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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:substance abuse
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Accession:DOID:302 term browser browse the term
Definition:A substance-related disorder that involves a maladaptive pattern of substance use leading to significant impairment in functioning. (DO)
Synonyms:exact_synonym: substance abuses
 broad_synonym: drug misuse
 xref: EFO:0011049;   MONDO:0002491;   NCI:C16522
For additional species annotation, visit the Alliance of Genome Resources.


show annotations for term's descendants           Sort by:
substance abuse term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra2a adrenoceptor alpha 2A sexual_dimorphism ISO DNA:SNP:promoter: C-1291G (rs1800544) (human) RGD PMID:21140256 RGD:401976460 NCBI chr 1:253,061,480...253,064,280
Ensembl chr 1:253,060,218...253,064,365 		JBrowse link
G Drd4 dopamine receptor D4 onset ISO associated with depressive disorder;DNA:repeats:exon:
DNA:duplication:promoter: 120bp repeat		 RGD PMID:34828440 PMID:33544778 RGD:401959596, RGD:401959602 NCBI chr 1:196,396,366...196,400,824
Ensembl chr 1:196,396,366...196,399,553 		JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A ISO DNA:SNP:promoter:-1019G>C (rs6295) RGD PMID:26926882 RGD:11555812 NCBI chr 2:36,693,462...36,698,026
Ensembl chr 2:36,694,174...36,695,442 		JBrowse link
G Htr1b 5-hydroxytryptamine receptor 1B sexual_dimorphism
susceptibility		 ISO associated with attention deficit hyperactivity disorder;DNA:SNP: :rs130058(human)
associated with disease of mental health; DNA:SNP: :861G>C(human)		 RGD PMID:28923721 PMID:12496953 RGD:405650695, RGD:405818271 NCBI chr 8:82,513,572...82,534,670
Ensembl chr 8:82,517,360...82,534,549 		JBrowse link
G Nrg1 neuregulin 1 susceptibility ISO associated with stressful life event;DNA:SNP: :rs6994992(human) RGD PMID:27353026 RGD:405100235 NCBI chr16:59,250,658...60,304,519
Ensembl chr16:59,250,854...60,296,884 		JBrowse link
G Slc6a4 solute carrier family 6 member 4 sexual_dimorphism ISO DNA:SNP:promoter:: RGD PMID:21140256 RGD:401976460 NCBI chr10:61,824,208...61,858,924
Ensembl chr10:61,826,123...61,858,384 		JBrowse link
alcohol use disorder term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acads acyl-CoA dehydrogenase short chain susceptibility ISO DNA:SNP:: (rs1799958) (human) RGD PMID:20554694 RGD:401976551 NCBI chr12:41,493,650...41,502,897
Ensembl chr12:41,493,626...41,502,898 		JBrowse link
G Adh1c alcohol dehydrogenase 1C (class I), gamma polypeptide ISO CTD Direct Evidence: marker/mechanism CTD PMID:16404797 NCBI chr 2:226,797,303...226,808,892
Ensembl chr 2:226,797,303...226,808,892 		JBrowse link
G Adh5 alcohol dehydrogenase 5 (class III), chi polypeptide IMP RGD PMID:8462548 RGD:5129091 NCBI chr 2:226,975,184...226,987,591
Ensembl chr 2:226,947,466...226,987,591 		JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:16404797 PMID:17590986 PMID:10780266 RGD:734551 NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521 		JBrowse link
G Ankk1 ankyrin repeat and kinase domain containing 1 severity ISO DNA:polymorphism: :rs1800497(human)
DNA:SNP,haplotype: :rs11604671, rs4938015 (human)		 RGD PMID:32889058 PMID:21936764 RGD:401940151, RGD:401959296 NCBI chr 8:49,779,862...49,788,024
Ensembl chr 8:49,779,862...49,788,024 		JBrowse link
G Arc activity-regulated cytoskeleton-associated protein ISO associated with Prenatal Exposure Delayed Effects and anxiety disorder:DNA:Hypermthylation:promoter RGD PMID:30016666 RGD:401959614 NCBI chr 7:106,555,968...106,559,697
Ensembl chr 7:106,555,785...106,559,378 		JBrowse link
G Bdnf brain-derived neurotrophic factor IEP
ISO		 protein:decreased expression:plasma
protein:decreased expression:cerebellum, hippocampus
protein:altered expression:brain
mRNA:decreased expression:hippocampus
mRNA,protein:decreased expression:hippocampus, plasma (rat)
protein:decreased expression:plasma (human)		 RGD PMID:32135570 PMID:19100286 PMID:15307153 PMID:32497709 PMID:30277635 More... RGD:35673317, RGD:401976492, RGD:401965482, RGD:401950485, RGD:401938665, RGD:401938665 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Calb1 calbindin 1 IEP mRNA:decreased expression:hippocampus (rat) RGD PMID:30277635 RGD:401938665 NCBI chr 5:29,375,624...29,402,532
Ensembl chr 5:29,375,642...29,402,431 		JBrowse link
G Camk2n1 calcium/calmodulin-dependent protein kinase II inhibitor 1 ISO mRNA:increased expression:prefrontal cortex RGD PMID:28714806 RGD:18337277 NCBI chr 5:150,674,819...150,676,600
Ensembl chr 5:150,673,507...150,676,600 		JBrowse link
G Camk4 calcium/calmodulin-dependent protein kinase IV IEP protein:decreased expression:brain, cingulate gyrus RGD PMID:11181917 RGD:401959326 NCBI chr18:24,582,988...24,811,918
Ensembl chr18:24,585,269...24,802,487 		JBrowse link
G Cast calpastatin IEP protein:increased expression:gastrocnemius (rat) RGD PMID:28800153 RGD:405100967 NCBI chr 2:3,973,112...4,082,658
Ensembl chr 2:3,973,112...4,082,659 		JBrowse link
G Cat catalase treatment IEP associated with diabetes; protein:decreased activity;testis, epididymis (rat)
associated with cardiomyopathy
associated with cognitive disorder; protein:altered activity:hippocampus (rat)
associated with diabetes;protein:decreased activity:liver, kidney (rat)		 RGD PMID:22596042 PMID:25541261 PMID:7195942 PMID:27367870 PMID:21713042 RGD:405255659, RGD:405255664, RGD:405255663, RGD:405255662, RGD:405255660 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cckar cholecystokinin A receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:9922984 NCBI chr14:57,292,397...57,300,747
Ensembl chr14:57,292,397...57,300,747 		JBrowse link
G Cdk20 cyclin-dependent kinase 20 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18438686 NCBI chr17:701,122...707,869
Ensembl chr17:701,124...707,826 		JBrowse link
G Chrna3 cholinergic receptor nicotinic alpha 3 subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:18414406 NCBI chr 8:55,401,668...55,415,165
Ensembl chr 8:55,401,702...55,415,165 		JBrowse link
G Chrna5 cholinergic receptor nicotinic alpha 5 subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:18414406 NCBI chr 8:55,369,794...55,398,526
Ensembl chr 8:55,369,794...55,398,146 		JBrowse link
G Chrna6 cholinergic receptor nicotinic alpha 6 subunit severity ISO DNA:haplotypes: : RGD PMID:19698703 RGD:405849410 NCBI chr16:64,697,741...64,704,441
Ensembl chr16:64,697,741...64,704,441 		JBrowse link
G Clock clock circadian regulator susceptibility ISO DNA:SNP:: (rs2412648) (human) RGD PMID:20554694 RGD:401976551 NCBI chr14:31,908,542...31,992,673
Ensembl chr14:31,908,566...31,990,400 		JBrowse link
G Cnr1 cannabinoid receptor 1 sexual_dimorphism IEP associated with chronic stress in female rats RGD PMID:27894930 RGD:401959751 NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099 		JBrowse link
G Comt catechol-O-methyltransferase disease_progression ISO CTD Direct Evidence: marker/mechanism
DNA:polymorphism: :rs4680(human)
DNA:polymorphism::		 CTD
RGD		 PMID:10395222 PMID:32889058 PMID:10395222 RGD:401940151, RGD:401940114 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 sexual_dimorphism IEP
IDA		 mRNA, protein:decreased expression:amygdala
protein:increased phosphorylation:liver
protein:altered expression, altered phosphorylation:liver, nucleus		 RGD PMID:29991681 PMID:31262967 PMID:22269225 RGD:401938626, RGD:401959334, RGD:401959317 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Crebbp CREB binding protein IEP mRNA, protein:decreased expression:amygdala RGD PMID:29991681 RGD:401938626 NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888 		JBrowse link
G Crh corticotropin releasing hormone IEP mRNA:increased expression:central amygdaloid nucleus (rat) RGD PMID:20060104 RGD:5508173 NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919 		JBrowse link
G Crhr1 corticotropin releasing hormone receptor 1 ISO RGD PMID:11988580 RGD:734822 NCBI chr10:89,040,186...89,083,481
Ensembl chr10:89,040,203...89,083,481 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 ISO
IEP		 CTD Direct Evidence: marker/mechanism
protein:increased expression:plasma, extracellular exosome		 CTD
RGD		 PMID:20843640 PMID:23819932 PMID:29404485 PMID:29404485 RGD:14700915, RGD:14700911, RGD:14700911 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Dbh dopamine beta-hydroxylase no_association ISO DNA:polymorphism:5' utr:g.-1021C>T (human)
DNA:polymorphism:cds:g.444G>A (human)		 RGD PMID:16133787 PMID:16252068 RGD:1625572, RGD:1625571 NCBI chr 3:10,488,260...10,505,245
Ensembl chr 3:10,488,260...10,505,248 		JBrowse link
G Dcx doublecortin IEP mRNA:decreased expression:hippocampus (rat) RGD PMID:30277635 RGD:401938665 NCBI chr  X:107,430,767...107,573,612
Ensembl chr  X:107,430,767...107,507,476 		JBrowse link
G Dlg4 discs large MAGUK scaffold protein 4 ISO associated with Prenatal Exposure Delayed Effects and anxiety disorder:mRNA,protein:decreased expression:brain (mouse) RGD PMID:30016666 RGD:401959614 NCBI chr10:54,740,700...54,769,097
Ensembl chr10:54,739,470...54,767,153 		JBrowse link
G Drd2 dopamine receptor D2 IEA GAD PMID:15118671 RGD:1331525 NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875 		JBrowse link
G Drd4 dopamine receptor D4 treatment
susceptibility		 ISO DNA:repeats:exon:
associated with peer pressure;DNA:repeats:exon:		 RGD PMID:25640830 PMID:26307243 RGD:11064848, RGD:401959598 NCBI chr 1:196,396,366...196,400,824
Ensembl chr 1:196,396,366...196,399,553 		JBrowse link
G Ep300 E1A binding protein p300 IEP mRNA, protein:decreased expression:amygdala RGD PMID:29991681 RGD:401938626 NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088
Ensembl chr 7:113,106,247...113,136,088 		JBrowse link
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit IEP RGD PMID:23095216 RGD:10045658 NCBI chr 1:78,971,310...79,007,963
Ensembl chr 1:78,996,390...79,007,963 		JBrowse link
G Fmr1 fragile X messenger ribonucleoprotein 1 IEP mRNA:increased expression:cerebellum RGD PMID:34453331 RGD:401938639 NCBI chr  X:147,240,239...147,278,057
Ensembl chr  X:147,240,301...147,278,050 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit treatment IEP
IDA
ISO		 protein:increased expression:brain
protein:increased expression:parvocellular oculomotor nucleus 		RGD PMID:14741756 PMID:29210146 PMID:11164784 RGD:405255650, RGD:405295495, RGD:405255652 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit treatment IEP
ISO		 protein:increased expression:dorsal striatum (mouse)
protein:increased expression:brain (mouse)		 RGD PMID:22792289 PMID:27380261 PMID:9835277 RGD:401851082, RGD:401901287, RGD:401901184 NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465 		JBrowse link
G Fshb follicle stimulating hormone subunit beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:8590623 NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370 		JBrowse link
G Gabbr1 gamma-aminobutyric acid type B receptor subunit 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22253714 NCBI chr20:1,464,534...1,494,114
Ensembl chr20:1,464,534...1,493,994 		JBrowse link
G Gabbr2 gamma-aminobutyric acid type B receptor subunit 2 susceptibility ISO DNA:SNP:intron: (rs2900512) (human) RGD PMID:28118741 RGD:401940105 NCBI chr 5:60,947,517...61,288,104
Ensembl chr 5:60,947,526...61,288,104 		JBrowse link
G Gabra2 gamma-aminobutyric acid type A receptor subunit alpha 2 susceptibility ISO DNA:SNPs:multiple:
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:22253714 PMID:15024690 RGD:6480257 NCBI chr14:37,097,251...37,230,030
Ensembl chr14:37,097,279...37,228,944 		JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22253714 NCBI chr10:26,374,693...26,463,937
Ensembl chr10:26,374,694...26,464,346 		JBrowse link
G Gata4 GATA binding protein 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20585342 NCBI chr15:37,459,601...37,531,291
Ensembl chr15:37,459,601...37,505,636 		JBrowse link
G Gdnf glial cell derived neurotrophic factor treatment ISO
IEP
IDA		 protein:increased expression:serum
associated with Tobacco Use Disorder;mRNA:decreased expression:ventral tegmental area
DNA:hypomethylation:nucleus accumbens		 RGD PMID:25623403 PMID:28559549 PMID:22238721 PMID:31710958 RGD:401965480, RGD:405850249, RGD:405849387, RGD:405820205 NCBI chr 2:56,894,022...56,919,935
Ensembl chr 2:56,895,010...56,917,209 		JBrowse link
G Ggt1 gamma-glutamyltransferase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12747453 NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442 		JBrowse link
G Ghsr growth hormone secretagogue receptor ISO CTD Direct Evidence: therapeutic CTD PMID:23977009 NCBI chr 2:110,268,489...110,271,865
Ensembl chr 2:110,268,489...110,271,865 		JBrowse link
G Gphn gephyrin ISO CTD Direct Evidence: marker/mechanism CTD PMID:22253714 NCBI chr 6:96,954,365...97,483,617
Ensembl chr 6:96,892,148...97,483,612 		JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 ISO
IEP		 protein:increased phosphorylation:lumbar spinal cord (mouse)
protein:decreased expression:neocortex (rat)
protein:increased expression, increased phosphorylation:cingulate cortex (rat)
protein:increased expression:nucleus accumbens (mouse)
protein:increased expression:nucleus accumbens (rat)		 RGD PMID:28585190 PMID:12036520 PMID:34280506 PMID:21041654 PMID:21041654 RGD:405100727, RGD:405820203, RGD:405818275, RGD:405650686, RGD:405650686 NCBI chr10:41,210,713...41,527,283
Ensembl chr10:41,210,713...41,527,283 		JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 ISO RGD PMID:14573320 RGD:1642372 NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603 		JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B ISO RGD PMID:14573320 PMID:16911840 RGD:1642372, RGD:1642200 NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279 		JBrowse link
G Hdac2 histone deacetylase 2 IMP RGD PMID:23485013 RGD:9590265 NCBI chr20:40,548,244...40,571,609
Ensembl chr20:40,548,250...40,571,609 		JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A treatment IMP RGD PMID:9631953 RGD:401900760 NCBI chr 2:36,693,462...36,698,026
Ensembl chr 2:36,694,174...36,695,442 		JBrowse link
G Htr1b 5-hydroxytryptamine receptor 1B sexual_dimorphism
onset
no_association		 ISO associated with attention deficit hyperactivity disorder;DNA:SNP: :rs11568817(human)
DNA:SNP: :rs13212041 (human)
DNA:SNPs: :multiples (human)		 RGD PMID:28923721 PMID:30774345 PMID:11496363 RGD:405650695, RGD:405847403, RGD:405818272 NCBI chr 8:82,513,572...82,534,670
Ensembl chr 8:82,517,360...82,534,549 		JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A treatment ISO
IMP
IEP		 CTD Direct Evidence: marker/mechanism
protein:increased expression:dorsal raphe, nucleus accumbens
mRNA, protein:decreased expression:cerebral cortex, liver		 CTD
RGD		 PMID:9631953 PMID:9347073 PMID:9347075 PMID:20501057 RGD:401900760, RGD:401900742, RGD:401900740, RGD:401900301 NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928 		JBrowse link
G Htr2c 5-hydroxytryptamine receptor 2C treatment IDA RGD PMID:24041931 RGD:401900761 NCBI chr  X:110,640,777...110,870,288
Ensembl chr  X:110,641,153...110,870,287 		JBrowse link
G Htr3a 5-hydroxytryptamine receptor 3A ISO DNA:hypermethylation, hypomethylation:promoter: (mouse) RGD PMID:22834954 RGD:404976877 NCBI chr 8:49,242,018...49,254,475
Ensembl chr 8:49,242,020...49,254,389 		JBrowse link
G Htr3b 5-hydroxytryptamine receptor 3B susceptibility ISO DNA:SNP:cds:rs1176744(human) RGD PMID:20838391 RGD:6480660 NCBI chr 8:49,279,291...49,308,444
Ensembl chr 8:49,279,173...49,308,444 		JBrowse link
G Htr7 5-hydroxytryptamine receptor 7 ISO DNA:SNP:intron: (rs7916403) (human) RGD PMID:21184583 RGD:150429835 NCBI chr 1:233,636,442...233,761,063
Ensembl chr 1:233,636,452...233,760,626 		JBrowse link
G Igf2 insulin-like growth factor 2 ISO protein:decreased expression:plasma (human) RGD PMID:30277635 RGD:401938665 NCBI chr 1:197,814,409...197,831,802
Ensembl chr 1:197,814,410...197,823,018 		JBrowse link
G Il10 interleukin 10 IEP mRNA:increased expression:liver RGD PMID:22269225 RGD:401959317 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Kcnj6 potassium inwardly-rectifying channel, subfamily J, member 6 ISO DNA:SNP:promoter:rs2836016 (human) RGD PMID:21307845 RGD:6483053 NCBI chr11:34,061,702...34,308,758
Ensembl chr11:34,061,708...34,308,758 		JBrowse link
G Lhb luteinizing hormone subunit beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:8590623 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972 		JBrowse link
G Maoa monoamine oxidase A susceptibility ISO RGD PMID:15900229 RGD:1600720 NCBI chr  X:6,032,172...6,098,308
Ensembl chr  X:6,030,795...6,099,593 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 IEP protein:increased expression:liver RGD PMID:31262967 RGD:401959334 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 ISO protein:increased expression, increased phosphorylation:liver RGD PMID:31262967 RGD:401959334 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 IEP protein:increased expression:liver RGD PMID:31262967 RGD:401959334 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 IDA RGD PMID:31262967 RGD:401959334 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mcm5 minichromosome maintenance complex component 5 IEP RGD PMID:23095216 RGD:10045658 NCBI chr19:13,483,030...13,504,389
Ensembl chr19:13,483,066...13,504,389 		JBrowse link
G Mir191 microRNA 191 onset IEP RGD PMID:32135570 RGD:35673317 NCBI chr 8:109,264,098...109,264,188 JBrowse link
G Mir195 microRNA 195 onset IEP RGD PMID:32135570 RGD:35673317 NCBI chr10:54,951,838...54,951,924
Ensembl chr10:54,951,838...54,951,924 		JBrowse link
G Mir206 microRNA 206 onset IEP RGD PMID:32135570 RGD:35673317 NCBI chr 9:23,094,249...23,094,332
Ensembl chr 9:23,094,249...23,094,332 		JBrowse link
G Mir30a microRNA 30a onset IEP RGD PMID:32135570 RGD:35673317 NCBI chr 9:25,737,600...25,737,670
Ensembl chr 9:25,737,600...25,737,670 		JBrowse link
G Mki67 marker of proliferation Ki-67 IEP mRNA:decreased expression:hippocampus (rat) RGD PMID:30277635 RGD:401938665 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762 		JBrowse link
G Mmp2 matrix metallopeptidase 2 IEP RGD PMID:24966898 RGD:13207311 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp9 matrix metallopeptidase 9 IEP RGD PMID:24966898 RGD:13207311 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Ncam1 neural cell adhesion molecule 1 sexual_dimorphism
treatment		 IEP mRNA:decreased expression:hippocampus (rat)
associated with chronic stress in female rats		 RGD PMID:30277635 PMID:27894930 PMID:16207289 RGD:401938665, RGD:401959751, RGD:401959613 NCBI chr 8:49,865,629...50,165,687
Ensembl chr 8:49,865,633...50,166,014 		JBrowse link
G Ngf nerve growth factor ISO
IEP		 protein:increased expression:serum
protein:decreased expression:cerebral cortex, hippocampus
protein:decreased expression:brain		 RGD PMID:25623403 PMID:19100286 PMID:15307153 RGD:401965480, RGD:401976492, RGD:401965482 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452 		JBrowse link
G Npy neuropeptide Y IAGP
ISO		 DNA:deletion:intron:g.4666_4674del (rat)
CTD Direct Evidence: marker/mechanism
DNA:missense mutation: :p.L7P (human)		 CTD
RGD		 PMID:17572454 PMID:15749341 PMID:12215082 RGD:1357412, RGD:10430830 NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495 		JBrowse link
G Npy2r neuropeptide Y receptor Y2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18828811 NCBI chr 2:167,901,999...167,912,165
Ensembl chr 2:167,903,879...167,905,024 		JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 treatment
sexual_dimorphism 		IMP RGD PMID:29437012 PMID:30171933 PMID:33007359 RGD:401965466, RGD:401976281, RGD:401966865 NCBI chr19:30,715,634...31,059,885
Ensembl chr19:30,715,648...31,059,885 		JBrowse link
G Nrg1 neuregulin 1 sexual_dimorphism ISO in female, associated with stressful life event;DNA:SNP: :rs6994992(human) RGD PMID:27353026 RGD:405100235 NCBI chr16:59,250,658...60,304,519
Ensembl chr16:59,250,854...60,296,884 		JBrowse link
G Ntf3 neurotrophin 3 ISO
IEP		 protein:decreased expression:plasma (human)
protein:increased expression:brain
mRNA,protein:decreased expression:hippocampus, plasma (rat)		 RGD PMID:30277635 PMID:15307153 PMID:30277635 RGD:401938665, RGD:401965482, RGD:401938665 NCBI chr 4:158,914,984...158,984,453
Ensembl chr 4:158,914,957...158,984,596 		JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 ISO
IEP		 associated with Prenatal Exposure Delayed Effects and anxiety disorder:protein:decreased acetylation:brain RGD PMID:30016666 PMID:8840027 RGD:401959614, RGD:401965407 NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136 		JBrowse link
G Oprd1 opioid receptor, delta 1 IEP
ISO
IMP		 associated with stress-related disorder; mRNA:decreased expression:dorsal striatum (rat)
DNA:SNPs, haplotype:intron 1:multiple (human)		 RGD PMID:28511993 PMID:24533225 PMID:7501658 RGD:401976432, RGD:402525443, RGD:401976439 NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960 		JBrowse link
G Oprk1 opioid receptor, kappa 1 severity
susceptibility
no_association		 ISO
IEP		 DNA:SNP, haplotype: :rs6473797 (human)
associated with stress-related disorder; mRNA:decreased expression:dorsal striatum (rat)
DNA:SNP: :rs6473797 (human)
DNA:SNP: :rs997917 (human)		 RGD PMID:31004399 PMID:28511993 PMID:37177778 PMID:37177778 RGD:401831037, RGD:401976432, RGD:401850581, RGD:401850581 NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823 		JBrowse link
G Oprl1 opioid related nociceptin receptor 1 IMP RGD PMID:11814626 RGD:9835016 NCBI chr 3:168,831,934...168,839,920
Ensembl chr 3:168,834,003...168,839,920 		JBrowse link
G Oprm1 opioid receptor, mu 1 treatment
no_association		 ISO CTD Direct Evidence: marker/mechanism
DNA:missense mutation:exon:p.N40D (118A>G) (rs 1799971) (human)
DNA:missense mutations, SNP:exon, intron:p.A6V, p.S147C, p.N40D (118A>G) (rs 1799971), IVS2+691G>C (human)
DNA:SNP: :rs510769		 CTD
RGD		 PMID:12815747 PMID:32772383 PMID:9399694 PMID:26042510 RGD:401827947, RGD:401827934, RGD:401827930 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409 		JBrowse link
G Pde4b phosphodiesterase 4B ISO CTD Direct Evidence: marker/mechanism CTD PMID:18438686 NCBI chr 5:116,799,819...117,369,155
Ensembl chr 5:116,799,971...117,367,696 		JBrowse link
G Pdyn prodynorphin no_association
susceptibility		 ISO
IEP		 CTD Direct Evidence: marker/mechanism
mRNA, protein:decreased expression:hippocampus, granule cell
DNA:SNPs: :rs2281285, rs2225749, rs910080 (human)
DNA:SNP: :rs2281285 (human)
DNA, mRNA:SNP, decreased expression:promoter, dorsolateral prefrontal cortex:rs1997794 (human)
associated with cocaine dependence;DNA, mRNA:SNPs, haplotype:3' utr:rs910080, rs910079, rs2235749 (human)		 CTD
RGD		 PMID:17559549 PMID:18923396 PMID:1589146 PMID:37177778 PMID:36099111 More... RGD:401851059, RGD:401850581, RGD:401850566, RGD:401850559, RGD:401850550 NCBI chr 3:116,900,990...116,913,334
Ensembl chr 3:116,900,992...116,913,334 		JBrowse link
G Penk proenkephalin IEP mRNA:increased expression:frontal lobe: RGD PMID:22703995 RGD:10003152 NCBI chr 5:17,183,799...17,189,160
Ensembl chr 5:17,183,806...17,189,129 		JBrowse link
G Pomc proopiomelanocortin IEP protein:decreased expression:brain (rat) RGD PMID:18162070 RGD:401976284 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664 		JBrowse link
G Rpl18a ribosomal protein L18A IEP mRNA:decreased expression:parietal cortex RGD PMID:11244494 RGD:11038708 NCBI chr16:18,542,555...18,544,578
Ensembl chr16:18,542,566...18,545,546 		JBrowse link
G Shbg sex hormone binding globulin ISO CTD Direct Evidence: marker/mechanism CTD PMID:8590623 NCBI chr10:54,332,939...54,350,409
Ensembl chr10:54,332,941...54,351,057 		JBrowse link
G Slc6a3 solute carrier family 6 member 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27219321 NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413 		JBrowse link
G Slc6a4 solute carrier family 6 member 4 susceptibility ISO protein:decreased activity: :
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:15520362 PMID:17000009 PMID:20838391 RGD:6480660 NCBI chr10:61,824,208...61,858,924
Ensembl chr10:61,826,123...61,858,384 		JBrowse link
G Snca synuclein alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:18055133 NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262 		JBrowse link
G Sod1 superoxide dismutase 1 IEP associated with diabetes; protein:decreased activity;testis, epididymis (rat) RGD PMID:25541261 RGD:405255664 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sox2 SRY-box transcription factor 2 IEP mRNA:decreased expression:hippocampus (rat) RGD PMID:30277635 RGD:401938665 NCBI chr 2:117,536,929...117,539,340
Ensembl chr 2:117,536,929...117,539,338 		JBrowse link
G Spi1 Spi-1 proto-oncogene treatment IEP
IDA		 protein:decreased expression:alveolar macrophage RGD PMID:16272341 PMID:21447000 RGD:9586723, RGD:9586725 NCBI chr 3:77,059,744...77,093,730
Ensembl chr 3:77,073,012...77,092,393 		JBrowse link
G Spn sialophorin ISO associated with Prenatal Exposure Delayed Effects and anxiety disorder:DNA:Hypermthylation:promoter RGD PMID:30016666 RGD:401959614 NCBI chr 1:181,746,937...181,759,564
Ensembl chr 1:181,746,429...181,759,628 		JBrowse link
G St6gal1 ST6 beta-galactoside alpha-2,6-sialyltransferase 1 severity ISO mRNA,protein:decreased expression:liver: RGD PMID:17697868 RGD:10043133 NCBI chr11:77,526,837...77,653,474
Ensembl chr11:77,526,837...77,653,310 		JBrowse link
G Syp synaptophysin sexual_dimorphism IEP associated with chronic stress in female rats RGD PMID:27894930 RGD:401959751 NCBI chr  X:14,849,444...14,864,553
Ensembl chr  X:14,849,444...14,864,745 		JBrowse link
G Tacr1 tachykinin receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19204064 NCBI chr 4:114,920,844...115,089,733
Ensembl chr 4:114,920,844...115,089,733 		JBrowse link
G Tacr3 tachykinin receptor 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18422838 NCBI chr 2:223,266,536...223,363,791
Ensembl chr 2:223,266,536...223,363,791 		JBrowse link
G Tas2r118 taste receptor, type 2, member 118 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16385453 PMID:17250611 NCBI chr 4:52,449,208...52,450,107
Ensembl chr 4:52,449,208...52,450,107 		JBrowse link
G Tas2r138 taste receptor, type 2, member 138 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17250611 NCBI chr 4:69,428,344...69,429,339
Ensembl chr 4:69,428,344...69,429,339 		JBrowse link
G Tbx19 T-box transcription factor 19 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18438686 NCBI chr13:77,450,848...77,484,475
Ensembl chr13:77,450,849...77,504,163 		JBrowse link
G Tf transferrin ISO CTD Direct Evidence: marker/mechanism CTD PMID:11000917 PMID:21792595 NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511 		JBrowse link
G Timeless timeless circadian regulator susceptibility ISO DNA:SNP:: (rs2291738) (human) RGD PMID:20554694 RGD:401976551 NCBI chr 7:654,804...678,769
Ensembl chr 7:654,822...678,738 		JBrowse link
G Tph1 tryptophan hydroxylase 1 ISO RGD PMID:15654285 RGD:1580464 NCBI chr 1:97,157,375...97,178,415
Ensembl chr 1:97,157,409...97,178,344 		JBrowse link
G Vip vasoactive intestinal peptide susceptibility ISO DNA:SNPs, haplotype:: (rs3823082,rs688136) (human) RGD PMID:20554694 RGD:401976551 NCBI chr 1:42,064,878...42,073,219
Ensembl chr 1:42,065,120...42,073,216 		JBrowse link
amphetamine abuse term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase ISO CTD Direct Evidence: marker/mechanism CTD PMID:16470869 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Acsl6 acyl-CoA synthetase long-chain family member 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr10:38,439,914...38,501,182
Ensembl chr10:38,440,080...38,498,757 		JBrowse link
G Adora2a adenosine A2a receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:20799992 NCBI chr20:13,315,848...13,333,386
Ensembl chr20:13,315,853...13,333,386 		JBrowse link
G Ak5 adenylate kinase 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr 2:241,397,297...241,581,483
Ensembl chr 2:241,397,297...241,581,458 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15982448 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Aoah acyloxyacyl hydrolase ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr17:43,808,110...44,049,458
Ensembl chr17:43,809,638...44,049,148 		JBrowse link
G Arc activity-regulated cytoskeleton-associated protein disease_progression ISO mRNA:increased expression:brain (mouse) RGD PMID:25959066 RGD:401938592 NCBI chr 7:106,555,968...106,559,697
Ensembl chr 7:106,555,785...106,559,378 		JBrowse link
G Arrb2 arrestin, beta 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17233643 NCBI chr10:55,146,887...55,154,854
Ensembl chr10:55,146,818...55,154,850 		JBrowse link
G Astn2 astrotactin 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr 5:78,758,142...79,744,021
Ensembl chr 5:78,758,142...79,748,273 		JBrowse link
G Bdnf brain-derived neurotrophic factor ISO
IEP		 CTD Direct Evidence: marker/mechanism
protein:decreased expression:hippocampus		 CTD
RGD		 PMID:20736000 PMID:24407463 RGD:401976437 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Cat catalase treatment IEP RGD PMID:24445072 RGD:405255657 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cchcr1 coiled-coil alpha-helical rod protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr20:3,205,675...3,218,437
Ensembl chr20:3,205,676...3,218,308 		JBrowse link
G Cd55 CD55 molecule (Cromer blood group) ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr13:41,857,242...41,885,966
Ensembl chr13:41,857,395...41,885,831 		JBrowse link
G Cdh13 cadherin 13 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr19:46,349,562...47,387,462
Ensembl chr19:46,349,430...47,387,459 		JBrowse link
G Cdk5 cyclin-dependent kinase 5 ISO protein:increased expression:ventral tegmental area, nucleus accumbens (mouse) RGD PMID:28782589 RGD:401900303 NCBI chr 4:10,754,682...10,760,110
Ensembl chr 4:10,754,687...10,760,112 		JBrowse link
G Cfh complement factor H ISO
IEP		 protein:increased expression:serum:
protein:increased expression:serum, hippocampus:		 RGD PMID:22871478 PMID:22871478 RGD:7364944, RGD:7364944 NCBI chr13:51,512,376...51,613,829
Ensembl chr13:51,511,828...51,613,838 		JBrowse link
G Col28a1 collagen type XXVIII alpha 1 chain ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr 4:36,069,980...36,223,128
Ensembl chr 4:36,069,970...36,223,220 		JBrowse link
G Comt catechol-O-methyltransferase susceptibility ISO CTD Direct Evidence: marker/mechanism
DNA:SNP:cd: p.V158M (human)
DNA:SNPs,haplotypes:exon,3'utr: (rs4680, rs165599) (human)
ClinVar Annotator: match by term: methamphetamine use disorder		 CTD
ClinVar
RGD		 PMID:15274053 PMID:25741868 PMID:33544778 PMID:21934638 PMID:17187009 More... RGD:401959602, RGD:401940147, RGD:401940150, RGD:401940124 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 treatment ISO
IEP		 protein:increases activity:ventral tegmental area, nucleus accumbens (mouse)
protein:increased expression, increased phosphorylation:nucleus accumbens, ventral tegmental area		 RGD PMID:28782589 PMID:31900897 RGD:401900303, RGD:401938636 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Csmd1 CUB and Sushi multiple domains 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr16:72,218,189...73,818,380
Ensembl chr16:72,218,503...73,817,614 		JBrowse link
G Cubn cubilin ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr17:76,385,046...76,593,133
Ensembl chr17:76,385,060...76,593,231 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18280655 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759 		JBrowse link
G Dcstamp dendrocyte expressed seven transmembrane protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr 7:70,807,455...70,822,067
Ensembl chr 7:70,807,581...70,822,078 		JBrowse link
G Drd1 dopamine receptor D1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18363855 PMID:19444617 NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002 		JBrowse link
G Drd2 dopamine receptor D2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18363855 PMID:18555060 PMID:19940168 NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875 		JBrowse link
G Drd3 dopamine receptor D3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19940168 NCBI chr11:56,879,689...56,931,901
Ensembl chr11:56,879,689...56,940,596 		JBrowse link
G Drd4 dopamine receptor D4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15274053 NCBI chr 1:196,396,366...196,400,824
Ensembl chr 1:196,396,366...196,399,553 		JBrowse link
G Ephx1 epoxide hydrolase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19598248 NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235 		JBrowse link
G Fhit fragile histidine triad diadenosine triphosphatase ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr15:13,935,029...15,442,620
Ensembl chr15:13,934,995...15,442,340 		JBrowse link
G Fkbp15 FKBP prolyl isomerase family member 15 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr 5:75,750,786...75,815,038
Ensembl chr 5:75,750,787...75,814,990 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit ISO
IEP		 CTD Direct Evidence: marker/mechanism
protein:increased expression:nucleus accumbens,striatum
mRNA:increased expression:nucleus accumbens		 CTD
RGD		 PMID:19689456 PMID:18834549 PMID:24183790 RGD:405255667, RGD:405100720 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit ISO
IEP		 protein:increased expression:ventral tegmental area, nucleus accumbens (mouse)
associated with stress related disorder;protein:increased expression:brain (rat)		 RGD PMID:28782589 PMID:27672362 PMID:31373119 RGD:401900303, RGD:401901183, RGD:401900735 NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465 		JBrowse link
G Gabbr1 gamma-aminobutyric acid type B receptor subunit 1 susceptibility ISO DNA:SNPs, halotypes:intron (rs2076483,rs29221,rs715044) (human) RGD PMID:30143926 RGD:401940101 NCBI chr20:1,464,534...1,494,114
Ensembl chr20:1,464,534...1,493,994 		JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 sexual_dimorphism ISO CTD Direct Evidence: marker/mechanism
DNA:missense mutation:exon 8:p.K289M (rs4480617) (human)		 CTD
RGD		 PMID:15772696 PMID:14569258 RGD:402528887 NCBI chr10:26,374,693...26,463,937
Ensembl chr10:26,374,694...26,464,346 		JBrowse link
G Gad1 glutamate decarboxylase 1 susceptibility ISO DNA:haplotype: :rs769404���rs701492(human) RGD PMID:27967329 RGD:401900122 NCBI chr 3:55,369,704...55,410,335
Ensembl chr 3:55,369,704...55,410,333 		JBrowse link
G Gad2 glutamate decarboxylase 2 susceptibility ISO DNA:SNP: :rs2236418(human) RGD PMID:27967329 RGD:401900122 NCBI chr17:84,763,630...84,826,155
Ensembl chr17:84,763,628...84,826,155 		JBrowse link
G Gdnf glial cell derived neurotrophic factor treatment ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:17356005 PMID:23432945 RGD:405850210 NCBI chr 2:56,894,022...56,919,935
Ensembl chr 2:56,895,010...56,917,209 		JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 IEP methamphetamine abuse;protein:increased expression:hippocampal formation, striatum, prefrontal cortex (rat) RGD PMID:37778205 RGD:405100237 NCBI chr10:41,210,713...41,527,283
Ensembl chr10:41,210,713...41,527,283 		JBrowse link
G Grm2 glutamate metabotropic receptor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20211215 NCBI chr 8:107,280,099...107,293,159
Ensembl chr 8:107,280,099...107,293,146 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19254865 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15729709 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Gstt1 glutathione S-transferase theta 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18186040 PMID:19254865 NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585 		JBrowse link
G Hdac8 histone deacetylase 8 IEP mRNA:decreased expression:striatum (rat) RGD PMID:25452209 RGD:9681719 NCBI chr  X:67,385,288...67,593,014
Ensembl chr  X:67,385,289...67,592,923 		JBrowse link
G Hs3st4 heparan sulfate-glucosamine 3-sulfotransferase 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr 1:178,539,078...178,944,850
Ensembl chr 1:178,539,093...178,944,107 		JBrowse link
G Htr1b 5-hydroxytryptamine receptor 1B ISO CTD Direct Evidence: therapeutic CTD PMID:10780831 NCBI chr 8:82,513,572...82,534,670
Ensembl chr 8:82,517,360...82,534,549 		JBrowse link
G Htr3a 5-hydroxytryptamine receptor 3A ISO CTD Direct Evidence: marker/mechanism CTD PMID:19689456 NCBI chr 8:49,242,018...49,254,475
Ensembl chr 8:49,242,020...49,254,389 		JBrowse link
G Htr6 5-hydroxytryptamine receptor 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20705401 NCBI chr 5:151,295,269...151,312,853
Ensembl chr 5:151,296,662...151,311,912 		JBrowse link
G Large1 LARGE xylosyl- and glucuronyltransferase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr19:11,603,129...12,048,930
Ensembl chr19:11,603,129...12,048,930 		JBrowse link
G Lingo2 leucine rich repeat and Ig domain containing 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr 5:50,370,744...51,687,252
Ensembl chr 5:50,367,101...50,516,956 		JBrowse link
G Map2k5 mitogen activated protein kinase kinase 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr 8:63,625,220...63,852,090
Ensembl chr 8:63,625,221...63,851,983 		JBrowse link
G Mtarc1 mitochondrial amidoxime reducing component 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr13:96,324,377...96,362,677
Ensembl chr13:96,339,757...96,397,796 		JBrowse link
G Mtarc2 mitochondrial amidoxime reducing component 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr13:96,362,810...96,397,284 JBrowse link
G Myo5b myosin Vb ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr18:68,038,759...68,341,568
Ensembl chr18:68,038,759...68,338,745 		JBrowse link
G Nos1 nitric oxide synthase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15542708 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945 		JBrowse link
G Npy1r neuropeptide Y receptor Y1 ISO CTD Direct Evidence: marker/mechanism
DNA:SNP:intron: (rs7687423) (human)		 CTD
RGD		 PMID:19566775 PMID:19566775 RGD:402463941 NCBI chr16:23,037,788...23,047,330
Ensembl chr16:23,037,789...23,046,759 		JBrowse link
G Nrg1 neuregulin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr16:59,250,658...60,304,519
Ensembl chr16:59,250,854...60,296,884 		JBrowse link
G Oprm1 opioid receptor, mu 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16402083 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409 		JBrowse link
G PCOLCE2 procollagen C-endopeptidase enhancer 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr 8:96,193,461...96,251,116
Ensembl chr 8:96,193,461...96,251,114 		JBrowse link
G Pde4b phosphodiesterase 4B ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr 5:116,799,819...117,369,155
Ensembl chr 5:116,799,971...117,367,696 		JBrowse link
G Pde4d phosphodiesterase 4D ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr 2:40,014,933...41,529,190
Ensembl chr 2:40,019,933...41,525,884 		JBrowse link
G Pde6c phosphodiesterase 6C ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr 1:235,909,583...235,965,435
Ensembl chr 1:235,909,775...235,965,315 		JBrowse link
G Pdyn prodynorphin ISO
IEP		 CTD Direct Evidence: marker/mechanism
mRNA:increased expression:nucleus acccumbens
mRNA:increased expression:nucleus accumbens
mRNA:increased expression:central amygdaloid nucleus
mRNA:altered expression:brain
DNA:repeat:promoter:rs35286251 (human)		 CTD
RGD		 PMID:16529859 PMID:27989838 PMID:22390687 PMID:12523490 PMID:16289352 More... RGD:401851910, RGD:401851043, RGD:401850585, RGD:401850564, RGD:401850552 NCBI chr 3:116,900,990...116,913,334
Ensembl chr 3:116,900,992...116,913,334 		JBrowse link
G Pick1 protein interacting with PRKCA 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17606663 NCBI chr 7:110,796,623...110,816,850
Ensembl chr 7:110,797,117...110,816,848 		JBrowse link
G Plat plasminogen activator, tissue type ISO CTD Direct Evidence: marker/mechanism CTD PMID:15659235 NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223 		JBrowse link
G Pou5f1 POU class 5 homeobox 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891 		JBrowse link
G Prdm2 PR/SET domain 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr 5:155,421,066...155,531,884
Ensembl chr 5:155,422,134...155,531,825 		JBrowse link
G Prkaca protein kinase cAMP-activated catalytic subunit alpha treatment IEP protein:increased expression, increased phosphorylation:nucleus accumbens, ventral tegmental area RGD PMID:31900897 RGD:401938636 NCBI chr19:24,155,081...24,178,430
Ensembl chr19:24,155,090...24,178,430 		JBrowse link
G Prkg1 protein kinase cGMP-dependent 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr 1:228,409,605...229,638,794
Ensembl chr 1:228,408,947...229,639,080 		JBrowse link
G Prokr2 prokineticin receptor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20576534 NCBI chr 3:119,624,738...119,639,442
Ensembl chr 3:119,627,601...119,635,718 		JBrowse link
G Psd3 pleckstrin and Sec7 domain containing 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr16:21,465,643...22,035,846
Ensembl chr16:21,465,639...22,034,547 		JBrowse link
G Raly RALY heterogeneous nuclear ribonucleoprotein ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr 3:143,306,039...143,370,542
Ensembl chr 3:143,306,300...143,370,539 		JBrowse link
G Rapgef5 Rap guanine nucleotide exchange factor 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr 6:138,445,184...138,679,943
Ensembl chr 6:138,437,991...138,679,936 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:19689456 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Rgs17 regulator of G-protein signaling 17 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr 1:42,222,248...42,324,625
Ensembl chr 1:42,227,070...42,324,609 		JBrowse link
G Serpina5 serpin family A member 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr 6:123,009,224...123,028,412
Ensembl chr 6:123,023,306...123,028,407 		JBrowse link
G Sgcz sarcoglycan zeta ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr16:53,660,283...54,740,811
Ensembl chr16:53,660,502...54,735,193 		JBrowse link
G Sh3rf3 SH3 domain containing ring finger 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr20:26,765,278...27,099,261
Ensembl chr20:26,765,015...27,099,257 		JBrowse link
G Slc6a3 solute carrier family 6 member 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12931138 NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413 		JBrowse link
G Slc6a4 solute carrier family 6 member 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19689456 NCBI chr10:61,824,208...61,858,924
Ensembl chr10:61,826,123...61,858,384 		JBrowse link
G Slc6a9 solute carrier family 6 member 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17582620 NCBI chr 5:131,374,562...131,408,733
Ensembl chr 5:131,374,542...131,408,728 		JBrowse link
G Smyd3 SET and MYND domain containing 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr13:90,709,263...91,266,209
Ensembl chr13:90,709,270...91,266,253 		JBrowse link
G Snca synuclein alpha treatment IMP
ISO		 CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:15542733 PMID:32278788 PMID:20551914 RGD:13506280 NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262 		JBrowse link
G Trpm3 transient receptor potential cation channel, subfamily M, member 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr 1:219,673,200...220,557,610
Ensembl chr 1:219,672,892...220,560,717 		JBrowse link
G Usp48 ubiquitin specific peptidase 48 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr 5:149,800,189...149,867,838
Ensembl chr 5:149,800,179...149,867,719 		JBrowse link
G Zfp385d zinc finger protein 385D ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr15:5,040,182...5,849,975
Ensembl chr15:5,042,572...5,423,367 		JBrowse link
G Zfp423 zinc finger protein 423 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr19:19,111,213...19,407,373
Ensembl chr19:19,110,238...19,407,373 		JBrowse link
cannabis abuse term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A ISO CTD Direct Evidence: marker/mechanism CTD PMID:19625010 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21041608 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Apol2 apolipoprotein L2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17205118 NCBI chr 7:109,331,367...109,338,632
Ensembl chr 7:109,331,392...109,338,558 		JBrowse link
G Bche butyrylcholinesterase ISO protein:increased activity:blood plasma (human) RGD PMID:30707402 RGD:401960085 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148 		JBrowse link
G Calm1 calmodulin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17205118 NCBI chr 6:119,487,691...119,495,759
Ensembl chr 6:119,487,621...119,498,227 		JBrowse link
G Calm2 calmodulin 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17205118 NCBI chr 6:7,091,624...7,104,284
Ensembl chr 6:7,091,567...7,104,287
Ensembl chr15:7,091,567...7,104,287 		JBrowse link
G Camk2b calcium/calmodulin-dependent protein kinase II beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:17205118 NCBI chr14:80,845,206...80,934,172
Ensembl chr14:80,845,238...80,933,994 		JBrowse link
G Cnr1 cannabinoid receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19016476 NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099 		JBrowse link
G Comt catechol-O-methyltransferase susceptibility
onset		 ISO DNA:SNP:cd: p.V158M (human)
associated with alcohol use disorder; DNA:hypermethylation:promoter		 RGD PMID:19259017 PMID:33781176 PMID:30790675 RGD:401959590, RGD:401959741, RGD:401959592 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642 		JBrowse link
G Drd4 dopamine receptor D4 susceptibility ISO DNA:duplication:promoter: 120bp repeat RGD PMID:33544778 RGD:401959602 NCBI chr 1:196,396,366...196,400,824
Ensembl chr 1:196,396,366...196,399,553 		JBrowse link
G Fdft1 farnesyl diphosphate farnesyl transferase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17205118 NCBI chr15:37,412,143...37,440,198
Ensembl chr15:37,412,146...37,440,287 		JBrowse link
G Gcc1 GRIP and coiled-coil domain containing 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17205118 NCBI chr 4:57,030,817...57,042,682
Ensembl chr 4:57,032,314...57,042,663 		JBrowse link
G Ngf nerve growth factor ISO protein:decreased expression:serum RGD PMID:18774699 RGD:401965396 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452 		JBrowse link
G Nrg1 neuregulin 1 ISO associated with schizophrenia;protein:increased expression:blood: RGD PMID:30799217 RGD:405112241 NCBI chr16:59,250,658...60,304,519
Ensembl chr16:59,250,854...60,296,884 		JBrowse link
G Scarb1 scavenger receptor class B, member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17205118 NCBI chr12:31,296,143...31,362,649
Ensembl chr12:31,296,156...31,362,647 		JBrowse link
cocaine abuse term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bche butyrylcholinesterase severity ISO RGD PMID:21540357 RGD:401960084 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 severity ISO RGD PMID:21806491 RGD:401794583 NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377 		JBrowse link
G Cd40lg CD40 ligand severity ISO RGD PMID:21806491 RGD:401794583 NCBI chr  X:135,127,052...135,138,768
Ensembl chr  X:135,126,969...135,138,306 		JBrowse link
G Chrna5 cholinergic receptor nicotinic alpha 5 subunit onset ISO DNA:SNP:exon:rs16969968(human) RGD PMID:32841724 RGD:150530292 NCBI chr 8:55,369,794...55,398,526
Ensembl chr 8:55,369,794...55,398,146 		JBrowse link
G Chrna6 cholinergic receptor nicotinic alpha 6 subunit susceptibility ISO DNA:SNP::rs892413(human) RGD PMID:24675634 RGD:405849277 NCBI chr16:64,697,741...64,704,441
Ensembl chr16:64,697,741...64,704,441 		JBrowse link
G Chrnb4 cholinergic receptor nicotinic beta 4 subunit onset ISO DNA:SNP::rs950776(human) RGD PMID:32841724 RGD:150530292 NCBI chr 8:55,417,583...55,437,027
Ensembl chr 8:55,418,313...55,437,027 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 ISO
IDA		 protein:increased expression, increased phosphorylation:prefrontal cortex RGD PMID:24205196 PMID:18001273 RGD:401940185, RGD:401959587 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Fkbp5 FKBP prolyl isomerase 5 sexual_dimorphism IEP mRNA:increased expression:brain (rat) RGD PMID:31029877 RGD:401976486 NCBI chr20:6,457,207...6,575,404
Ensembl chr20:6,457,216...6,541,674 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit treatment ISO RGD PMID:28366798 RGD:405100962 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit IEP associated with alcohol dependence;protein:increased expression: caudate-putamen (rat) RGD PMID:17572394 RGD:401900302 NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465 		JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 sexual_dimorphism ISO
IEP		 protein:increased expression:prefrontal cortex (mouse)
protein:increased expression:nucleus accumbens (rat)
protein:decreased expression:nucleus accumbens (mouse)		 RGD PMID:33497752 PMID:11801363 PMID:22197517 RGD:401976469, RGD:405650201, RGD:405650197 NCBI chr10:41,210,713...41,527,283
Ensembl chr10:41,210,713...41,527,283 		JBrowse link
G Hcrt hypocretin neuropeptide precursor treatment ISO RGD PMID:29454841 RGD:401960065 NCBI chr10:85,689,979...85,691,214
Ensembl chr10:85,689,465...85,691,210 		JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A IEP protein:decreased expression:dentate gyrus, hypothalamus RGD PMID:9723786 RGD:401900605 NCBI chr 2:36,693,462...36,698,026
Ensembl chr 2:36,694,174...36,695,442 		JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A treatment IEP
IMP		 mRNA:increased expression:orbitofrontal cortex RGD PMID:27733540 PMID:20814782 PMID:11259563 RGD:401900753, RGD:401901179, RGD:401900755 NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928 		JBrowse link
G Htr2c 5-hydroxytryptamine receptor 2C treatment IMP RGD PMID:20814782 RGD:401901179 NCBI chr  X:110,640,777...110,870,288
Ensembl chr  X:110,641,153...110,870,287 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 IDA protein:increased phosphorylation:nucleus accumbens RGD PMID:25522720 RGD:401851063 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 IDA protein:increased phosphorylation:nucleus accumbens RGD PMID:25522720 RGD:401851063 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Npy1r neuropeptide Y receptor Y1 susceptibility ISO DNA:SNP:intron: (rs4518200) (human) RGD PMID:33242852 RGD:402463938 NCBI chr16:23,037,788...23,047,330
Ensembl chr16:23,037,789...23,046,759 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 treatment IMP RGD PMID:12805318 PMID:9765324 RGD:401976288, RGD:401976376 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375 		JBrowse link
G Pdyn prodynorphin IEP mRNA:increased expression:caudate putamen
mRNA:increased expression:central amygdaloid nucleus, dentate gyrus of hippocampal formation		 RGD PMID:7694032 PMID:12523490 RGD:401850578, RGD:401850585 NCBI chr 3:116,900,990...116,913,334
Ensembl chr 3:116,900,992...116,913,334 		JBrowse link
G Prl prolactin treatment ISO RGD PMID:17391744 RGD:401960113 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062 		JBrowse link
Intravenous Substance Abuse term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cnr1 cannabinoid receptor 1 ISO RGD PMID:9106242 RGD:1358448 NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099 		JBrowse link
opioid abuse term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ankk1 ankyrin repeat and kinase domain containing 1 susceptibility ISO associated with phlegm syndrome;DNA:polymorphism:exon: RGD PMID:26138154 RGD:11065747 NCBI chr 8:49,779,862...49,788,024
Ensembl chr 8:49,779,862...49,788,024 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 treatment IEP
ISO		 protein:increased phosphorylation:Prefrontal Cortex, nucleus accumbens (rat) RGD PMID:30632799 PMID:31081159 RGD:401901180, RGD:401940188 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Dlg4 discs large MAGUK scaffold protein 4 treatment ISO RGD PMID:31081159 RGD:401940188 NCBI chr10:54,740,700...54,769,097
Ensembl chr10:54,739,470...54,767,153 		JBrowse link
G Drd4 dopamine receptor D4 ISO association with inhaler;DNA:repeats:exon: RGD PMID:11054768 RGD:401960062 NCBI chr 1:196,396,366...196,400,824
Ensembl chr 1:196,396,366...196,399,553 		JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit IEP protein:increased expression:Prefrontal Cortex, nucleus accumbens (rat) RGD PMID:30632799 RGD:401901180 NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465 		JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 ISO protein:increased expression:medial prefrontal cortex,lateral prefrontal cortex,orbitofrontal cortex RGD PMID:29766293 RGD:401938658 NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603 		JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A ISO protein:increased expression:orbitofrontal cortex: RGD PMID:29766293 RGD:401938658 NCBI chr10:5,629,683...6,053,262
Ensembl chr10:5,631,369...6,044,637 		JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B ISO protein:increased expression:medial prefrontal cortex,lateral prefrontal cortex,orbitofrontal cortex RGD PMID:29766293 RGD:401938658 NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279 		JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A ISO mRNA:altered expression:striatum RGD PMID:30059705 RGD:401900306 NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928 		JBrowse link
G Ncam1 neural cell adhesion molecule 1 IMP RGD PMID:24399412 RGD:401959321 NCBI chr 8:49,865,629...50,165,687
Ensembl chr 8:49,865,633...50,166,014 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 treatment IMP RGD PMID:9636221 RGD:401965473 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375 		JBrowse link
G Oprd1 opioid receptor, delta 1 treatment
susceptibility		 ISO mRNA:increased expression:ventral striatum
associated with females, buprenorphine;DNA:SNP:intron (rs581111|rs529520) (human)
mRNA:altered expression:testis, omentum (human)
DNA:SNP:CDS: rs569356|rs678849 (human)		 RGD PMID:30059705 PMID:24126707 PMID:37660978 PMID:37146669 RGD:401900306, RGD:402463962, RGD:402463943, RGD:401976452 NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960 		JBrowse link
G Oprk1 opioid receptor, kappa 1 severity ISO mRNA:decreased expression:peripheral blood lymphocyte
DNA:SNP:CDS: rs997917|rs12548098|rs6473797|rs963549 (human)		 RGD PMID:31710992 PMID:37146669 RGD:401850570, RGD:401976452 NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823 		JBrowse link
G Oprl1 opioid related nociceptin receptor 1 ISO mRNA:increased expression:ventral striatum RGD PMID:30059705 RGD:401900306 NCBI chr 3:168,831,934...168,839,920
Ensembl chr 3:168,834,003...168,839,920 		JBrowse link
G Oprm1 opioid receptor, mu 1 treatment
susceptibility		 ISO DNA:SNP:CDS: rs648893 (human)
DNA:methylation:exon 1 (rs1799971) (human)		 RGD PMID:37146669 PMID:37660978 RGD:401976452, RGD:402463943 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409 		JBrowse link
G Pdyn prodynorphin ISO
IEP		 mRNA, protein:increased expression:peripheral blood lymphocyte
protein:increased expression:nucleus accumbens		 RGD PMID:31710992 PMID:24305833 RGD:401850570, RGD:401850592 NCBI chr 3:116,900,990...116,913,334
Ensembl chr 3:116,900,992...116,913,334 		JBrowse link
G Pomc proopiomelanocortin ISO mRNA:increased expression:ventral striatum RGD PMID:30059705 RGD:401900306 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664 		JBrowse link
G Rgs10 regulator of G-protein signaling 10 IEP RGD PMID:22056472 RGD:13524518 NCBI chr 1:182,946,334...182,987,729
Ensembl chr 1:182,946,336...182,987,697 		JBrowse link
G Rgs2 regulator of G-protein signaling 2 IEP RGD PMID:19664213 RGD:13524573 NCBI chr13:55,799,749...55,802,354
Ensembl chr13:55,798,829...55,802,385 		JBrowse link
G Rgs4 regulator of G-protein signaling 4 IEP RGD PMID:22056472 RGD:13524518 NCBI chr13:81,936,775...81,943,103
Ensembl chr13:81,936,775...81,943,068 		JBrowse link
phencyclidine abuse term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apol2 apolipoprotein L2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17205118 NCBI chr 7:109,331,367...109,338,632
Ensembl chr 7:109,331,392...109,338,558 		JBrowse link
G Calm1 calmodulin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17205118 NCBI chr 6:119,487,691...119,495,759
Ensembl chr 6:119,487,621...119,498,227 		JBrowse link
G Calm2 calmodulin 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17205118 NCBI chr 6:7,091,624...7,104,284
Ensembl chr 6:7,091,567...7,104,287
Ensembl chr15:7,091,567...7,104,287 		JBrowse link
G Camk2b calcium/calmodulin-dependent protein kinase II beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:17205118 NCBI chr14:80,845,206...80,934,172
Ensembl chr14:80,845,238...80,933,994 		JBrowse link
G Fdft1 farnesyl diphosphate farnesyl transferase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17205118 NCBI chr15:37,412,143...37,440,198
Ensembl chr15:37,412,146...37,440,287 		JBrowse link
G Gcc1 GRIP and coiled-coil domain containing 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17205118 NCBI chr 4:57,030,817...57,042,682
Ensembl chr 4:57,032,314...57,042,663 		JBrowse link
G Scarb1 scavenger receptor class B, member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17205118 NCBI chr12:31,296,143...31,362,649
Ensembl chr12:31,296,156...31,362,647 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 18976
    Chemically-Induced Disorders 1394
      substance-related disorder 713
        substance abuse 235
          Intravenous Substance Abuse 1
          alcohol use disorder 150
          amphetamine abuse 86
          antidepressant type abuse 0
          barbiturate abuse 0
          cannabis abuse 15
          cocaine abuse 21
          hallucinogen abuse 0
          opioid abuse 20
          phencyclidine abuse 7
          polysubstance abuse 0
Path 2
Term Annotations click to browse term
  disease 18976
    disease of anatomical entity 18260
      nervous system disease 14116
        central nervous system disease 12429
          brain disease 11666
            disease of mental health 8318
              substance-related disorder 713
                substance abuse 235
                  Intravenous Substance Abuse 1
                  alcohol use disorder 150
                  amphetamine abuse 86
                  antidepressant type abuse 0
                  barbiturate abuse 0
                  cannabis abuse 15
                  cocaine abuse 21
                  hallucinogen abuse 0
                  opioid abuse 20
                  phencyclidine abuse 7
                  polysubstance abuse 0
paths to the root