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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2922
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Irs1
Name: insulin receptor substrate 1
Acc ID: CHEBI:28790
Term: serotonin
Definition: A primary amino compound that is the 5-hydroxy derivative of tryptamine.
Chemical ID: MESH:D012701
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:108166480464CTD[[Ketanserin inhibits the reaction [Serotonin results in increased activity of AKT1 protein]] promotes the reaction [Serotonin inhibits the reaction [IRS1 protein binds to YWHAB protein]]] which results in increased ubiquitination of and results in increased degradation of IRS1 protein, [Ketanserin inhibits the reaction [Serotonin results in increased activity of AKT1 protein]] promotes the reaction [Serotonin inhibits the reaction [IRS1 protein binds to YWHAB protein]], [sarpogrelate results in increased activity of AKT1 protein] inhibits the reaction [Serotonin results in increased ubiquitination of and results in increased degradation of IRS1 protein], Serotonin affects the localization of and results in increased ubiquitination of and results in increased degradation of IRS1 protein, Serotonin inhibits the reaction [IRS1 protein binds to YWHAB protein]

PMID:22975078
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.