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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2922
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Irs1
Name: insulin receptor substrate 1
Acc ID: CHEBI:40279
Term: allopurinol
Definition: A bicyclic structure comprising a pyrazole ring fused to a hydroxy-substituted pyrimidine ring.
Chemical ID: MESH:D000493
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTDAllopurinol inhibits the reaction [Fructose results in decreased phosphorylation of IRS1 protein]

PMID:22426011
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.