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Icaritin - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Icaritin
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Accession:CHEBI:201674 term browser browse the term
Synonyms:exact_synonym: 3,5,7-trihydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-enyl)chromen-4-one
 related_synonym: Formula=C21H20O6;   InChI=1S/C21H20O6/c1-11(2)4-9-14-15(22)10-16(23)17-18(24)19(25)20(27-21(14)17)12-5-7-13(26-3)8-6-12/h4-8,10,22-23,25H,9H2,1-3H3;   InChIKey=TUUXBSASAQJECY-UHFFFAOYSA-N;   SMILES=O=C1C(O)=C(OC2=C1C(O)=CC(=C2CC=C(C)C)O)C3=CC=C(OC)C=C3
 xref: Chemspider:4477409;   DrugBank:DB12672
 xref_mesh: MESH:C499403

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Icaritin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO 2-chloro-5-nitrobenzanilide inhibits the reaction [icaritin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]]; 2-chloro-5-nitrobenzanilide inhibits the reaction [icaritin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]]; icaritin inhibits the reaction [Bleomycin results in increased expression of ACTA2 protein]; icaritin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]; icaritin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; PPARG protein affects the reaction [icaritin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]]
2-chloro-5-nitrobenzanilide inhibits the reaction [icaritin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]]; 2-chloro-5-nitrobenzanilide inhibits the reaction [icaritin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]]; icaritin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]; icaritin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]		 CTD PMID:34153405 NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Alpl alkaline phosphatase, biomineralization associated increases expression EXP icaritin results in increased expression of ALPL mRNA CTD PMID:17764702 NCBI chr 5:155,234,770...155,289,785
Ensembl chr 5:149,951,409...150,006,446 		JBrowse link
G Bglap bone gamma-carboxyglutamate protein increases expression EXP icaritin results in increased expression of BGLAP mRNA CTD PMID:17764702 NCBI chr 2:176,136,341...176,137,318
Ensembl chr 2:173,838,518...173,839,495 		JBrowse link
G Chat choline O-acetyltransferase increases expression ISO icaritin results in increased expression of CHAT protein CTD PMID:19135036 NCBI chr16:7,663,665...7,723,416
Ensembl chr16:7,657,362...7,717,093 		JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions ISO icaritin inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]
icaritin inhibits the reaction [Bleomycin results in increased expression of COL1A1 mRNA]; icaritin inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]; PPARG protein affects the reaction [icaritin inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]]		 CTD PMID:34153405 NCBI chr10:80,380,458...80,397,461
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Col1a2 collagen type I alpha 2 chain increases expression EXP icaritin results in increased expression of COL1A2 mRNA CTD PMID:17764702 NCBI chr 4:33,518,557...33,553,484
Ensembl chr 4:32,563,381...32,598,867 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions
increases expression		 ISO icaritin inhibits the reaction [[lead nitrate results in increased abundance of Lead] which results in decreased expression of and affects the localization of CTNNB1 protein]; icaritin inhibits the reaction [[lead nitrate results in increased abundance of Lead] which results in decreased expression of CTNNB1 mRNA]
icaritin results in increased expression of CTNNB1 mRNA; icaritin results in increased expression of CTNNB1 protein		 CTD PMID:30731080 NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO icaritin results in decreased activity of CYP1A2 protein CTD PMID:29753067 NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 decreases activity ISO icaritin results in decreased activity of CYP2C19 protein CTD PMID:29753067 NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases metabolic processing
affects activity		 ISO CYP3A4 protein results in increased metabolism of icaritin
icaritin affects the activity of CYP3A4 protein		 CTD PMID:29753067 PMID:30938510 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 increases metabolic processing ISO CYP3A5 protein results in increased metabolism of icaritin CTD PMID:30938510 NCBI chr12:21,919,955...21,960,160
Ensembl chr12:16,806,207...16,846,422 		JBrowse link
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 decreases expression
multiple interactions		 ISO icaritin results in decreased expression of DKK1 mRNA; icaritin results in decreased expression of DKK1 protein
icaritin inhibits the reaction [[lead nitrate results in increased abundance of Lead] which results in increased expression of DKK1 mRNA]; icaritin inhibits the reaction [[lead nitrate results in increased abundance of Lead] which results in increased expression of DKK1 protein]		 CTD PMID:30731080 NCBI chr 1:237,794,969...237,798,650
Ensembl chr 1:228,381,521...228,385,202 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
increases activity		 ISO [Fulvestrant binds to and results in decreased activity of ESR1 protein] inhibits the reaction [icaritin results in increased activity of ESR1 protein] CTD PMID:22613215 NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esr2 estrogen receptor 2 increases activity
multiple interactions		 ISO icaritin results in increased activity of ESR2 protein
[4-(2-phenyl-5,7-bis(trifluoromethyl)pyrazolo(1,5-a)pyrimidin-3-yl)phenol results in decreased activity of ESR2 protein] inhibits the reaction [icaritin results in increased activity of ESR2 protein]		 CTD PMID:22613215 NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Fgf5 fibroblast growth factor 5 increases expression ISO icaritin results in increased expression of FGF5 mRNA CTD PMID:19135036 NCBI chr14:11,627,906...11,650,243
Ensembl chr14:11,325,334...11,345,997 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions
increases phosphorylation		 ISO icaritin inhibits the reaction [[lead nitrate results in increased abundance of Lead] which results in decreased phosphorylation of GSK3B protein]
icaritin results in increased phosphorylation of GSK3B protein		 CTD PMID:30731080 NCBI chr11:76,004,502...76,154,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Ldha lactate dehydrogenase A decreases expression
multiple interactions		 ISO icaritin results in decreased expression of LDHA mRNA; icaritin results in decreased expression of LDHA protein
Acetylcysteine inhibits the reaction [icaritin results in decreased expression of LDHA protein]; pifithrin inhibits the reaction [icaritin results in decreased expression of LDHA mRNA]; pifithrin inhibits the reaction [icaritin results in decreased expression of LDHA protein]		 CTD PMID:38431053 NCBI chr 1:106,508,092...106,517,512
Ensembl chr 1:97,366,021...97,433,472 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions
increases phosphorylation		 ISO Acetylcysteine inhibits the reaction [icaritin results in increased phosphorylation of MAPK14 protein]; SB 203580 inhibits the reaction [icaritin results in increased phosphorylation of MAPK14 protein] CTD PMID:38431053 NCBI chr20:6,751,288...6,812,294
Ensembl chr20:6,749,670...6,810,589 		JBrowse link
G Mdm2 MDM2 proto-oncogene decreases expression ISO icaritin results in decreased expression of MDM2 protein CTD PMID:38431053 NCBI chr 7:55,176,558...55,201,757
Ensembl chr 7:53,290,664...53,314,915 		JBrowse link
G Pgr progesterone receptor increases expression
multiple interactions		 ISO icaritin results in increased expression of PGR mRNA
Fulvestrant inhibits the reaction [icaritin results in increased expression of PGR mRNA]		 CTD PMID:16323292 NCBI chr 8:14,354,398...14,413,271
Ensembl chr 8:6,072,673...6,131,344 		JBrowse link
G Pkm pyruvate kinase M1/2 decreases expression
multiple interactions		 ISO icaritin results in decreased expression of PKM mRNA; icaritin results in decreased expression of PKM protein
Acetylcysteine inhibits the reaction [icaritin results in decreased expression of PKM protein]; pifithrin inhibits the reaction [icaritin results in decreased expression of PKM mRNA]; pifithrin inhibits the reaction [icaritin results in decreased expression of PKM protein]		 CTD PMID:38431053 NCBI chr 8:68,949,731...68,975,394
Ensembl chr 8:60,057,402...60,079,599 		JBrowse link
G Pou5f1 POU class 5 homeobox 1 decreases expression ISO icaritin results in decreased expression of POU5F1 mRNA CTD PMID:19135036 NCBI chr20:3,227,836...3,232,598
Ensembl chr20:3,223,129...3,227,891 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression
multiple interactions		 ISO icaritin results in increased expression of PPARG mRNA; icaritin results in increased expression of PPARG protein
icaritin inhibits the reaction [TGFB1 protein results in decreased expression of PPARG mRNA]
icaritin inhibits the reaction [TGFB1 protein results in decreased expression of PPARG mRNA]; PPARG protein affects the reaction [icaritin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]]; PPARG protein affects the reaction [icaritin inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]]		 CTD PMID:34153405 NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Runx2 RUNX family transcription factor 2 increases expression
multiple interactions		 ISO icaritin results in increased expression of RUNX2 mRNA; icaritin results in increased expression of RUNX2 protein
icaritin inhibits the reaction [[lead nitrate results in increased abundance of Lead] which results in decreased expression of RUNX2 mRNA]; icaritin inhibits the reaction [[lead nitrate results in increased abundance of Lead] which results in decreased expression of RUNX2 protein]		 CTD PMID:30731080 NCBI chr 9:23,661,278...23,990,248
Ensembl chr 9:16,167,482...16,492,167 		JBrowse link
G Slc2a1 solute carrier family 2 member 1 multiple interactions
decreases expression		 ISO Acetylcysteine inhibits the reaction [icaritin results in decreased expression of SLC2A1 protein]; pifithrin inhibits the reaction [icaritin results in decreased expression of SLC2A1 mRNA]; pifithrin inhibits the reaction [icaritin results in decreased expression of SLC2A1 protein]
icaritin results in decreased expression of SLC2A1 mRNA; icaritin results in decreased expression of SLC2A1 protein		 CTD PMID:38431053 NCBI chr 5:138,002,522...138,030,742
Ensembl chr 5:132,717,196...132,745,416 		JBrowse link
G Tbx1 T-box transcription factor 1 increases expression ISO icaritin results in increased expression of TBX1 mRNA CTD PMID:19135036 NCBI chr11:95,913,610...95,923,392
Ensembl chr11:82,409,275...82,418,380 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO 2-chloro-5-nitrobenzanilide inhibits the reaction [icaritin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]]; 2-chloro-5-nitrobenzanilide inhibits the reaction [icaritin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]]; icaritin inhibits the reaction [TGFB1 protein results in decreased expression of PPARG mRNA]; icaritin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]; icaritin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; icaritin inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]
2-chloro-5-nitrobenzanilide inhibits the reaction [icaritin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]]; 2-chloro-5-nitrobenzanilide inhibits the reaction [icaritin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]]; icaritin inhibits the reaction [TGFB1 protein results in decreased expression of PPARG mRNA]; icaritin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]; icaritin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; icaritin inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]; PPARG protein affects the reaction [icaritin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]]; PPARG protein affects the reaction [icaritin inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]]		 CTD PMID:34153405 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B increases expression EXP icaritin results in increased expression of TNFRSF11B mRNA CTD PMID:17764702 NCBI chr 7:87,456,318...87,484,324
Ensembl chr 7:85,566,520...85,594,538 		JBrowse link
G Tnfsf11 TNF superfamily member 11 decreases expression EXP icaritin results in decreased expression of TNFSF11 mRNA CTD PMID:17764702 NCBI chr15:60,083,008...60,114,479
Ensembl chr15:53,673,877...53,705,445 		JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO Acetylcysteine inhibits the reaction [icaritin results in increased phosphorylation of TP53 protein]; icaritin results in decreased degradation of and results in increased expression of and results in increased phosphorylation of TP53 protein; SB 203580 inhibits the reaction [icaritin results in increased phosphorylation of TP53 protein] CTD PMID:38431053 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Tubb3 tubulin, beta 3 class III increases expression ISO icaritin results in increased expression of TUBB3 protein CTD PMID:19135036 NCBI chr19:68,365,687...68,374,741
Ensembl chr19:51,457,184...51,466,243 		JBrowse link
G Wnt3a Wnt family member 3A increases expression
multiple interactions		 ISO icaritin results in increased expression of WNT3A mRNA; icaritin results in increased expression of WNT3A protein
icaritin inhibits the reaction [[lead nitrate results in increased abundance of Lead] which results in decreased expression of WNT3A mRNA]; icaritin inhibits the reaction [[lead nitrate results in increased abundance of Lead] which results in decreased expression of WNT3A protein]		 CTD PMID:30731080 NCBI chr10:44,533,734...44,577,919
Ensembl chr10:44,034,194...44,078,324 		JBrowse link
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  CHEBI ontology 19887
    chemical entity 19885
      atom 19885
        nonmetal atom 19809
          oxygen atom 19551
            oxygen molecular entity 19551
              flavonoids 11632
                flavonoid 7234
                  flavones 4587
                    Icaritin 32
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  CHEBI ontology 19887
    subatomic particle 19885
      composite particle 19885
        hadron 19885
          baryon 19885
            nucleon 19885
              atomic nucleus 19885
                atom 19885
                  main group element atom 19824
                    p-block element atom 19824
                      carbon group element atom 19763
                        carbon atom 19760
                          organic molecular entity 19760
                            organic molecule 19713
                              organic cyclic compound 19505
                                organic heterocyclic compound 18875
                                  oxacycle 17906
                                    benzopyran 11990
                                      1-benzopyran 11744
                                        flavonoid 7234
                                          anthoxanthin 4587
                                            flavones 4587
                                              Icaritin 32
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