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Gene-Chemical Interaction AnnotationsGene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (S)-nicotine | decreases expression | ISO | RGD:10962 | 6480464 | Nicotine results in decreased expression of MYO5B mRNA | CTD | PMID:17997037 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:10962 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of MYO5B mRNA | CTD | PMID:15034205 | 2,6-dinitrotoluene | affects expression | EXP | | 6480464 | 2,6-dinitrotoluene affects the expression of MYO5B mRNA | CTD | PMID:21346803 | aflatoxin B1 | decreases expression | ISO | RGD:736652 | 6480464 | Aflatoxin B1 results in decreased expression of MYO5B mRNA | CTD | PMID:21641981 | all-trans-retinoic acid | increases expression | ISO | RGD:736652 | 6480464 | Tretinoin results in increased expression of MYO5B mRNA | CTD | PMID:21934132 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of MYO5B mRNA | CTD | PMID:16483693 | benzo[a]pyrene | decreases expression | ISO | RGD:736652 | 6480464 | Benzo(a)pyrene results in decreased expression of MYO5B mRNA | CTD | PMID:20106945 | benzo[a]pyrene | decreases expression | ISO | RGD:10962 | 6480464 | Benzo(a)pyrene results in decreased expression of MYO5B mRNA | CTD | PMID:15034205 | benzo[a]pyrene | multiple interactions | ISO | RGD:10962 | 6480464 | AHR protein promotes the reaction [Benzo(a)pyrene results in decreased expression of MYO5B mRNA] | CTD | PMID:15034205 | benzo[a]pyrene | decreases expression | ISO | RGD:736652 | 6480464 | Benzo(a)pyrene results in decreased expression of MYO5B mRNA | CTD | PMID:20106945 PMID:21632981 | benzo[a]pyrene | multiple interactions | ISO | RGD:10962 | 6480464 | [Benzo(a)pyrene co-treated with XPA gene mutant form co-treated with TRP53 gene mutant form] results in decreased expression of MYO5B mRNA | CTD | PMID:21715664 | calcitriol | increases expression | ISO | RGD:736652 | 6480464 | Calcitriol results in increased expression of MYO5B mRNA | CTD | PMID:21592394 | calcitriol | multiple interactions | ISO | RGD:736652 | 6480464 | [Testosterone co-treated with Calcitriol] results in increased expression of MYO5B mRNA | CTD | PMID:21592394 | coumestrol | multiple interactions | ISO | RGD:736652 | 6480464 | [Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of MYO5B mRNA | CTD | PMID:19167446 | diarsenic trioxide | increases expression | ISO | RGD:736652 | 6480464 | arsenic trioxide results in increased expression of MYO5B mRNA | CTD | PMID:22521957 | dibutyl phthalate | decreases expression | ISO | RGD:10962 | 6480464 | Dibutyl Phthalate results in decreased expression of MYO5B mRNA | CTD | PMID:21266533 | ethanol | multiple interactions | EXP | | 6480464 | [Fish Oils co-treated with Ethanol] results in increased expression of MYO5B mRNA | CTD | PMID:17347304 | kainic acid | decreases expression | ISO | RGD:10962 | 6480464 | Kainic Acid results in decreased expression of MYO5B mRNA | CTD | PMID:17997037 | methamphetamine | affects response to substance | ISO | RGD:736652 | 6480464 | MYO5B gene SNP affects the susceptibility to Methamphetamine | CTD | PMID:18316681 | paracetamol | decreases expression | ISO | RGD:736652 | 6480464 | Acetaminophen results in decreased expression of MYO5B mRNA | CTD | PMID:21420995 | perfluorooctanoic acid | increases expression | EXP | | 6480464 | perfluorooctanoic acid results in increased expression of MYO5B mRNA | CTD | PMID:16221955 PMID:19162173 | perfluorooctanoic acid | increases expression | EXP | | 6480464 | perfluorooctanoic acid results in increased expression of MYO5B mRNA | CTD | PMID:19162173 PMID:16221955 | phenobarbital | multiple interactions | ISO | RGD:10962 | 6480464 | NR1I3 protein affects the reaction [Phenobarbital results in increased expression of MYO5B mRNA] | CTD | PMID:19482888 | phenobarbital | increases expression | ISO | RGD:10962 | 6480464 | Phenobarbital results in increased expression of MYO5B mRNA | CTD | PMID:19482888 | pirinixic acid | multiple interactions | ISO | RGD:10962 | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of MYO5B mRNA | CTD | PMID:19710929 | pirinixic acid | increases expression | ISO | RGD:10962 | 6480464 | pirinixic acid results in increased expression of MYO5B mRNA | CTD | PMID:20059764 PMID:18301758 | pirinixic acid | multiple interactions | ISO | RGD:10962 | 6480464 | PPARA protein promotes the reaction [pirinixic acid results in increased expression of MYO5B mRNA] | CTD | PMID:20059764 | pirinixic acid | increases expression | EXP | | 6480464 | pirinixic acid results in increased expression of MYO5B mRNA | CTD | PMID:19162173 | pirinixic acid | increases expression | ISO | RGD:10962 | 6480464 | pirinixic acid results in increased expression of MYO5B mRNA | CTD | PMID:18301758 PMID:20059764 | testosterone | increases expression | ISO | RGD:736652 | 6480464 | Testosterone results in increased expression of MYO5B mRNA | CTD | PMID:21592394 | testosterone | multiple interactions | ISO | RGD:736652 | 6480464 | [Testosterone co-treated with Calcitriol] results in increased expression of MYO5B mRNA | CTD | PMID:21592394 | trimellitic anhydride | decreases expression | ISO | RGD:10962 | 6480464 | trimellitic anhydride results in decreased expression of MYO5B mRNA | CTD | PMID:19042947 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology AnnotationsMolecular Pathway AnnotationsDisease AnnotationsGene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway AnnotationsReferences - curatedReferences - uncuratedRGD Disease Portals| Myo5b has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Myo5b (Rattus norvegicus) |
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| MYO5B (Homo sapiens) |
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| Myo5b (Mus musculus) |
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Position Markers| D18Rat10 |
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| BF403782 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. |  | Full Report | | CSV | | TAB | | Printer | | Gviewer |
Nucleotide Sequences| RefSeq Acc Id: | NM_017083 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_058779 | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_058779 | (Get FASTA) |
| GenBank Protein | AAB38840 | (Get FASTA) |
| EDL82886 | (Get FASTA) | |
| EDL82887 | (Get FASTA) | |
| EDL82888 | (Get FASTA) | |
| P70569 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000014104 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Protein | ENSRNOP00000019512 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Transcript | ENSRNOT00000019512 | ENTREZGENE, UniProtKB/TrEMBL |
| Entrez Gene | 25132 | ENTREZGENE |
| Gene3D-CATH | 7.10 | UniProtKB/TrEMBL |
| Germonline | ENSRNOG00000014104 | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 49481 | ENTREZGENE |
| InterPro | Dil_domain | UniProtKB/Swiss-Prot |
| Dilute | UniProtKB/Swiss-Prot | |
| IQ_CaM_bd_region | UniProtKB/Swiss-Prot | |
| Myosin_head_motor_dom | UniProtKB/Swiss-Prot | |
| Thiolase-like_subgr | UniProtKB/TrEMBL | |
| IPI | IPI00189725 | UniProtKB/Swiss-Prot |
| IPI00948899 | UniProtKB/TrEMBL | |
| KEGG Report | rno:25132 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Pfam | DIL | UniProtKB/Swiss-Prot |
| Myosin_head | UniProtKB/Swiss-Prot | |
| PF00612 | UniProtKB/Swiss-Prot | |
| PRINTS | MYOSINHEAVY | UniProtKB/Swiss-Prot |
| PROSITE | DILUTE | UniProtKB/Swiss-Prot |
| PS50096 | UniProtKB/Swiss-Prot | |
| SMART | MYSc | UniProtKB/Swiss-Prot |
| SM00015 | UniProtKB/Swiss-Prot | |
| UniGene | Rn.10640 | ENTREZGENE |
| UniProt | F1M3R4_RAT | UniProtKB/TrEMBL |
| MYO5B_RAT | UniProtKB/Swiss-Prot |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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| 2008-05-27 | Myo5b | myosin Vb | Myo5b | myosin 5B | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2003-04-09 | Myo5b | myosin 5B | Symbol and Name updated | 2574 | APPROVED | ||
| 2003-03-06 | Myo5b | myosin 5B | Myr6 | Myosin of the dilute-myosin-V family | Data Merged | 2447 | PROVISIONAL |
| 2002-08-07 | Myo5b | Symbol and Name status set to provisional | 1724 | PROVISIONAL | |||
| 2002-06-10 | Myr6 | Myosin of the dilute-myosin-V family | Symbol and Name status set to approved | 1490 | APPROVED |
RGD Curation Notes| Note Type | Note | Reference |
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| gene_expression | expressed in brain, highest expression in choroid plexus and the limbic system, | 633433 |
| More on Myo5b | |
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Entrez Gene |
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Ensembl Gene |
| Genome Browser |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 621347 |
| Created: | 2002-08-06 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.