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Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1-naphthyl isothiocyanate | increases expression | EXP | | 6480464 | 1-Naphthylisothiocyanate results in increased expression of SERPINA5 mRNA | CTD | PMID:12832660 | 17alpha-ethynylestradiol | multiple interactions | ISO | RGD:1346137 | 6480464 | [Ethinyl Estradiol co-treated with Levonorgestrel] results in increased expression of SERPINA5 protein | CTD | PMID:14551147 | 17beta-estradiol | multiple interactions | ISO | RGD:1346137 | 6480464 | [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of SERPINA5 mRNA | CTD | PMID:19619570 | 17beta-estradiol | increases expression | ISO | RGD:1346137 | 6480464 | Estradiol results in increased expression of SERPINA5 mRNA | CTD | PMID:19619570 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:1346137 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of SERPINA5 mRNA | CTD | PMID:19619570 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of SERPINA5 mRNA | CTD | PMID:21215274 PMID:21724226 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of SERPINA5 mRNA | CTD | PMID:22298810 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of SERPINA5 mRNA | CTD | PMID:21215274 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | RGD:1346137 | 6480464 | [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of SERPINA5 mRNA | CTD | PMID:19619570 | 2,3-dimethoxynaphthalene-1,4-dione | decreases expression | ISO | RGD:1346137 | 6480464 | 2,3-dimethoxy-1,4-naphthoquinone results in decreased expression of SERPINA5 mRNA | CTD | PMID:17547211 | 4,4'-diaminodiphenylmethane | decreases expression | ISO | RGD:734302 | 6480464 | 4,4'-diaminodiphenylmethane results in decreased expression of SERPINA5 mRNA | CTD | PMID:18648102 | 5-fluorouracil | increases expression | ISO | RGD:1346137 | 6480464 | Fluorouracil results in increased expression of SERPINA5 mRNA | CTD | PMID:17039268 | aflatoxin B1 | affects expression | ISO | RGD:1346137 | 6480464 | Aflatoxin B1 affects the expression of SERPINA5 protein | CTD | PMID:20106945 | aflatoxin B1 | decreases expression | ISO | RGD:1346137 | 6480464 | Aflatoxin B1 results in decreased expression of SERPINA5 mRNA | CTD | PMID:22100608 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of SERPINA5 mRNA | CTD | PMID:16483693 | benzo[a]pyrene | decreases expression | ISO | RGD:734302 | 6480464 | Benzo(a)pyrene results in decreased expression of SERPINA5 mRNA | CTD | PMID:22228805 | C60 fullerene | decreases expression | EXP | | 6480464 | fullerene C60 results in decreased expression of SERPINA5 mRNA | CTD | PMID:19167457 | copper(2+) sulfate | decreases expression | ISO | RGD:1346137 | 6480464 | Copper Sulfate results in decreased expression of SERPINA5 mRNA | CTD | PMID:19549813 | cyclosporin A | decreases expression | ISO | RGD:1346137 | 6480464 | Cyclosporine results in decreased expression of SERPINA5 mRNA | CTD | PMID:20106945 | dextran sulfate | multiple interactions | ISO | RGD:1346137 | 6480464 | Dextran Sulfate affects the reaction [SEMG2 protein binds to SERPINA5 protein] | CTD | PMID:17253189 | dibutyl phthalate | decreases expression | ISO | RGD:734302 | 6480464 | Dibutyl Phthalate results in decreased expression of SERPINA5 mRNA | CTD | PMID:21266533 | genistein | increases expression | ISO | RGD:734302 | 6480464 | Genistein results in increased expression of SERPINA5 mRNA | CTD | PMID:21810550 | hydrogen peroxide | affects expression | ISO | RGD:1346137 | 6480464 | Hydrogen Peroxide affects the expression of SERPINA5 mRNA | CTD | PMID:20044591 | hydroquinone O-beta-D-glucopyranoside | decreases expression | ISO | RGD:1346137 | 6480464 | Arbutin results in decreased expression of SERPINA5 mRNA | CTD | PMID:17103032 | kojic acid | decreases expression | ISO | RGD:1346137 | 6480464 | kojic acid results in decreased expression of SERPINA5 mRNA | CTD | PMID:16595896 | levonorgestrel | multiple interactions | ISO | RGD:1346137 | 6480464 | [Ethinyl Estradiol co-treated with Levonorgestrel] results in increased expression of SERPINA5 protein | CTD | PMID:14551147 | methamphetamine | affects response to substance | ISO | RGD:1346137 | 6480464 | SERPINA5 gene SNP affects the susceptibility to Methamphetamine | CTD | PMID:18316681 | methotrexate | affects expression | ISO | RGD:734302 | 6480464 | Methotrexate affects the expression of SERPINA5 mRNA | CTD | PMID:18502557 | N-nitrosodimethylamine | decreases expression | ISO | RGD:1346137 | 6480464 | Dimethylnitrosamine results in decreased expression of SERPINA5 mRNA | CTD | PMID:17547211 | zinc atom | multiple interactions | ISO | RGD:1346137 | 6480464 | Zinc affects the reaction [SEMG2 protein binds to SERPINA5 protein] | CTD | PMID:17253189 | zinc(0) | multiple interactions | ISO | RGD:1346137 | 6480464 | Zinc affects the reaction [SEMG2 protein binds to SERPINA5 protein] | CTD | PMID:17253189 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Complement and coagulation cascades |
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | Complement and coagulation cascades |
References - curated| 1. |
Anway MD, etal., J Androl. 2005 Sep-Oct;26(5):578-85. |
| 2. |
Meijers JC, etal., Br J Haematol. 2002 Aug;118(2):604-9. |
| 3. |
MGD data from the GO Consortium |
| 4. |
NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 5. |
Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
| 6. |
RGD automated data pipeline |
| 7. |
RGD automated import pipeline for gene-chemical interactions |
| 8. |
Strausberg RL, etal., Proc Natl Acad Sci U S A 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11. |
| 9. |
Wakita T, etal., FEBS Lett 1998 Jun 16;429(3):263-8. |
RGD Disease Portals| Serpina5 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Serpina5 (Rattus norvegicus) |
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| SERPINA5 (Homo sapiens) |
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| Serpina5 (Mus musculus) |
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Position Markers| BE121264 |
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| BI280884 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_001244739 | (Get FASTA) | Search GEO for Microarray Profiles |
| NM_022957 | (Get FASTA) | Search GEO for Microarray Profiles | |
| GenBank Nucleotide | AABR06046008 | (Get FASTA) | Search GEO for Microarray Profiles |
| AABR06046009 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01046287 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01046288 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AB013128 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC081797 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC097315 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH473982 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CK603584 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_022957 | ||||||||||||||||||||
| RefSeq Status: | VALIDATED | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_075246 | ||||||||||||||||||||
| Peptide Label: | isoform 2 precursor | ||||||||||||||||||||
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| RefSeq Acc Id: | NM_001244739 | |||||||||||||||
| RefSeq Status: | VALIDATED | |||||||||||||||
| Type: | CODING | |||||||||||||||
| Protein Acc Id: | NP_001231668 | |||||||||||||||
| Peptide Label: | isoform 1 | |||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_001231668 | (Get FASTA) |
| NP_075246 | (Get FASTA) | |
| GenBank Protein | AAH81797 | (Get FASTA) |
| AAH97315 | (Get FASTA) | |
| BAA32591 | (Get FASTA) | |
| EDL81797 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000009855 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Protein | ENSRNOP00000013138 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Transcript | ENSRNOT00000013138 | ENTREZGENE, UniProtKB/TrEMBL |
| Entrez Gene | 65051 | ENTREZGENE |
| HomoloGene Group ID | 20159 | ENTREZGENE |
| IMAGE_CLONE | IMAGE:7112069 | IMAGE-MGC_LOAD |
| IMAGE:7453034 | IMAGE-MGC_LOAD | |
| InterPro | Protease_inhib_I4_serpin | UniProtKB/TrEMBL |
| Sepin_dom | UniProtKB/TrEMBL | |
| IPI | IPI00207600 | UniProtKB/TrEMBL |
| KEGG Report | rno:65051 | ENTREZGENE, UniProtKB/TrEMBL |
| MGC_CLONE | MGC:114315 | IMAGE-MGC_LOAD |
| MGC:93420 | IMAGE-MGC_LOAD | |
| PANTHER | Prot_inh_serpin | UniProtKB/TrEMBL |
| Pfam | Serpin | UniProtKB/TrEMBL |
| SMART | SERPIN | UniProtKB/TrEMBL |
| Superfamily-SCOP | Prot_inh_serpin | UniProtKB/TrEMBL |
| UniGene | Rn.30006 | ENTREZGENE |
| UniProt | F7EMJ6_RAT | UniProtKB/TrEMBL |
| Q66HL5_RAT | UniProtKB/TrEMBL |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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| 2012-10-16 | Serpina5 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 | Serpina5 | serpin peptidase inhibitor, clade A, member 5 | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2012-03-05 | Serpina5 | serpin peptidase inhibitor, clade A, member 5 | Serpina5 | serine (or cysteine) peptidase inhibitor, clade A, member 5 | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2005-01-20 | Serpina5 | serine (or cysteine) peptidase inhibitor, clade A, member 5 | Pci | protein C inhibitor | Symbol and Name updated | 10779 | APPROVED |
| 2002-08-07 | Pci | protein C inhibitor | Symbol and Name status set to provisional | 1724 | PROVISIONAL |
RGD Curation Notes| Note Type | Note | Reference |
|---|---|---|
| gene_regulation | expression is androgen dependent | 633526 |
| More on Serpina5 | |
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Entrez Gene |
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Ensembl Gene |
![]() | Genome Browser |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 619817 |
| Created: | 2002-08-06 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




