GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Irs1 | decreases expression | ISO | IRS1 (Homo sapiens) | 6480464 | CTD | Glucose results in decreased expression of IRS1 protein; Glucose results in decreased expression of IRS1 protein modified form | PMID:24262486 | Irs1 | decreases phosphorylation | ISO | IRS1 (Homo sapiens) | 6480464 | CTD | Glucose results in decreased phosphorylation of IRS1 protein | PMID:33957017 | Irs1 | increases phosphorylation | ISO | IRS1 (Homo sapiens) | 6480464 | CTD | Glucose results in increased phosphorylation of IRS1 protein | PMID:10430617 | Irs1 | multiple interactions | ISO | IRS1 (Homo sapiens) | 6480464 | CTD | ACACB protein affects the reaction [Glucose results in decreased phosphorylation of IRS1 protein]; Catechin inhibits the reaction [Glucose results in decreased expression of IRS1 protein modified form]; Catechin inhibits the reaction [Glucose results in decreased expression of IRS1 protein]; Glucose promotes the reaction [PIK3R1 protein binds to IRS1 protein]; IRS1 protein polymorphism inhibits the reaction [Glucose results in increased secretion of INS protein]; Plant Extracts inhibits the reaction [Glucose results in decreased expression of IRS1 protein modified form]; Plant Extracts inhibits the reaction [Glucose results in decreased expression of IRS1 protein] | PMID:10430617 PMID:24262486 PMID:33957017 | | ||||||||||||||||||||||
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