RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: cannabis abuse
Accession: DOID:9505
browse the term
Definition: A substance abuse that involves the recurring use of cannabis despite negative consequences. (DO)
Synonyms: exact_synonym: Hashish Abuse; cannabis related disorder; cannabis use disorder; marihuana abuse; marijuana abuse
primary_id: MESH:D002189
xref: ICD10CM:F12 ; ICD10CM:F12.1 ; ICD9CM:305.2
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Abcb1a
ATP binding cassette subfamily B member 1A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19625010
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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Akt1
AKT serine/threonine kinase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21041608
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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Apol2
apolipoprotein L2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17205118
NCBI chr 7:109,331,367...109,338,632
Ensembl chr 7:109,331,392...109,338,558
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Bche
butyrylcholinesterase
ISO
protein:increased activity:blood plasma (human)
RGD
PMID:30707402
RGD:401960085
NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148
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Calm1
calmodulin 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17205118
NCBI chr 6:119,487,691...119,495,759
Ensembl chr 6:119,487,621...119,498,227
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Calm2
calmodulin 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17205118
NCBI chr 6:7,091,624...7,104,284
Ensembl chr 6:7,091,567...7,104,287 Ensembl chr15:7,091,567...7,104,287
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Camk2b
calcium/calmodulin-dependent protein kinase II beta
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17205118
NCBI chr14:80,845,206...80,934,172
Ensembl chr14:80,845,238...80,933,994
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Cnr1
cannabinoid receptor 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19016476
NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099
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Comt
catechol-O-methyltransferase
susceptibility onset
ISO
DNA:SNP:cd: p.V158M (human) associated with alcohol use disorder; DNA:hypermethylation:promoter
RGD
PMID:19259017 PMID:30790675 PMID:33781176
RGD:401959590 , RGD:401959592 , RGD:401959741
NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642
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Drd4
dopamine receptor D4
susceptibility
ISO
DNA:duplication:promoter: 120bp repeat
RGD
PMID:33544778
RGD:401959602
NCBI chr 1:196,396,366...196,400,824
Ensembl chr 1:196,396,366...196,399,553
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Fdft1
farnesyl diphosphate farnesyl transferase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17205118
NCBI chr15:37,412,143...37,440,198
Ensembl chr15:37,412,146...37,440,287
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Gcc1
GRIP and coiled-coil domain containing 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17205118
NCBI chr 4:57,030,817...57,042,682
Ensembl chr 4:57,032,314...57,042,663
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Ngf
nerve growth factor
ISO
protein:decreased expression:serum
RGD
PMID:18774699
RGD:401965396
NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452
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Nrg1
neuregulin 1
ISO
associated with schizophrenia;protein:increased expression:blood:
RGD
PMID:30799217
RGD:405112241
NCBI chr16:59,250,658...60,304,519
Ensembl chr16:59,250,854...60,296,884
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Scarb1
scavenger receptor class B, member 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17205118
NCBI chr12:31,296,143...31,362,649
Ensembl chr12:31,296,156...31,362,647
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