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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (https://rgd.mcw.edu/rgdweb/contact/contactus.html).
Term:autophagy pathway
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Accession:PW:0000278 term browser browse the term
Definition:The autophagic pathway involves the sequestration of misfolded or long-lived proteins and of defective organelles within double membrane vesicles, and delivery of the cargo to lysosomes for degradation and recycling. It is also known as macroautophagy, or bulk autophagy.
Synonyms:related_synonym: Macroautophagy
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autophagy pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acp2 acid phosphatase 2, lysosomal IDA RGD PMID:18690537 RGD:4892631 NCBI chr 3:97,630,654...97,642,601
Ensembl chr 3:97,631,326...97,642,565 		JBrowse link
G Atg10 autophagy related 10 ISO RGD PMID:15325588 PMID:20034776 RGD:1643329, RGD:4889529 NCBI chr 2:23,843,695...24,133,459
Ensembl chr 2:23,844,482...24,133,368 		JBrowse link
G Atg12 autophagy related 12 ISO
IMP
IEA 		KEGG
RGD		 PMID:15325588 PMID:18059433 PMID:20034776 rno:04140, RGD:1643329, RGD:2301217, RGD:4889529 NCBI chr18:41,638,841...41,649,311
Ensembl chr18:41,635,835...41,649,261 		JBrowse link
G Atg13 autophagy related 13 ISO RGD PMID:20034776 RGD:4889529 NCBI chr 3:98,102,831...98,136,741
Ensembl chr 3:98,101,552...98,136,743 		JBrowse link
G Atg14 autophagy related 14 ISO RGD PMID:20034776 RGD:4889529 NCBI chr15:23,275,457...23,306,817
Ensembl chr15:23,275,457...23,306,815 		JBrowse link
G Atg16l1 autophagy related 16-like 1 ISO RGD PMID:15325588 PMID:20034776 RGD:1643329, RGD:4889529 NCBI chr 9:95,869,839...95,905,354
Ensembl chr 9:95,869,865...95,905,357 		JBrowse link
G Atg16l2 autophagy related 16-like 2 ISO RGD PMID:15325588 PMID:20034776 RGD:1643329, RGD:4889529 NCBI chr 1:165,100,946...165,123,307
Ensembl chr 1:165,102,936...165,115,473 		JBrowse link
G Atg3 autophagy related 3 IEP
ISO
IEA 		KEGG
RGD		 PMID:17110912 PMID:15325588 PMID:20034776 rno:04140, RGD:1643237, RGD:1643329, RGD:4889529 NCBI chr11:69,130,948...69,159,280
Ensembl chr11:69,121,952...69,159,280 		JBrowse link
G Atg4a autophagy related 4A, cysteine peptidase ISO RGD PMID:15325588 RGD:1643329 NCBI chr  X:109,453,712...109,553,758
Ensembl chr  X:109,453,689...109,553,760 		JBrowse link
G Atg4b autophagy related 4B, cysteine peptidase ISO
IEA 		KEGG
RGD		 PMID:15325588 rno:04140, RGD:1643329 NCBI chr 9:101,729,772...101,761,456
Ensembl chr 9:101,726,782...101,761,622 		JBrowse link
G Atg4c autophagy related 4C, cysteine peptidase ISO
IEA 		KEGG
RGD		 PMID:15325588 rno:04140, RGD:1643329 NCBI chr 5:118,977,594...119,050,894
Ensembl chr 5:118,982,918...119,052,695 		JBrowse link
G Atg4d autophagy related 4D, cysteine peptidase ISO
IEA 		KEGG
RGD		 PMID:15325588 rno:04140, RGD:1643329 NCBI chr 8:28,083,902...28,093,491
Ensembl chr 8:28,083,936...28,093,491 		JBrowse link
G Atg5 autophagy related 5 IMP
ISO
IEA 		KEGG
RGD		 PMID:18059433 PMID:20034776 rno:04140, RGD:2301217, RGD:4889529 NCBI chr20:49,380,835...49,471,826
Ensembl chr20:49,380,813...49,471,821 		JBrowse link
G Atg7 autophagy related 7 ISO
IEA
IEP 		KEGG
RGD		 PMID:15325588 PMID:20034776 PMID:17665967 rno:04140, RGD:1643329, RGD:4889529, RGD:1643198 NCBI chr 4:149,390,000...149,597,534
Ensembl chr 4:149,391,390...149,598,319 		JBrowse link
G Atg9a autophagy related 9A ISO RGD PMID:20034776 RGD:4889529 NCBI chr 9:84,126,071...84,136,723
Ensembl chr 9:84,126,071...84,136,666 		JBrowse link
G Atg9b autophagy related 9B ISO RGD PMID:20034776 RGD:4889529 NCBI chr 4:11,678,548...11,686,097
Ensembl chr 4:11,678,299...11,686,079 		JBrowse link
G Becn1 beclin 1 IMP
ISO
IEA 		KEGG
RGD		 PMID:16697404 PMID:15325588 PMID:20034776 rno:04140, RGD:1643194, RGD:1643329, RGD:4889529 NCBI chr10:86,731,649...86,747,002
Ensembl chr10:86,731,650...86,747,002 		JBrowse link
G Chmp2b charged multivesicular body protein 2B ISO RGD PMID:19535733 RGD:4892619 NCBI chr11:16,783,971...16,810,500
Ensembl chr11:16,783,971...16,828,868 		JBrowse link
G Chmp3 charged multivesicular body protein 3 ISO RGD PMID:19535733 RGD:4892619 NCBI chr 4:105,134,860...105,180,862
Ensembl chr 4:105,134,755...105,182,262 		JBrowse link
G Gabarap GABA type A receptor-associated protein ISO
IEA 		KEGG
RGD		 PMID:15325588 PMID:20562859 rno:04140, RGD:1643329, RGD:4890444 NCBI chr10:55,213,465...55,216,787
Ensembl chr10:55,212,075...55,216,154 		JBrowse link
G Gabarapl1 GABA type A receptor associated protein like 1 ISO
IEA 		KEGG
RGD		 PMID:20562859 rno:04140, RGD:4890444 NCBI chr 4:164,666,332...164,675,474
Ensembl chr 4:164,666,246...164,674,578 		JBrowse link
G Gabarapl2 GABA type A receptor associated protein like 2 ISO
IEA 		KEGG
RGD		 PMID:15325588 PMID:20562859 rno:04140, RGD:1643329, RGD:4890444 NCBI chr19:56,819,826...56,830,662
Ensembl chr19:56,819,791...56,830,660 		JBrowse link
G Hgs hepatocyte growth factor-regulated tyrosine kinase substrate ISO RGD PMID:19535733 RGD:4892619 NCBI chr10:106,237,988...106,256,174
Ensembl chr10:106,237,824...106,256,174 		JBrowse link
G Ifna1 interferon, alpha 1 IEA KEGG rno:04140 NCBI chr 5:108,143,240...108,143,809
Ensembl chr 5:108,143,240...108,143,809 		JBrowse link
G Ifna2 interferon alpha 2 IEA KEGG rno:04140 NCBI chr 5:108,374,363...108,374,941
Ensembl chr 5:108,374,363...108,374,941 		JBrowse link
G Ifna4 interferon, alpha 4 IEA KEGG rno:04140 NCBI chr 5:108,115,064...108,116,010
Ensembl chr 5:108,115,064...108,116,010 		JBrowse link
G Ifna4l1 interferon, alpha 4 like 1 IEA KEGG rno:04140 NCBI chr 5:108,640,546...108,641,115 JBrowse link
G Ifna5 interferon, alpha 5 IEA KEGG rno:04140 NCBI chr 5:108,233,736...108,234,314
Ensembl chr 5:108,233,736...108,234,314 		JBrowse link
G Ifng interferon gamma IEA KEGG rno:04140 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216 		JBrowse link
G Ins1 insulin 1 IEA KEGG rno:04140 NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:261,186,119...261,186,682 		JBrowse link
G Ins2 insulin 2 IEA KEGG rno:04140 NCBI chr 1:207,272,738...207,421,998
Ensembl chr 1:207,272,742...207,273,805 		JBrowse link
G Lamp1 lysosomal-associated membrane protein 1 ISO
IDA 		RGD PMID:20548331 PMID:18690537 RGD:4892310, RGD:4892631 NCBI chr16:83,058,131...83,082,843
Ensembl chr16:83,058,385...83,075,159 		JBrowse link
G Lamp2 lysosomal-associated membrane protein 2 ISO RGD PMID:20548331 RGD:4892310 NCBI chr  X:122,038,734...122,087,745
Ensembl chr  X:121,922,187...122,087,675 		JBrowse link
G Map1lc3a microtubule-associated protein 1 light chain 3 alpha IEP
ISO 		RGD PMID:17665967 PMID:15325588 PMID:20562859 RGD:1643198, RGD:1643329, RGD:4890444 NCBI chr 3:164,243,204...164,244,850
Ensembl chr 3:164,243,093...164,244,850 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta ISO RGD PMID:15325588 PMID:20562859 RGD:1643329, RGD:4890444 NCBI chr19:66,571,631...66,582,270
Ensembl chr19:66,574,407...66,584,358
Ensembl chr16:66,574,407...66,584,358 		JBrowse link
G Pik3c3 phosphatidylinositol 3-kinase, catalytic subunit type 3 ISO
IEA 		KEGG
RGD		 PMID:20034776 rno:04140, RGD:4889529 NCBI chr18:22,119,677...22,203,546
Ensembl chr18:22,119,792...22,203,539 		JBrowse link
G Pik3r4 phosphoinositide-3-kinase, regulatory subunit 4 ISO
IEA 		KEGG
RGD		 PMID:20034776 rno:04140, RGD:4889529 NCBI chr 8:115,146,660...115,195,326
Ensembl chr 8:115,146,687...115,195,326 		JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 IEA KEGG rno:04140 NCBI chr 2:55,967,766...56,003,450
Ensembl chr 2:55,967,351...56,003,450 		JBrowse link
G Prkaa2 protein kinase AMP-activated catalytic subunit alpha 2 IEA KEGG rno:04140 NCBI chr 5:125,036,945...125,109,010
Ensembl chr 5:125,042,179...125,108,324 		JBrowse link
G Rab11a RAB11a, member RAS oncogene family ISO RGD PMID:20548331 RGD:4892310 NCBI chr 8:74,118,922...74,141,760
Ensembl chr 8:74,118,922...74,141,837 		JBrowse link
G Rab33b RAB33B, member RAS oncogene family ISO RGD PMID:20548331 RGD:4892310 NCBI chr 2:137,678,953...137,689,581
Ensembl chr 2:137,678,978...137,689,581 		JBrowse link
G Rab5a RAB5A, member RAS oncogene family ISO RGD PMID:20548331 RGD:4892310 NCBI chr 9:6,720,057...6,749,456
Ensembl chr 9:6,721,122...6,749,447 		JBrowse link
G Rab7a RAB7A, member RAS oncogene family ISO RGD PMID:20548331 RGD:4892310 NCBI chr 4:122,019,281...122,068,067
Ensembl chr 4:121,983,938...122,064,185 		JBrowse link
G Rb1cc1 RB1-inducible coiled-coil 1 ISO RGD PMID:20034776 RGD:4889529 NCBI chr 5:17,948,522...18,012,434
Ensembl chr 5:17,948,522...18,012,434 		JBrowse link
G Rubcn rubicon autophagy regulator ISO RGD PMID:20034776 RGD:4889529 NCBI chr11:81,420,261...81,469,415
Ensembl chr11:81,412,617...81,469,424 		JBrowse link
G Snf8 SNF8 subunit of ESCRT-II ISO RGD PMID:19535733 RGD:4892619 NCBI chr10:81,481,054...81,493,430
Ensembl chr10:81,481,057...81,494,610 		JBrowse link
G Tsg101 tumor susceptibility 101 ISO RGD PMID:19535733 RGD:4892619 NCBI chr 1:106,549,035...106,578,859
Ensembl chr 1:106,535,021...106,578,775 		JBrowse link
G Ulk1 unc-51 like autophagy activating kinase 1 ISO
IEA 		KEGG
RGD		 PMID:15325588 PMID:20034776 rno:04140, RGD:1643329, RGD:4889529 NCBI chr12:51,511,492...51,537,746
Ensembl chr12:51,511,492...51,537,746 		JBrowse link
G Ulk2 unc-51 like autophagy activating kinase 2 ISO
IEA 		KEGG
RGD		 PMID:20034776 rno:04140, RGD:4889529 NCBI chr10:46,951,038...47,029,844
Ensembl chr10:46,951,038...47,029,844 		JBrowse link
G Ulk3 unc-51 like kinase 3 IEA KEGG rno:04140 NCBI chr 8:66,888,820...66,895,380
Ensembl chr 8:66,888,788...66,895,379 		JBrowse link
G Uvrag UV radiation resistance associated ISO RGD PMID:20034776 RGD:4889529 NCBI chr 1:162,596,514...162,854,348
Ensembl chr 1:162,596,515...162,854,348 		JBrowse link
G Vamp3 vesicle-associated membrane protein 3 ISO RGD PMID:20548331 RGD:4892310 NCBI chr 5:166,780,927...166,791,522
Ensembl chr 5:166,780,929...166,791,549 		JBrowse link
G Vamp7 vesicle-associated membrane protein 7 ISO RGD PMID:20548331 RGD:4892310 NCBI chr12:21,842,206...21,958,556
Ensembl chr12:21,842,228...21,958,552 		JBrowse link
G Vps4a vacuolar protein sorting 4 homolog A ISO RGD PMID:19535733 RGD:4892619 NCBI chr19:51,838,411...51,858,639
Ensembl chr19:51,833,914...51,872,423 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6091
    regulatory pathway 3864
      cell death pathway 243
        programmed cell death pathway 243
          non-apoptotic cell death pathway 85
            cellular autophagy pathway 85
              autophagy pathway 54
                altered autophagy pathway 0
paths to the root