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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2922
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Irs1
Name: insulin receptor substrate 1
Acc ID: CHEBI:42758
Term: aldehydo-D-glucose
Definition: The open chain form of D-glucose.
Chemical ID: MESH:D005947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:7334736480464CTDGlucose results in decreased expression of IRS1 protein, Glucose results in decreased expression of IRS1 protein modified form

PMID:24262486
increases phosphorylationISORGD:7334736480464CTDGlucose results in increased phosphorylation of IRS1 protein

PMID:10430617
multiple interactionsISORGD:7334736480464CTDCatechin inhibits the reaction [Glucose results in decreased expression of IRS1 protein modified form], Catechin inhibits the reaction [Glucose results in decreased expression of IRS1 protein], Glucose promotes the reaction [PIK3R1 protein binds to IRS1 protein], IRS1 protein polymorphism inhibits the reaction [Glucose results in increased secretion of INS protein], Plant Extracts inhibits the reaction [Glucose results in decreased expression of IRS1 protein modified form], Plant Extracts inhibits the reaction [Glucose results in decreased expression of IRS1 protein]

PMID:10430617, PMID:24262486
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.