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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2922
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Irs1
Name: insulin receptor substrate 1
Acc ID: CHEBI:16243
Term: quercetin
Definition: A pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. It is one of the most abundant flavonoids in edible vegetables, fruit and wine.
Chemical ID: MESH:D011794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTDQuercetin inhibits the reaction [Dehydroepiandrosterone results in decreased phosphorylation of IRS1 protein], Quercetin inhibits the reaction [Fructose results in decreased phosphorylation of IRS1 protein]

PMID:22426011, PMID:27634381
decreases expressionISORGD:7334736480464CTDQuercetin results in decreased expression of IRS1 mRNA, Quercetin results in decreased expression of IRS1 protein

PMID:12653748, PMID:21632981
multiple interactionsISORGD:108166480464CTDQuercetin inhibits the reaction [IGF1 protein results in increased phosphorylation of IRS1 protein]

PMID:24353828
multiple interactionsISORGD:7334736480464CTDQuercetin inhibits the reaction [Palmitates inhibits the reaction [INS protein results in increased phosphorylation of IRS1 protein]], Quercetin inhibits the reaction [Palmitates results in increased phosphorylation of IRS1 protein]

PMID:23504962
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.