SERPINA5 (serpin family A member 5) - Rat Genome Database

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Gene: SERPINA5 (serpin family A member 5) Canis lupus familiaris
Analyze
Symbol: SERPINA5
Name: serpin family A member 5
RGD ID: 12401612
Description: ENCODES a protein that exhibits serine-type endopeptidase inhibitor activity (ortholog); INVOLVED IN negative regulation of proteolysis (ortholog); seminal vesicle development (ortholog); spermatogenesis (ortholog); PARTICIPATES IN fibrinolysis pathway; ASSOCIATED WITH amphetamine abuse (ortholog); Arterial Occlusive Diseases (ortholog); cholestasis (ortholog); FOUND IN acrosomal membrane (inferred); external side of plasma membrane (inferred); extracellular exosome (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC480424; plasma serine protease inhibitor
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1863,567,060 - 63,577,015 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl863,566,356 - 63,576,308 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha863,143,801 - 63,153,748 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0863,834,133 - 63,844,074 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl863,833,699 - 63,843,370 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1863,509,369 - 63,519,317 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0863,561,712 - 63,571,667 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0863,892,389 - 63,902,350 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
SERPINA5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1863,567,060 - 63,577,015 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl863,566,356 - 63,576,308 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha863,143,801 - 63,153,748 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0863,834,133 - 63,844,074 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl863,833,699 - 63,843,370 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1863,509,369 - 63,519,317 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0863,561,712 - 63,571,667 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0863,892,389 - 63,902,350 (+)NCBIUU_Cfam_GSD_1.0
SERPINA5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381494,581,426 - 94,593,118 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1494,561,442 - 94,593,118 (+)EnsemblGRCh38hg38GRCh38
GRCh371495,047,763 - 95,059,455 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361494,117,564 - 94,129,205 (+)NCBINCBI36Build 36hg18NCBI36
Build 341494,117,563 - 94,129,204NCBI
Celera1475,103,903 - 75,115,619 (+)NCBICelera
Cytogenetic Map14q32.13NCBI
HuRef1475,228,133 - 75,239,873 (+)NCBIHuRef
CHM1_11494,985,498 - 94,997,214 (+)NCBICHM1_1
T2T-CHM13v2.01488,811,397 - 88,823,118 (+)NCBIT2T-CHM13v2.0
Serpina5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912104,065,572 - 104,072,397 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12104,067,372 - 104,072,396 (+)EnsemblGRCm39 Ensembl
GRCm3812104,099,313 - 104,106,138 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12104,101,113 - 104,106,137 (+)EnsemblGRCm38mm10GRCm38
MGSCv3712105,339,323 - 105,344,347 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3612104,502,163 - 104,507,187 (+)NCBIMGSCv36mm8
Celera12105,318,382 - 105,323,416 (+)NCBICelera
Cytogenetic Map12ENCBI
cM Map1253.3NCBI
Serpina5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86128,774,006 - 128,793,187 (+)NCBIGRCr8
mRatBN7.26123,009,224 - 123,028,412 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6123,023,306 - 123,028,407 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6123,164,246 - 123,169,377 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06123,459,540 - 123,464,673 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06122,796,353 - 122,801,488 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06127,753,152 - 127,772,403 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6127,766,470 - 127,772,420 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06136,972,583 - 136,990,812 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46128,156,901 - 128,161,334 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16128,160,647 - 128,165,080 (+)NCBI
Celera6120,503,068 - 120,508,038 (+)NCBICelera
Cytogenetic Map6q32NCBI
Serpina5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543817,787,399 - 17,796,414 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543817,787,398 - 17,796,013 (-)NCBIChiLan1.0ChiLan1.0
SERPINA5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21595,729,564 - 95,742,189 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11494,946,069 - 94,958,694 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01475,205,446 - 75,217,114 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11494,537,115 - 94,548,803 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1494,537,115 - 94,548,803 (+)Ensemblpanpan1.1panPan2
LOC101958459
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864010,883,273 - 10,897,335 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936846146,116 - 150,438 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936846141,334 - 150,381 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SERPINA5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl7115,802,150 - 115,810,824 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.17115,799,414 - 115,810,825 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27122,916,002 - 122,927,421 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SERPINA5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12472,369,082 - 72,388,439 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2472,381,119 - 72,384,903 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605359,588,553 - 59,602,023 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Serpina5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247347,236,833 - 7,244,752 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247347,236,833 - 7,245,579 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in SERPINA5
166 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 6 6 6 8
Low 1 1
Below cutoff 2 3 4 6 3 3 5 3

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005623771 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022422352 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038484124 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038484125 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038484126 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038545635 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038545636 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038545637 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038609730 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038609731 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038609732 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038674541 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038674542 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038674543 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_537545 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000088 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000096 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000053 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000028038   ⟹   ENSCAFP00000026080
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl863,566,356 - 63,576,308 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845005529   ⟹   ENSCAFP00845004386
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl863,833,699 - 63,843,370 (+)Ensembl
RefSeq Acc Id: XM_005623771   ⟹   XP_005623828
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1863,567,338 - 63,577,015 (+)NCBI
Dog10K_Boxer_Tasha863,144,072 - 63,153,748 (+)NCBI
Sequence:
RefSeq Acc Id: XM_022422352   ⟹   XP_022278060
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1863,570,904 - 63,577,015 (+)NCBI
Dog10K_Boxer_Tasha863,147,647 - 63,153,748 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038484124   ⟹   XP_038340052
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1863,509,369 - 63,519,317 (+)NCBI
RefSeq Acc Id: XM_038484125   ⟹   XP_038340053
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1863,513,212 - 63,519,317 (+)NCBI
RefSeq Acc Id: XM_038484126   ⟹   XP_038340054
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1863,509,640 - 63,519,317 (+)NCBI
RefSeq Acc Id: XM_038545635   ⟹   XP_038401563
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0863,892,660 - 63,902,350 (+)NCBI
RefSeq Acc Id: XM_038545636   ⟹   XP_038401564
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0863,892,389 - 63,902,350 (+)NCBI
RefSeq Acc Id: XM_038545637   ⟹   XP_038401565
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0863,896,236 - 63,902,350 (+)NCBI
RefSeq Acc Id: XM_038609730   ⟹   XP_038465658
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0863,561,712 - 63,571,667 (+)NCBI
RefSeq Acc Id: XM_038609731   ⟹   XP_038465659
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0863,565,555 - 63,571,667 (+)NCBI
RefSeq Acc Id: XM_038609732   ⟹   XP_038465660
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0863,561,983 - 63,571,667 (+)NCBI
RefSeq Acc Id: XM_038674541   ⟹   XP_038530469
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0863,834,404 - 63,844,074 (+)NCBI
RefSeq Acc Id: XM_038674542   ⟹   XP_038530470
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0863,834,133 - 63,844,074 (+)NCBI
RefSeq Acc Id: XM_038674543   ⟹   XP_038530471
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0863,837,973 - 63,844,074 (+)NCBI
RefSeq Acc Id: XM_537545   ⟹   XP_537545
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1863,567,060 - 63,577,015 (+)NCBI
Dog10K_Boxer_Tasha863,143,801 - 63,153,748 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_537545   ⟸   XM_537545
- UniProtKB: A0A8C0KP50 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005623828   ⟸   XM_005623771
- UniProtKB: A0A8C0KP50 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_022278060   ⟸   XM_022422352
- UniProtKB: A0A8C0KP50 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000026080   ⟸   ENSCAFT00000028038
RefSeq Acc Id: XP_038340052   ⟸   XM_038484124
RefSeq Acc Id: XP_038340054   ⟸   XM_038484126
RefSeq Acc Id: XP_038340053   ⟸   XM_038484125
RefSeq Acc Id: XP_038465658   ⟸   XM_038609730
RefSeq Acc Id: XP_038465660   ⟸   XM_038609732
RefSeq Acc Id: XP_038465659   ⟸   XM_038609731
RefSeq Acc Id: XP_038530470   ⟸   XM_038674542
- UniProtKB: A0A8C0KP50 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038530469   ⟸   XM_038674541
- UniProtKB: A0A8C0KP50 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038530471   ⟸   XM_038674543
- UniProtKB: A0A8C0KP50 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038401564   ⟸   XM_038545636
- UniProtKB: A0A8C0KP50 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038401563   ⟸   XM_038545635
- UniProtKB: A0A8C0KP50 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038401565   ⟸   XM_038545637
- UniProtKB: A0A8C0KP50 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845004386   ⟸   ENSCAFT00845005529
Protein Domains
SERPIN

Promoters
RGD ID:13684323
Promoter ID:EPDNEW_C2393
Type:initiation region
Name:SERPINA5_1
Description:serpin family A member 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1863,567,138 - 63,567,198EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000029000 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00845003146 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000028038.5 UniProtKB/TrEMBL
  ENSCAFT00845005529 ENTREZGENE
  ENSCAFT00845005529.1 UniProtKB/TrEMBL
Gene3D-CATH 2.30.39.10 UniProtKB/TrEMBL
  3.30.497.10 UniProtKB/TrEMBL
InterPro Serpin_CS UniProtKB/TrEMBL
  Serpin_dom UniProtKB/TrEMBL
  Serpin_fam UniProtKB/TrEMBL
  Serpin_sf UniProtKB/TrEMBL
  Serpin_sf_1 UniProtKB/TrEMBL
  Serpin_sf_2 UniProtKB/TrEMBL
NCBI Gene SERPINA5 ENTREZGENE
PANTHER PLASMA SERINE PROTEASE INHIBITOR UniProtKB/TrEMBL
  PTHR11461 UniProtKB/TrEMBL
Pfam Serpin UniProtKB/TrEMBL
PROSITE SERPIN UniProtKB/TrEMBL
SMART SERPIN UniProtKB/TrEMBL
Superfamily-SCOP SSF56574 UniProtKB/TrEMBL
UniProt A0A8C0KP50 ENTREZGENE
  A0A8I3MQ40_CANLF UniProtKB/TrEMBL
  A0A8P0NJ65_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:103705 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-01-12 SERPINA5  serpin family A member 5  LOC480424  plasma serine protease inhibitor  Symbol and/or name change 5135510 APPROVED
2017-09-12 LOC480424  plasma serine protease inhibitor  SERPINA5  serpin family A member 5  Symbol and/or name change 5135510 APPROVED