Irs1 (insulin receptor substrate 1) - Rat Genome Database

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Gene: Irs1 (insulin receptor substrate 1) Rattus norvegicus
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Symbol: Irs1
Name: insulin receptor substrate 1
RGD ID: 2922
Description: Enables several functions, including SH2 domain binding activity; protein kinase binding activity; and signaling receptor binding activity. Involved in several processes, including cellular response to peptide hormone stimulus; regulation of insulin receptor signaling pathway; and regulation of peptide hormone secretion. Part of insulin receptor complex. Used to study end stage renal disease; obesity; and type 2 diabetes mellitus. Biomarker of Alzheimer's disease; metabolic dysfunction-associated steatotic liver disease; and osteoporosis. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease; type 2 diabetes mellitus; and uterine fibroid. Orthologous to human IRS1 (insulin receptor substrate 1); PARTICIPATES IN insulin signaling pathway; insulin-like growth factor signaling pathway; interleukin-2 signaling pathway; INTERACTS WITH (S)-nicotine; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: IRS-1; IRS1IRM; pp185
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8991,001,137 - 91,053,959 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl990,993,519 - 91,054,538 (-)EnsemblGRCr8
mRatBN7.2983,552,964 - 83,605,797 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl983,548,944 - 83,606,122 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx991,983,252 - 92,036,073 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0997,111,732 - 97,164,548 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0995,494,674 - 95,547,492 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0988,033,668 - 88,086,488 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl988,033,668 - 88,086,488 (-)Ensemblrn6Rnor6.0
Rnor_5.0987,782,499 - 87,835,248 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4981,585,251 - 81,638,071 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera980,997,490 - 81,050,250 (-)NCBICelera
RGSC_v3.1981,768,669 - 81,821,490 (-)NCBI
Cytogenetic Map9q34NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(1->4)-beta-D-glucan  (ISO)
(S)-nicotine  (EXP)
(Z)-ligustilide  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dinitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methyladenine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-nitrophenol  (ISO)
4-phenylbutyric acid  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
9-cis,11-trans-octadecadienoic acid  (EXP,ISO)
acetylsalicylic acid  (ISO)
acrolein  (EXP)
acrylamide  (EXP)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
allopurinol  (EXP)
alloxan  (EXP,ISO)
ammonium chloride  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antirheumatic drug  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
asiatic acid  (EXP)
atrazine  (EXP,ISO)
azathioprine  (ISO)
Azoxymethane  (ISO)
bellidifolin  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
biotin  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
buta-1,3-diene  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
capsaicin  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carmustine  (ISO)
chloroprene  (ISO)
chlorpyrifos  (EXP)
cholesterol  (ISO)
choline  (ISO)
chromium atom  (EXP,ISO)
chromium(6+)  (EXP,ISO)
cisplatin  (ISO)
CL316243  (EXP)
cobalt dichloride  (ISO)
coenzyme Q10  (EXP)
colforsin daropate hydrochloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
CU-O LINKAGE  (ISO)
curcumin  (EXP,ISO)
cycloheximide  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (EXP,ISO)
D-glucose  (ISO)
DDE  (ISO)
decabromodiphenyl ether  (ISO)
dehydroepiandrosterone  (EXP)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
Didymin  (ISO)
diethyl phthalate  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ethanol  (EXP,ISO)
flavonol  (ISO)
folic acid  (ISO)
folpet  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fructose  (EXP,ISO)
fulvestrant  (ISO)
gamma-hexachlorocyclohexane  (EXP)
Ganoderic acid A  (ISO)
genistein  (ISO)
gentamycin  (EXP)
Gingerenone A  (ISO)
gingerol  (ISO)
ginsenoside Re  (ISO)
Ginsenoside Rh4  (ISO)
glucose  (ISO)
glyburide  (EXP,ISO)
glyphosate  (ISO)
gypenoside LXXV  (ISO)
hexachlorobenzene  (EXP,ISO)
hexadecanoic acid  (EXP,ISO)
hydroquinone  (ISO)
isoprenaline  (ISO)
ketanserin  (ISO)
ketoconazole  (EXP)
L-ascorbic acid  (EXP,ISO)
L-methionine  (ISO)
lead diacetate  (EXP)
leflunomide  (ISO)
linsidomine  (ISO)
lipopolysaccharide  (ISO)
lovastatin  (ISO)
LY294002  (EXP)
melatonin  (ISO)
mercury atom  (ISO)
mercury dibromide  (ISO)
mercury(0)  (ISO)
metformin  (EXP,ISO)
methamphetamine  (ISO)
methoxychlor  (EXP)
methylglyoxal  (EXP)
methylmercury chloride  (ISO)
metyrapone  (EXP)
microcystin-LR  (ISO)
miquelianin  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
myricetin  (EXP)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (EXP)
N-nitrosomorpholine  (EXP)
N-phosphocreatine  (EXP)
naringin  (ISO)
nerolidol  (EXP)
nickel atom  (ISO)
nicotine  (EXP)
okadaic acid  (ISO)
oleanolic acid  (EXP)
orientin  (ISO)
ozone  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
paroxetine  (EXP)
perfluorododecanoic acid  (EXP)
perfluorononanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
permethrin  (ISO)
phenethyl caffeate  (ISO)
phenylmercury acetate  (ISO)
phosgene  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
procyanidin B1  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
propionic acid  (ISO)
quercetin  (EXP,ISO)
rebaudioside A  (ISO)
resveratrol  (EXP,ISO)
rivastigmine  (EXP)
rutin  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
sarpogrelate  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
serotonin  (ISO)
sertraline  (EXP)
silicon dioxide  (ISO)
simvastatin  (ISO)
sirolimus  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
Sodium salicylate  (ISO)
steviol  (ISO)
stevioside  (ISO)
streptozocin  (EXP,ISO)
sucrose  (ISO)
sulpiride  (EXP)
sunitinib  (ISO)
tamoxifen  (ISO)
taurine  (EXP,ISO)
temozolomide  (ISO)
Tesaglitazar  (EXP)
testosterone  (EXP,ISO)
tetrachloromethane  (ISO)
thapsigargin  (ISO)
theophylline  (ISO)
thymoquinone  (EXP)
Tiron  (ISO)
titanium dioxide  (ISO)
tributylstannane  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
triclosan  (EXP)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (ISO)
tris(picolinato)chromium  (EXP)
troglitazone  (EXP)
tunicamycin  (ISO)
urethane  (ISO)
Ursonic acid  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vanillic acid  (ISO)
vitamin E  (EXP,ISO)
wortmannin  (EXP,ISO)
zinc atom  (EXP,ISO)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to angiotensin  (IEP)
cellular response to brain-derived neurotrophic factor stimulus  (IEP)
cellular response to fatty acid  (ISO)
cellular response to insulin stimulus  (ISO)
cellular response to radiation  (IEP)
cytokine-mediated signaling pathway  (ISO)
insulin receptor signaling pathway  (IBA,IDA,IEA,ISO)
insulin-like growth factor receptor signaling pathway  (ISO,ISS)
lipid catabolic process  (ISO)
mammary gland development  (ISO)
negative regulation of insulin receptor signaling pathway  (IMP)
negative regulation of insulin secretion  (IMP,ISO)
negative regulation of somatostatin secretion  (IMP)
phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of D-glucose import across plasma membrane  (ISO)
positive regulation of fatty acid beta-oxidation  (ISO)
positive regulation of glucagon secretion  (IMP)
positive regulation of glucose metabolic process  (ISO)
positive regulation of glycogen biosynthetic process  (ISO)
positive regulation of insulin receptor signaling pathway  (IMP,ISO)
positive regulation of mesenchymal cell proliferation  (ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IDA,IEA,ISO)
positive regulation of phosphorylation  (IDA)
protein localization to nucleus  (ISO)
regulation of gene expression  (ISO)
response to activity  (IEP)
response to caffeine  (IDA,IEP)
response to ethanol  (IDA)
response to insulin  (ISO)
signal transduction  (IEA)

Cellular Component
caveola  (ISO)
ciliary basal body  (ISO)
cytoplasm  (IEA,ISO,ISS)
cytosol  (IBA,TAS)
insulin receptor complex  (IMP)
nucleus  (IEA,ISO,ISS)
plasma membrane  (IBA,IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Insulin receptor substrate proteins create a link between the tyrosine phosphorylation cascade and the Ca2+-ATPases in muscle and heart. Algenstaedt P, etal., J Biol Chem. 1997 Sep 19;272(38):23696-702.
2. Tumor necrosis factor (TNF)-a-induced repression of GKAP42 protein levels through cGMP-dependent kinase (cGK)-Ia causes insulin resistance in 3T3-L1 adipocytes. Ando Y, etal., J Biol Chem. 2015 Feb 27;290(9):5881-92. doi: 10.1074/jbc.M114.624759. Epub 2015 Jan 13.
3. Blockade of IRS1 in isolated rat pancreatic islets improves glucose-induced insulin secretion. Araujo EP, etal., FEBS Lett 2002 Nov 20;531(3):437-42.
4. Phosphatidylinositol 3'-kinase is activated by association with IRS-1 during insulin stimulation. Backer JM, etal., EMBO J. 1992 Sep;11(9):3469-79.
5. Effects of selenium and exendin-4 on glucagon-like peptide-1 receptor, IRS-1, and Raf-1 in the liver of diabetic rats. Barakat GM, etal., Biochem Genet. 2012 Dec;50(11-12):922-35. doi: 10.1007/s10528-012-9532-2. Epub 2012 Sep 16.
6. A common mutation of the insulin receptor substrate-1 gene is a risk factor for coronary artery disease. Baroni MG, etal., Arterioscler Thromb Vasc Biol. 1999 Dec;19(12):2975-80.
7. An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer's disease-associated Abeta oligomers. Bomfim TR, etal., J Clin Invest. 2012 Mar 22. pii: 57256. doi: 10.1172/JCI57256.
8. Insulin receptor substrate-1 is present in hepatocyte nuclei from intact rats. Boylan JM and Gruppuso PA, Endocrinology 2002 Nov;143(11):4178-83.
9. Insulin resistance: interactions between obesity and a common variant of insulin receptor substrate-1. Clausen JO, etal., Lancet. 1995 Aug 12;346(8972):397-402.
10. G-protein and tyrosine kinase receptor cross-talk in rat aortic smooth muscle cells: thrombin- and angiotensin II-induced tyrosine phosphorylation of insulin receptor substrate-1 and insulin-like growth factor 1 receptor. Du J, etal., Biochem Biophys Res Commun. 1996 Jan 26;218(3):934-9.
11. SH2-B promotes insulin receptor substrate 1 (IRS1)- and IRS2-mediated activation of the phosphatidylinositol 3-kinase pathway in response to leptin. Duan C, etal., J Biol Chem. 2004 Oct 15;279(42):43684-91. Epub 2004 Aug 16.
12. Protein-tyrosine phosphatase-1B negatively regulates insulin signaling in l6 myocytes and Fao hepatoma cells. Egawa K, etal., J Biol Chem. 2001 Mar 30;276(13):10207-11. Epub 2001 Jan 2.
13. Caffeine modulates phosphorylation of insulin receptor substrate-1 and impairs insulin signal transduction in rat skeletal muscle. Egawa T, etal., J Appl Physiol. 2011 Dec;111(6):1629-36. Epub 2011 Sep 22.
14. Molecular pathology in the obese spontaneous hypertensive Koletsky rat: a model of syndrome X. Ernsberger P, etal., Ann N Y Acad Sci. 1999 Nov 18;892:272-88.
15. A novel T608R missense mutation in insulin receptor substrate-1 identified in a subject with type 2 diabetes impairs metabolic insulin signaling. Esposito DL, etal., J Clin Endocrinol Metab. 2003 Apr;88(4):1468-75.
16. Cloning and characterization of PHIP, a novel insulin receptor substrate-1 pleckstrin homology domain interacting protein. Farhang-Fallah J, etal., J Biol Chem. 2000 Dec 22;275(51):40492-7.
17. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
18. Soluble and cell-associated insulin receptor dysfunction correlates with severity of HAND in HIV-infected women. Gerena Y, etal., PLoS One. 2012;7(5):e37358. doi: 10.1371/journal.pone.0037358. Epub 2012 May 22.
19. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
20. Tyrosine dephosphorylation and deactivation of insulin receptor substrate-1 by protein-tyrosine phosphatase 1B. Possible facilitation by the formation of a ternary complex with the Grb2 adaptor protein. Goldstein BJ, etal., J Biol Chem. 2000 Feb 11;275(6):4283-9.
21. Aging-sensitive cellular and molecular mechanisms associated with skeletal muscle hypertrophy. Haddad F and Adams GR, J Appl Physiol. 2006 Apr;100(4):1188-203. Epub 2005 Dec 22.
22. 53BP2S, interacting with insulin receptor substrates, modulates insulin signaling. Hakuno F, etal., J Biol Chem. 2007 Dec 28;282(52):37747-58. Epub 2007 Oct 26.
23. Changes in insulin-signaling transduction pathway underlie learning/memory deficits in an Alzheimer's disease rat model. Han X, etal., J Neural Transm. 2012 Nov;119(11):1407-16. doi: 10.1007/s00702-012-0803-1. Epub 2012 Apr 17.
24. Pre-germinated brown rice extract ameliorates high-fat diet-induced metabolic syndrome. Hao CL, etal., J Food Biochem. 2019 Mar;43(3):e12769. doi: 10.1111/jfbc.12769. Epub 2019 Jan 13.
25. Insulin receptor substrate-1/SHP-2 interaction, a phenotype-dependent switching machinery of insulin-like growth factor-I signaling in vascular smooth muscle cells. Hayashi K, etal., J Biol Chem. 2004 Sep 24;279(39):40807-18. Epub 2004 Jul 21.
26. Modulation of IR/PTP1B interaction and downstream signaling in insulin sensitive tissues of MSG-rats. Hirata AE, etal., Life Sci. 2003 Aug 1;73(11):1369-81.
27. Activation of the insulin receptor by insulin and a synthetic peptide leads to divergent metabolic and mitogenic signaling and responses. Jensen M, etal., J Biol Chem. 2007 Nov 30;282(48):35179-86. Epub 2007 Oct 9.
28. (-)-Epigallocatechin-3-gallate alleviates spatial memory impairment in APP/PS1 mice by restoring IRS-1 signaling defects in the hippocampus. Jia N, etal., Mol Cell Biochem. 2013 Aug;380(1-2):211-8. doi: 10.1007/s11010-013-1675-x. Epub 2013 May 10.
29. Reduction of adiposity with prolonged growth hormone treatment in old obese rats: effects on glucose handling and early insulin signaling. Johansen T, etal., Growth Horm IGF Res. 2005 Feb;15(1):55-63. Epub 2005 Jan 22.
30. Insulin signaling through insulin receptor substrate 1 and 2 in normal liver development. Khamzina L, etal., Gastroenterology 2003 Aug;125(2):572-85.
31. Exercise maintains euglycemia in association with decreased activation of c-Jun NH2-terminal kinase and serine phosphorylation of IRS-1 in the liver of ZDF rats. Kiraly MA, etal., Am J Physiol Endocrinol Metab. 2010 Mar;298(3):E671-82. Epub 2009 Dec 8.
32. Comparative analysis of the signaling capabilities of the insulin receptor-related receptor. Klammt J, etal., Biochem Biophys Res Commun. 2005 Feb 11;327(2):557-64.
33. The role of insulin receptor substrate-1 gene (IRS1) in type 2 diabetes in Pima Indians. Kovacs P, etal., Diabetes. 2003 Dec;52(12):3005-9.
34. MicroRNAs: a new ray of hope for diabetes mellitus. Kumar M, etal., Protein Cell. 2012 Oct;3(10):726-38. doi: 10.1007/s13238-012-2055-0. Epub 2012 Oct 11.
35. Altered gene expression involved in insulin signaling pathway in type II diabetic osteoporosis rats model. Li B, etal., Endocrine. 2013 Feb;43(1):136-46. doi: 10.1007/s12020-012-9757-1. Epub 2012 Jul 22.
36. Upregulation of IRS-1 expression in Goto-Kakizaki rats following Roux-en-Y gastric bypass surgery: resolution of type 2 diabetes? Li SQ, etal., Tohoku J Exp Med. 2011;225(3):179-86.
37. A novel IRS-1-associated protein, DGK¿ regulates GLUT4 translocation in 3T3-L1 adipocytes. Liu T, etal., Sci Rep. 2016 Oct 14;6:35438. doi: 10.1038/srep35438.
38. Insulin stimulates PKCzeta -mediated phosphorylation of insulin receptor substrate-1 (IRS-1). A self-attenuated mechanism to negatively regulate the function of IRS proteins. Liu YF, etal., J Biol Chem. 2001 Apr 27;276(17):14459-65. Epub 2001 Jan 29.
39. The diabetes drug liraglutide ameliorates aberrant insulin receptor localisation and signalling in parallel with decreasing both amyloid-beta plaque and glial pathology in a mouse model of Alzheimer's disease. Long-Smith CM, etal., Neuromolecular Med. 2013 Mar;15(1):102-14. doi: 10.1007/s12017-012-8199-5. Epub 2012 Sep 21.
40. Genome-wide DNA methylation analysis reveals a potential mechanism for the pathogenesis and development of uterine leiomyomas. Maekawa R, etal., PLoS One. 2013 Jun 20;8(6):e66632. doi: 10.1371/journal.pone.0066632. Print 2013.
41. Regulation of synthesis and oxidation of fatty acids by adiponectin receptors (AdipoR1/R2) and insulin receptor substrate isoforms (IRS-1/-2) of the liver in a nonalcoholic steatohepatitis animal model. Matsunami T, etal., Metabolism. 2011 Jun;60(6):805-14. Epub 2010 Sep 16.
42. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
43. Protein kinase C-zeta-induced phosphorylation of Ser318 in insulin receptor substrate-1 (IRS-1) attenuates the interaction with the insulin receptor and the tyrosine phosphorylation of IRS-1. Moeschel K, etal., J Biol Chem. 2004 Jun 11;279(24):25157-63. Epub 2004 Apr 5.
44. Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling. Moloney AM, etal., Neurobiol Aging. 2010 Feb;31(2):224-43. doi: 10.1016/j.neurobiolaging.2008.04.002. Epub .
45. Regulation of insulin receptor substrate 1 pleckstrin homology domain by protein kinase C: role of serine 24 phosphorylation. Nawaratne R, etal., Mol Endocrinol. 2006 Aug;20(8):1838-52. Epub 2006 Mar 30.
46. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
47. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
48. Insulin receptor substrate-1 (IRS-1) forms a ribonucleoprotein complex associated with polysomes. Ozoe A, etal., FEBS Lett. 2013 Aug 2;587(15):2319-24. doi: 10.1016/j.febslet.2013.05.066. Epub 2013 Jun 13.
49. Effects of treadmill exercise and training frequency on anabolic signaling pathways in the skeletal muscle of aged rats. Pasini E, etal., Exp Gerontol. 2012 Jan;47(1):23-8. doi: 10.1016/j.exger.2011.10.003. Epub 2011 Oct 12.
50. The role of the C-terminal domain of protein tyrosine phosphatase-1B in phosphatase activity and substrate binding. Picha KM, etal., J Biol Chem. 2007 Feb 2;282(5):2911-7. Epub 2006 Nov 29.
51. Endotoxin mediated-iNOS induction causes insulin resistance via ONOO(-) induced tyrosine nitration of IRS-1 in skeletal muscle. Pilon G, etal., PLoS One. 2010 Dec 28;5(12):e15912.
52. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
53. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
54. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
55. Phosphoinositide 3-kinase-mediated reduction of insulin receptor substrate-1/2 protein expression via different mechanisms contributes to the insulin-induced desensitization of its signaling pathways in L6 muscle cells. Pirola L, etal., J Biol Chem 2003 May 2;278(18):15641-51. Epub 2003 Feb 18.
56. Selective modulation of the CAP/Cbl pathway in the adipose tissue of high fat diet treated rats. Prada PO, etal., FEBS Lett. 2006 Sep 4;580(20):4889-94. Epub 2006 Aug 10.
57. GOA pipeline RGD automated data pipeline
58. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
59. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
60. Pulsed electromagnetic fields rapidly modulate intracellular signaling events in osteoblastic cells: comparison to parathyroid hormone and insulin. Schnoke M and Midura RJ, J Orthop Res. 2007 Jul;25(7):933-40.
61. Mechanism for differential effect of protein-tyrosine phosphatase 1B on Akt versus mitogen-activated protein kinase in 3T3-L1 adipocytes. Shimizu S, etal., Endocrinology. 2002 Dec;143(12):4563-9.
62. Effects of acute ethanol exposure on regulatory mechanisms of Bcl-2-associated apoptosis promoter, bad, in neonatal rat cerebellum: differential effects during vulnerable and resistant developmental periods. Siler-Marsiglio KI, etal., Alcohol Clin Exp Res. 2006 Jun;30(6):1031-8. doi: 10.1111/j.1530-0277.2006.000126.x.
63. The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS1 and Shc: implications for insulin control of ras signalling. Skolnik EY, etal., EMBO J. 1993 May;12(5):1929-36.
64. Englerin A stimulates PKCtheta to inhibit insulin signaling and to simultaneously activate HSF1: pharmacologically induced synthetic lethality. Sourbier C, etal., Cancer Cell. 2013 Feb 11;23(2):228-37. doi: 10.1016/j.ccr.2012.12.007. Epub 2013 Jan 23.
65. The Fyn tyrosine kinase binds Irs-1 and forms a distinct signaling complex during insulin stimulation. Sun XJ, etal., J Biol Chem. 1996 May 3;271(18):10583-7.
66. Pleiotropic insulin signals are engaged by multisite phosphorylation of IRS-1. Sun XJ, etal., Mol Cell Biol. 1993 Dec;13(12):7418-28.
67. Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein. Sun XJ, etal., Nature 1991 Jul 4;352(6330):73-7.
68. Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline. Talbot K, etal., J Clin Invest. 2012 Mar 22. pii: 59903. doi: 10.1172/JCI59903.
69. Caffeine-induced fetal rat over-exposure to maternal glucocorticoid and histone methylation of liver IGF-1 might cause skeletal growth retardation. Tan Y, etal., Toxicol Lett. 2012 Nov 15;214(3):279-87. doi: 10.1016/j.toxlet.2012.09.007. Epub 2012 Sep 17.
70. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
71. Interleukin-1 beta impairs brain derived neurotrophic factor-induced signal transduction. Tong L, etal., Neurobiol Aging. 2008 Sep;29(9):1380-93. Epub 2007 Apr 27.
72. Altered subcellular distribution of IRS-1 and IRS-3 is associated with defective Akt activation and GLUT4 translocation in insulin-resistant old rat adipocytes. Villar M, etal., Biochim Biophys Acta. 2006 Feb;1763(2):197-206. Epub 2006 Jan 4.
73. Arg972 insulin receptor substrate-1 polymorphism and risk and severity of Alzheimer's disease. Wang W, etal., J Clin Neurosci. 2014 Jul;21(7):1233-7. doi: 10.1016/j.jocn.2013.09.028. Epub 2013 Dec 19.
74. Phosphorylation of Ser357 of rat insulin receptor substrate-1 mediates adverse effects of protein kinase C-delta on insulin action in skeletal muscle cells. Waraich RS, etal., J Biol Chem. 2008 Apr 25;283(17):11226-33. doi: 10.1074/jbc.M708588200. Epub 2008 Feb 19.
75. Ethanol impairs insulin-stimulated neuronal survival in the developing brain: role of PTEN phosphatase. Xu J, etal., J Biol Chem. 2003 Jul 18;278(29):26929-37. Epub 2003 Apr 16.
76. [Nuclear factor kappa B impairs insulin signaling pathway in skeletal muscle cells of rat with sepsis]. Yan XW, etal., Zhonghua Wai Ke Za Zhi. 2009 Aug 15;47(16):1257-60.
77. Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle. Yu C, etal., J Biol Chem 2002 Dec 27;277(52):50230-6.
78. Association studies of insulin receptor substrate 1 gene (IRS1) variants in type 2 diabetes samples enriched for family history and early age of onset. Zeggini E, etal., Diabetes. 2004 Dec;53(12):3319-22.
79. Vascular insulin resistance related to endoplasmic reticulum stress in aortas from a rat model of chronic kidney disease. Zhou QG, etal., Am J Physiol Heart Circ Physiol. 2012 Nov 1;303(9):H1154-65. doi: 10.1152/ajpheart.00407.2012. Epub 2012 Aug 31.
80. Insulin receptor and IRS-1 co-immunoprecipitation with SOCS-3, and IKKalpha/beta phosphorylation are increased in obese Zucker rat skeletal muscle. Zolotnik IA, etal., Life Sci. 2012 Oct 22;91(15-16):816-22. doi: 10.1016/j.lfs.2012.08.038. Epub 2012 Sep 13.
Additional References at PubMed
PMID:2022647   PMID:7493946   PMID:7537849   PMID:7539611   PMID:7541045   PMID:7559478   PMID:7782332   PMID:8316835   PMID:8349691   PMID:8628286   PMID:9062343   PMID:9415395  
PMID:11120660   PMID:11342531   PMID:11375348   PMID:11606564   PMID:11739394   PMID:12006586   PMID:12166618   PMID:12242307   PMID:12538627   PMID:12594288   PMID:12821126   PMID:12837295  
PMID:12857426   PMID:12878164   PMID:12960006   PMID:12970360   PMID:14550547   PMID:14733908   PMID:15001544   PMID:15161606   PMID:15182363   PMID:15240146   PMID:15249583   PMID:15456867  
PMID:15550510   PMID:15572028   PMID:15574412   PMID:15591151   PMID:15604215   PMID:15764607   PMID:15802620   PMID:15845625   PMID:15849359   PMID:15862035   PMID:15924411   PMID:16043515  
PMID:16128672   PMID:16210359   PMID:16516141   PMID:16814735   PMID:16896943   PMID:16921752   PMID:16940436   PMID:17003331   PMID:17008371   PMID:17021050   PMID:17279354   PMID:17496209  
PMID:17555093   PMID:17593555   PMID:17646573   PMID:17662267   PMID:17728140   PMID:17823255   PMID:17905199   PMID:17974582   PMID:17993726   PMID:18299886   PMID:18347658   PMID:18559242  
PMID:18828053   PMID:18854316   PMID:18923160   PMID:19088829   PMID:19169352   PMID:19229113   PMID:19386987   PMID:19546233   PMID:19563078   PMID:19569009   PMID:19596798   PMID:19626997  
PMID:19671924   PMID:19703555   PMID:19801385   PMID:19843521   PMID:19952108   PMID:20179297   PMID:20207740   PMID:20459025   PMID:20624904   PMID:20655720   PMID:21185755   PMID:21228767  
PMID:21301931   PMID:21478152   PMID:21602124   PMID:21788123   PMID:21900690   PMID:21986524   PMID:21991327   PMID:22248283   PMID:22328823   PMID:22761437   PMID:23383252   PMID:23401856  
PMID:23607966   PMID:23715867   PMID:23872130   PMID:24462861   PMID:24652289   PMID:24704288   PMID:25268311   PMID:25352752   PMID:25372512   PMID:25667086   PMID:25883115   PMID:25931508  
PMID:26027876   PMID:26111627   PMID:26702053   PMID:26919700   PMID:27322312   PMID:27434075   PMID:27619406   PMID:28084108   PMID:28115529   PMID:28651236   PMID:29248832   PMID:30701536  
PMID:30716312   PMID:31008486   PMID:31065679   PMID:32045698   PMID:33000267   PMID:33336396   PMID:34942345   PMID:35347917   PMID:36346578   PMID:37248076  


Genomics

Comparative Map Data
Irs1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8991,001,137 - 91,053,959 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl990,993,519 - 91,054,538 (-)EnsemblGRCr8
mRatBN7.2983,552,964 - 83,605,797 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl983,548,944 - 83,606,122 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx991,983,252 - 92,036,073 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0997,111,732 - 97,164,548 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0995,494,674 - 95,547,492 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0988,033,668 - 88,086,488 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl988,033,668 - 88,086,488 (-)Ensemblrn6Rnor6.0
Rnor_5.0987,782,499 - 87,835,248 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4981,585,251 - 81,638,071 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera980,997,490 - 81,050,250 (-)NCBICelera
RGSC_v3.1981,768,669 - 81,821,490 (-)NCBI
Cytogenetic Map9q34NCBI
IRS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382226,731,312 - 226,799,820 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2226,731,312 - 226,799,820 (-)Ensemblhg38GRCh38
GRCh372227,596,028 - 227,664,536 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362227,308,182 - 227,372,719 (-)NCBIBuild 36Build 36hg18NCBI36
Build 342227,425,442 - 227,489,980NCBI
Celera2221,365,560 - 221,433,036 (-)NCBICelera
Cytogenetic Map2q36.3NCBI
HuRef2219,439,592 - 219,507,082 (-)NCBIHuRef
CHM1_12227,601,926 - 227,669,382 (-)NCBICHM1_1
T2T-CHM13v2.02227,214,139 - 227,282,678 (-)NCBIT2T-CHM13v2.0
Irs1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39182,210,826 - 82,269,160 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl182,210,822 - 82,269,137 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38182,233,105 - 82,291,439 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl182,233,101 - 82,291,416 (-)Ensemblmm10GRCm38
GRCm38.p6 Ensembl182,233,112 - 82,235,933 (+)Ensemblmm10GRCm38
MGSCv37182,229,680 - 82,288,014 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36182,115,634 - 82,170,440 (-)NCBIMGSCv36mm8
Celera182,301,640 - 82,360,019 (-)NCBICelera
Cytogenetic Map1C5NCBI
cM Map142.0NCBI
Irs1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554537,685,715 - 7,742,262 (+)Ensembl
ChiLan1.0NW_0049554537,685,715 - 7,742,262 (+)NCBIChiLan1.0ChiLan1.0
IRS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213129,350,601 - 129,415,120 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B129,365,570 - 129,430,086 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B113,973,191 - 114,041,127 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B232,785,822 - 232,853,997 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B232,849,239 - 232,852,967 (-)EnsemblpanPan2panpan1.1
IRS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12539,624,554 - 39,687,991 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2540,246,368 - 40,306,296 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02539,876,307 - 39,936,286 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2539,932,409 - 39,936,152 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12539,811,057 - 39,873,068 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02539,647,771 - 39,707,665 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02539,826,700 - 39,886,691 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Irs1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303181,813,749 - 181,875,259 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365259,064,466 - 9,122,635 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365259,064,442 - 9,125,972 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IRS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15128,245,846 - 128,307,284 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.115128,245,846 - 128,307,321 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215142,086,134 - 142,147,797 (+)NCBISscrofa10.2Sscrofa10.2susScr3
IRS1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110112,748,283 - 112,812,368 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604086,628,478 - 86,694,818 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Irs1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248431,120,974 - 1,178,859 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248431,113,075 - 1,178,859 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Irs1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v14155,129,339 - 155,184,611 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Irs1
481 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:163
Count of miRNA genes:114
Interacting mature miRNAs:143
Transcripts:ENSRNOT00000019579
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)956047863101047863Rat
1582203Gluco19Glucose level QTL 193.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)963376862108376862Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)965657365108376720Rat
724547Cm21Cardiac mass QTL 212.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)986720043110356905Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)94445825699506504Rat
2303178Bp334Blood pressure QTL 3343.70.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)986720043121768150Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)964220169109220169Rat
6903941Pur31Proteinuria QTL 310.036urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)98672213292642305Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)964220169109220169Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)944458256121768150Rat
11353949Bp393Blood pressure QTL 393arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)99062451792642305Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)964220169109220169Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)968875497121768150Rat
1354626Bvd1Brain ventricular dilatation QTL 13.730.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)983161999118999486Rat
4889852Pur26Proteinuria QTL 26150.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)985262459109044727Rat
7794784Mcs31Mammary carcinoma susceptibility QTL 312.98mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)985262459118999486Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)948718864108376862Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)964220169109220169Rat
4889943Bss90Bone structure and strength QTL 904.1tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)95450650499506504Rat

Markers in Region
D9Wox25  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2983,605,650 - 83,605,766 (+)MAPPERmRatBN7.2
Rnor_6.0988,086,342 - 88,086,457NCBIRnor6.0
Rnor_5.0987,835,102 - 87,835,217UniSTSRnor5.0
RGSC_v3.4981,637,925 - 81,638,040UniSTSRGSC3.4
Celera981,050,104 - 81,050,219UniSTS
Cytogenetic Map9q34UniSTS
D9Wox26  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2983,602,435 - 83,602,639 (+)MAPPERmRatBN7.2
Rnor_6.0988,083,127 - 88,083,330NCBIRnor6.0
Rnor_5.0987,831,887 - 87,832,090UniSTSRnor5.0
RGSC_v3.4981,634,710 - 81,634,913UniSTSRGSC3.4
Celera981,046,889 - 81,047,092UniSTS
Cytogenetic Map9q34UniSTS
UniSTS:464713  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2983,601,592 - 83,601,734 (+)MAPPERmRatBN7.2
Rnor_6.0988,082,284 - 88,082,425NCBIRnor6.0
Rnor_5.0987,831,044 - 87,831,185UniSTSRnor5.0
RGSC_v3.4981,633,867 - 81,634,008UniSTSRGSC3.4
Celera981,046,046 - 81,046,187UniSTS
Cytogenetic Map9q34UniSTS
UniSTS:464712  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2983,602,226 - 83,602,598 (+)MAPPERmRatBN7.2
Rnor_6.0988,082,918 - 88,083,289NCBIRnor6.0
Rnor_5.0987,831,678 - 87,832,049UniSTSRnor5.0
RGSC_v3.4981,634,501 - 81,634,872UniSTSRGSC3.4
Celera981,046,680 - 81,047,051UniSTS
Cytogenetic Map9q34UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 154 91 90 59 86 59 6 349 186 11 133 80 92 31 13 13

Sequence


Ensembl Acc Id: ENSRNOT00000019579   ⟹   ENSRNOP00000019579
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl990,997,697 - 91,054,538 (-)Ensembl
mRatBN7.2 Ensembl983,548,944 - 83,606,122 (-)Ensembl
Rnor_6.0 Ensembl988,033,668 - 88,086,488 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000144395   ⟹   ENSRNOP00000101528
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl990,993,519 - 91,054,525 (-)Ensembl
RefSeq Acc Id: NM_012969   ⟹   NP_037101
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8991,001,137 - 91,053,959 (-)NCBI
mRatBN7.2983,552,964 - 83,605,797 (-)NCBI
Rnor_6.0988,033,668 - 88,086,488 (-)NCBI
Rnor_5.0987,782,499 - 87,835,248 (-)NCBI
RGSC_v3.4981,585,251 - 81,638,071 (-)RGD
Celera980,997,490 - 81,050,250 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_037101 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAA41264 (Get FASTA)   NCBI Sequence Viewer  
  EDL75502 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000101528
GenBank Protein P35570 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_037101   ⟸   NM_012969
- UniProtKB: P35570 (UniProtKB/Swiss-Prot),   G3V7V7 (UniProtKB/TrEMBL),   A6JW94 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000019579   ⟸   ENSRNOT00000019579
Ensembl Acc Id: ENSRNOP00000101528   ⟸   ENSRNOT00000144395
Protein Domains
IRS-type PTB   PH

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P35570-F1-model_v2 AlphaFold P35570 1-1235 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696795
Promoter ID:EPDNEW_R7320
Type:single initiation site
Name:Irs1_1
Description:insulin receptor substrate 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0988,086,546 - 88,086,606EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2922 AgrOrtholog
BioCyc Gene G2FUF-26987 BioCyc
Ensembl Genes ENSRNOG00000014597 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000144395 ENTREZGENE
Gene3D-CATH 2.30.29.30 UniProtKB/Swiss-Prot
InterPro IRS UniProtKB/Swiss-Prot
  IRS_PTB UniProtKB/Swiss-Prot
  PH-like_dom_sf UniProtKB/Swiss-Prot
  PH_domain UniProtKB/Swiss-Prot
KEGG Report rno:25467 UniProtKB/Swiss-Prot
NCBI Gene 25467 ENTREZGENE
PANTHER INSULIN RECEPTOR SUBSTRATE 1 UniProtKB/Swiss-Prot
  PTHR10614 UniProtKB/Swiss-Prot
Pfam IRS UniProtKB/Swiss-Prot
  PF00169 UniProtKB/Swiss-Prot
PharmGKB IRS1 RGD
PhenoGen Irs1 PhenoGen
PRINTS INSULINRSI UniProtKB/Swiss-Prot
PROSITE IRS_PTB UniProtKB/Swiss-Prot
  PH_DOMAIN UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000014597 RatGTEx
SMART IRS UniProtKB/Swiss-Prot
  PTBI UniProtKB/Swiss-Prot
  SM00233 UniProtKB/Swiss-Prot
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot
TIGR TC236234
UniProt A6JW94 ENTREZGENE, UniProtKB/TrEMBL
  G3V7V7 ENTREZGENE, UniProtKB/TrEMBL
  IRS1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Irs1  Insulin receptor substrate 1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_physical_interaction binds phosphatidylinositol 3-kinase 728920
gene_protein phosphorylated on tyrosines following insulin stimulation 728920