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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:abamectin
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Accession:CHEBI:39214 term browser browse the term
Definition:Mixture of 80% avermectin B1a and 20% avermectin B1b.
Synonyms:related_synonym: Agri-Mek;   Avid;   MK 936;   Zephyr;   avermectin B1
 xref: CAS:71751-41-2
 xref_mesh: MESH:C048324


show annotations for term's descendants           Sort by:
abamectin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
decreases activity
decreases expression
decreases response to substance
increases expression		 ISO
EXP		 abamectin inhibits the reaction [ABCB1 protein results in increased transport of bisbenzimide ethoxide trihydrochloride]
abamectin results in decreased activity of ABCB1 protein
abamectin inhibits the reaction [ABCB1A protein results in increased transport of bisbenzimide ethoxide trihydrochloride]
abamectin results in decreased activity of ABCB1A protein
abamectin results in decreased expression of ABCB1A protein
ABCB1A protein results in decreased susceptibility to abamectin
[Ascorbic Acid co-treated with Sesame Oil] inhibits the reaction [abamectin results in increased expression of ABCB1A mRNA]; Ascorbic Acid inhibits the reaction [abamectin results in increased expression of ABCB1A mRNA]; Sesame Oil inhibits the reaction [abamectin results in increased expression of ABCB1A mRNA]		 CTD PMID:9144452 PMID:17134887 PMID:19879343 PMID:25865432 PMID:31739238 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 multiple interactions
decreases activity		 ISO abamectin inhibits the reaction [ABCC1 protein results in increased transport of bisbenzimide ethoxide trihydrochloride]
abamectin results in decreased activity of ABCC1 protein		 CTD PMID:25865432 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114 		JBrowse link
G Actb actin, beta decreases expression ISO abamectin results in decreased expression of ACTB protein CTD PMID:19879343 NCBI chr12:11,663,112...11,666,697
Ensembl chr12:11,663,109...11,672,877 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases expression ISO abamectin results in decreased expression of AKT1 protein CTD PMID:30958899 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Ano1 anoctamin 1 decreases activity ISO abamectin results in decreased activity of ANO1 protein CTD PMID:32201246 NCBI chr 1:199,751,439...199,900,099
Ensembl chr 1:199,751,439...199,900,069 		JBrowse link
G Atf6 activating transcription factor 6 multiple interactions
increases expression		 EXP Hesperidin inhibits the reaction [abamectin results in increased expression of ATF6 mRNA] CTD PMID:34748272 NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression		 EXP Hesperidin inhibits the reaction [abamectin results in increased expression of BAX mRNA]; Hesperidin inhibits the reaction [abamectin results in increased expression of BAX protein]
abamectin results in increased expression of BAX mRNA; abamectin results in increased expression of BAX protein		 CTD PMID:34748272 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression		 EXP Hesperidin inhibits the reaction [abamectin results in decreased expression of BCL2 mRNA]; Hesperidin inhibits the reaction [abamectin results in decreased expression of BCL2 protein]
abamectin results in decreased expression of BCL2 mRNA; abamectin results in decreased expression of BCL2 protein		 CTD PMID:34748272 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Becn1 beclin 1 increases expression
multiple interactions		 EXP abamectin results in increased expression of BECN1 protein
Hesperidin inhibits the reaction [abamectin results in increased expression of BECN1 protein]		 CTD PMID:34748272 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
increases expression		 ISO
EXP		 abamectin results in increased activity of CASP3 protein
[Ascorbic Acid co-treated with Sesame Oil] inhibits the reaction [abamectin results in increased expression of CASP3 protein]; Ascorbic Acid inhibits the reaction [abamectin results in increased expression of CASP3 protein]; Hesperidin inhibits the reaction [abamectin results in increased expression of CASP3 mRNA]; Hesperidin inhibits the reaction [abamectin results in increased expression of CASP3 protein]; Sesame Oil inhibits the reaction [abamectin results in increased expression of CASP3 protein]
abamectin results in increased expression of CASP3 mRNA; abamectin results in increased expression of CASP3 protein		 CTD PMID:30958899 PMID:31739238 PMID:34748272 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cat catalase multiple interactions
increases activity
decreases activity		 EXP [Ascorbic Acid co-treated with Sesame Oil] inhibits the reaction [abamectin results in increased activity of CAT protein]; Ascorbic Acid inhibits the reaction [abamectin results in increased activity of CAT protein]; Hesperidin inhibits the reaction [abamectin results in decreased activity of CAT protein]; Sesame Oil inhibits the reaction [abamectin results in increased activity of CAT protein] CTD PMID:31739238 PMID:34748272 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
increases expression		 EXP [Ascorbic Acid co-treated with Sesame Oil] inhibits the reaction [abamectin results in increased expression of CYP2E1 protein]; Ascorbic Acid inhibits the reaction [abamectin results in increased expression of CYP2E1 protein]; Sesame Oil inhibits the reaction [abamectin results in increased expression of CYP2E1 protein] CTD PMID:31739238 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 increases expression
multiple interactions		 EXP abamectin results in increased expression of EIF2AK3 mRNA
Hesperidin inhibits the reaction [abamectin results in increased expression of EIF2AK3 mRNA]		 CTD PMID:34748272 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911 		JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 increases expression
multiple interactions		 EXP abamectin results in increased expression of ERN1 mRNA
Hesperidin inhibits the reaction [abamectin results in increased expression of ERN1 mRNA]		 CTD PMID:34748272 NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
decreases expression		 EXP Hesperidin inhibits the reaction [abamectin results in decreased expression of HMOX1 mRNA] CTD PMID:34748272 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression
multiple interactions		 EXP abamectin results in increased expression of HSPA5 mRNA
Hesperidin inhibits the reaction [abamectin results in increased expression of HSPA5 mRNA]		 CTD PMID:34748272 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Il1b interleukin 1 beta increases expression
multiple interactions		 EXP abamectin results in increased expression of IL1B mRNA
Hesperidin inhibits the reaction [abamectin results in increased expression of IL1B mRNA]		 CTD PMID:34748272 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression		 EXP Hesperidin inhibits the reaction [abamectin results in increased expression of IL6 mRNA] CTD PMID:34748272 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Jak2 Janus kinase 2 increases expression
multiple interactions		 EXP abamectin results in increased expression of JAK2 mRNA
Hesperidin inhibits the reaction [abamectin results in increased expression of JAK2 mRNA]		 CTD PMID:34748272 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189 		JBrowse link
G Map1lc3a microtubule-associated protein 1 light chain 3 alpha multiple interactions
increases expression		 EXP Hesperidin inhibits the reaction [abamectin results in increased expression of MAP1LC3A mRNA] CTD PMID:34748272 NCBI chr 3:143,783,024...143,784,670
Ensembl chr 3:143,783,024...143,784,670 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions
increases expression		 EXP Hesperidin inhibits the reaction [abamectin results in increased expression of MAP1LC3B mRNA] CTD PMID:34748272 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 increases expression
multiple interactions		 EXP abamectin results in increased expression of MAPK14 mRNA
Hesperidin inhibits the reaction [abamectin results in increased expression of MAPK14 mRNA]		 CTD PMID:34748272 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
decreases expression		 EXP Hesperidin inhibits the reaction [abamectin results in decreased expression of NFE2L2 mRNA] CTD PMID:34748272 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 increases expression
multiple interactions		 EXP abamectin results in increased expression of NFKB1 mRNA
Hesperidin inhibits the reaction [abamectin results in increased expression of NFKB1 mRNA]		 CTD PMID:34748272 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO abamectin inhibits the reaction [Chenodeoxycholic Acid results in increased activity of NR1H4 protein]; abamectin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein] CTD PMID:25257666 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047 		JBrowse link
G Sqstm1 sequestosome 1 decreases expression ISO abamectin results in decreased expression of SQSTM1 protein CTD PMID:30958899 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 increases expression
multiple interactions		 EXP abamectin results in increased expression of STAT3 mRNA
Hesperidin inhibits the reaction [abamectin results in increased expression of STAT3 mRNA]		 CTD PMID:34748272 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions		 EXP abamectin results in increased expression of TNF mRNA; abamectin results in increased expression of TNF protein
[Ascorbic Acid co-treated with Sesame Oil] inhibits the reaction [abamectin results in increased expression of TNF protein]; Ascorbic Acid inhibits the reaction [abamectin results in increased expression of TNF protein]; Hesperidin inhibits the reaction [abamectin results in increased expression of TNF mRNA]; Sesame Oil inhibits the reaction [abamectin results in increased expression of TNF protein]		 CTD PMID:31739238 PMID:34748272 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tubb3 tubulin, beta 3 class III decreases expression ISO abamectin results in decreased expression of TUBB3 protein CTD PMID:19879343 NCBI chr19:51,457,187...51,466,243
Ensembl chr19:51,457,184...51,466,243 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19841
    chemical entity 19839
      chemical substance 14405
        mixture 13722
          abamectin 29
Path 2
Term Annotations click to browse term
  CHEBI ontology 19841
    subatomic particle 19839
      composite particle 19839
        hadron 19839
          baryon 19839
            nucleon 19839
              atomic nucleus 19839
                atom 19839
                  main group element atom 19789
                    p-block element atom 19789
                      carbon group element atom 19737
                        carbon atom 19733
                          organic molecular entity 19733
                            heteroorganic entity 19492
                              organochalcogen compound 19255
                                organooxygen compound 19172
                                  ester 17354
                                    carboxylic ester 16736
                                      lactone 13238
                                        macrocyclic lactone 7580
                                          macrolide 7528
                                            macrolide antibiotic 733
                                              macrolide pesticide 56
                                                macrolide insecticide 56
                                                  avermectin insecticide 55
                                                    abamectin 29
paths to the root