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The fibrinolytic pathway is activated by fibrin clots. Coagulation, anticoagulant systems and fibrinolysis pathways coordinate to maintain proper hemostasis. The coagulation cascade, tightly controlled by anticoagulation and intimately connected with the complement system of innate immunity, culminates in the activation of thrombin (F2) - the last protease of the cascade, and the subsequent formation of insoluble fibrin clots. Fibrin, in turn, is a substrate for the initiation of the fibrinolyti

Pathway Diagram:

Elsevier Inc. Serpine1 other fibrinolysis serpin inhibitors fibrin coagulation cascade pathway Plaur Plg receptors other plasmin substrates Serpinf2 plasmin Plg Plat Plau Cpb2 Plg ---- Plg receptors Plau ---- Plaur Cpb2 ---> fibrin Cpb2 ---| fibrin plasmin ---> other plasmin substrates Plat ---> Plg Serpinf2 ---| plasmin plasmin ---- Serpinf2 Serpine1 ---| Plat Serpine1 ---| Plau fibrin ---- Plg Plau ---> Plg Plau --+> plasmin clot dissolution plasmin ---> fibrin fibrin ---- Plat Plat --+> plasmin Plau ---- Serpine1 Plat ---- Serpine1 coagulation cascade pathway --+> fibrin

Genes in Pathway:

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fibrinolysis pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cpb2 carboxypeptidase B2 JBrowse link 15 57,290,849 57,339,762 RGD:11352249
G Fga fibrinogen alpha chain JBrowse link 2 181,997,562 182,013,726 RGD:11352249
G Fgb fibrinogen beta chain JBrowse link 2 182,028,044 182,035,026 RGD:11352249
G Fgg fibrinogen gamma chain JBrowse link 2 181,987,080 181,994,523 RGD:11352249
G Plat plasminogen activator, tissue type JBrowse link 16 74,098,263 74,122,897 RGD:11352249
G Plau plasminogen activator, urokinase JBrowse link 15 3,644,296 3,650,765 RGD:11352249
G Plg plasminogen JBrowse link 1 48,521,828 48,563,895 RGD:11352249
G Serpina5 serpin family A member 5 JBrowse link 6 127,753,152 127,772,403 RGD:11352249
G Serpinb2 serpin family B member 2 JBrowse link 13 27,449,907 27,463,015 RGD:11352249
G Serpine1 serpin family E member 1 JBrowse link 12 22,641,104 22,651,482 RGD:11352249
G Serpine2 serpin family E member 2 JBrowse link 9 85,560,852 85,629,410 RGD:11352249
G Serpinf2 serpin family F member 2 JBrowse link 10 62,264,247 62,272,353 RGD:11352249

Pathway Gene Annotations

Disease Annotations Associated with Genes in the fibrinolysis pathway
Disease TermsGene Symbols
Acidosis, LacticPlat
Acute Kidney InjuryFga , Plat
Acute Lung InjuryFga , Plau , Serpine1
Acute Traumatic CoagulopathyPlat
AfibrinogenemiaFga , Fgb , Fgg
Airway ObstructionPlat
Alzheimer DiseasePlau , Serpine2
Amphetamine-Related DisordersPlat , Serpina5
Amyloidosis, FamilialFga
Amyloidosis, Familial VisceralFga
Angina PectorisCpb2 , Plau
Angina, UnstablePlau
Anterior Wall Myocardial InfarctionSerpine1
Anti-Plasmin Deficiency, CongenitalSerpinf2
Antiphospholipid SyndromePlat
Aortic AneurysmSerpine1
Aortic Aneurysm, AbdominalSerpine1
Aortic Aneurysm, ThoracicSerpine1
Aortic RemodelingSerpine1
Arterial Occlusive DiseasesPlat , Plau
Arterial ThrombosisPlat , Serpine1
Arthritis, ExperimentalPlau
AsthmaFga , Plau , Serpine1
AtherosclerosisPlat , Plau , Serpine1
Autistic DisorderSerpine1
Back PainPlat
BacteremiaCpb2 , Plat
Behcet SyndromeCpb2 , Serpine1
Blood Coagulation DisordersFga , Fgg , Plat
Bone NeoplasmsPlau
Brain EdemaPlat , Plau , Serpine2
Brain InfarctionPlat
Brain IschemiaFga , Plat , Plau , Serpine1
Breast NeoplasmsPlau , Serpinb2 , Serpine1
Bronchopulmonary DysplasiaSerpine1
BurnsCpb2 , Fga , Plat
Carcinoma, Non-Small-Cell LungPlau
Carcinoma, Renal CellPlau
Carcinoma, Squamous CellPlau
Carcinoma, Squamous Cell of Head and NeckSerpine1
Carcinoma, Transitional CellPlau
Cardiac FibrosisSerpine1
Cardiac TamponadePlat
Cardiovascular DiseasesFgb
Carotid Artery DiseasesFgb , Plau
Carotid Artery InjuriesPlat , Serpine1
Central Nervous System Viral DiseasesPlat
Central Serous ChorioretinopathySerpine1
Cerebral HemorrhagePlat , Plau
Cerebral InfarctionPlat , Plau , Serpine1
Cerebral Small Vessel DiseasesFga , Fgg
Cerebrovascular DisordersPlau
Chemical and Drug Induced Liver InjuryCpb2 , Fga , Plat , Plg
CholestasisFga , Serpina5 , Serpine1
Choroidal Neovascularization, ExperimentalSerpine1
Chronic Allograft NephropathyPlau , Serpine1
Colitis, IschemicSerpine1
Colonic NeoplasmsPlau
Coronary Artery DiseaseFgb , Serpine1 , Serpinf2
Coronary DiseasePlau , Serpinf2
Coronary ThrombosisPlat
Crohn DiseaseFga
Dermal FibrosisSerpine1
Dermatitis, Allergic ContactPlat
Diabetes MellitusCpb2 , Serpine1
Diabetes Mellitus, ExperimentalFga , Serpine1
Diabetes Mellitus, Type 1Plat
Diabetes Mellitus, Type 2Cpb2 , Fga , Fgb , Fgg , Plat , Serpine1
Diabetes, GestationalPlat
Diabetic AngiopathiesPlat , Serpine1
Diabetic FootPlat
Diabetic NephropathiesCpb2 , Plat , Plau , Serpine1
Diabetic NeuropathiesPlat
Diabetic RetinopathySerpine1
Disease Models, AnimalSerpine1
Disseminated Intravascular CoagulationFga , Plat , Serpine1
Drug-Related Side Effects and Adverse ReactionsFga
Dysfibrinogenemia, CongenitalFga , Fgb , Fgg
Embolism and ThrombosisPlat
Embolism, CholesterolPlat , Plau
Empyema, PleuralPlau
Encephalomyelitis, Autoimmune, ExperimentalCpb2 , Serpine1
EndotoxemiaFga , Plat , Serpine1
Experimental Autoimmune Encephalomyelitis, Chronic RelapsingSerpine1
Familial Mediterranean FeverSerpine1
Fatty LiverSerpine1
Fatty Liver, AlcoholicSerpine1
Femur Head NecrosisPlat
Fetal Growth RetardationSerpine1
Fibromatosis, AggressiveSerpine1
GliomaPlau , Serpine1
GlomerulonephritisCpb2 , Serpine1
Glomerulonephritis, IGAPlau
Glomerulonephritis, MembranousPlg
Glomerulosclerosis, Focal SegmentalSerpine1
Graft Occlusion, VascularPlau
Graft vs Host DiseaseSerpine1
Graves DiseaseSerpine1
Graves OphthalmopathySerpine1
Hearing Loss, SuddenSerpine1
Heart FailurePlat , Serpine1
Heart Rupture, Post-InfarctionPlau
Hematologic DiseasesSerpine1
Hematoma, Epidural, SpinalPlat
Hematoma, SubduralPlat
Hemolytic-Uremic SyndromePlat
Hemophilia APlat
HemorrhagePlat , Plau , Serpine1 , Serpinf2
Hepatitis BPlau
Hepatitis C, ChronicPlau
Hepatitis, ChronicPlat
Hirschsprung Disease 1Plau
Hyaline Membrane DiseaseSerpine1
HypercholesterolemiaCpb2 , Serpinf2
Hypercholesterolemia, FamilialSerpine1
Hyperlipidemia, Familial CombinedSerpine1
HyperlipidemiasPlau , Serpinf2
HypertensionPlat , Plg , Serpine1 , Serpine2 , Serpinf2
Hypertension, PulmonarySerpine1
Hypertrophy, Left VentricularPlau
Hypertrophy, Right VentricularPlat
Hypodysfibrinogenemia, CongenitalFga , Fgg
HypotensionPlat , Plau
Hypoxia-Ischemia, BrainPlat , Plau , Serpine1
Idiopathic Pulmonary FibrosisPlau
Infarction, Middle Cerebral ArteryPlat , Plau , Serpine1
InflammationFgg , Plau
Insulin ResistanceCpb2 , Serpine1
Intestinal PolypsSerpine1
Intestinal Reperfusion InjurySerpine1
Intracranial AneurysmPlau
Intracranial Embolism and ThrombosisPlat , Plau
Intracranial HemorrhagesPlat , Plau
Intracranial ThrombosisPlat
Ischemic Attack, TransientPlat , Plau , Serpine1
Jaw CystsPlau
Kidney DiseasesFga
Kidney Failure, ChronicFgb , Plau , Serpine1
Kidney NeoplasmsPlau
Kidney Reperfusion InjuryFga , Fgb , Fgg
Leukemia, Promyelocytic, AcutePlat
Liver CirrhosisPlau
Liver Cirrhosis, AlcoholicPlau
Liver Cirrhosis, ExperimentalFgg , Plat , Plau , Plg
Liver Failure, AcuteFga
Liver InjuryFgg
Liver NeoplasmsSerpine1
Liver Reperfusion InjuryFga , Serpine1
Low Back PainPlat
Lung DiseasesSerpine1
Lung Diseases, InterstitialSerpine1
Lung InjuryPlau
Lung NeoplasmsPlau
Lung Reperfusion InjurySerpine1
Macular DegenerationSerpine1
Mammary Neoplasms, ExperimentalPlau
Meningococcal InfectionsCpb2
Metabolic Syndrome XPlat , Serpine1
Mitral Valve ProlapsePlau
Mouth NeoplasmsFga , Plau
Multiple MyelomaFgg
Multiple Organ FailureCpb2 , Plat , Serpine1
Multiple Sclerosis, Relapsing-RemittingSerpine1
Multiple TraumaSerpine1
Muscular AtrophySerpine1
Myocardial InfarctionFgb , Plat , Plau , Serpine1
Myocardial Reperfusion InjurySerpine1
Neoplasm InvasivenessPlau
Neoplasm MetastasisPlau
Neoplasm Recurrence, LocalPlau
Neovascularization, PathologicSerpine1
Nephrotic SyndromeCpb2 , Serpine1
Nerve DegenerationPlat
Nervous System DiseasesSerpine1
Neurotoxicity SyndromesPlat
Non-alcoholic Fatty Liver DiseaseSerpinb2 , Serpine1
Noonan SyndromePlat , Plg , Serpine1
ObesityCpb2 , Fgg , Plat , Serpine1
Optic Nerve InjuriesPlau
Oral Squamous Cell CarcinomaPlau , Serpine1
OsteoporosisFga , Fgb
Oxygen-Induced RetinopathySerpine1
Pancreatic AdenocarcinomaPlat
Pancreatic NeoplasmsPlau
PancreatitisFga , Fgb , Fgg
Pancreatitis, Acute NecrotizingSerpine1 , Serpinf2
Parkinson DiseaseFgb
Pericardial EffusionPlat
Peripheral Arterial DiseaseSerpine1
Peripheral Nerve InjuriesPlau
Peripheral Nervous System DiseasesSerpinb2
Peritoneal AdhesionsSerpine1
Peritoneal FibrosisSerpine1
PeritonitisPlat , Plau
Placental InsufficiencySerpine1
Plasminogen Activator Inhibitor-1 DeficiencySerpine1
Plasminogen Deficiency, Type IPlg
Platelet Glycoprotein IV DeficiencySerpine1
Pleomorphic Xanthoastrocytoma Serpine1
Pneumonia, BacterialSerpine1
Polycystic Ovary SyndromeSerpine1
Pre-EclampsiaSerpine1 , Serpinf2
Precursor Cell Lymphoblastic Leukemia-LymphomaFga
Pregnancy ComplicationsSerpine1
Prion DiseasesPlau
Proliferative Diabetic RetinopathySerpine1
Prostatic NeoplasmsPlau , Serpine1
Protein C Deficiency, AcquiredSerpine1
Pulmonary Disease, Chronic ObstructivePlau , Serpine1
Pulmonary EmbolismFga , Fgb , Fgg , Plat , Plau , Serpinf2
Pulmonary EmphysemaFga
Pulmonary FibrosisPlau , Serpine1
Purpura, Schoenlein-HenochPlat , Plau
Purpura, Thrombocytopenic, IdiopathicPlat
Quebec Platelet DisorderPlau
Radiation nephropathySerpine1
Renal FibrosisCpb2 , Plau , Serpine1
Renal Insufficiency, ChronicCpb2
Reperfusion InjuryPlat , Plau , Serpine2
Respiratory Distress Syndrome, AdultPlau , Serpine1
Respiratory HypersensitivitySerpine1
Respiratory InsufficiencyPlat
Retinal Vein OcclusionSerpine1
Retinopathy of PrematuritySerpine1
RhinitisPlau , Serpine1
Rhinitis, AllergicSerpine1
Rhinitis, Allergic, SeasonalFga
Sagittal Sinus ThrombosisPlau
Sciatic NeuropathyPlat , Plau , Serpine1
Scleroderma, LimitedSerpine1
Scleroderma, SystemicSerpine1 , Serpinf2
SepsisCpb2 , Fga , Plat , Plau , Serpine1
Shock, CardiogenicPlat
Shock, SepticSerpine1
Sleep Apnea SyndromesSerpine1
Sleep Apnea, ObstructiveSerpine1
Spinal Cord CompressionPlat
Spinal Cord InjuriesPlau
Status EpilepticusPlat , Plau
Stomach NeoplasmsFgg , Plau , Serpinb2 , Serpine1
StrokeFgb , Fgg , Plat , Plau , Serpine1
Strongylida InfectionsPlau
ThromboembolismCpb2 , Plat , Plau
ThrombophiliaFga , Plg
Thrombophilia, Familial, due to Decreased Release of Tissue Plasminogen ActivatorPlat
ThrombosisFga , Fgb , Plat , Plau , Serpine1
Thrombotic MicroangiopathiesCpb2 , Fgg
Thyroid cancer, papillaryPlau
Transplant RejectionPlat , Plau
Ureteral ObstructionSerpine1
Urinary Bladder NeoplasmsPlau , Serpine1
Uveal MelanomaSerpine1
Vascular DepressionSerpine1
Vascular RemodelingSerpine1
Vasospasm, IntracranialPlat
Venous ThromboembolismFga , Plat , Serpine1
Venous ThrombosisFga , Plat , Plau , Plg , Serpina5 , Serpine1
Ventilator-Induced Lung InjurySerpine1
Ventricular Dysfunction, LeftPlat
Ventricular FibrillationPlau
Viral MyocarditisPlau
von Willebrand Disease, Type 1Plat
Wounds and InjuriesPlat
Wounds, PenetratingSerpine1
Pathway Annotations Associated with Genes in the fibrinolysis pathway
Pathway TermsGene Symbols
acenocoumarol pharmacodynamics pathwayFga , Fgb , Fgg , Plat , Plg
alteplase pharmacodynamics pathwayFga , Fgb , Fgg , Plat , Plg
aminocaproic acid pharmacodynamics pathwayFga , Fgb , Fgg , Plat , Plg
anistreplase pharmacodynamics pathwayFga , Fgb , Fgg , Plat , Plg
aprotinin pharmacodynamics pathwayFga , Fgb , Fgg , Plat , Plg
argatroban pharmacodynamics pathwayFga , Fgb , Fgg , Plat , Plg
bivalirudin pharmacodynamics pathwayFga , Fgb , Fgg , Plat , Plg
coagulation cascade pathwayCpb2 , Fga , Fgb , Fgg , Plat , Plau , Plg , Serpina5 , Serpine1 , Serpinf2
complement system pathwayCpb2 , Fga , Fgb , Fgg , Plat , Plau , Plg , Serpina5 , Serpine1 , Serpinf2
dicoumarol pharmacodynamics pathwayFga , Fgb , Fgg , Plat , Plg
enoxaparin pharmacodynamics pathwayFga , Fgb , Fgg , Plat , Plg
Entamoeba histolyca infection pathwaySerpinb2
ephrin - ephrin receptor bidirectional signaling axisFga , Fgb , Fgg
fibrinolysis pathwayCpb2 , Fga , Fgb , Fgg , Plat , Plau , Plg , Serpina5 , Serpinb2 , Serpine1 , Serpine2 , Serpinf2
fibroblast growth factor signaling pathwayPlau
fondaparinux pharmacodynamics pathwayFga , Fgb , Fgg , Plat , Plg
heparin pharmacodynamics pathwayFga , Fgb , Fgg , Plat , Plg
hypoxia inducible factor pathwaySerpine1
influenza A virus infection pathwayPlg
interleukin-6 signaling pathwayFgg
oxygen homeostasis pathwaySerpine1
p53 signaling pathwaySerpine1
phenindione pharmacodynamics pathwayFga , Fgb , Fgg , Plat , Plg
reteplase pharmacodynamics pathwayFga , Fgb , Fgg , Plat , Plg
Staphylococcus aureus infection pathwayFgg , Plg
syndecan signaling pathwayPlg
tranexamic acid pharmacodynamics pathwayFga , Fgb , Fgg , Plat , Plg
Trypanosoma cruzi infection pathwaySerpine1
warfarin pharmacodynamics pathwayFga , Fgb , Fgg , Plat , Plg
Phenotype Annotations Associated with Genes in the fibrinolysis pathway
Phenotype TermsGene Symbols
decreased metastatic potentialSerpine1

References Associated with the fibrinolysis pathway:

Ontology Path Diagram:

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