RGD Reference Report - Basic mechanisms and regulation of fibrinolysis. - Rat Genome Database

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Basic mechanisms and regulation of fibrinolysis.

Authors: Longstaff, C  Kolev, K 
Citation: Longstaff C and Kolev K, J Thromb Haemost. 2015 Jun;13 Suppl 1:S98-105. doi: 10.1111/jth.12935.
RGD ID: 11352249
Pubmed: PMID:26149056   (View Abstract at PubMed)
DOI: DOI:10.1111/jth.12935   (Journal Full-text)

Fibrinolysis appears in many diverse physiological situations, and the components of the system are well established, along with mechanistic details for the individual reactions and some high-resolution structures. Key questions in understanding the regulation of fibrinolysis surround mechanisms of initiation and propagation, the localization of fibrinolysis reactions to the fibrin clot, and the influence of fibrin structure and clot composition on thrombolysis. This review covers these key areas with a focus on recent developments on fibrin structure and binding, the effects of a variety of cell types, the consequences of histones and DNA released by neutrophils, and the influence of flow. A complete understanding of the regulation of fibrinolysis will come from the building of detailed mathematical models. Suitable models are at an early stage of development, but may improve as model clots increase in complexity to incorporate the components and interactions listed above.

Objects Annotated

Genes (Rattus norvegicus)
Cpb2  (carboxypeptidase B2)
Fga  (fibrinogen alpha chain)
Fgb  (fibrinogen beta chain)
Fgg  (fibrinogen gamma chain)
Plat  (plasminogen activator, tissue type)
Plau  (plasminogen activator, urokinase)
Plg  (plasminogen)
Serpina5  (serpin family A member 5)
Serpinb2  (serpin family B member 2)
Serpine1  (serpin family E member 1)
Serpine2  (serpin family E member 2)
Serpinf2  (serpin family F member 2)

Genes (Mus musculus)
Cpb2  (carboxypeptidase B2)
Fga  (fibrinogen alpha chain)
Fgb  (fibrinogen beta chain)
Fgg  (fibrinogen gamma chain)
Plat  (plasminogen activator, tissue)
Plau  (plasminogen activator, urokinase)
Plg  (plasminogen)
Serpina5  (serine (or cysteine) peptidase inhibitor, clade A, member 5)
Serpinb2  (serine (or cysteine) peptidase inhibitor, clade B, member 2)
Serpine1  (serine (or cysteine) peptidase inhibitor, clade E, member 1)
Serpine2  (serine (or cysteine) peptidase inhibitor, clade E, member 2)
Serpinf2  (serine (or cysteine) peptidase inhibitor, clade F, member 2)

Genes (Homo sapiens)
CPB2  (carboxypeptidase B2)
FGA  (fibrinogen alpha chain)
FGB  (fibrinogen beta chain)
FGG  (fibrinogen gamma chain)
PLAT  (plasminogen activator, tissue type)
PLAU  (plasminogen activator, urokinase)
PLG  (plasminogen)
SERPINA5  (serpin family A member 5)
SERPINB2  (serpin family B member 2)
SERPINE1  (serpin family E member 1)
SERPINE2  (serpin family E member 2)
SERPINF2  (serpin family F member 2)


Additional Information