RGD Reference Report - Association study of polymorphisms in N-methyl-D-aspartate receptor 2B subunits (GRIN2B) gene with Korean alcoholism. - Rat Genome Database

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Association study of polymorphisms in N-methyl-D-aspartate receptor 2B subunits (GRIN2B) gene with Korean alcoholism.

Authors: Kim, JH  Park, M  Yang, SY  Jeong, BS  Yoo, HJ  Kim, JW  Chung, JH  Kim, SA 
Citation: Kim JH, etal., Neurosci Res. 2006 Oct;56(2):220-3. Epub 2006 Sep 5.
RGD ID: 1642200
Pubmed: PMID:16911840   (View Abstract at PubMed)
DOI: DOI:10.1016/j.neures.2006.06.013   (Journal Full-text)

The N-methyl-D-aspartate (NMDA) receptor 2B gene (GRIN2B) was studied as a candidate gene of alcoholism. This study aimed to investigate the association between each of the three GRIN2B polymorphisms (rs1806201, rs1805247, and rs1805502) and alcoholism. This study included 206 alcoholic patients and 189 unrelated control subjects of Korean origin. Associations between genotype, allele, and haplotype frequencies of the polymorphisms and alcoholism were investigated. The genotype frequencies of rs1806201 and the haplotype analysis of SNPs in this study show significantly differences between the case and controls. These findings suggest new candidate SNPs in GRIN2B for studying the genetic susceptibility to alcoholism.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
alcohol use disorder  IAGP 1642200 RGD 
alcohol use disorder  ISOGRIN2B (Homo sapiens)1642200; 1642200 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Grin2b  (glutamate ionotropic receptor NMDA type subunit 2B)

Genes (Mus musculus)
Grin2b  (glutamate receptor, ionotropic, NMDA2B (epsilon 2))

Genes (Homo sapiens)
GRIN2B  (glutamate ionotropic receptor NMDA type subunit 2B)


Additional Information