.
4-oxo monocarboxylic acid - Ontology Report - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:4-oxo monocarboxylic acid
go back to main search page
Accession:CHEBI:35950 term browser browse the term
Synonyms:related_synonym: 4-oxo acid;   4-oxo monocarboxylic acids
 cyclic_relationship: is_conjugate_acid_of CHEBI:35974

 Loading Annotations... 
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
X

show annotations for term's descendants           Sort by:
5-aminolevulinic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alad aminolevulinate dehydratase increases metabolic processing
multiple interactions
increases activity 		ISO
EXP 		ALAD protein results in increased metabolism of Aminolevulinic Acid
ALAD gene SNP affects the reaction [ALAD protein results in increased metabolism of Aminolevulinic Acid]
Aminolevulinic Acid results in increased activity of ALAD protein
Bilirubin inhibits the reaction [Aminolevulinic Acid results in increased activity of ALAD protein] 		CTD PMID:8687997 PMID:12853123 PMID:30025905 NCBI chr 5:80,977,562...80,987,901
Ensembl chr 5:75,961,993...75,972,474 		JBrowse link
G Alas1 5'-aminolevulinate synthase 1 decreases expression
increases activity
multiple interactions 		ISO
EXP 		Aminolevulinic Acid results in decreased expression of ALAS1 mRNA
Aminolevulinic Acid results in increased activity of ALAS1 protein
Bilirubin inhibits the reaction [Aminolevulinic Acid results in increased activity of ALAS1 protein] 		CTD PMID:12853123 PMID:22859313 NCBI chr 8:115,755,238...115,768,642
Ensembl chr 8:106,876,514...106,889,917 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO Aminolevulinic Acid analog results in increased expression of BAX mRNA CTD PMID:20676910 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Aminolevulinic Acid analog results in decreased expression of BCL2 mRNA CTD PMID:20676910 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity 		EXP
ISO 		3-methyladenine inhibits the reaction [Aminolevulinic Acid analog results in increased activity of CASP3 protein] CTD PMID:11281435 PMID:17245620 PMID:20426806 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 increases activity
multiple interactions 		ISO Aminolevulinic Acid analog results in increased activity of CASP8 protein
pyrazolanthrone inhibits the reaction [Aminolevulinic Acid analog results in increased activity of CASP8 protein] 		CTD PMID:21138480 NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 multiple interactions
increases activity 		ISO
EXP 		pyrazolanthrone inhibits the reaction [Aminolevulinic Acid analog results in increased activity of CASP9 protein]
3-methyladenine inhibits the reaction [Aminolevulinic Acid analog results in increased activity of CASP9 protein] 		CTD PMID:17245620 PMID:20426806 PMID:21138480 Ensembl chr 5:154,109,046...154,126,626 JBrowse link
G Cat catalase decreases activity
multiple interactions 		EXP Aminolevulinic Acid results in decreased activity of CAT protein
Bilirubin inhibits the reaction [Aminolevulinic Acid results in decreased activity of CAT protein] 		CTD PMID:12853123 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cs citrate synthase decreases activity EXP Aminolevulinic Acid results in decreased activity of CS protein CTD PMID:1537718 NCBI chr 7:1,348,389...1,374,624
Ensembl chr 7:758,345...791,421 		JBrowse link
G Fadd Fas associated via death domain multiple interactions
increases phosphorylation 		ISO 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Aminolevulinic Acid analog results in increased phosphorylation of FADD protein]; FADD mutant form inhibits the reaction [Aminolevulinic Acid analog results in increased cleavage of PARP1 protein]; pyrazolanthrone inhibits the reaction [Aminolevulinic Acid analog results in increased phosphorylation of FADD protein] CTD PMID:21138480 NCBI chr 1:209,169,245...209,175,423
Ensembl chr 1:199,739,994...199,745,653 		JBrowse link
G Fech ferrochelatase multiple interactions ISO [Aminolevulinic Acid results in decreased activity of FECH protein] which results in increased abundance of Iron CTD PMID:15078340 NCBI chr18:60,215,325...60,248,525
Ensembl chr18:57,945,122...57,979,348 		JBrowse link
G Gpx1 glutathione peroxidase 1 decreases activity
multiple interactions 		EXP Aminolevulinic Acid results in decreased activity of GPX1 protein
Bilirubin inhibits the reaction [Aminolevulinic Acid results in decreased activity of GPX1 protein] 		CTD PMID:12853123 NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:109,026,905...109,028,024 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
increases activity 		ISO
EXP 		Aminolevulinic Acid results in increased expression of HMOX1 mRNA
NFE2L2 gene mutant form promotes the reaction [Aminolevulinic Acid results in increased expression of HMOX1 mRNA]
Aminolevulinic Acid results in increased activity of HMOX1 protein
Bilirubin inhibits the reaction [Aminolevulinic Acid results in increased activity of HMOX1 protein]; tin protoporphyrin IX inhibits the reaction [Aminolevulinic Acid results in increased activity of HMOX1 protein] 		CTD PMID:12853123 PMID:22859313 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Mag myelin-associated glycoprotein decreases expression EXP Aminolevulinic Acid results in decreased expression of MAG protein CTD PMID:18665889 NCBI chr 1:86,148,227...86,163,726
Ensembl chr 1:86,148,228...86,163,656 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases activity EXP Aminolevulinic Acid analog results in increased activity of MAPK1 protein CTD PMID:20426806 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases activity EXP Aminolevulinic Acid analog results in increased activity of MAPK3 protein CTD PMID:20426806 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mmp1 matrix metallopeptidase 1 affects expression
multiple interactions 		ISO Aminolevulinic Acid affects the expression of MMP1 mRNA; Aminolevulinic Acid affects the expression of MMP1 protein
Sodium Azide inhibits the reaction [Aminolevulinic Acid affects the expression of MMP1 protein] 		CTD PMID:12542540 NCBI chr 8:12,943,453...12,963,966
Ensembl chr 8:4,658,588...4,679,097 		JBrowse link
G Mmp2 matrix metallopeptidase 2 increases activity
multiple interactions 		EXP Aminolevulinic Acid analog results in increased activity of MMP2 protein
Chitosan inhibits the reaction [Aminolevulinic Acid analog results in increased activity of MMP2 protein] 		CTD PMID:18806744 NCBI chr19:30,327,643...30,355,856
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp3 matrix metallopeptidase 3 affects expression
multiple interactions 		ISO Aminolevulinic Acid affects the expression of MMP3 mRNA; Aminolevulinic Acid affects the expression of MMP3 protein
Sodium Azide inhibits the reaction [Aminolevulinic Acid affects the expression of MMP3 protein] 		CTD PMID:12542540 NCBI chr 8:12,925,267...12,938,828
Ensembl chr 8:4,640,416...4,653,961 		JBrowse link
G Mpz myelin protein zero decreases expression EXP Aminolevulinic Acid results in decreased expression of MPZ protein CTD PMID:18665889 NCBI chr13:86,103,290...86,109,156
Ensembl chr13:83,570,811...83,576,679 		JBrowse link
G Ndufb8 NADH:ubiquinone oxidoreductase subunit B8 decreases expression EXP Aminolevulinic Acid results in decreased expression of NDUFB8 protein CTD PMID:18665889 NCBI chr 1:253,357,878...253,362,936
Ensembl chr 1:243,408,619...243,413,817 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO NFE2L2 gene mutant form inhibits the reaction [Aminolevulinic Acid results in increased expression of CYP2A5 mRNA]; NFE2L2 gene mutant form promotes the reaction [Aminolevulinic Acid results in increased expression of HMOX1 mRNA] CTD PMID:22859313 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage 		ISO FADD mutant form inhibits the reaction [Aminolevulinic Acid analog results in increased cleavage of PARP1 protein] CTD PMID:21138480 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pmp22 peripheral myelin protein 22 decreases expression EXP Aminolevulinic Acid results in decreased expression of PMP22 protein CTD PMID:18665889 NCBI chr10:48,294,932...48,324,941
Ensembl chr10:47,795,709...47,825,714 		JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 increases activity EXP Aminolevulinic Acid analog results in increased activity of PRKAA1 protein CTD PMID:20426806 NCBI chr 2:55,967,766...56,003,450
Ensembl chr 2:54,240,137...54,275,978 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit affects localization ISO Aminolevulinic Acid analog affects the localization of RELA protein CTD PMID:21138480 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Sod1 superoxide dismutase 1 decreases activity
multiple interactions 		EXP Aminolevulinic Acid results in decreased activity of SOD1 protein
Bilirubin inhibits the reaction [Aminolevulinic Acid results in decreased activity of SOD1 protein] 		CTD PMID:12853123 NCBI chr11:42,942,742...42,948,399
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sod2 superoxide dismutase 2 decreases activity EXP Aminolevulinic Acid results in decreased activity of SOD2 protein CTD PMID:1537718 NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Tp53 tumor protein p53 increases expression ISO Aminolevulinic Acid analog results in increased expression of TP53 CTD PMID:17311614 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Urod uroporphyrinogen decarboxylase decreases activity
multiple interactions 		ISO Aminolevulinic Acid results in decreased activity of UROD protein
Hexachlorobenzene promotes the reaction [Aminolevulinic Acid results in decreased activity of UROD protein] 		CTD PMID:8937451 NCBI chr 5:135,701,294...135,705,380
Ensembl chr 5:130,455,217...130,468,808 		JBrowse link
fenbufen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nos1 nitric oxide synthase 1 multiple interactions ISO 7-nitroindazole inhibits the reaction [[Enoxacin co-treated with fenbufen] results in increased activity of NOS1 protein]; [Enoxacin co-treated with fenbufen] results in increased activity of NOS1 protein CTD PMID:9623721 NCBI chr12:44,276,011...44,456,371
Ensembl chr12:38,626,714...38,710,945 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19887
    role 19858
      chemical role 19483
        donor 18943
          Bronsted acid 18824
            oxoacid 18797
              carbon oxoacid 18676
                carboxylic acid 18673
                  monocarboxylic acid 18012
                    oxo monocarboxylic acid 6303
                      4-oxo monocarboxylic acid 31
                        (1S,4S)-4-hydroxy-3-oxocyclohexane-1-carboxylic acid 0
                        (2,2,3-trimethyl-5-oxocyclopent-3-en-1-yl)acetic acid + 0
                        (R)-1-isopropyl-3,3,5-trimethyl-6-succinylindane 0
                        (R)-3-hydroxy-4-oxobutanoic acid 0
                        (S,S)-trans-1-isopropyl-2,3,3,5-tetramethyl-6-succinylindane 0
                        (S,S)-trans-2-ethyl-1-isopropyl-3,3,5-trimethyl-6-succinylindane 0
                        1,4,5,6-tetrahydro-6-oxonicotinic acid 0
                        19-hydroxy-2,3-dinor-6-oxoprostaglandin F1alpha 0
                        2,3-dinor-6-oxoprostaglandin F1alpha + 0
                        2-(hydroxymethyl)-4-oxobutanoic acid 0
                        2-amino-4-oxopentanoic acid + 0
                        3-dehydroquinic acid 0
                        3-dehydroshikimic acid 0
                        3-oxocyclopentanecarboxylic acid 0
                        4-(2-aminophenyl)-2,4-dioxobutanoic acid 0
                        4-(5-ethyl-2-thienyl)-4-oxobutyric acid 0
                        4-(6-hydroxypyridin-3-yl)-4-oxobutyric acid 0
                        4-oxo-4-(2-thienyl)butyric acid 0
                        4-oxo-4-phenylbutyric acid 0
                        4-oxoglutaramic acid 0
                        5-amino-5-deoxy-3-dehydroshikimic acid 0
                        5-aminolevulinic acid + 30
                        DM-4103 0
                        alpha-licanic acid 0
                        cis-acetylacrylic acid 0
                        fenbufen 1
                        prohexadione 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19887
    subatomic particle 19885
      composite particle 19885
        hadron 19885
          baryon 19885
            nucleon 19885
              atomic nucleus 19885
                atom 19885
                  main group element atom 19824
                    p-block element atom 19824
                      carbon group element atom 19763
                        carbon atom 19760
                          organic molecular entity 19760
                            heteroorganic entity 19521
                              organochalcogen compound 19282
                                organooxygen compound 19197
                                  carbon oxoacid 18676
                                    carboxylic acid 18673
                                      monocarboxylic acid 18012
                                        oxo monocarboxylic acid 6303
                                          4-oxo monocarboxylic acid 31
                                            (1S,4S)-4-hydroxy-3-oxocyclohexane-1-carboxylic acid 0
                                            (2,2,3-trimethyl-5-oxocyclopent-3-en-1-yl)acetic acid + 0
                                            (R)-1-isopropyl-3,3,5-trimethyl-6-succinylindane 0
                                            (R)-3-hydroxy-4-oxobutanoic acid 0
                                            (S,S)-trans-1-isopropyl-2,3,3,5-tetramethyl-6-succinylindane 0
                                            (S,S)-trans-2-ethyl-1-isopropyl-3,3,5-trimethyl-6-succinylindane 0
                                            1,4,5,6-tetrahydro-6-oxonicotinic acid 0
                                            19-hydroxy-2,3-dinor-6-oxoprostaglandin F1alpha 0
                                            2,3-dinor-6-oxoprostaglandin F1alpha + 0
                                            2-(hydroxymethyl)-4-oxobutanoic acid 0
                                            2-amino-4-oxopentanoic acid + 0
                                            3-dehydroquinic acid 0
                                            3-dehydroshikimic acid 0
                                            3-oxocyclopentanecarboxylic acid 0
                                            4-(2-aminophenyl)-2,4-dioxobutanoic acid 0
                                            4-(5-ethyl-2-thienyl)-4-oxobutyric acid 0
                                            4-(6-hydroxypyridin-3-yl)-4-oxobutyric acid 0
                                            4-oxo-4-(2-thienyl)butyric acid 0
                                            4-oxo-4-phenylbutyric acid 0
                                            4-oxoglutaramic acid 0
                                            5-amino-5-deoxy-3-dehydroshikimic acid 0
                                            5-aminolevulinic acid + 30
                                            DM-4103 0
                                            alpha-licanic acid 0
                                            cis-acetylacrylic acid 0
                                            fenbufen 1
                                            prohexadione 0
paths to the root