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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2922
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Irs1
Name: insulin receptor substrate 1
Acc ID: CHEBI:50102
Term: N-methyl-N-nitrosourea
Definition: A member of the class of N-nitrosoureas that is urea in which one of the nitrogens is substituted by methyl and nitroso groups.
Chemical ID: MESH:D008770
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases phosphorylationEXP 6480464CTDMethylnitrosourea results in increased phosphorylation of IRS1 protein

PMID:16237195
multiple interactionsEXP 6480464CTDHexachlorobenzene inhibits the reaction [Methylnitrosourea results in increased phosphorylation of IRS1 protein]

PMID:16237195
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.