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Effects of selenium and exendin-4 on glucagon-like peptide-1 receptor, IRS-1, and Raf-1 in the liver of diabetic rats.

Authors: Barakat, GM  Moustafa, ME  Bikhazi, AB 
Citation: Barakat GM, etal., Biochem Genet. 2012 Dec;50(11-12):922-35. doi: 10.1007/s10528-012-9532-2. Epub 2012 Sep 16.
Pubmed: (View Article at PubMed) PMID:22983684
DOI: Full-text: DOI:10.1007/s10528-012-9532-2

Selenium and exendin-4 exert antidiabetic effects by unknown mechanisms. Herein, we investigated their effects on the expression of glucagon-like peptide-1 receptor (GLP-1R), insulin receptor substrate-1 (IRS-1), and Raf-1 in the livers of rats with streptozotocin-induced diabetes. Diabetic rats were injected intraperitoneally with exendin-4 (0.03 mug/kg body weight) twice daily or treated with 5 ppm selenium as sodium selenite in drinking water for 4 weeks. Both selenium and exendin-4 reduced the hyperglycemia in diabetic rats. Induction of diabetes mellitus resulted in decreased level of GLP-1R and increased levels of IRS-1 and Raf-1 in the liver. Treatment of diabetic rats with selenium or exendin-4 resulted in increased level of GLP-1R and decreased levels of IRS-1 and Raf-1 in the liver, compared with the levels in diabetic rats. Therefore, the antidiabetic actions of selenium and exendin-4 involve their effects on GLP-1R, IRS-1, and Raf-1 levels in the liver.


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RGD Object Information
RGD ID: 7207061
Created: 2013-01-17
Species: All species
Last Modified: 2013-01-17
Status: ACTIVE


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