Ankk1 (ankyrin repeat and kinase domain containing 1) - Rat Genome Database

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Gene: Ankk1 (ankyrin repeat and kinase domain containing 1) Rattus norvegicus
Analyze
Symbol: Ankk1
Name: ankyrin repeat and kinase domain containing 1
RGD ID: 1305538
Description: Predicted to enable ATP binding activity and protein kinase activity. Involved in cellular response to retinoic acid. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; alcohol use disorder; alexithymia; drug dependence (multiple); and mild cognitive impairment. Orthologous to human ANKK1 (ankyrin repeat and kinase domain containing 1); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ankyrin repeat and protein kinase domain-containing protein 1; LOC367080; LOC690279; similar to ankyrin repeat and kinase domain containing 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8858,676,327 - 58,685,012 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl858,676,327 - 58,684,489 (-)EnsemblGRCr8
mRatBN7.2849,779,862 - 49,788,024 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl849,779,862 - 49,788,024 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx855,283,981 - 55,292,160 (-)NCBIUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0853,562,857 - 53,571,036 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0851,427,117 - 51,435,296 (-)NCBIUTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd859,498,467 - 59,506,646 (-)NCBI
Lyon_Normotensive861,697,321 - 61,705,500 (-)NCBI
Lyon_Hypertensive860,127,994 - 60,136,173 (-)NCBI
F344_StmMcwi851,531,289 - 51,539,468 (-)NCBI
Rnor_6.0853,750,631 - 53,758,925 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl853,751,091 - 53,758,774 (-)EnsemblRnor_6.0 Ensemblrn6Rnor6.0
Rnor_5.0852,370,801 - 52,378,944 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4852,714,745 - 52,722,913 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera849,331,721 - 49,340,015 (-)NCBICelera
RGSC_v3.1852,734,164 - 52,741,935 (-)NCBI
Cytogenetic Map8q23NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA,IEA,ISO)
nucleus  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. NCAM1-TTC12-ANKK1-DRD2 variants and smoking motives as intermediate phenotypes for nicotine dependence. Bidwell LC, etal., Psychopharmacology (Berl). 2015 Apr;232(7):1177-86. doi: 10.1007/s00213-014-3748-2. Epub 2014 Oct 3.
2. Association between the traditional Chinese medicine pathological factors of opioid addiction and DRD2/ANKK1 TaqIA polymorphisms. Cai M, etal., BMC Complement Altern Med. 2015 Jul 3;15:209. doi: 10.1186/s12906-015-0727-z.
3. Genetic variants altering dopamine D2 receptor expression or function modulate the risk of opiate addiction and the dosage requirements of methadone substitution. Doehring A, etal., Pharmacogenet Genomics. 2009 Jun;19(6):407-14. doi: 10.1097/FPC.0b013e328320a3fd.
4. Associations of prenatal nicotine exposure and the dopamine related genes ANKK1 and DRD2 to verbal language. Eicher JD, etal., PLoS One. 2013 May 15;8(5):e63762. doi: 10.1371/journal.pone.0063762. Print 2013.
5. Dopamine DRD2/ANKK1 Taq1A and DAT1 VNTR polymorphisms are associated with a cognitive flexibility profile in pathological gamblers. Fagundo AB, etal., J Psychopharmacol. 2014 Dec;28(12):1170-7. doi: 10.1177/0269881114551079. Epub 2014 Sep 18.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Haplotype spanning TTC12 and ANKK1, flanked by the DRD2 and NCAM1 loci, is strongly associated to nicotine dependence in two distinct American populations. Gelernter J, etal., Hum Mol Genet. 2006 Dec 15;15(24):3498-507. doi: 10.1093/hmg/ddl426. Epub 2006 Nov 3.
8. The ANKK1 gene associated with addictions is expressed in astroglial cells and upregulated by apomorphine. Hoenicka J, etal., Biol Psychiatry. 2010 Jan 1;67(1):3-11. doi: 10.1016/j.biopsych.2009.08.012.
9. Significant association of ANKK1 and detection of a functional polymorphism with nicotine dependence in an African-American sample. Huang W, etal., Neuropsychopharmacology. 2009 Jan;34(2):319-30. doi: 10.1038/npp.2008.37. Epub 2008 Mar 19.
10. Epistatic effect of Ankyrin repeat and kinase domain containing 1 - Dopamine receptor D2 and catechol-o-methyltransferase single nucleotide polymorphisms on the risk for hazardous use of alcohol in Lithuanian population. Kaminskaite M, etal., Gene. 2021 Jan 10;765:145107. doi: 10.1016/j.gene.2020.145107. Epub 2020 Sep 2.
11. The role of ANKK1 and TTC12 genes on drinking behaviour in tobacco dependent subjects. Lobo DS, etal., World J Biol Psychiatry. 2012 Mar;13(3):232-8. doi: 10.3109/15622975.2011.598560. Epub 2011 Sep 22.
12. ANKK1, TTC12, and NCAM1 polymorphisms and heroin dependence: importance of considering drug exposure. Nelson EC, etal., JAMA Psychiatry. 2013 Mar;70(3):325-33. doi: 10.1001/jamapsychiatry.2013.282.
13. DRD2 and ANKK1 genotype in alcohol-dependent patients with psychopathic traits: association and interaction study. Ponce G, etal., Br J Psychiatry. 2008 Aug;193(2):121-5. doi: 10.1192/bjp.bp.107.041582.
14. Association of ankyrin repeats & kinase domain containing 1 (ANKK1) gene polymorphism with co-morbid alcohol & nicotine dependence: A pilot study from a tertiary care treatment centre in north India. Quraishi R, etal., Indian J Med Res. 2017 Jan;145(1):33-38. doi: 10.4103/ijmr.IJMR_458_14.
15. GOA pipeline RGD automated data pipeline
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. ANKK1 and DRD2 pharmacogenetics of disulfiram treatment for cocaine abuse. Spellicy CJ, etal., Pharmacogenet Genomics. 2013 Jul;23(7):333-40. doi: 10.1097/FPC.0b013e328361c39d.
19. Association between DRD2/ANKK1 Taq1A genotypes, depression and smoking cessation with nicotine replacement therapy. Stapleton JA, etal., Pharmacogenet Genomics. 2011 Aug;21(8):447-53. doi: 10.1097/FPC.0b013e328347473a.
20. DRD2 and ANKK1 gene polymorphisms and alcohol dependence: a case-control study among a Mendelian population of East Asian ancestry. Suraj Singh H, etal., Alcohol Alcohol. 2013 Jul-Aug;48(4):409-14. doi: 10.1093/alcalc/agt014. Epub 2013 Feb 26.
21. DRD2 and ANKK1 genes associate with late-onset heroin dependence in men. Tsou CC, etal., World J Biol Psychiatry. 2019 Oct;20(8):605-615. doi: 10.1080/15622975.2017.1372630. Epub 2017 Sep 25.
22. Multivariate analysis of dopaminergic gene variants as risk factors of heroin dependence. Vereczkei A, etal., PLoS One. 2013 Jun 28;8(6):e66592. doi: 10.1371/journal.pone.0066592. Print 2013.
23. A DRD2 and ANKK1 haplotype is associated with nicotine dependence. Voisey J, etal., Psychiatry Res. 2012 Apr 30;196(2-3):285-9. doi: 10.1016/j.psychres.2011.09.024. Epub 2012 Feb 29.
24. DRD2/ANKK1 TaqI A genotype moderates the relationship between alexithymia and the relative value of alcohol among male college binge drinkers. Wahlstrom LC, etal., Pharmacol Biochem Behav. 2012 Sep;102(3):471-6. doi: 10.1016/j.pbb.2012.06.012. Epub 2012 Jun 21.
25. Haplotypic variants in DRD2, ANKK1, TTC12, and NCAM1 are associated with comorbid alcohol and drug dependence. Yang BZ, etal., Alcohol Clin Exp Res. 2008 Dec;32(12):2117-27. doi: 10.1111/j.1530-0277.2008.00800.x. Epub 2008 Sep 30.
26. A 35.8 kilobases haplotype spanning ANKK1 and DRD2 is associated with heroin dependence in Han Chinese males. Zhang J, etal., Brain Res. 2018 Jun 1;1688:54-64. doi: 10.1016/j.brainres.2018.03.017. Epub 2018 Mar 14.
Additional References at PubMed
PMID:8889548   PMID:27166167  


Genomics

Comparative Map Data
Ankk1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8858,676,327 - 58,685,012 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl858,676,327 - 58,684,489 (-)EnsemblGRCr8
mRatBN7.2849,779,862 - 49,788,024 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl849,779,862 - 49,788,024 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx855,283,981 - 55,292,160 (-)NCBIUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0853,562,857 - 53,571,036 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0851,427,117 - 51,435,296 (-)NCBIUTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd859,498,467 - 59,506,646 (-)NCBI
Lyon_Normotensive861,697,321 - 61,705,500 (-)NCBI
Lyon_Hypertensive860,127,994 - 60,136,173 (-)NCBI
F344_StmMcwi851,531,289 - 51,539,468 (-)NCBI
Rnor_6.0853,750,631 - 53,758,925 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl853,751,091 - 53,758,774 (-)EnsemblRnor_6.0 Ensemblrn6Rnor6.0
Rnor_5.0852,370,801 - 52,378,944 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4852,714,745 - 52,722,913 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera849,331,721 - 49,340,015 (-)NCBICelera
RGSC_v3.1852,734,164 - 52,741,935 (-)NCBI
Cytogenetic Map8q23NCBI
ANKK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811113,387,779 - 113,400,416 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11113,387,774 - 113,400,585 (+)EnsemblGRCh38.p14 Ensemblhg38GRCh38
GRCh3711113,258,501 - 113,271,138 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611112,763,723 - 112,776,350 (+)NCBIBuild 36Build 36hg18NCBI36
Build 3411112,763,722 - 112,776,350NCBI
Celera11110,411,445 - 110,424,071 (+)NCBICelera
Cytogenetic Map11q23.2NCBI
HuRef11109,186,137 - 109,198,762 (+)NCBIHuRef
CHM1_111113,141,499 - 113,154,124 (+)NCBICHM1_1
T2T-CHM13v2.011113,398,282 - 113,410,917 (+)NCBIT2T-CHM13v2.0
Ankk1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39949,326,494 - 49,338,341 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl949,326,494 - 49,338,321 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38949,415,194 - 49,427,041 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl949,415,194 - 49,427,021 (-)EnsemblGRCm38.p6 Ensemblmm10GRCm38
MGSCv37949,223,327 - 49,235,126 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36949,167,452 - 49,179,251 (-)NCBIMGSCv36mm8
Celera946,712,988 - 46,724,868 (-)NCBICelera
Cytogenetic Map9A5.3NCBI
cM Map926.83NCBI
Ankk1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541215,035,388 - 15,046,139 (+)EnsemblChiLan1.0 Ensembl
ChiLan1.0NW_00495541215,036,071 - 15,046,118 (+)NCBIChiLan1.0ChiLan1.0
ANKK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29114,132,094 - 114,145,920 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111115,226,472 - 115,240,295 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011108,267,717 - 108,280,635 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111112,111,003 - 112,125,952 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11112,111,003 - 112,123,382 (+)EnsemblPanPan1.1 EnsemblpanPan2panpan1.1
ANKK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1519,801,511 - 19,814,359 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl519,801,542 - 19,814,481 (-)EnsemblCanFam3.1 EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha519,723,265 - 19,736,301 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0519,822,410 - 19,835,444 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl519,822,441 - 19,835,756 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1519,884,965 - 19,897,951 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0519,786,175 - 19,799,184 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0519,833,938 - 19,846,967 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ankk1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mIctTri1.hap1496,814,015 - 96,850,778 (+)NCBImIctTri1.hap1
HiC_Itri_2NW_02440494795,531,923 - 95,543,648 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049366121,161,961 - 1,173,318 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ANKK1
(Sus scrofa - pig)		 No map positions available.
ANKK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mChlSab1.0.hap11109,704,008 - 109,727,337 (+)NCBImChlSab1.0.hap1
Vero_WHO_p1.0NW_02366604321,245,489 - 21,261,506 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
ChlSab1.11104,752,023 - 104,765,071 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Ankk1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247848,810,409 - 8,821,732 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
HetGla_female_1.0 EnsemblNW_0046247848,810,559 - 8,820,444 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
Naked mole-rat maternal Ensembl553,906,354 - 53,917,413 (-)Ensembl
Ankk1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1843,903,272 - 43,911,049 (-)NCBIRrattus_CSIRO_v1Rrattus_CSIRO_v1

Variants

.
Variants in Ankk1
67 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:112
Count of miRNA genes:103
Interacting mature miRNAs:107
Transcripts:ENSRNOT00000068040
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83910625891341052Rat
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83975280384752803Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)858337123103337123Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)81699464261994642Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)849849908118871671Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83910625891341052Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)839106363103375781Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)81595227960952279Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)85076395195763951Rat
11556286Cm81Cardiac mass QTL 810.01heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)83910625884106258Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)85158969999045312Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)839106363103375781Rat
5684993Bmd84Bone mineral density QTL 844.1tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)85158969958991895Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)81699464261994642Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)84447792689477926Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)839106258103375958Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83910625891341052Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)835464071107982864Rat
2302278Gluco36Glucose level QTL 364.2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)83776085958991895Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)84754141992541419Rat
631648Stl5Serum triglyceride level QTL 540.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)83546407171842899Rat
724514Uae15Urinary albumin excretion QTL 152.9urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)83776085961459705Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83910625884106258Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)855428416107963099Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)83154366176543661Rat
737824Hcar10Hepatocarcinoma resistance QTL 102.9liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)84961020468373388Rat
1359033Bp273Blood pressure QTL 273arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83910625884106258Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)850763951107970527Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84444783789447837Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84961020494610204Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)835464071107982864Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)81799386262252873Rat
1331744Bp217Blood pressure QTL 2173.398arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83910625867378345Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)855428333127966348Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83910625891341052Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)839106363114525825Rat
1582254Kidm31Kidney mass QTL 313kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)84924517894245178Rat
724540Uae8Urinary albumin excretion QTL 85urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)839106258103375958Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)835464071107982864Rat
631216Stl9Serum triglyceride level QTL 94.710.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)85076395167219641Rat
1582243Bw66Body weight QTL 663.40.0048body mass (VT:0001259)body weight (CMO:0000012)84924517894245178Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)84447504389475043Rat

Markers in Region
BM384954  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2849,779,921 - 49,780,088 (+)MAPPERmRatBN7.2
Rnor_6.0853,750,691 - 53,750,857NCBIRnor6.0
Rnor_5.0852,370,861 - 52,371,027UniSTSRnor5.0
RGSC_v3.4852,714,798 - 52,714,964UniSTSRGSC3.4
Celera849,331,781 - 49,331,947UniSTS
RH 3.4 Map8534.9UniSTS
Cytogenetic Map8q23UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
pharyngeal arch
renal system
reproductive system
respiratory system
sensory system
visual system
32 32 30 133 2309 106 409 29 11 55 4 80 943 377 47 2240 2 674 298 403 124 123

Sequence


Ensembl Acc Id: ENSRNOT00000068040   ⟹   ENSRNOP00000062510
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl858,676,327 - 58,684,489 (-)Ensembl
mRatBN7.2 Ensembl849,779,862 - 49,788,024 (-)Ensembl
Rnor_6.0 Ensembl853,751,091 - 53,758,774 (-)Ensembl
RefSeq Acc Id: NM_001108999   ⟹   NP_001102469
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8858,676,327 - 58,684,489 (-)NCBI
mRatBN7.2849,779,862 - 49,788,024 (-)NCBI
Dahl_SR_JrHsd859,498,467 - 59,506,646 (-)NCBI
Lyon_Normotensive861,697,321 - 61,705,500 (-)NCBI
Lyon_Hypertensive860,127,994 - 60,136,173 (-)NCBI
F344_StmMcwi851,531,289 - 51,539,468 (-)NCBI
RefSeq Acc Id: XM_063265876   ⟹   XP_063121946
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8858,676,327 - 58,685,012 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001102469 (Get FASTA)   NCBI Sequence Viewer  
  XP_063121946 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL95442 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000062510
  ENSRNOP00000062510.3
Ensembl Acc Id: ENSRNOP00000062510   ⟸   ENSRNOT00000068040
RefSeq Acc Id: NP_001102469   ⟸   NM_001108999
- UniProtKB: D3ZDY2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063121946   ⟸   XM_063265876
- Peptide Label: isoform X1
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZDY2-F1-model_v2 AlphaFold D3ZDY2 1-746 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305538 AgrOrtholog
BioCyc Gene G2FUF-30583 BioCyc
Ensembl Genes ENSRNOG00000025037 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000068040 ENTREZGENE
  ENSRNOT00000068040.4 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.20 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Ankyrin_rpt UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/TrEMBL
  Kinase-like_dom UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Ser-Thr/Tyr-Pkinase UniProtKB/TrEMBL
  Ser/Thr_prot_kinase_AS UniProtKB/TrEMBL
KEGG Report rno:367080 UniProtKB/TrEMBL
NCBI Gene 367080 ENTREZGENE
PANTHER ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
  ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN 1 UniProtKB/TrEMBL
Pfam Ank UniProtKB/TrEMBL
  Ank_2 UniProtKB/TrEMBL
  Ank_4 UniProtKB/TrEMBL
  Pkinase_Tyr UniProtKB/TrEMBL
PhenoGen Ankk1 PhenoGen
PRINTS ANKYRIN UniProtKB/TrEMBL
PROSITE ANK_REP_REGION UniProtKB/TrEMBL
  ANK_REPEAT UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
RatGTEx ENSRNOG00000025037 RatGTEx
SMART ANK UniProtKB/TrEMBL
  S_TKc UniProtKB/TrEMBL
Superfamily-SCOP ANK UniProtKB/TrEMBL
  Kinase_like UniProtKB/TrEMBL
UniProt D3ZDY2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-07-29 Ankk1  ankyrin repeat and kinase domain containing 1  LOC690279  similar to ankyrin repeat and kinase domain containing 1  Data merged from RGD:1582835 737654 PROVISIONAL
2008-04-30 Ankk1  ankyrin repeat and kinase domain containing 1   Ankk1_predicted  ankyrin repeat and kinase domain containing 1 (predicted)  'predicted' is removed 2292626 APPROVED
2008-01-09 LOC690279  similar to ankyrin repeat and kinase domain containing 1  LOC684394  similar to ankyrin repeat and kinase domain containing 1  Data merged from RGD:1591418 1643240 APPROVED
2006-11-20 LOC684394  similar to ankyrin repeat and kinase domain containing 1      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC690279  similar to ankyrin repeat and kinase domain containing 1      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-01-12 Ankk1_predicted  ankyrin repeat and kinase domain containing 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED