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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2922
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Irs1
Name: insulin receptor substrate 1
Acc ID: CHEBI:5078
Term: flavonol
Definition: A monohydroxyflavone that is the 3-hydroxy derivative of flavone.
Chemical ID: MESH:C041477
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:7334736480464CTD3-hydroxyflavone inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of IRS1 protein]

PMID:17458902
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.