co-treated with benazepril] results in increased expression of MYH6 mRNA
Valsartan inhibits the reaction [Isoproterenol results in increased expression of MYH6 protein]
Valsartan results in increased expression of MYH6 mRNA

PMID:11136700 PMID:31009642

NCBI chr15:32,388,102...32,413,663
Ensembl chr15:28,417,616...28,441,720

G

myosin heavy chain 7

multiple interactions

Valsartan inhibits the reaction [Isoproterenol results in increased expression of MYH7 mRNA]

NCBI chr15:32,416,525...32,439,851
Ensembl chr15:28,446,550...28,468,217

G

nuclear factor, interleukin 3 regulated

multiple interactions

Valsartan inhibits the reaction [AGT protein results in increased expression of NFIL3 mRNA]

NCBI chr17:12,432,376...12,447,605
Ensembl chr17:12,280,484...12,295,858

G

nitric oxide synthase 1

decreases expression

Valsartan results in decreased expression of NOS1 protein

NCBI chr12:44,276,011...44,456,371
Ensembl chr12:38,626,714...38,710,945

G

nitric oxide synthase 2

multiple interactions

Valsartan inhibits the reaction [Cyclophosphamide results in increased expression of NOS2 protein]

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210

G

nitric oxide synthase 3

multiple interactions
decreases expression

[fluvastatin co-treated with Valsartan] results in increased expression of NOS3 mRNA; Valsartan inhibits the reaction [Oxygen deficiency promotes the reaction [AGT protein results in increased expression of NOS3 protein]]
Valsartan results in decreased expression of NOS3 protein
Valsartan inhibits the reaction [Oxygen deficiency results in increased phosphorylation of NOS3 protein]

PMID:11897773 PMID:18436887 PMID:28951255 PMID:31023080

NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:10,793,834...10,814,166

G

NPHS1 adhesion molecule, nephrin

multiple interactions

Valsartan inhibits reaction [streptozotocin decreases expression of Nphs1 mRNA and protein in kidney]
Valsartan inhibits the reaction [Streptozocin results in decreased expression of NPHS1 mRNA]; Valsartan inhibits the reaction [Streptozocin results in decreased expression of NPHS1 protein]

CTD
RGD

PMID:17624267 PMID:17624267

NCBI chr 1:94,848,261...94,876,522
Ensembl chr 1:85,720,812...85,749,078

G

natriuretic peptide A

multiple interactions
decreases expression

[Valsartan co-treated with benazepril] results in decreased expression of NPPA mRNA; Valsartan inhibits the reaction [Isoproterenol results in increased expression of NPPA mRNA]
Valsartan inhibits the reaction [Isoproterenol results in increased expression of NPPA mRNA]; Valsartan inhibits the reaction [Isoproterenol results in increased expression of NPPA protein]
Valsartan results in decreased expression of NPPA mRNA

PMID:11136700 PMID:23288202 PMID:31009642

NCBI chr 5:163,712,184...163,713,493
Ensembl chr 5:158,429,042...158,430,351

G

natriuretic peptide B

multiple interactions
decreases expression

Valsartan inhibits the reaction [CHOP protocol results in increased expression of NPPB protein]
Valsartan inhibits the reaction [Isoproterenol results in increased expression of NPPB mRNA]; Valsartan inhibits the reaction [Isoproterenol results in increased expression of NPPB protein]
Valsartan results in decreased expression of NPPB mRNA
[Valsartan co-treated with benazepril] results in decreased expression of NPPB mRNA
Valsartan results in decreased expression of NPPB protein

PMID:11136700 PMID:12417542 PMID:16247790 PMID:31009642

NCBI chr 5:163,699,955...163,701,314
Ensembl chr 5:158,416,866...158,418,168

G

NAD(P)H quinone dehydrogenase 1

multiple interactions

Valsartan inhibits the reaction [Cyclophosphamide results in decreased expression of NQO1 protein]

NCBI chr19:52,205,374...52,220,267
Ensembl chr19:35,295,573...35,310,557

G

nucleoporin 98 and 96 precursor

multiple interactions

Valsartan inhibits the reaction [AGT protein results in increased expression of NUP98 mRNA]

NCBI chr 1:165,906,405...166,003,366
Ensembl chr 1:156,494,423...156,591,415

G

odd-skipped related transcription factor 1

multiple interactions

Valsartan inhibits the reaction [AGT protein results in increased phosphorylation of OSR1 protein]

NCBI chr 6:32,369,561...32,380,822
Ensembl chr 6:32,373,816...32,380,817

G

phosphodiesterase 3A

increases expression

Valsartan results in increased expression of PDE3A mRNA

NCBI chr 4:175,904,276...176,170,531
Ensembl chr 4:174,172,868...174,438,274

G

plasminogen activator, urokinase receptor

multiple interactions

Valsartan inhibits the reaction [AGT protein results in increased expression of PLAUR mRNA]

NCBI chr 1:89,181,363...89,196,308
Ensembl chr 1:80,050,324...80,068,595

G

periostin

multiple interactions

Valsartan inhibits the reaction [AGT protein results in increased expression of POSTN mRNA]

NCBI chr 2:140,677,774...140,709,304
Ensembl chr 2:138,527,696...138,559,099

G

peroxisome proliferator-activated receptor gamma

decreases expression

Valsartan results in decreased expression of PPARG mRNA

NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:148,423,194...148,548,468

G

protein phosphatase 1, regulatory subunit 3C

multiple interactions

Valsartan inhibits the reaction [AGT protein results in decreased expression of PPP1R3C mRNA]

NCBI chr 1:243,873,524...243,878,527
Ensembl chr 1:234,460,652...234,465,961

G

prostaglandin-endoperoxide synthase 2

multiple interactions

Valsartan inhibits the reaction [AGT protein results in increased expression of PTGS2 mRNA]
Valsartan inhibits the reaction [AGT protein results in increased expression of PTGS2 protein]

PMID:19145780 PMID:19225232

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188

G

protein tyrosine phosphatase, non-receptor type 6

multiple interactions

Valsartan promotes the reaction [AGT protein promotes the reaction [PTPN6 protein binds to MTUS1 protein]]

NCBI chr 4:159,212,320...159,237,069
Ensembl chr 4:157,526,035...157,550,984

G

retinol binding protein 4

decreases expression

valsartan decreases expression of Rbp4 protein in blood plasma

RGD

NCBI chr 1:245,306,349...245,313,551
Ensembl chr 1:235,893,917...235,901,399

G

regulator of calcineurin 1

multiple interactions

Valsartan inhibits the reaction [AGT protein results in increased expression of RCAN1 mRNA]

NCBI chr11:45,108,123...45,188,065
Ensembl chr11:31,622,210...31,702,045

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

Valsartan inhibits the reaction [Cyclophosphamide results in increased phosphorylation of RELA protein]

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484

G

renin

multiple interactions
increases expression
increases activity

[benazepril co-treated with Valsartan] results in increased activity of REN protein
Valsartan results in increased expression of REN protein
[benazepril co-treated with Valsartan] results in increased activity of REN protein; Valsartan inhibits the reaction [Purines analog results in increased secretion of REN protein]
Valsartan results in increased activity of REN protein

PMID:8505092 PMID:10836730 PMID:11501062 PMID:36464070

NCBI chr13:47,348,312...47,359,539
Ensembl chr13:44,796,091...44,807,489

G

regulator of G-protein signaling 3

multiple interactions

Valsartan inhibits the reaction [AGT protein results in increased expression of RGS3 mRNA]

NCBI chr 5:76,022,038...76,161,895
Ensembl chr 5:76,022,001...76,161,894

G

selectin E

multiple interactions

Valsartan inhibits the reaction [sodium arsenite results in increased expression of SELE protein]

NCBI chr13:78,935,997...78,945,905
Ensembl chr13:76,403,304...76,412,741

G

serpin family E member 1

multiple interactions
decreases expression

Valsartan inhibits the reaction [AGT protein results in increased secretion of SERPINE1 protein]
Valsartan results in decreased expression of SERPINE1 mRNA; Valsartan results in decreased expression of SERPINE1 protein
[Valsartan co-treated with Fosinopril] results in decreased expression of SERPINE1 mRNA; [Valsartan co-treated with Fosinopril] results in decreased expression of SERPINE1 protein; Valsartan inhibits the reaction [AGT protein results in increased activity of SERPINE1 protein]; Valsartan inhibits the reaction [AGT protein results in increased expression of SERPINE1 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of SERPINE1 protein]

PMID:11244025 PMID:21051829

NCBI chr12:25,237,977...25,248,356
Ensembl chr12:19,601,272...19,611,657

G

solute carrier family 12 member 3

multiple interactions

Valsartan inhibits the reaction [AGT protein results in increased phosphorylation of SLC12A3 protein]

NCBI chr19:10,636,594...10,690,008
Ensembl chr19:10,631,393...10,669,091

G

solute carrier family 22 member 12

multiple interactions

Valsartan inhibits the reaction [Purines analog results in decreased expression of SLC22A12 protein]

NCBI chr 1:203,845,039...203,852,496
Ensembl chr 1:203,845,048...203,853,555

G

solute carrier family 22, member 25

multiple interactions

Valsartan inhibits the reaction [SLC22A9 protein results in increased uptake of estrone sulfate]

NCBI chr 1:214,767,837...214,956,535
Ensembl chr 1:205,338,699...205,433,085

G

solute carrier family 22 member 6

multiple interactions

[adefovir co-treated with Probenecid co-treated with Valsartan] affects the expression of SLC22A6 protein; Valsartan inhibits the reaction [[adefovir co-treated with Probenecid] results in decreased expression of SLC22A6 protein]; Valsartan inhibits the reaction [Purines analog results in decreased expression of SLC22A6 protein]

PMID:35114312 PMID:36464070

NCBI chr 1:214,951,493...214,960,317
Ensembl chr 1:205,522,729...205,531,173

G

solute carrier family 22 member 8

multiple interactions
increases expression

[adefovir co-treated with Probenecid co-treated with Valsartan] results in increased expression of SLC22A8 protein; Valsartan inhibits the reaction [Purines analog results in decreased expression of SLC22A8 protein]
Valsartan results in increased expression of SLC22A8 protein

PMID:35114312 PMID:36464070

NCBI chr 1:214,925,506...214,945,516
Ensembl chr 1:205,498,084...205,517,450

G

solute carrier family 25 member 32

multiple interactions

Valsartan inhibits the reaction [AGT protein results in increased expression of SLC25A32 mRNA]

NCBI chr 7:70,142,958...70,160,726
Ensembl chr 7:70,142,964...70,160,770

G

solute carrier family 2 member 4

multiple interactions

naloxonazine inhibits the reaction [Valsartan inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 mRNA]]; naloxonazine inhibits the reaction [Valsartan inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 protein]]; Valsartan inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 mRNA]; Valsartan inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 protein]

PMID:12658023 PMID:17199717

NCBI chr10:55,164,721...55,170,289
Ensembl chr10:54,666,015...54,671,565

G

SMAD family member 3

multiple interactions
decreases expression

Valsartan inhibits the reaction [Carbon Tetrachloride results in increased expression of SMAD3 protein]
Valsartan results in decreased expression of SMAD3 protein

PMID:15619341 PMID:16872305

NCBI chr 8:73,022,204...73,132,324
Ensembl chr 8:64,110,039...64,236,960

G

SMAD family member 7

multiple interactions
increases expression

Valsartan inhibits the reaction [Carbon Tetrachloride results in decreased expression of SMAD7 protein]
Valsartan results in increased expression of SMAD7 protein

PMID:15619341 PMID:16872305

NCBI chr18:71,263,508...71,291,849
Ensembl chr18:68,988,429...69,016,765

G

stannin

multiple interactions

Valsartan inhibits the reaction [AGT protein results in increased expression of SNN mRNA]

NCBI chr10:4,572,933...4,581,606
Ensembl chr10:4,572,376...4,584,021
Ensembl chr 1:4,572,376...4,584,021

G

superoxide dismutase 1

multiple interactions

[benazepril co-treated with Valsartan] results in increased expression of SOD1 protein
Valsartan inhibits the reaction [Purines analog results in decreased expression of SOD1 protein]

PMID:20445533 PMID:36464070

NCBI chr11:42,942,742...42,948,399
Ensembl chr11:29,456,558...29,462,249

G

secreted phosphoprotein 1

multiple interactions

Valsartan inhibits the reaction [AGT protein results in increased expression of SPP1 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of SPP1 protein]

NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,308,885...5,315,162

G

sprouty RTK signaling antagonist 2

multiple interactions

Valsartan inhibits the reaction [AGT protein results in increased expression of SPRY2 mRNA]

NCBI chr15:89,106,809...89,111,926
Ensembl chr15:82,692,143...82,698,009

G

sequestosome 1

multiple interactions

Valsartan inhibits the reaction [Doxorubicin results in decreased expression of SQSTM1 protein]

NCBI chr10:35,026,598...35,037,750
Ensembl chr10:34,525,519...34,536,673

G

signal transducer and activator of transcription 1

multiple interactions

Valsartan inhibits the reaction [AGT protein affects the localization of STAT1 protein]; Valsartan inhibits the reaction [AGT protein results in increased activity of STAT1 protein]; Valsartan inhibits the reaction [AGT protein results in increased phosphorylation of STAT1 protein]

NCBI chr 9:56,911,522...56,951,926
Ensembl chr 9:49,419,340...49,588,540

G

signal transducer and activator of transcription 3

multiple interactions

Valsartan inhibits the reaction [AGT protein affects the localization of STAT3 protein]; Valsartan inhibits the reaction [AGT protein results in increased activity of STAT3 protein]; Valsartan inhibits the reaction [AGT protein results in increased phosphorylation of STAT3 protein]

NCBI chr10:86,311,528...86,363,513
Ensembl chr10:85,811,218...85,863,057

G

synaptophysin

multiple interactions

Valsartan inhibits the reaction [Streptozocin results in decreased expression of SYP protein]
Valsartan inhibits the reaction [AGT protein results in decreased expression of SYP protein]; Valsartan inhibits the reaction [AGT protein results in increased ubiquitination of SYP protein]

NCBI chr X:17,521,348...17,536,449
Ensembl chr X:14,849,444...14,864,745

G

TEK receptor tyrosine kinase

multiple interactions

Valsartan inhibits the reaction [AGT protein results in increased expression of TEK mRNA]

NCBI chr 5:114,722,815...114,849,535
Ensembl chr 5:109,607,077...109,733,804

G

transforming growth factor, beta 1

multiple interactions
decreases expression

[benazepril co-treated with Valsartan] results in decreased expression of TGFB1 protein
Valsartan inhibits the reaction [Glucose results in increased expression of TGFB1 protein]; Valsartan inhibits the reaction [Streptozocin results in increased expression of TGFB1 mRNA]; Valsartan inhibits the reaction [Streptozocin results in increased expression of TGFB1 protein]
Valsartan results in decreased expression of TGFB1 protein
[Tacrolimus co-treated with Valsartan] results in increased expression of TGFB1 protein; Valsartan inhibits the reaction [[adefovir co-treated with Probenecid] results in increased expression of TGFB1 protein]; Valsartan inhibits the reaction [Bleomycin results in increased expression of TGFB1 protein]; Valsartan inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 mRNA]; Valsartan inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]; Valsartan inhibits the reaction [Ovalbumin results in increased expression of TGFB1 protein]; Valsartan inhibits the reaction [Streptozocin results in increased expression of TGFB1 mRNA]; Valsartan inhibits the reaction [Streptozocin results in increased expression of TGFB1 protein]; Valsartan inhibits the reaction [Tacrolimus results in increased expression of TGFB1 protein]

PMID:11798641 PMID:15619341 PMID:16115399 PMID:16549154 PMID:16872305 More...

NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847

G

transforming growth factor, beta receptor 2

multiple interactions
decreases expression

Valsartan inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFBR2 mRNA]
Valsartan results in decreased expression of TGFBR2 mRNA

PMID:15619341 PMID:16872305

NCBI chr 8:124,672,677...124,761,741
Ensembl chr 8:115,794,537...115,883,228

G

TGFB-induced factor homeobox 1

multiple interactions

Valsartan inhibits the reaction [AGT protein results in increased expression of TGIF1 mRNA]

NCBI chr 9:110,748,094...110,757,714
Ensembl chr 9:110,720,921...110,757,802

G

TIMP metallopeptidase inhibitor 1

multiple interactions
decreases expression

Valsartan inhibits the reaction [AGT protein results in increased expression of TIMP1 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of TIMP1 protein]
Valsartan results in decreased expression of TIMP1 mRNA; Valsartan results in decreased expression of TIMP1 protein
[Valsartan co-treated with Fosinopril] results in decreased expression of TIMP1 mRNA; [Valsartan co-treated with Fosinopril] results in decreased expression of TIMP1 protein; Valsartan inhibits the reaction [Dimethylnitrosamine results in increased expression of TIMP1 mRNA]

PMID:12846741 PMID:15504291 PMID:21051829

NCBI chr X:3,766,509...3,772,578
Ensembl chr X:1,212,972...1,217,664

G

tumor necrosis factor

multiple interactions

[Metformin co-treated with rosiglitazone co-treated with Valsartan co-treated with Ezetimibe] inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TNF protein]; [Metformin co-treated with rosiglitazone co-treated with Valsartan] inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TNF protein]; Valsartan inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TNF protein]
Valsartan inhibits the reaction [Oxygen deficiency results in increased expression of TNF mRNA]

PMID:16865780 PMID:18436887

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629

G

tumor protein p53

multiple interactions

Valsartan inhibits the reaction [Cyclophosphamide results in increased expression of TP53 mRNA]; Valsartan inhibits the reaction [Doxorubicin results in increased expression of TP53 protein]

PMID:32197949 PMID:34273911

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524

G

tubulin, beta 3 class III

multiple interactions

Valsartan promotes the reaction [AGT protein results in increased expression of TUBB3 protein]

NCBI chr19:68,365,687...68,374,741
Ensembl chr19:51,457,184...51,466,243

G

taurine up-regulated 1

multiple interactions

Valsartan inhibits the reaction [Cyclophosphamide results in decreased expression of TUG1 mRNA]

NCBI chr14:82,743,501...82,750,534
Ensembl chr14:78,522,506...78,526,927

G

ubiquitin conjugating enzyme E2 V2

multiple interactions

Valsartan promotes the reaction [AGT protein results in increased expression of UBE2V2 mRNA]; Valsartan promotes the reaction [AGT protein results in increased expression of UBE2V2 protein]; Valsartan promotes the reaction [Oxygen deficiency results in increased expression of UBE2V2 mRNA]

PMID:16769992 PMID:17068200

NCBI chr11:98,808,681...98,842,583
Ensembl chr11:85,304,526...85,336,369

G

vascular endothelial growth factor A

decreases expression
multiple interactions

Valsartan results in decreased expression of VEGFA mRNA
Valsartan inhibits the reaction [AGT protein results in increased expression of VEGFA mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of VEGFA protein]; Valsartan inhibits the reaction [Oxygen deficiency promotes the reaction [AGT protein results in increased expression of VEGFA protein]]; Valsartan inhibits the reaction [Streptozocin results in increased expression of VEGFA mRNA]; Valsartan inhibits the reaction [Streptozocin results in increased expression of VEGFA protein]
Fluorouracil promotes the reaction [Valsartan results in decreased expression of VEGFA mRNA]; Valsartan inhibits the reaction [Streptozocin results in increased expression of VEGFA mRNA]; Valsartan promotes the reaction [Fluorouracil results in decreased expression of VEGFA mRNA]

PMID:11897773 PMID:14638905 PMID:14718351 PMID:17724226 PMID:22768174 More...

NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:14,955,300...14,970,641

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19909
chemical entity	19907
molecular entity	19906
polyatomic entity	19857
molecule	19750
cyclic compound	19545
ring assembly	9230
biphenyls	6271
biphenylyltetrazole	333
5-biphenyl-2-yl-1H-tetrazole	0
O-desethyl candesartan	0
candesartan	75
irbesartan	44
losartan +	179
losartan carboxylic acid	1
olmesartan	29
pratosartan	0
valsartan +	160
Path 2
Term	Annotations
CHEBI ontology	19909
subatomic particle	19907
composite particle	19907
hadron	19907
baryon	19907
nucleon	19907
atomic nucleus	19907
atom	19907
main group element atom	19846
p-block element atom	19846
carbon group element atom	19784
carbon atom	19781
organic molecular entity	19781
organic molecule	19735
organic cyclic compound	19528
organic heterocyclic compound	18895
heteroarene	17170
monocyclic heteroarene	15017
azole	14514
tetrazoles	366
biphenylyltetrazole	333
5-biphenyl-2-yl-1H-tetrazole	0
O-desethyl candesartan	0
candesartan	75
irbesartan	44
losartan +	179
losartan carboxylic acid	1
olmesartan	29
pratosartan	0
valsartan +	160

paths to the root