Serpina5 (serpin family A member 5)

Gene: Serpina5 (serpin family A member 5) Chinchilla lanigera

Analyze

Symbol:

Serpina5

Name:

serpin family A member 5

RGD ID:

9012750

Description:

ENCODES a protein that exhibits acrosin binding (ortholog); phosphatidylcholine binding (ortholog); protease binding (ortholog); INVOLVED IN negative regulation of proteolysis (ortholog); seminal vesicle development (ortholog); spermatogenesis (ortholog); PARTICIPATES IN fibrinolysis pathway; ASSOCIATED WITH amphetamine abuse (ortholog); Arterial Occlusive Diseases (ortholog); cholestasis (ortholog); FOUND IN acrosomal membrane (ortholog); external side of plasma membrane (ortholog); extracellular exosome (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

plasma serine protease inhibitor; serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955438	17,787,399 - 17,796,414 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955438	17,787,398 - 17,796,013 (-)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

amphetamine abuse (ISO)

Arterial Occlusive Diseases (ISO)

cholestasis (ISO)

DICER1 syndrome (ISO)

genetic disease (ISO)

pleuropulmonary blastoma (ISO)

Venous Thrombosis (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

negative regulation of proteolysis (ISO)

seminal vesicle development (ISO)

spermatogenesis (ISO)

Cellular Component

acrosomal membrane (ISO)

external side of plasma membrane (ISO)

extracellular exosome (ISO)

extracellular space (ISO)

membrane (ISO)

platelet alpha granule (ISO)

platelet dense tubular network (ISO)

protein C inhibitor-coagulation factor V complex (ISO)

protein C inhibitor-coagulation factor Xa complex (ISO)

protein C inhibitor-coagulation factor XI complex (ISO)

protein C inhibitor-KLK3 complex (ISO)

protein C inhibitor-plasma kallikrein complex (ISO)

protein C inhibitor-PLAT complex (ISO)

protein C inhibitor-PLAU complex (ISO)

protein C inhibitor-thrombin complex (ISO)

protein C inhibitor-TMPRSS11E complex (ISO)

protein C inhibitor-TMPRSS7 complex (ISO)

protein-containing complex (ISO)

Molecular Function

acrosin binding (ISO)

phosphatidylcholine binding (ISO)

protease binding (ISO)

protein binding (ISO)

retinoic acid binding (ISO)

serine-type endopeptidase inhibitor activity (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

fibrinolysis pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

Serpina5
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955438	17,787,399 - 17,796,414 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955438	17,787,398 - 17,796,013 (-)	NCBI	ChiLan1.0	ChiLan1.0

SERPINA5
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	14	94,581,426 - 94,593,118 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	14	94,561,442 - 94,593,118 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	14	95,047,763 - 95,059,455 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	14	94,117,564 - 94,129,205 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	14	94,117,563 - 94,129,204	NCBI
Celera	14	75,103,903 - 75,115,619 (+)	NCBI		Celera
Cytogenetic Map	14	q32.13	NCBI
HuRef	14	75,228,133 - 75,239,873 (+)	NCBI		HuRef
CHM1_1	14	94,985,498 - 94,997,214 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	14	88,811,397 - 88,823,118 (+)	NCBI		T2T-CHM13v2.0

Serpina5
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	12	104,065,572 - 104,072,397 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	12	104,067,372 - 104,072,396 (+)	Ensembl		GRCm39 Ensembl
GRCm38	12	104,099,313 - 104,106,138 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	12	104,101,113 - 104,106,137 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	12	105,339,323 - 105,344,347 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	12	104,502,163 - 104,507,187 (+)	NCBI		MGSCv36	mm8
Celera	12	105,318,382 - 105,323,416 (+)	NCBI		Celera
Cytogenetic Map	12	E	NCBI
cM Map	12	53.3	NCBI

Serpina5
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	128,774,006 - 128,793,187 (+)	NCBI		GRCr8
mRatBN7.2	6	123,009,224 - 123,028,412 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	123,023,306 - 123,028,407 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	6	123,164,246 - 123,169,377 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	123,459,540 - 123,464,673 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	122,796,353 - 122,801,488 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	127,753,152 - 127,772,403 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	127,766,470 - 127,772,420 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	6	136,972,583 - 136,990,812 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	6	128,156,901 - 128,161,334 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	6	128,160,647 - 128,165,080 (+)	NCBI
Celera	6	120,503,068 - 120,508,038 (+)	NCBI		Celera
Cytogenetic Map	6	q32	NCBI

SERPINA5
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	15	95,729,564 - 95,742,189 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	14	94,946,069 - 94,958,694 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	14	75,205,446 - 75,217,114 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	14	94,537,115 - 94,548,803 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	14	94,537,115 - 94,548,803 (+)	Ensembl	panpan1.1		panPan2

SERPINA5
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	8	63,567,060 - 63,577,015 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	8	63,566,356 - 63,576,308 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	8	63,143,801 - 63,153,748 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	8	63,834,133 - 63,844,074 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	8	63,833,699 - 63,843,370 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	8	63,509,369 - 63,519,317 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	8	63,561,712 - 63,571,667 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	8	63,892,389 - 63,902,350 (+)	NCBI		UU_Cfam_GSD_1.0

LOC101958459
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	10,883,273 - 10,897,335 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936846	146,116 - 150,438 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936846	141,334 - 150,381 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SERPINA5
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	115,802,150 - 115,810,824 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	115,799,414 - 115,810,825 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	122,916,002 - 122,927,421 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SERPINA5
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	24	72,369,082 - 72,388,439 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	24	72,381,119 - 72,384,903 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666053	59,588,553 - 59,602,023 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Serpina5
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624734	7,236,833 - 7,244,752 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624734	7,236,833 - 7,245,579 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005390388	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01035451	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDF01001290	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCLAT00000020526 ⟹ ENSCLAP00000020330

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955438	17,787,399 - 17,796,414 (-)	Ensembl

RefSeq Acc Id:

XM_005390388 ⟹ XP_005390445

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955438	17,787,398 - 17,796,013 (-)	NCBI

Sequence:

show sequence

CCTGAGCCTGGTGGACGGCCACTCCAGCGGTGTTCAAGTGGCTGTGGGACAGAGATCGGCAGCC
ACAATGCAGCTCCTTCTGCTCTTGTGCCTGGCTCTCCTCAGCCCTCAGGGGGCCCTGTCCCGCC
GCCTCCGGGCTAAGACGAAGCTGCCCAAGGAGCCGAGCAGCAGGGACTTCACCTTCGAACTCTA
CAGGGCCTTGGCTTCCGCTTCCCCCAGCCAGAACGTCTTCTTCTCCCCACTGAGCGTGTCCACG
ATCCTGGCCATACTGTCCTTGGGGGCCAAGGGCAACACCCAGGAGCAGATCCTGGGGGCCCTGG
GCTTCAAGCCCCAGCACCAAGCAATGGCCCAGTTCCACGACAACTTCCGGCAGCTGCTGATGGG
GCTCACTCAGCACAGAGATAGCTTCCAGCTGAACCTCGGCAATGCCCTTTTCATCAACAAGGGG
CTGGTCATCGACAACATCTTCCAGCTCACCATAATGACCACATACCTGGCCAAGATTTATCCCA
CCAACTTTGAAGACCCTGCAGCAGCCCAGAAGCAGATCAATGACTATCTGGCCAAGCAAACCCA
GGGCAAGATTGCAGGCCTGATCCAGAACCTTGACAGCACCGCCGTTATGGTGATGGTGAATTAC
ATCTGCTTTAAAGCTAAGTGGGAGATTGGCTTCAACAACAAAACCACTCAGGATCAGGACTTCT
ACGTGACCCCGGAGAATAAGCTTCAGGTGCCCATGATGAACCGCGCAGACCAGTACTTCTACTT
CCTGGACAAGGACCTCTCCTGCACTGTGGTGGGCATCCCCTATGAAGGCAATGCCACCGCCTAC
TTCATTCTCCCCAACCCGGGCAAGATGCAGCAGGTGGAGAGCGGCCTGAGCAAGAAGACACTGA
GGAAGTGGAATCAGATGACAATGCGCAGGAGGCTGAATCTTTATCTTCCCAAGTTCTCCATTGA
GGGCTCCTACCAACTGGAGAAAATCTTCCCCAACCTGGGCGTCAGGGACATCTTCACCCTCAGT
GCTAACCTGTCAGGCATCTTCAAGCACTCCAACATCCAGGTGTCTCAGGTGGTGCACAAAGCCA
CGGTGGAGGTGGATGAGTCGGGAACCAGAGCGGTGTCAGGCACAGGCACGGTCTTCAGCTTCAG
ATCAGCCTATCCGAACTCCAGAACTATCAGGTTCAATAGGCCCTTTCTGATAGCCATTCTGGAG
CCCTCGACCATCCTCTTCTTTGGCAGAGTGACCCAGCCCTGAGCTGGGGCCTGTTCACAGGCCC
GCACAGTGGGAGGCAGGGTTGTGTCCTGGCCCATCTGTCTGCTGGTAGCTAGAGATTTGCTTAG
GTTTAGTTACTAAAGAGGTGTCCAATAATCCTAAGAAGATCAATAAGCTAAAGATCTCATCTTG
TCACTCAGTTGCAAGACATAGGTGCCTTGGAGAAATGTTCAGCAGTGGAGATTATCACAGAGGC
CCAGCGAGTCCAGGGTGCTTGTCCAGGTTCACACAGCATGCTCTTAGCAGCACAGACAGCCCGA
GTCCAAGCCACTGATGCTCCGCCCAGGGCCCAAAAACCCTGTGAGAAGGTGGTCCCAGCCCCCC
AGAAGCAGGTGGGTGAGTCTGGCCTCCCGTGGTATGGAAGGGGTACTGGAATGGGTGTGCAGTG
GGGCTGTCGTCCCTGCTCTAACCCACCCAGTAGCACTGCAGTGACATTGTCTCAGGACCTCAGT
TTTCTCATGAATACAGTGAAGGATCAGGGCAAGGTTCCCATCCAAGGCCCCTTAATGTCATTAA
AAAGGCTGGGCTGTTCCATGCCAGCCCTGGTCCATTTCAGTACACTCGGGAGCCACTCACGAGT
TAAGTAAAGCAGTTGGGCATCAGGTTGGAATTGTACCAGTGCAGGACGGTGCCATCCCCTGAAT
CGAGGTGTAATCTCCTGGGCCTGGCCAGTGTAGAATAGAGATCTACAGCAAGCAAAAGAGGGTC
AATTGCAGACACCGTGGCTAACTTTCTGAATTTTATGTCCACTACTATAATAAAGCATTTTGCA
AGGAC

hide sequence

Protein Sequences


Protein RefSeqs	XP_005390445	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000020330
	ENSCLAP00000020330.1

RefSeq Acc Id:

XP_005390445 ⟸ XM_005390388

- UniProtKB:

A0A8C2VTA2 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MQLLLLLCLALLSPQGALSRRLRAKTKLPKEPSSRDFTFELYRALASASPSQNVFFSPLSVSTI
LAILSLGAKGNTQEQILGALGFKPQHQAMAQFHDNFRQLLMGLTQHRDSFQLNLGNALFINKGL
VIDNIFQLTIMTTYLAKIYPTNFEDPAAAQKQINDYLAKQTQGKIAGLIQNLDSTAVMVMVNYI
CFKAKWEIGFNNKTTQDQDFYVTPENKLQVPMMNRADQYFYFLDKDLSCTVVGIPYEGNATAYF
ILPNPGKMQQVESGLSKKTLRKWNQMTMRRRLNLYLPKFSIEGSYQLEKIFPNLGVRDIFTLSA
NLSGIFKHSNIQVSQVVHKATVEVDESGTRAVSGTGTVFSFRSAYPNSRTIRFNRPFLIAILEP
STILFFGRVTQP

hide sequence

RefSeq Acc Id:

ENSCLAP00000020330 ⟸ ENSCLAT00000020526

Protein Domains

SERPIN

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000013925	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000020526	ENTREZGENE
	ENSCLAT00000020526.1	UniProtKB/TrEMBL
Gene3D-CATH	2.30.39.10	UniProtKB/TrEMBL
	3.30.497.10	UniProtKB/TrEMBL
InterPro	Serpin_CS	UniProtKB/TrEMBL
	Serpin_dom	UniProtKB/TrEMBL
	Serpin_fam	UniProtKB/TrEMBL
	Serpin_sf	UniProtKB/TrEMBL
	Serpin_sf_1	UniProtKB/TrEMBL
	Serpin_sf_2	UniProtKB/TrEMBL
NCBI Gene	Serpina5	ENTREZGENE
PANTHER	PLASMA SERINE PROTEASE INHIBITOR	UniProtKB/TrEMBL
	PTHR11461	UniProtKB/TrEMBL
Pfam	Serpin	UniProtKB/TrEMBL
PROSITE	SERPIN	UniProtKB/TrEMBL
SMART	SERPIN	UniProtKB/TrEMBL
Superfamily-SCOP	SSF56574	UniProtKB/TrEMBL
UniProt	A0A8C2VTA2	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-08-03	Serpina5	serpin family A member 5		serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations